Yiming Chen^1,2, Qiong Luo^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.3, 2026, DOI:10.32604/phyton.2026.077896 - 31 March 2026

Abstract Lycium ruthenicum Murray (black goji berry) is an economically important crop rich in anthocyanins, however, the post-transcriptional regulatory mechanisms underlying anthocyanin accumulation in its fruits are unknown. Here, we used whole-transcriptome sequencing to identify differentially expressed circRNAs and lncRNAs in black goji (BS4) and white goji (WS4). Furthermore, we analyzed the regulatory networks of the key ncRNAs and their target genes by combining targeted phytohormone metabolomics with molecular docking technology. We found that the circRNA plantcirc_001165 synergistically upregulated the flavonoid biosynthesis gene LrHCT with the lncRNA MSTRG.28703 to promote anthocyanin accumulation. However, MSTRG.28703 repressed LrZOX1 expression, leading More >

Kai Tang¹, Shengxing Lu¹, Cuie He², Ruozeng Rong^1,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2026.072154 - 23 March 2026

Abstract Objectives: Prostate cancer (PCa) is a highly prevalent male malignancy with limited efficacy in advanced stages. Dysregulated modulation of necroptosis was reported to be tightly correlated with PCa initiation and progression. Herein, we aimed to identify necroptosis-associated long non-coding RNAs (lncRNAs) and delineate their functional roles in PCa through an integrated approach combining bioinformatic analyses and in vitro experimental validation. Methods: RNA sequencing data and corresponding clinical information of PCa were downloaded from The Cancer Genome Atlas (TCGA). Differentially expressed necroptosis-related genes (NRGs) and lncRNAs were screened, and necroptosis activity was assessed by single-sample gene set… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.080056 - 24 February 2026

Abstract This article has no abstract. More >

Yimao Wu^1,2,#, Yitong Liu^2,#, Ruowei Sun^3,#, Yiyuan Zhang², Qian Zhang^4,*, Chen Li^5,*, Mengyao Li^1,6,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.075012 - 24 February 2026

Abstract Tumor metabolic reprogramming is a core hallmark of cancer, characterized by pathways such as aerobic glycolysis, aberrant lipid metabolism, and glutaminolysis that support rapid proliferation and immunosuppressive microenvironments. Circular RNAs (circRNAs) are highly stable, evolutionarily conserved non-coding RNAs that have emerged as critical modulators of these metabolic shifts. This review aims to systematically elucidate the roles and mechanisms of circRNAs in reprogramming tumor metabolism, and to discuss their clinical potential as biomarkers and therapeutic targets. Through mechanisms including miRNA sponging, protein interactions, regulation of mitochondrial dynamics, and modulation of metabolic enzymes, circRNAs influence key metabolic… More >

Lihua Wang¹, Zhimin Zhang^1,*, Tao Wang^2,*

BIOCELL, Vol.50, No.2, 2026, DOI:10.32604/biocell.2025.074782 - 14 February 2026

Abstract Objectives: The discovery of novel molecular targets to enhance the osteogenesis of human bone marrow-derived mesenchymal stem cells (H-BMSCs) represents a promising strategy for preventing and treating osteoporosis. Thus, the primary objective of this study is to elucidate the mechanisms by which long non-coding RNA FOXD2-AS1 (lncRNA FOXD2-AS1) regulates early osteogenic differentiation in H-BMSCs, thereby identifying potential therapeutic targets. Methods: Lentivirus-mediated vectors were constructed to either overexpress or silence FOXD2-AS1 in H-BMSCs. The effects of FOXD2-AS1 on osteogenesis were subsequently assessed by analyzing osteogenic marker expression and alkaline phosphatase (ALP) staining. To clarify the role… More >

Yating Wei¹, Hongkang Yao¹, Xian Shi², Hong Chen³, Rongzong Ye^4,*, Chaoqian Li^1,*

