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  • Open Access

    ARTICLE

    Screen for autophagy-related biomarkers in osteoarthritis based on bioinformatic analysis

    CHAO LIU*

    BIOCELL, Vol.48, No.2, pp. 339-351, 2024, DOI:10.32604/biocell.2023.047044

    Abstract Introduction: Osteoarthritis (OA) is still an important health problem, and understanding its pathological mechanisms is essential for its diagnosis and treatment. There is evidence that autophagy may play a role in OA progression, but the exact mechanism remains unclear. Methods: In this study, we adopted a multi-prong approach to systematically identify the key autophagy-related genes (ARGs) associated with OA. Through weighted gene co-expression network analysis, we initially identified significant gene modules associated with OA. Subsequent differential gene analysis performed on normal and OA specimens. Further analysis later using the MCC algorithm highlighted hub ARGs. These genes were then incorporated into… More >

  • Open Access

    REVIEW

    New insight into the role of exosomes in idiopathic membrane nephropathy

    JIANHONG LIU1,#, KAI HE2,#, HAN WANG3,#, XIAOHONG CHENG1,*

    BIOCELL, Vol.48, No.1, pp. 21-32, 2024, DOI:10.32604/biocell.2023.045631

    Abstract Exosomes, nanoscale extracellular vesicles (EVs) derived from the invagination of the endosomal membrane, are secreted by a majority of cell types. As carriers of DNA, mRNA, proteins, and microRNAs, exosomes are implicated in regulating biological activities under physiological and pathological conditions. Kidney-derived exosomes, which vary in origin and function, may either contribute to the pathogenesis of disease or represent a potential therapeutic resource. Membranous nephropathy (MN), an autoimmune kidney disease characterized by glomerular damage, is a predominant cause of nephrotic syndrome. Notably, MN, especially idiopathic membranous nephropathy (IMN), often results in end-stage renal disease (ESRD), affecting approximately 30% of patients… More > Graphic Abstract

    New insight into the role of exosomes in idiopathic membrane nephropathy

  • Open Access

    ARTICLE

    A Work Review on Clinical Laboratory Data Utilizing Machine Learning Use-Case Methodology

    Uma Ramasamy*, Sundar Santhoshkumar

    Journal of Intelligent Medicine and Healthcare, Vol.2, pp. 1-14, 2024, DOI:10.32604/jimh.2023.046995

    Abstract More than 140 autoimmune diseases have distinct autoantibodies and symptoms, and it makes it challenging to construct an appropriate model using Machine Learning (ML) for autoimmune disease. Arthritis-related autoimmunity requires special attention. Although many conventional biomarkers for arthritis have been established, more biomarkers of arthritis autoimmune diseases remain to be identified. This review focuses on the research conducted using data obtained from clinical laboratory testing of real-time arthritis patients. The collected data is labelled the Arthritis Profile Data (APD) dataset. The APD dataset is the retrospective data with many missing values. We undertook a comprehensive APD dataset study comprising four… More >

  • Open Access

    ARTICLE

    NAD+ associated genes as potential biomarkers for predicting the prognosis of gastric cancer

    XIANGDONG SUN1,2,#, HUIJUAN WEN1,2,#, FAZHAN LI1,2, IHTISHAM BUKHARI1,2, FEIFEI REN1,2, XIA XUE1,2, PENGYUAN ZHENG1,2,*, YANG MI1,2,*

    Oncology Research, Vol.32, No.2, pp. 283-296, 2024, DOI:10.32604/or.2023.044618

    Abstract Nicotinamide adenine dinucleotide (NAD+) plays an essential role in cellular metabolism, mitochondrial homeostasis, inflammation, and senescence. However, the role of NAD+-regulated genes, including coding and long non-coding genes in cancer development is poorly understood. We constructed a prediction model based on the expression level of NAD+ metabolism-related genes (NMRGs). Furthermore, we validated the expression of NMRGs in gastric cancer (GC) tissues and cell lines; additionally, β-nicotinamide mononucleotide (NMN), a precursor of NAD+, was used to treat the GC cell lines to analyze its effects on the expression level of NMRGs lncRNAs and cellular proliferation, cell cycle, apoptosis, and senescence-associated secretory… More > Graphic Abstract

    NAD+ associated genes as potential biomarkers for predicting the prognosis of gastric cancer

  • Open Access

    REVIEW

    A perspective on molecular and cellular biology-based developmental toxicology biomarkers

    SUKHENDU DEY1,#, SANDIPAN PAL2,#, APURBA RATAN GHOSH1, PALAS SAMANTA3,*

    BIOCELL, Vol.47, No.12, pp. 2579-2590, 2023, DOI:10.32604/biocell.2023.031114

    Abstract The process of development is intricate and couple-dependent phenomenon. Accordingly, the study of molecular and cellular biology-based developmental toxicology biomarkers increasingly is becoming an important part of risk assessment and management of chemicals for detection of health outcomes and/or biological endpoint like cytotoxicity, cell death, etc. Since, the evolution of developmental toxicology field a number of tools/markers have been developed or addressed to deal with developmental outcomes, which can ultimately be used for the development of adverse outcome pathways (AOPs) of developmental toxicants. As a result, this paper provides an overview of the current state of developmental toxicology biomarkers and… More >

  • Open Access

    REVIEW

    The bacterial small RNAs: The new biomarkers of oral microbiota-associated cancers and diseases

