MASOUMEH OGHABI^1,2, AVA SAFAROGHLI-AZAR^1,2, ATIEH POURBAGHERI-SIGAROODI^1,2, MOHAMMAD SAYYADI³, MOHSEN HAMIDPOUR¹, MOHAMMAD HOSSEIN MOHAMMADI¹, DAVOOD BASHASH^1,*

BIOCELL, Vol.44, No.2, pp. 183-192, 2020, DOI:10.32604/biocell.2020.08880 - 27 May 2020

Abstract Pathogenesis of chronic myeloid leukemia (CML) has mostly been studied with regard to the oncogenic role of BCR/ABL fusion; however, recent disclosures have declared that the challenges with the treatment of CML patients would not be resolved until the role of other aberrancies is ignored. Given the involvement of cyclin-dependent kinases (CDKs) in the pathogenesis of CML, the present study aimed to investigate the effects of a multi-CDK inhibitor AT7519 on BCR/ABL-harboring CML-derived K562 cells. Our results showed that AT7519 effectively reduced the survival of K562 and induced its anti-proliferative effect through the induction of… More >

WENJUAN LI^*, GE SONG

BIOCELL, Vol.44, No.2, pp. 127-135, 2020, DOI:10.32604/biocell.2020.010018 - 27 May 2020

Abstract From late December 2019 a new human-adapted coronavirus, SARS-CoV-2, was observed and isolated in clustered patients in Wuhan, China. It has been proved to be able to transmit human-to-human and cause pneumonia, leading to about 2% fatality. Its genome characteristics, immune responses and related potential treatments, such as chemical drugs, serum transfusion and vaccines including DNA vaccines, are discussed in this review for a brief summary. More >

Bin Zhang^*, Yongzhen Wang, Jiaqing Zheng, Dan Liu

FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.3, pp. 665-674, 2020, DOI:10.32604/fdmp.2020.09314 - 25 May 2020

Abstract The relationship among the working temperature, pressure and current density of a Solid oxide fuel cell (SOFC) and its output power and efficiency are analyzed in the framework of a theoretical model able to provide, among other things, the volt ampere characteristic curve. In particular, following the principle of temperature matching and cascade utilization, we consider a gas turbine (GT) and a LiBr absorption chiller to recycle the high-grade exhaust heat produced by the considered SOFC. This distributed total energy system is set up with the intent to meet typical needs of buildings for cooling, More >

Yongkang Zheng^1,2,*, Chao Yan¹

FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.3, pp. 637-650, 2020, DOI:10.32604/fdmp.2020.09694 - 25 May 2020

Abstract The flow field inside the combustor of a scramjet is highly complicated and the related turbulent Prandtl and Schmidt numbers have a significant impact on the effective numerical prediction of such dynamics. As in many cases researchers set these parameters on the basis of purely empirical laws, assessing their impact (via parametric numerical simulations) is a subject of great importance. In the present work, in particular, two test cases with different characteristics are selected for further evaluation of the role played by these non-dimensional numbers: Burrows-Kurkov case and DLR case. The numerical results indicate that More >

Lin Wang¹, Chunguo An², Nini Wang², Yaming Ping¹, Kun Wang¹, Ming Gao^1,*, Suoying He¹

FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.3, pp. 585-600, 2020, DOI:10.32604/fdmp.2020.09611 - 25 May 2020

Abstract Numerical simulation are conducted to explore the characteristics of the axial inflow and related aerodynamic noise for a large-scale adjustable fan with the installation angle changing from −12° to 12°. In such a range the maximum static (gauge) pressure at the inlet changes from −2280 Pa to 382 Pa, and the minimum static pressure decreases from −3389 Pa to −8000 Pa. As for the axial intermediate flow surface, one low pressure zone is located at the junction of the suction surface and the hub, another is located at the suction surface close to the casing… More >

Chong Liu, Yang Du, Jianjun Liang, Hong Meng, Jian Wang, Peili Zhang^*

FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.3, pp. 537-547, 2020, DOI:10.32604/fdmp.2020.09119 - 25 May 2020

Abstract Gas explosion is a process involving complex hydrodynamics and chemical reactions. In order to investigate the interaction between the flame behavior and the dynamic overpressure resulting from the explosion of a premixed gasoline-air mixture in a confined space, a large eddy simulation (LES) strategy coupled with sub-grid combustion model has been implemented. The considered confined space consists of a long duct and four branches symmetrically distributed on both sides of the long duct. Comparisons between the simulated and experimental results have been considered with regard to the flame structure, flame speed and overpressure characteristics. It… More >

Chunsheng Wang^*, Dongxing Shang

FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.3, pp. 465-473, 2020, DOI:10.32604/fdmp.2020.08828 - 25 May 2020

Abstract Electroosmosis is an effective method for liquid mixing. It is associated with the motion of a liquid in a microchannel induced by an applied electric field. In this manuscript, a numerical model is elaborated and implemented for the case of a straight channel with a single electrode pair. In particular, the Navier-Stokes equation combined with the Convection-diffusion and Helmholtz-Smoluchowski equation are used to simulate the resulting flow field. The influence of various electrode parameters on the mixing efficiency and the related mechanisms are investigated. The numerical results show that a pair of eddies are produced More >

Jing Sun^1,2,3,*, Dehua Liu^1,2,3, Xiang Zhu^1,2,3, Wenjun Huang^1,2,3, Liang Cheng^1,2,3

FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.3, pp. 425-440, 2020, DOI:10.32604/fdmp.2020.08531 - 25 May 2020

Abstract Low permeability tight sandstone reservoirs have a high filtrational resistance and a very low fluid flow rate. As a result, the propagation speed of the formation pressure is low and fluid flow behaves as a non-Darcy flow, which typically displays a highly non-linear behavior. In this paper, the characteristics and mechanism of pressure propagation in this kind of reservoir are revealed through a laboratory pressure propagation experiment and through data from an actual tight reservoir development. The main performance mechanism is as follows: A new pressure cage concept is proposed based on the pressure variation… More >

Hailin Chen¹, Gang Xu³, Yuling Chen², Xiubo Chen^{1, 2, *}, Yixian Yang^{1, 2}, Ruibin Fan⁴, Kaixiang Zhang⁴, Huizhong Li⁴

Journal of Quantum Computing, Vol.2, No.1, pp. 57-83, 2020, DOI:10.32604/jqc.2020.09291 - 28 May 2020

Abstract Most existing blockchain schemes are based on the design concept “openness and transparency” to realize data security, which usually require transaction data to be presented in the form of plaintext. However, it inevitably brings the issues with respect to data privacy and operating performance. In this paper, we proposed a novel blockchain scheme called Cipherchain, which can process and maintain transaction data in the form of ciphertext while the characteristics of immutability and auditability are guaranteed. Specifically in our scheme, transactions can be encrypted locally based on a searchable encryption scheme called multi-user public key More >

Shengyao Wu¹, Wenjie Liu², Zhiguo Qu^{3, *}

Journal of Quantum Computing, Vol.2, No.1, pp. 33-55, 2020, DOI:10.32604/jqc.2019.08898 - 28 May 2020

Abstract In order to improve the anti-noise performance of quantum teleportation, this paper proposes a novel dynamic quantum anti-noise scheme based on the quantum teleportation which transmits single qubit state using Bell state. Considering that quantum noise only acts on the transmitted qubit, i.e., the entangled state that Alice and Bob share in advance is affected by the noise, thus affecting the final transmission result. In this paper, a method for dynamically adjusting the shared entangled state according to the noise environment is proposed. By calculating the maximum fidelity of the output state to determine the More >