Xiangyu Yan^1,#, Yusheng Jin^1,#, Yan Yuan¹, Xubaihe Zhang¹, Jiayi Li¹, Ying Xu¹, Yangyang Ge², Anqing Wu^1,*

BIOCELL, Vol.49, No.10, pp. 1929-1946, 2025, DOI:10.32604/biocell.2025.066935 - 22 October 2025

Abstract Objectives: Fractionated radiotherapy represents a standardized and widely adopted treatment modality for cancer management, with approximately 40% of non-small cell lung cancer (NSCLC) patients receiving it. However, repeated irradiation may induce radioresistance in cancer cells, reducing treatment effectiveness and raising recurrence risk. The long noncoding RNA CRYBG3 (lncRNA CRYBG3), which is upregulated in lung cancer cells after X-ray irradiation, contributes to the radioresistance of NSCLC cells by promoting wild-type p53 protein degradation. This study aims to elucidate the mechanism of fractionated irradiation-induced radioresistance, in which lncRNA CRYBG3 regulates radiation-induced mitochondrial damage and reactive oxygen species… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.10, pp. 3157-3157, 2025, DOI:10.32604/or.2025.073033 - 26 September 2025

Abstract This article has no abstract. More >

Jianwei Wang^1,2, Xinzhi Yang³, Lvbiao Lin⁴, Jianbo Yu^5,*, Jie Mao^4,*

Oncology Research, Vol.33, No.10, pp. 3023-3040, 2025, DOI:10.32604/or.2025.065380 - 26 September 2025

Abstract Objectives: Glioma, as the most lethal primary brain malignancy with poor prognosis, requires further elucidation on the functional role of long noncoding RNA (lncRNA) DDX11 antisense RNA 1 (DDX11-AS1) in its pathogenesis, despite its established oncogenic functions in other cancers. Therefore, this study sought to characterize the oncogenic role and molecular mechanism of DDX11-AS1 in glioma. Methods: DDX11-AS1 expression levels were analyzed in clinical surgical glioma specimens and publicly available datasets. The functional roles of DDX11-AS1 on glioma cell proliferation and migration were investigated using in vitro knockdown and overexpression assays. In vivo tumor growth was assessed… More > Graphic Abstract

Luyao Jiang^1,#, Longsheng Fu^2,#, Shaofeng Xiong^2,3, Guosheng Cao⁴, Yanqin Mei^2,3, Yaoqi Wu², Jin Chen^1,*, Yanni LV^2,5,6,*

BIOCELL, Vol.49, No.9, pp. 1749-1769, 2025, DOI:10.32604/biocell.2025.068507 - 25 September 2025

Abstract Background: After ischemic stroke, neutrophils hyperactivate, increasing in number and worsening inflammation, causing neural damage. Prior scRNA-seq showed Lrg1 modulates cells subsentence to cerebral ischemia-reperfusion injury, but its mechanism in regulating neutrophil accumulation/differentiation post-injury is unclear. Methods: Lrg1 knockout impact on neutrophil accumulation was assessed via immunofluorescence and western blot. Three-dimensional reconstruction of immunofluorescent staining analyzed cell-cell interactions among neutrophils and microglia. scRNA-seq of WT and Lrg1^-/- mice from GSE245386 and GSE279462 was conducted. Each group conducted oxidative phosphorylation scoring via Gene Set Enrichment Analysis (GSEA), while Metascape was employed to perform GO and KEGG enrichment… More > Graphic Abstract

Akari Fukumoto, Satoru Matsuda^*

Oncology Research, Vol.33, No.9, pp. 2205-2219, 2025, DOI:10.32604/or.2025.062810 - 28 August 2025

Abstract The non-coding RNAs (ncRNAs) are a family of single-stranded RNAs that have become recognized as crucial gene expression regulators in normal and cancer cell biology. The gut microbiota, which consists of several different bacteria, can actively contribute to the regulation of host metabolism, immunity, and inflammation. Roles of ncRNAs and gut microbiota could significantly interact with each other to regulate the growth of various types of cancer. In particular, a causal relationship among ncRNAs, gut microbiota, and immune cells has been shown for their potential importance in the development of breast cancer. Alteration of ncRNA More >

Yuhan Wang, Yimei Meng, Wanqiu Xia, Yusen Liang, Yaru Wang, Peiling Li^*, Lei Fang^*

Oncology Research, Vol.33, No.8, pp. 2141-2159, 2025, DOI:10.32604/or.2025.064367 - 18 July 2025

Abstract Background: Ovarian cancer (OC) is a representative malignancy of the female reproductive system, with a poor prognosis. Long non-coding RNAs (lncRNAs) crucially affect tumor development. This study aimed to identify lncRNAs that potentially participated in OC. Methods: LncRNA expression in cells and tissues was quantified using reverse transcription-quantitative PCR, while fluorescence in situ hybridization determined their cellular localization. Various in vitro assays, together with a mouse xenograft model, were employed to elucidate the function of CYMP antisense RNA 1 (CYMP-AS1) in OC. The molecular mechanisms underlying CYMP-AS1 regulation were investigated through RNA pull-down and immunoprecipitation assays, immunofluorescence… More > Graphic Abstract

YUANLIN LIU^1,3, YAN LIU², YAN WANG², QIANG WANG², YAN YAN¹, DANDAN ZHANG^2,*, HUIQIN LIU^2,*

Oncology Research, Vol.33, No.6, pp. 1505-1505, 2025, DOI:10.32604/or.2024.056768 - 29 May 2025

Abstract This article has no abstract. More >

LIBO LIANG¹, XINYI WANG^2,3,4, YUPING ZENG^2,3,4, HAO CHEN^2,3,4, WEN ZHOU¹, HONGYING MU^2,3,4, GA LIAO^5,6,*

Oncology Research, Vol.33, No.6, pp. 1405-1421, 2025, DOI:10.32604/or.2024.056708 - 29 May 2025

Abstract Objectives: Exosomal long noncoding RNAs (lncRNAs) might facilitate epithelial–mesenchymal transition (EMT) in liver cancer after transarterial chemoembolization (TACE), thereby enhancing tumor cell invasiveness and migration. This study investigated the prognostic role of plasma exosomal long noncoding RNA-plasmacytoma variant translocation 1 (lncRNA-PVT1) in TACE treated hepatocellular carcinoma (HCC). Methods: Plasma exosomal lncRNA-PVT1 was evaluated via qPCR before and after TACE. Hepatoma cell behavior was investigated in different HCC cell lines. A lncRNA-PVT1 plasmid was synthesized and overexpressed, and si-lncRNA PVT1 was transfected into poorly invasive cells to reveal its influence on cell characteristics. The lncRNA-PVT1–FoxM1 interaction… More > Graphic Abstract

Dang Hung Tran, Van Tinh Nguyen^*

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 4679-4698, 2025, DOI:10.32604/cmc.2025.063228 - 19 May 2025

Abstract It is known that long non-coding RNAs (lncRNAs) play vital roles in biological processes and contribute to the progression, development, and treatment of various diseases. Obviously, understanding associations between diseases and lncRNAs significantly enhances our ability to interpret disease mechanisms. Nevertheless, the process of determining lncRNA-disease associations is costly, labor-intensive, and time-consuming. Hence, it is expected to foster computational strategies to uncover lncRNA-disease relationships for further verification to save time and resources. In this study, a collaborative filtering and graph attention network-based LncRNA-Disease Association (CFGANLDA) method was nominated to expose potential lncRNA-disease associations. First, it… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.5, pp. 1251-1252, 2025, DOI:10.32604/or.2025.065346 - 18 April 2025

Abstract This article has no abstract. More >