Libin Wang^1,2,3,#, Xiaohan Li^1,3,#, Jinhai Tian^1,2,3, Jingjing Yu^1,2,3, Qi Huang^1,2,3, Rong Ma^1,2,3, Jia Wang^1,2,3, Jia Cao^1,2,3, Jinping Li^4,*, Xu Zhang^1,2,3,*

Oncologie, Vol.24, No.4, pp. 789-801, 2022, DOI:10.32604/oncologie.2022.026589 - 31 December 2022

Abstract Background: To investigate the characteristics of circular RNA hsa-circ-0006969 in breast cancer and identify it as a novel biomarker for breast cancer. Methods: Three breast cancer (BC) patient tissues were selected to perform human circRNA microarray analysis. GeneSpring 13.0 (Agilent) software was applied for analyzing the data. Another 116 BC patients were recruited for verification. Hsa-circ-0006969 was found as a potential circRNA for BC diagnostic biomarker. The structure of hsa-circ-0006969 was predicted by circPrimer1.2 software. MiRanda v3.3, RNA hybrid 2.1, and Cytoscape 3.6.0 were used for predicting the networks of circRNA-miRNA. T-test, Curve regression, and ROC… More >

Lei Hu^1,2,#, Meng Chen^2,3,#, Haiming Dai^2,3,4, Hongzhi Wang^2,3,4,*, Wulin Yang^2,3,4,*

Oncologie, Vol.24, No.4, pp. 803-822, 2022, DOI:10.32604/oncologie.2022.026419 - 31 December 2022

Abstract Background and Aim: Hundreds of consistently altered metabolic genes have been identified in breast cancer (BC), but their prognostic value remains to be explored. Therefore, we aimed to build a prediction model based on metabolism-related genes (MRGs) to guide BC prognosis. Methods: Current work focuses on constructing a novel MRGs signature to predict the prognosis of BC patients using MRGs derived from the Virtual Metabolic Human (VMH) database, and expression profiles and clinicopathological data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Results: The 3-MRGs-signature constructed by SERPINA1, QPRT and PXDNL was found… More >

Junwei Cui¹, Minghua Li², Ruifang Pang^2,*, Yinhua Liu^1,*

Oncologie, Vol.24, No.4, pp. 743-768, 2022, DOI:10.32604/oncologie.2022.025419 - 31 December 2022

Abstract Background: Aspirin (ASA) has been reported to have an antitumor effect but the role of ASA in the prevention and treatment of breast cancer (BC) is still controversial. This study aimed to identify clinical effectiveness of ASA in the treatment of BC and explore the antitumor target proteins of ASA that may be involved in overcoming tamoxifen resistance in estrogen receptor (ER)-positive BC cells. Materials and Methods: Randomized controlled trials (RCTs) of ASA in the treatment of BC were queried from the databases, including PubMed, Web of Science, Cochrane Library, WanFang, and Chinese National Knowledge Infrastructure. According… More >

Qian Zhang^1,2,#, Yuanyuan Cao^2,#, Mingming Fang³, Qin Yang², Pingyang Zhang^1,*

Oncologie, Vol.24, No.4, pp. 717-727, 2022, DOI:10.32604/oncologie.2022.026998 - 31 December 2022

Abstract Background: Breast cancer (BC) is the most common malignant tumor in women, and its morbidity and mortality are increasing each year, due to the lack of specific clinical symptoms in the early stage of BC, and the lack of diagnostic methods for early breast cancer. Therefore, identifying an effective diagnostic method for early BC has become urgent. Materials and Methods: Breast lesions with a histological diagnosis that were examined by ultrasonic elastography (UE) in our department from June 2020 to December 2021 were reviewed. qRT-PCR was performed to measure the expression levels of miR-144-5p and miR-26b-5p in… More >

Xuelian Du^1,#, Hao Shi^2,#, Haiyan Liu¹, Linghua Zhou¹, Anqun Xie¹, Jufang Guo^1,*

Oncologie, Vol.24, No.4, pp. 769-787, 2022, DOI:10.32604/oncologie.2022.026248 - 31 December 2022

Abstract Background: Gestational diabetes mellitus (GDM) affects the health of numerous women around the world. A recent study has shown that GDM is associated with an increased incidence of cancer. In this study, we aimed to explore the possible shared mechanisms and potential common therapeutic targets between GDM and cancer. Methods: The limma package was used to identify differentially expressed genes (DEGs) in GDM. The Cytoscape plugin cytoHubba was used to screen hub genes. The CIBERSORT algorithm was used to explore the correlation between hub genes and immunity. Cox regression analysis was used to assess the relationship… More >

