Wen-Shou Tan^1,#, Hsuan Kuo^2,#, Chang-Ge Jiang¹, Mei-Han Lu¹, Yi-He Lu¹, Yung-Li Wang¹, Ching-Shuen Wang¹, Thi Thuy Tien Vo³, I-Ta Lee^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070871 - 30 December 2025

Abstract This narrative review examines recent advances in salivary biomarkers for oral squamous cell carcinoma (OSCC), a major subtype of oral cancer with persistently low five-year survival rates due to delayed diagnosis. Saliva has emerged as a noninvasive diagnostic medium capable of reflecting both local tumor activity and systemic physiological changes. Various salivary biomarkers, including microRNAs, cytokines, proteins, metabolites, and exosomes, have been linked to oncogenic signaling pathways involved in tumor progression, immune modulation, and therapeutic resistance. Advances in quantitative polymerase chain reaction, mass spectrometry, and next-generation sequencing have enabled comprehensive biomarker profiling, while point-of-care detection More >

Sandra Kałużna^1,*, Monika Świerczewska^1,2, Sylwia Ciesiółka¹, Małgorzata Partyka¹, Michał Nowicki¹, Karolina Wojtowicz¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070356 - 30 December 2025

Abstract The last research focuses on the role of exosomes in cancer treatment. Exosomes are extracellular vesicles. They can be secreted by cancer cells, and they can modulate chemotherapy sensitivity. Determining exosomal content opens the possibility for guiding treatment strategies for cancer diseases. Exosomal microRNA are considered one of the prime candidates for exosomal biomarkers. Exosomal circular RNAs represent excellent biomarkers for liquid biopsy because of their stability in many types of cancer. Exosomal proteins remain reliable biomarkers also. Exosomes have emerged as promising therapeutic candidates. Their biological properties render them ideal vectors for drug delivery.… More >

Ashok Kumar Sah^1,*, Ranjay Kumar Choudhary^1,2, Velilyaeva Alie Sabrievna³, Karomatov Inomdzhon Dzhuraevich⁴, Anass M. Abbas⁵, Manar G. Shalabi⁵, Nadeem Ahmad Siddique⁶, Raji Rubayyi Alshammari⁷, Navjyot Trivedi⁸, Rabab H. Elshaikh¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068238 - 30 December 2025

Abstract Male breast cancer (MBC) is rare, representing 0.5%–1% of all breast cancers, but its incidence is increasing due to improved diagnostics and awareness. MBC typically presents in older men, is human epidermal growth factor receptor 2 (HER2)-negative and estrogen receptor (ER)-positive, and lacks routine screening, leading to delayed diagnosis and advanced disease. Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations. Clinically, it may resemble gynecomastia but usually appears as a unilateral, painless mass or nipple discharge. Advances in imaging and liquid biopsy have More >

Ilhong Son^1,2, Sun Jung Han², Dong Hwan Ho^1,3,*

BIOCELL, Vol.49, No.12, pp. 2283-2297, 2025, DOI:10.32604/biocell.2025.071119 - 24 December 2025

Abstract The potential of urinary biomarkers to facilitate non-invasive monitoring of Parkinson’s disease (PD) is a promising avenue, offering insights into the complex pathophysiology of the disease. The aggregation of α-synuclein, a central feature of PD, can be detected in urine, providing a diagnostic clue. Mutations in the LRRK2 gene, associated with increased kinase activity, can be estimated through the measurement of phosphorylated LRRK2 (pS1292) in urine. Oxidative stress, a hallmark of PD, is reflected in elevated levels of oxidized DJ-1 (oxDJ-1) in urine. Beyond these core biomarkers, other urinary components like DOPA decarboxylase, acetyl phenylalanine, More >

Xinke Chai, Shifeng Wu, Qian Shen, Qiulin Huang^*

Oncology Research, Vol.33, No.12, pp. 3731-3752, 2025, DOI:10.32604/or.2025.067546 - 27 November 2025

Abstract Gastric cancer (GC) is a prevalent malignant tumor globally, with high incidence and mortality rates. Advances in understanding molecular mechanisms underlying GC have highlighted the role of microRNAs (miRNAs) in its initiation, progression, and treatment. The Let-7 family, an important class of miRNAs, is closely associated with the biological behaviors of GC. Aberrant expression of various Let-7 family members in GC patients contributes to disease progression, as they target multiple molecular pathways and participate in diverse regulatory mechanisms throughout GC pathogenesis. This article systematically summarizes the expression patterns of Let-7 family members in GC, explores More >

Lihao Zhang^1,2, Lin Cao^1,2, Lige Huang^1,2, Jie Wang^1,2, Jiabing Li^2,3,*

Canadian Journal of Urology, Vol.32, No.5, pp. 457-468, 2025, DOI:10.32604/cju.2025.067364 - 30 October 2025

