Dong Zhang^1,#, Lingxia Tong^2,#, Qingjun Wang¹, Yunfeng Cao³, Yu Gao¹, Donghua Yang¹, Tianhao Bao^4,5, Zhitu Zhu^1,*

Oncologie, Vol.22, No.2, pp. 75-82, 2020, DOI:10.32604/oncologie.2020.012376

Abstract Predicting the onset and metastasis of early tumor is the primary means of improving lung cancer prognosis. The purpose of this study was to identify the ability of plasma metabolomics combined with blood markers to establish benign lung disease versus lung cancer regression models. Blood samples were collected from 174 lung cancer patients, 350 benign lung disease patients and 100 healthy volunteers and the metabolites were analyzed by mass spectrometry. The target metabolites consisted of 23 amino acids, 26 acylcarnitines and 45 conventional blood markers. A regression analysis model was established based on 12 metabolites and five blood markers selected… More >

Neslihan Duzkale^1,*, Hikmet Taner Teker²

Oncologie, Vol.22, No.2, pp. 65-74, 2020, DOI:10.32604/oncologie.2020.013707

Abstract BRCA1/2 genes are responsible for the hereditary breast and ovarian cancer syndrome. In this study, Turkish women with ovarian cancer were investigated in terms of demographic, clinicopathologic and family cancer stories according to their condition of the BRCA1/2 genes mutation carrier. During 2011 to 2017 in Turkey, BRCA1 and BRCA2 genes were analyzed in 38 women, who were diagnosed with cancer using Next Generation Sequencing technique. Pathogenic mutations were detected in 9 (23.7%) of patients. The diagnosis age for Ovarian cancer patients for BRCA1/2 mutation carriers was found higher. It was seen that mutations mostly occurred in the BRCA2 gene… More >

Wan Azani Mustafa^1,*, Afiqah Halim¹, Khairul Shakir Ab Rahman²

Oncologie, Vol.22, No.2, pp. 53-63, 2020, DOI:10.32604/oncologie.2020.013660

Abstract Cervical cancer develops as cells transformation in the cervix of a female that connects the uterus to the vagina. This cancer may impact the columnal epithelial cells of the cervix and therefore can be expanded to the lymphatic and circulatory system (metastasize), sometimes the kidneys, liver, prostate, vagina, and rectum. Many of the cervical cancer patients survived by taking early prevention by undergoing a Pap Smear Test. However, the result of the test usually takes a few weeks which is extremely time-consuming especially at the government hospital. The purpose of this research was to study the detection and classification method… More >

Chuanwei Xu¹, Renju Ding², Chuanping Xu^3,*

Oncologie, Vol.22, No.1, pp. 43-51, 2020, DOI:10.32604/oncologie.2020.012445

Abstract To analyze the effects of different surgical procedures for the treatment of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35, soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight patients with differentiated thyroid cancer were selected and grouped as control group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group (OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL- 2R expression levels; the incidence of complications; and the differentiated thyroid carcinoma (DTC) relapse rate were compared between the two groups. The serum IL-17 and SIL-2R levels were lower in the OG than… More >

Siqiang Tian^1,#, Yao Jiang^2,#, Ying Wang¹, Jie Song^1,*

Oncologie, Vol.22, No.1, pp. 13-21, 2020, DOI:10.32604/oncologie.2020.012492

Abstract To explore the effects of dexmedetomidine combined with remifentanil anesthesia and propofol combined with remifentanil anesthesia on perioperative inflammatory response and pulmonary function in patients with lung cancer. Totally 128 patients admitted to our hospital for lung cancer surgery were taken as the research object of this experiment. Among them, 67 cases were sedated with dexmedetomidine combined with remifentanil (Group A), and 61 cases were sedated with propofol combined with remifentanil (Group B). The changes of vital signs, respiratory interval (RR), blood oxygen saturation (SpO2) and blood sugar before and after sedation were recorded. The changes of inflammatory factors TNF-α,… More >

Anees Imtiaz¹, Oi-Mean Foong², Aamina Aamina¹, Nabeel Khan¹, Farhad Ali^{3, 4, *}, Ilyas Khan⁵