Yu Xiao^1,2,#, Jianping Jiang^3,#, Yan Chen^1,4, Yi Huang¹, Changyuan Wei^1,*

Oncologie, Vol.24, No.4, pp. 729-742, 2022, DOI:10.32604/oncologie.2022.026118 - 31 December 2022

Abstract Background: Immunotherapy is becoming a powerful approach in the treatment of breast cancer. However, high response rates in the majority of breast cancer patients have yet to be achieved. Materials and Methods: Based on public data sources, we identified 22 genes that are correlated with PD-1 expression as well as differentially expressed between tumor tissues and normal tissues, and high expression of all the key genes was correlated with a superior survival outcome. Using the least absolute shrinkage and selection operator Cox regression model, a risk score was constructed. Results: A multivariate Cox analysis showed that the… More >

GUODONG XIAO^1,#, FENG CHENG^1,#, JING YUAN¹, WEIPING LU¹, PEILI WANG², HUIJIE FAN^1,*

Oncology Research, Vol.30, No.1, pp. 35-51, 2022, DOI:10.32604/or.2022.026616 - 06 December 2022

Abstract Distant metastasis is a major cause of increased mortality in breast cancer patients, but the mechanisms underlying breast cancer metastasis remain poorly understood. In this study, we aimed to identify a metastasis-related gene (MRG) signature for predicting progression in breast cancer. By screening using three regression analysis methods, a 9-gene signature (NOTCH1, PTP4A3, MMP13, MACC1, EZR, NEDD9, PIK3CA, F2RL1 and CCR7) was constructed based on an MRG set in the BRCA cohort from TCGA. This signature exhibited strong robustness, and its generalizability was verified in the Metabric and GEO cohorts. Of the nine MRGs, EZR… More >

Xujie Zhou^1,2,3,#, Yuting Sang^1,3,#, Jiajian Chen^1,3, Miao Mo^3,4, Jianjing Hou^1,3, Benlong Yang^1,3,*, Jiong Wu^1,2,3,*

Oncologie, Vol.24, No.3, pp. 451-469, 2022, DOI:10.32604/oncologie.2022.025226 - 19 September 2022

Abstract Background: To compare the time-varying recurrence patterns of different molecular subtypes of breast cancer in the contemporary era with those in the past era. Patients and Methods: This retrospective study included 14627 consecutive invasive breast cancer patients who underwent surgery from 2008 to 2016 at Fudan University Shanghai Cancer Center. We defined the period from 2013 to 2016 as the contemporary era and that from 2008 to 2012 as the past era. Five subtypes were defined according to the immunohistochemistry results. Emphasis was made on the changing patterns of recurrence for patients with different molecular subtypes changed… More >

Rong Zeng^1,#, Lin Liu^1,2,#, Jingshan Zhao^1,2,3,#, Wenmei Zhang³, Guohong Zhang¹, Yunfeng Li^1,2,*

Oncologie, Vol.24, No.3, pp. 483-498, 2022, DOI:10.32604/oncologie.2022.025148 - 19 September 2022

Abstract Background: Breast cancer (BC) is the most frequent type of gynecology tumors with high morbidity and mortality. Ampelopsin, the main active compound of Ampelopsis grossedentata, exerts an anti-tumor effect on a variety of cancers. However, the anti-cancer role of ampelopsin in BC remains unclear. The aim of this study is to explore the mechanism of ampelopsin against breast cancer. Materials and Methods: The target genes of ampelopsin in the treatment of breast cancer were determined and analyzed by network pharmacology and molecular docking. Cytoscape software was used to identify the core target genes and construct a protein–protein interaction… More >

Dongliang Zhu^1,*, Jun Yang², Jiaxin Xu³

Oncologie, Vol.24, No.3, pp. 471-482, 2022, DOI:10.32604/oncologie.2022.024062 - 19 September 2022

Abstract G-protein coupled estrogen receptor (GPER) is a transmembrane receptor that mediates non-genomic effects of estrogen. This study aimed to investigate the role of GPER in the stemness formation and malignancies in triple negative breast cancer (TNBC) cells. Spheroids of MDA-MB-468 cells were induced by mammosphere culture, and the proportion of the CD44⁺ /CD24^−/low stem cell subpopulation was detected. Malignant characteristics, expression of GPER and stemness-related markers, and tumorigenesis in a xenograft assay were compared between the mammospheres and adherent cultured cells. The impacts of 17β-estradiol (E2) and the GPER-specific antagonist G15 were studied in in vitro assays.… More >