Abstract Background: Studies have indicated an association between inflammatory factors (IFs) in the blood and the development of bladder cancer (BC). This study aimed to explore the correlation and clinical significance of IFs with the pathological grading of BC. Methods: A retrospective analysis was conducted on the preoperative blood routine results, postoperative pathological findings, and baseline information of 163 patients. Patients were divided into high-grade and low-grade groups based on pathological grading. Group comparisons and logistic regression analyses were performed using R software version 4.1.3 to explore the relationships between IFs and BC pathological grading. Results: The… More >

Hui Yi^1,2,#, Hongjian Shi^2,3,#, Fuquan Kan^2,4,#, Fan Han², Lei Wan⁵, Xiaoyang Hong¹, Zhe Zhao¹, Junjie Shao², Gang Wang¹, Hui Wang¹, Hua Yan⁵, Xiujuan Shi¹, Ran Zhang^2,6,*, Gengxu Zhou^1,*

Congenital Heart Disease, Vol.20, No.4, pp. 519-530, 2025, DOI:10.32604/chd.2025.067164 - 18 September 2025

Abstract Background: To investigate the impact of preoperative extracorporeal membrane oxygenation (ECMO) on clinical outcomes in pediatric heart transplantation (PHT). Methods: This retrospective cohort analysis was conducted on 19 pediatric heart transplant recipients, divided into two groups: ECMO and non-ECMO, based on whether preoperative ECMO was utilized. We evaluated the patients’ surgical conditions, postoperative complications, and survival rates. Additionally, the analysis focused on the differences and correlations in clinical characteristics, inflammatory markers, and long-term survival outcomes. Results: There was no statistically significant difference in perioperative survival rates between the ECMO group (85.7%) and the non-ECMO group (83.3%). However,… More >

Shuyan Kong^1,#, Danting Li^1,#, Haonan Meng^1,#, Haoxiang Zhang¹, Xiaochun Jiang¹, Peilin Zheng², Shoujun Huang^1,*

BIOCELL, Vol.49, No.8, pp. 1481-1504, 2025, DOI:10.32604/biocell.2025.066205 - 29 August 2025

Abstract Background: Small ubiquitin-like modifier (SUMO)-specific proteases (SENPs) cleave the isopeptidic bond between SUMO1/2/3 and protein substrates, thus regulating the structure, activity, and lifetime of a variety of proteins. Recently, accumulating evidence has suggested that SENPs play a role in the initiation and progression of human cancers. Nevertheless, the potential role of the SENP family of proteins in liver cancer has yet to be fully elucidated. Methods: This study conducted a comprehensive bioinformatics analysis of the SENP family in liver cancer, including differential expression profiling, survival analysis, mutation and copy number variations (CNVs) assessment, immune infiltration… More >

Alejandra Sánchez-Reyna¹, Yolanda González-García², Ángel Gabriel Alpuche-Solís³, Gregorio Cadenas-Pliego⁴, Adalberto Benavides-Mendoza^5,6, Antonio Juárez-Maldonado^6,7,*

Phyton-International Journal of Experimental Botany, Vol.94, No.7, pp. 2097-2116, 2025, DOI:10.32604/phyton.2025.067092 - 31 July 2025

Abstract Tomato is an economically important crop that is susceptible to biotic and abiotic stresses, situations that negatively affect the crop cycle. Biotic stress is caused by phytopathogens such as Fusarium oxysporum f. sp. lycopersici (FOL), responsible for vascular wilt, a disease that causes economic losses of up to 100% in crops of interest. Nanomaterials represent an area of opportunity for pathogen control through stimulations that modify the plant development program, achieving greater adaptation and tolerance to stress. The aim of this study was to evaluate the antimicrobial capacity of the nanoparticles and the concentrations used in tomato… More >

Gloria Krajnc¹, Lara Metlika², Uroš Potočnik^1,2,3, Boris Gole^2,*

BIOCELL, Vol.49, No.6, pp. 991-1017, 2025, DOI:10.32604/biocell.2025.063486 - 24 June 2025

Abstract Vedolizumab is a humanized monoclonal antibody and one of the safest biologics for the treatment of both forms of inflammatory bowel disease (IBD)-Crohn’s disease and ulcerative colitis. It targets the α4β7 integrin and blocks leukocyte trafficking to the gut. Regardless of its efficacy in many patients, non-response to vedolizumab treatment poses a significant clinical challenge. In this review, we synthesize recent findings on genomic, transcriptomic, proteomic, and cellular biomarkers of vedolizumab response, emphasizing their roles in predicting therapeutic outcomes and understanding non-responsiveness. Key insights include the identification of epigenetic and transcriptomic signatures, the involvement of More >