Yuqin Xie¹, Shuang Deng¹, Qian Deng², Jiudong Xu^*

Oncologie, Vol.22, No.3, pp. 179-188, 2020, DOI:10.32604/Oncologie.2020.012544

Abstract This study aimed to explore LncRNA TUG1 targeted miR-222-3p in the proliferation and invasion of breast cancer (BC) cells. Seventy-six BC patients admitted to our hospital and 62 health check-ups at the same time were selected as the research objects. Among them, the former was seen as the observation group (OG), and the latter was considered as the control group (CG). The clinical significance of LncRNA TUG1 and miR-222-3p in BC was detected. Human BC cell MCF7 and normal human breast epithelial cell MCF-10A were purchased. After cells were transfected with LncRNA TUG1 and miR-222-3p, their proliferation, invasion, and apoptosis… More >

Haoliang Zhang^1,*, Xiaowei Xing², Yang Liu¹, Shuangli Li¹, Weiyuan Li³

Oncologie, Vol.22, No.2, pp. 107-116, 2020, DOI:10.32604/oncologie.2020.012494

Abstract Lung cancer is the leading cause of death in cancer patients. Based on a modular and comprehensive analysis method, it is intended to identify their common pathogenesis. We downloaded data and analyzed differences in lung adenocarcinoma samples, lung squamous cell carcinoma samples, and normal samples. Co-expression analysis, enrichment analysis, and hypergeometric testing were used to predict transcription factors, ncRNAs, and retrospective target genes. We get 4596 differentially expressed genes in common differences in high multiples and clustered into 14 modules dysfunction. The 14 genes (including DOK2, COL5A1, and TSPAN8) have the highest connectivity in the dysfunction module and are identified… More >

Amin Einipour¹, Mohammad Mosleh^{1, *}, Karim Ansari-Asl^{1, 2}

CMES-Computer Modeling in Engineering & Sciences, Vol.122, No.1, pp. 377-397, 2020, DOI:10.32604/cmes.2020.08496

Abstract The emergence of single-cell RNA-sequencing (scRNA-seq) technology has introduced new information about the structure of cells, diseases, and their associated biological factors. One of the main uses of scRNA-seq is identifying cell populations, which sometimes leads to the detection of rare cell populations. However, the new method is still in its infancy and with its advantages comes computational challenges that are just beginning to address. An important tool in the analysis is dimensionality reduction, which transforms high dimensional data into a meaningful reduced subspace. The technique allows noise removal, visualization and compression of high-dimensional data. This paper presents a new… More >

S. Baragetti¹, A. Terranova²

Structural Durability & Health Monitoring, Vol.1, No.4, pp. 267-276, 2005, DOI:10.3970/sdhm.2005.001.267

Abstract Aim of this work is to investigate into the possibility of enhancing the fatigue resistance of CrN PVD coated components. In particular PVD coated spur gears were tested and numerical simulation of crack propagation was carried out. The coating layer micro-hardness and the residual stresses characterising the surface film were measured and the obtained results were introduced in a numerical modelling predicting fatigue life procedure of coated gears used in gearboxes for automotive applications. The number of cycles necessary to reach specified crack depths of coated and uncoated samples was numerically determined and represents a powerful tool to predict fatigue… More >

Tong MA^{1, §}, Fafen WANG^{2, §}, Xiaohui WANG¹

BIOCELL, Vol.43, No.3, pp. 191-198, 2019, DOI:10.32604/biocell.2019.06989

Abstract Cervical cancer (CC), has been identified as one of the most frequent malignant tumors all over the world, with high mortality in females. A growing number of investigations have confirmed that long noncoding RNAs (lncRNAs) play a crucial role in the progression of multiple cancers. Nonetheless, the biological function and regulatory mechanism of LINC01772 in CC haven’t been explored so far. In this study, LINC01772 expression was found to be upregulated in tissues and cells of CC. Knocking down LINC01772 suppressed CC cell proliferation, migration and epithelial-mesenchymal transition (EMT) process. Through molecular mechanism assays, LINC01772 was verified to be bound… More >

Zahra HOSSEININIA¹, Sara SOLTANIAN², Naser MAHDAVI-SHAHRI³, Hesam DEHGHANI^1,4

BIOCELL, Vol.43, No.3, pp. 145-154, 2019, DOI:10.32604/biocell.2019.06468

Abstract Maintenance of pluripotency depends to diverse regulatory factors. Studies in embryonic stem cells (ESCs) have indicated that large intergenic non-coding RNAs (lincRNAs) are involved in the regulatory network of pluripotency. However, the presence and function of pluripotency-associated lincRNAs in cancer cells with pluripotency features are unknown. In this study, we used embryonal carcinoma (EC) P19 cell lines to investigate the expression level of Halr1 in pluripotency and retinoic acid (RA)-induced differentiated states. Down-regulation of pluripotency associated factors such as OCT4, NANOG, SSEA1 and alkaline phosphatase at transcript and protein levels were used to confirm the differentiated status of P19 cells.… More >