Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (16)
  • Open Access


    Alteration of Ornithine Metabolic Pathway in Colon Cancer and Multivariate Data Modelling for Cancer Diagnosis

    Xin Hu1,2,#, Fangyu Jing3,#, Qingjun Wang1,4, Linyang Shi1, Yunfeng Cao4,5, Zhitu Zhu1,4,*

    Oncologie, Vol.23, No.2, pp. 203-217, 2021, DOI:10.32604/Oncologie.2021.016155

    Abstract It is noteworthy that colon cancer is the fourth place in new cases and the fifth in mortalities according to global cancer statistics 2018. Tumorigenesis displays specific correlation with metabolic alterations. A variety of metabolites, including ornithine (Orn), are related to colon cancer according to sources of disease metabolic information retrieval in human metabolome database. The metabolic regulation of Orn pathway is a key link in the survival of cancer cells. In this study, the plasma Orn levels in colon cancer patients and healthy participants were measured by liquid chromatography tandem mass spectrometry, and the metabolic disturbances of Orn in… More >

  • Open Access


    Robust Magnification Independent Colon Biopsy Grading System over Multiple Data Sources

    Tina Babu1, Deepa Gupta1, Tripty Singh1,*, Shahin Hameed2, Mohammed Zakariah3, Yousef Ajami Alotaibi4

    CMC-Computers, Materials & Continua, Vol.69, No.1, pp. 99-128, 2021, DOI:10.32604/cmc.2021.016341

    Abstract Automated grading of colon biopsy images across all magnifications is challenging because of tailored segmentation and dependent features on each magnification. This work presents a novel approach of robust magnification-independent colon cancer grading framework to distinguish colon biopsy images into four classes: normal, well, moderate, and poor. The contribution of this research is to develop a magnification invariant hybrid feature set comprising cartoon feature, Gabor wavelet, wavelet moments, HSV histogram, color auto-correlogram, color moments, and morphological features that can be used to characterize different grades. Besides, the classifier is modeled as a multiclass structure with six binary class Bayesian optimized… More >

  • Open Access


    Serum Long Non-Coding RNA CCAT2 is a Potential Diagnostic and Prognostic Marker for Gastric Cancer

    Fei Han1, Jianghong Qu2, Fengyue Li1, Dapeng Zhang3, Jiangming Qu4, Guanghua Li5,*

    Oncologie, Vol.23, No.1, pp. 131-140, 2021, DOI:10.32604/Oncologie.2021.014153

    Abstract Aim: This study aims to explore the role of serum long non-coding RNA (lncRNA) colon cancer-associated transcript 2 (CCAT2) as a diagnostic marker for gastric cancer (GC). Methods: We recruited 76 patients with GC admitted to our hospital (the observation group, OG) and 83 healthy volunteers undergoing physical examinations during the same period (the control group, CG). CCAT2 expression was tested and its correlation with clinicopathological characteristics of GC was analyzed. We also explored the value of CCAT2 in assessing the treatment efficacy, predicting the fatality, and evaluating the prognosis of patients. Results: We detected higher CCAT2 levels in OG… More >

  • Open Access


    Silencing of Astrocyte Elevated Gene-1 (AEG-1) inhibits the proliferative and invasive potential through interaction with Exostosin-1 (EXT-1) in primary and metastatic colon cancer cells


    BIOCELL, Vol.45, No.3, pp. 563-576, 2021, DOI:10.32604/biocell.2021.014756

    Abstract Colon cancer is the third major cause of cancer deaths, accounting for about 8% in terms of mortality globally. The present study aims to explore the effect of silencing Astrocyte Elevated Gene-1 (AEG-1), a metastasis mediating factor, and how it interacts with Exostosin-1 (EXT-1) protein to inhibit the proliferative and invasive potential in colon cancer cells. Forward siRNA transfection was performed using AEG-1 siRNA in SW480 and SW620 colon cancer cell lines, and the expression levels of mRNA and protein were analyzed by Real-time PCR and Immunofluorescence. A simple bioinformatics approach was carried out to identify the possible interactions between… More >

  • Open Access


    Two Stage Classification with CNN for Colorectal Cancer Detection

    Pallabi Sharma1,*, Kangkana Bora2, Kunio Kasugai3, Bunil Kumar Balabantaray1

    Oncologie, Vol.22, No.3, pp. 129-145, 2020, DOI:10.32604/oncologie.2020.013870

    Abstract In this paper, we address a current problem in medical image processing, the detection of colorectal cancer from colonoscopy videos. According to worldwide cancer statistics, colorectal cancer is one of the most common cancers. The process of screening and the removal of pre-cancerous cells from the large intestine is a crucial task to date. The traditional manual process is dependent on the expertise of the medical practitioner. In this paper, a two-stage classification is proposed to detect colorectal cancer. In the first stage, frames of colonoscopy video are extracted and are rated as significant if it contains a polyp, and… More >

  • Open Access


    Mechanisms involved in the cytotoxic effects of berberine on human colon cancer HCT-8 cells


    BIOCELL, Vol.36, No.3, pp. 113-120, 2012, DOI:10.32604/biocell.2012.36.113

    Abstract Berberine, a constituent of some traditional Chinese medicinal plants, has been reported to have cytotoxicity effects on different human cancer cell lines. There is no available information about the effects and mechanism of action of berberine on human colon cancer cell line HCT-8. In this paper, the cytotoxicity of berberine on HCT-8 cancer cells was investigated by MTT assay, fluorescence microscopy and flow cytometry analysis. Our data revealed that berberine could significantly inhibit the growth of HCT-8 cells in a dose- and time-dependent manner. Morphology of apoptotic cells was studied with acridine orange/ ethidium bromide staining. The concentrations of lactate… More >

Displaying 11-20 on page 2 of 16. Per Page