    MENGYING MAO1,2,3,#, TING DONG1,2,3,#, YANJING LIANG3,4, KEYONG YUAN1,2,3, QIAOQIAO JIN1,2,3, PENGFEI ZHANG1,2,3, ZHENGWEI HUANG1,2,3,*

    BIOCELL, Vol.47, No.10, pp. 2187-2193, 2023, DOI:10.32604/biocell.2023.042357

    Abstract The oral microbiota is a vital part of the human microbiota that functions in various physiological processes and is highly relevant to cancers and other diseases. With the alterations of host immune competence, the homeostatic balance existing between the oral microbiota and host may be disturbed and result in the development of diseases. Numerous observations have suggested that small RNAs are key regulators of bacterial pathogenesis and bacteria-host interactions. Further, bacterial small RNAs are considered to be promising biomarkers for the development of novel, and efficacious therapies for oral dysbiosis. Mechanistic insights into how oral pathogens communicate with other bacteria… More > Graphic Abstract

    The bacterial small RNAs: The new biomarkers of oral microbiota-associated cancers and diseases

  • Open Access

    REVIEW

    Cellular and molecular insights into microbiota-mitochondria interplay, therapeutic biomarkers and interventional approaches in COVID-19: A review

    VIBHAV VARSHNEY1,*, PRASHANT SINGH KUSHWAH2, NEETU AGRAWAL1, AHSAS GOYAL1,*, GOVIND SINGH2

    BIOCELL, Vol.47, No.10, pp. 2141-2149, 2023, DOI:10.32604/biocell.2023.030853

    Abstract The persistent global pandemic, COVID-19, stems from the pathogenic influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yielding an unprecedented worldwide crisis. With reference to a WHO report, the count of COVID-19 cases had exceeded 754 million by February 03, 2023. Intriguingly, emerging research has spotlighted the intricate interplay of gut microbiota and mitochondrial entities, acting as potent immunomodulatory factors at the cellular and molecular levels. This interconnection operates through a series of dynamic mechanisms. SARS-CoV-2 infection perturbs the delicate equilibrium of gut microbiota, leading to dysbiosis—a signature biomarker. This imbalance is intrinsically linked to exacerbated COVID-19 progression. Mechanistically,… More >

  • Open Access

    ARTICLE

    Identification of lncRNAs associated with T cells as potential biomarkers and therapeutic targets in lung adenocarcinoma

    LU SUN1,2, HUAICHENG TAN1, TING YU3, RUICHAO LIANG4,*

    Oncology Research, Vol.31, No.6, pp. 967-988, 2023, DOI:10.32604/or.2023.042309

    Abstract Lung adenocarcinoma (LUAD) is the most common and deadliest subtype of lung cancer. To select more targeted and effective treatments for individuals, further advances in classifying LUAD are urgently needed. The number, type, and function of T cells in the tumor microenvironment (TME) determine the progression and treatment response of LUAD. Long noncoding RNAs (lncRNAs), may regulate T cell differentiation, development, and activation. Thus, our aim was to identify T cell-related lncRNAs (T cell-Lncs) in LUAD and to investigate whether T cell-Lncs could serve as potential stratifiers and therapeutic targets. Seven T cell-Lncs were identified to further establish the T… More >

  • Open Access

    ARTICLE

    Clinical implication of naive and memory T cells in locally advanced cervical cancer: A proxy for tumor biology and short-term response prediction

    YUTING WANG1,2,3, PEIWEN FAN1,2,3, YANING FENG1,2,3, XUAN YAO4, YANCHUN PENG4, RUOZHENG WANG1,2,3,*

    BIOCELL, Vol.47, No.6, pp. 1365-1375, 2023, DOI:10.32604/biocell.2023.027201

    Abstract Background: This study was designed to investigate the feasibility of tumor-infiltrating immune cells with different phenotypic characteristics for predicting short-term clinical responses in patients with locally advanced cervical cancer (LACC). Methods: Thirty-four patients who received concurrent chemoradiotherapy and twenty-one patients who merely underwent radiotherapy were enrolled in this study. We retrospectively analyzed the T cell markers (i.e., CD3, CD4, CD8), memory markers (i.e., CD45, CCR7), and differentiation markers (i.e., CD27) in the peripheral blood and tumor tissues of patients with LACC before treatment based on flow cytometry. We also analyzed the relationship of T cell subsets between peripheral blood and… More >

  • Open Access

    ARTICLE

    Proteomics analysis provides novel biomarkers and therapeutic target candidates in the treatment of the Huang-Pu-Tong-Qiao formula in an AD rat model

    QIAN CHEN1,#, XIN LEI1,#, GUANHUA HU1,#, YAN WANG2, ZHENGQING FANG1, GUOQUAN WANG1, HANG SONG1, SHU YE1,*, BIAO CAI1,*

    BIOCELL, Vol.47, No.6, pp. 1265-1277, 2023, DOI:10.32604/biocell.2023.028811

    Abstract Background: Huang-Pu-Tong-Qiao formula (HPTQ), a traditional Chinese herbal formula, has a variety of pharmacological effects. It has been used to treat Alzheimer’s disease (AD) for decades. This study aimed to screen differentially expressed proteins in the hippocampus of AD model rats treated with HPTQ. Proteomic studies of the effects of HPTQ on AD are key to understanding the therapeutic mechanisms of HPTQ and identifying potential therapeutic targets. Methods: We hence used the isobaric tags for relative and absolute quantification (ITRAQ) approach to investigate the differentially expressed proteins in the hippocampus of AD model rats before and after HPTQ administration and… More >

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