CMC-Computers, Materials & Continua, Vol.65, No.1, pp. 171-192, 2020, DOI:10.32604/cmc.2020.011397

Abstract Gold metallic nanoparticles are generally used within a lab as a tracer, to uncover on the presence of specific proteins or DNA in a sample, as well as for the recognition of various antibiotics. They are bio companionable and have properties to carry thermal energy to tumor cells by utilizing different clinical approaches. As the cancer cells are very smaller so for the infiltration, the properly sized nanoparticles have been injected in the blood. For this reason, gold nanoparticles are very effective. Keeping in mind the above applications, in the present work a generalized model of blood flow containing gold… More >

Hui Yao¹, Liqun Wang³, Jia Guo¹, Weimin Liu⁴, Jingjing Li¹, Yingxiao Wang², Linhong Deng^1,*, Mingxing Ouyang^1,2,3,*

Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 101-111, 2020, DOI:10.32604/mcb.2020.09595

Abstract Prostate cancer is the most common cancer among men beyond 50 years old, and ranked the second in mortality. The level of Prostate-specific antigen (PSA) in serum has been a routine biomarker for clinical assessment of the cancer development, which is detected mostly by antibody-based immunoassays. The proteolytic activity of PSA also has important functions. Here a genetically encoded biosensor based on fluorescence resonance energy transfer (FRET) technology was developed to measure PSA activity. In vitro assay showed that the biosensor containing a substrate peptide ‘RLSSYYSGAG’ had 400% FRET change in response to 1 µg/ml PSA within 90 min, and… More >

HONGYAN LI^1,#, CHUNLING LIAO^2,#, WENJUAN WENG², HONGZHEN ZHONG², TIANBIAO ZHOU^2,*

BIOCELL, Vol.44, No.2, pp. 257-262, 2020, DOI:10.32604/biocell.2020.08826

Abstract In this study, we used a meta-analysis method to evaluate the relationship between hypoxia-inducible factor-1α (HIF1α) 1772C/T gene polymorphism (rs 11549465) and renal cell carcinoma (RCC)/prostate cancer risk. We searched for relevant studies (before March 1, 2019) on Cochrane Library, Embase, and PubMed. Studies meeting the inclusion criteria were recruited into this meta-analysis. The outcome of dichotomous data was showed in the way of odds ratios (OR), and 95% confidence intervals (CI) were also counted. In this investigation, there was no association between HIF1α 1772C/T gene polymorphism and susceptibility to RCC in Caucasians, Asians as well as overall populations. In… More >

Jingjing Wan¹, Taiyue Chen^{2, *}, Bolun Chen^{2, 3, *}, Yongtao Yu², Yiyun Sheng², Xinggang Ma¹

CMC-Computers, Materials & Continua, Vol.63, No.3, pp. 1263-1272, 2020, DOI:10.32604/cmc.2020.010098

Abstract The incidence of colorectal cancer (CRC) in China has increased in recent years. The mortality rate of CRC has become one of the highest among all cancers; CRC increasingly affects the health and quality of people’s lives. However, due to the insufficiency of medical resources in China, the workload on medical doctors has further increased. In the past few decades, the adult CRC mortality and morbidity rate dropped sharply, mainly because of CRC screening and removal of adenomatous polyps. However, due to the differences in polyp itself and the skills of endoscopists, the detection rate of polyps varies greatly. In… More >

Xinxiong FEI, Wenbin HU, Gangsheng WANG, Chunyan SU, Xuqun HUANG, Zhongjun JIANG^*

BIOCELL, Vol.44, No.1, pp. 81-88, 2020, DOI:10.32604/biocell.2020.08125

Abstract Lung cancer poses a serious threat to human life with high incidence and miRNA is an important biomarker in tumors. This study aimed to explore the effect of miR-143-3p on the biological function of lung cancer cells and the underlying mechanism. Eighty-seven samples of lung cancer tissues and 81 samples of tumor-adjacent tissues from patients undergoing radical lung cancer surgery in our hospital were collected. The lung cancer cells and lung fibroblast cells (HFL-1) were purchased, and then miR-143-3p-mimics, miR-NC, si-CTNND1, and NC were transfected into A549 and PC-9 cells to establish cell models. MiR-143-3p and CTNND1 expression levels were… More >