Oncology Research Editorial Office

Oncology Research, Vol.33, No.5, pp. 1251-1252, 2025, DOI:10.32604/or.2025.065346 - 18 April 2025

Abstract This article has no abstract. More >

Antonio Rodrigues da Cunha Neto¹, Alexandra dos Santos Ambrósio¹, Arlinda de Jesus Rodrigues Resende¹, Breno Régis Santos¹, Michele Carla Nadal^2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 539-560, 2025, DOI:10.32604/phyton.2025.061776 - 31 March 2025

Abstract Cytokinins are plant hormones that are essential for plant growth and development and are involved in a variety of processes. They are synthesized by the modification of adenine with an isoprenoid chain, resulting in cytokinins such as isopentenyladenine and zeatin. The levels of these hormones are regulated by conjugation, degradation and oxidation processes that modulate their activity. Cytokinins are perceived by cells through specific receptors that, when activated, trigger signaling cascades responsible for regulating the expression of genes critical for development. In addition, cytokinins interact with other hormones, such as auxins, to coordinate plant growth… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.4, pp. 989-989, 2025, DOI:10.32604/or.2024.056912 - 19 March 2025

Abstract This article has no abstract. More >

Lingling Zhang^1,2, Hualing Wang³, Yawen Liu², Ling Li^2,*, Jianping Xiong^1,4,*

BIOCELL, Vol.49, No.2, pp. 253-267, 2025, DOI:10.32604/biocell.2025.061585 - 28 February 2025

Abstract Objective: Anillin (ANLN) is considered an oncogene in various cancers, but its effect on cervical cancer remains poorly understood. Hence, this study aimed to describe the action of ANLN on cervical cancer development and investigate the potential mechanism. Methods: Analysis of ANLN expression and its association with survival in carcinoma and endocervical adenocarcinoma (CESC) patients based on GEO and UALCAN databases. The tumor and adjacent normal tissues of 100 cervical cancer cases were harvested to detect the ANLN expression and explore its relationship with patient survival. Cell proliferation, apoptosis, migration, and invasion were measured by… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.3, pp. 739-739, 2025, DOI:10.32604/or.2024.056911 - 28 February 2025

Abstract This article has no abstract. More >

JUNWEI DU, QIANG ZHANG, JING ZHANG, MAIERDANJIANG MAIHEMUTI, HAIYANG HE, RENBING JIANG^*

Oncology Research, Vol.33, No.2, pp. 357-367, 2025, DOI:10.32604/or.2024.050878 - 16 January 2025

Abstract Objectives: Melanoma is a highly aggressive and metastatic form of cancer, and the role of exosomal microRNAs (miRNAs) in its progression remains largely unexplored. This study aimed to investigate the effects of melanoma cell-derived exosomal miR-424-5p on angiogenesis and its underlying mechanisms. Methods: Exosomes were isolated from melanoma cell lines A375 and A2058, and their effects on the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells (HUVECs) were examined. The interaction between miR-424-5p and its target gene, large tumor suppressor kinase 2 (LATS2), was analyzed using luciferase reporter assays and functional experiments. In vivo,… More >

YAJUN CAO^1,2,3,#, SHUANG YIN^1,2,#, YIDAN FANG⁴, JIEXIAN ZHOU^3,*, YOUTAN LIU^1,2,*

BIOCELL, Vol.48, No.12, pp. 1773-1780, 2024, DOI:10.32604/biocell.2024.056374 - 30 December 2024

Abstract Background: De novo lipogenesis (DNL) is a critical event for the development of tumors, in the present work, we revealed the role of propofol in colorectal cancer (CRC) cell proliferation. Methods: Western blotting (WB), Real-time PCR, and luciferase combined with chromatin immunoprecipitation (ChIP) were used to identify the mechanism underlying propofol-modulated cell proliferation in CRC cells. Results: Herein, we showed that propofol suppressed cell proliferation, which was attributed to the inhibition of DNL characterized by reduced fatty acid synthase (FASN), acetyl-coA carboxylase alpha (ACCA), and stearoyl-coA desaturase-1 (SCD1) expression. Mechanically, propofol stimulation decreased sterol regulatory element-binding proteins-1c (SREBP-1c) More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.11, pp. 1827-1827, 2024, DOI:10.32604/or.2024.056902 - 16 October 2024

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.11, pp. 1815-1815, 2024, DOI:10.32604/or.2024.056890 - 16 October 2024

Abstract This article has no abstract. More >

LICHEN XU^1,2, PAN ZHANG^3,*, GUIQI ZHANG², ZHAOLIANG SHEN⁴, XIZHUANG BAI^1,3,*

Oncology Research, Vol.32, No.11, pp. 1777-1789, 2024, DOI:10.32604/or.2024.047704 - 16 October 2024

Abstract Background: Osteosarcoma (OS), recognized as the predominant malignant tumor originating from bones, necessitates an in-depth comprehension of its intrinsic mechanisms to pinpoint novel therapeutic targets and enhance treatment methodologies. The role of fat mass and obesity-associated (FTO) in OS, particularly its correlation with malignant traits, and the fundamental mechanism, remains to be elucidated. Materials and Methods: 1. The FTO expression and survival rate in tumors were analyzed. 2. FTO in OS cell lines was quantified utilizing western blot and PCR. 3. FTO was upregulated and downregulated separately in MG63. 4. The impact of FTO on the… More >