BIOCELL, Vol.50, No.2, 2026, DOI:10.32604/biocell.2025.072780 - 14 February 2026

Abstract Atherosclerosis, characterized by the formation of fibrofatty lesions in the arterial wall, remains a leading cause of global morbidity and mortality. Emerging evidence highlights the critical regulatory roles of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in atherogenesis. LncRNAs can function as competing endogenous RNAs (ceRNAs) by sponging miRNAs, thereby modulating the expression of downstream target mRNAs. This review summarizes current knowledge on lncRNA-miRNA-mRNA regulatory networks and their functional roles in the three major cell types involved in atherosclerotic plaque development: endothelial cells (ECs), vascular smooth muscle cells (VSMCs), and macrophages. In ECs, these networks More >

SHAOFENG XIONG^1,2, WENKAI LV³, GUOSHENG CAO⁴, LONGSHENG FU¹, WEN LIU³, MENGFAN LEI², YANNI LV^1,5,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.073401 - 23 January 2026

Abstract Objective: Leucine-rich alpha-2 glycoprotein 1 (Lrg1) could regulate diverse cells in cerebral ischemia-reperfusion. Our study seeks to uncover Lrg1’s impact on endothelial cell heterogeneity via differentiation pathways and transcription factors. Method: The CSOmap model measured cell-to-brain-center distances using single-cell RNA sequencing (scRNA-seq) data in middle cerebral artery occlusion reperfusion (MCAO/R). Monocle2 mapped endothelial differentiation paths. Gene set enrichment analysis (GSEA) analyzed endothelial subcluster variations. Database searches revealed a zinc finger MIZ-type containing 1 protein-frizzled 3 (Zmiz1-Fzd3) promoter interaction. Endothelial cells were transfected with a Fzd3 promoter-luciferase plasmid. Polymerase chain reaction (PCR) and western blotting assessed… More >

Zhilong He^1,#, Jing Qin^1,#, Sixuan Wu^2,#, Xian Liang¹, Yu Liu¹, Jinfeng Qiu¹, Zhimin Li^2,*, Kai Hu^1,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070567 - 19 January 2026

Abstract Objective: The contribution of long non-coding RNAs (lncRNAs) associated with protein palmitoylation to the progression of hepatocellular carcinoma (HCC) remains largely unclear. This study sought to establish a prognostic signature based on palmitoylation-related lncRNAs and explore their functional implications in HCC. Methods: RNA sequencing and clinical data for HCC and normal tissues were sourced from the Cancer Genome Atlas (TCGA). Pearson correlation analysis was used to identify lncRNAs that were co-expressed with palmitoylation-related genes. Univariate Cox regression was applied to select lncRNAs with prognostic value, followed by the construction of a predictive model using the… More >

Se Ha Jang^1,2,#, Hyung Seok Kim^3,#, Jung Woo Eun^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072240 - 30 December 2025

Abstract Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal malignancies worldwide. Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of gene expression and cancer progression, yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome (BAC) clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated. This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC, outlining their genomic origins, molecular mechanisms, and biological significance. We highlight their roles in metabolic reprogramming, microRNA network modulation, and tumor progression, as well as their diagnostic and More >

Xiangyu Yan^1,#, Yusheng Jin^1,#, Yan Yuan¹, Xubaihe Zhang¹, Jiayi Li¹, Ying Xu¹, Yangyang Ge², Anqing Wu^1,*

BIOCELL, Vol.49, No.10, pp. 1929-1946, 2025, DOI:10.32604/biocell.2025.066935 - 22 October 2025

Abstract Objectives: Fractionated radiotherapy represents a standardized and widely adopted treatment modality for cancer management, with approximately 40% of non-small cell lung cancer (NSCLC) patients receiving it. However, repeated irradiation may induce radioresistance in cancer cells, reducing treatment effectiveness and raising recurrence risk. The long noncoding RNA CRYBG3 (lncRNA CRYBG3), which is upregulated in lung cancer cells after X-ray irradiation, contributes to the radioresistance of NSCLC cells by promoting wild-type p53 protein degradation. This study aims to elucidate the mechanism of fractionated irradiation-induced radioresistance, in which lncRNA CRYBG3 regulates radiation-induced mitochondrial damage and reactive oxygen species… More >