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  • Open Access


    Exploring Capillary Fringe Flow: Quasilinear Modeling with Kirchhoff Transforms and Gardner Model

    Rachid Karra1,*, Abdelatif Maslouhi2

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.7, pp. 1611-1631, 2024, DOI:10.32604/fdmp.2024.048447

    Abstract Recent studies have underscored the significance of the capillary fringe in hydrological and biochemical processes. Moreover, its role in shallow waters is expected to be considerable. Traditionally, the study of groundwater flow has centered on unsaturated-saturated zones, often overlooking the impact of the capillary fringe. In this study, we introduce a steady-state two-dimensional model that integrates the capillary fringe into a 2-D numerical solution. Our novel approach employs the potential form of the Richards equation, facilitating the determination of boundaries, pressures, and velocities across different ground surface zones. We utilized a two-dimensional Freefem++ finite element model… More >

  • Open Access


    Caching Strategies in NDN Based Wireless Ad Hoc Network: A Survey

    Ahmed Khalid1, Rana Asif Rehman1, Byung-Seo Kim2,*

    CMC-Computers, Materials & Continua, Vol.80, No.1, pp. 61-103, 2024, DOI:10.32604/cmc.2024.049981

    Abstract Wireless Ad Hoc Networks consist of devices that are wirelessly connected. Mobile Ad Hoc Networks (MANETs), Internet of Things (IoT), and Vehicular Ad Hoc Networks (VANETs) are the main domains of wireless ad hoc network. Internet is used in wireless ad hoc network. Internet is based on Transmission Control Protocol (TCP)/Internet Protocol (IP) network where clients and servers interact with each other with the help of IP in a pre-defined environment. Internet fetches data from a fixed location. Data redundancy, mobility, and location dependency are the main issues of the IP network paradigm. All these… More >

  • Open Access


    Open-Source Software Defined Networking Controllers: State-of-the-Art, Challenges and Solutions for Future Network Providers

    Johari Abdul Rahim1, Rosdiadee Nordin2,*, Oluwatosin Ahmed Amodu3,4

    CMC-Computers, Materials & Continua, Vol.80, No.1, pp. 747-800, 2024, DOI:10.32604/cmc.2024.047009

    Abstract Software Defined Networking (SDN) is programmable by separation of forwarding control through the centralization of the controller. The controller plays the role of the ‘brain’ that dictates the intelligent part of SDN technology. Various versions of SDN controllers exist as a response to the diverse demands and functions expected of them. There are several SDN controllers available in the open market besides a large number of commercial controllers; some are developed to meet carrier-grade service levels and one of the recent trends in open-source SDN controllers is the Open Network Operating System (ONOS). This paper… More >

  • Open Access


    LncRNA HOTAIR promotes DNA damage repair and radioresistance by targeting ATR in colorectal cancer


    Oncology Research, Vol.32, No.8, pp. 1335-1346, 2024, DOI:10.32604/or.2024.044174

    Abstract Long non-coding RNAs (lncRNAs) have been implicated in cancer progression and drug resistance development. Moreover, there is evidence that lncRNA HOX transcript antisense intergenic RNA (HOTAIR) is involved in colorectal cancer (CRC) progression. The present study aimed to examine the functional role of lncRNA HOTAIR in conferring radiotherapy resistance in CRC cells, as well as the underlying mechanism. The relative expression levels of HOTAIR were examined in 70 pairs of CRC tumor and para-cancerous tissues, as well as in radiosensitive and radioresistant samples. The correlations between HOTAIR expression levels and clinical features of patients with… More >

  • Open Access


    Correction: Applying Customized Convolutional Neural Network to Kidney Image Volumes for Kidney Disease Detection

    Ali Altalbe1,2,*, Abdul Rehman Javed3

    Computer Systems Science and Engineering, Vol.48, No.4, pp. 1075-1081, 2024, DOI:10.32604/csse.2024.054179

    Abstract This article has no abstract. More >

  • Open Access


    CoopAI-Route: DRL Empowered Multi-Agent Cooperative System for Efficient QoS-Aware Routing for Network Slicing in Multi-Domain SDN

    Meignanamoorthi Dhandapani*, V. Vetriselvi, R. Aishwarya

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2449-2486, 2024, DOI:10.32604/cmes.2024.050986

    Abstract The emergence of beyond 5G networks has the potential for seamless and intelligent connectivity on a global scale. Network slicing is crucial in delivering services for different, demanding vertical applications in this context. Next-generation applications have time-sensitive requirements and depend on the most efficient routing path to ensure packets reach their intended destinations. However, the existing IP (Internet Protocol) over a multi-domain network faces challenges in enforcing network slicing due to minimal collaboration and information sharing among network operators. Conventional inter-domain routing methods, like Border Gateway Protocol (BGP), cannot make routing decisions based on performance,… More >

  • Open Access


    Rapid and Accurate Identification of Concrete Surface Cracks via a Lightweight & Efficient YOLOv3 Algorithm

    Haoan Gu1, Kai Zhu1, Alfred Strauss2, Yehui Shi3,4, Dragoslav Sumarac5, Maosen Cao1,*

    Structural Durability & Health Monitoring, Vol.18, No.4, pp. 363-380, 2024, DOI:10.32604/sdhm.2024.042388

    Abstract Concrete materials and structures are extensively used in transformation infrastructure and they usually bear cracks during their long-term operation. Detecting cracks using deep-learning algorithms like YOLOv3 (You Only Look Once version 3) is a new trend to pursue intelligent detection of concrete surface cracks. YOLOv3 is a typical deep-learning algorithm used for object detection. Owing to its generality, YOLOv3 lacks specific efficiency and accuracy in identifying concrete surface cracks. An improved algorithm based on YOLOv3, specialized in the rapid and accurate identification of concrete surface cracks is worthy of investigation. This study proposes a tailored… More >

  • Open Access


    The Inhibitory Effects of HYDAMTIQ, a Novel PARP Inhibitor, on Growth in Human Tumor Cell Lines With Defective DNA Damage Response Pathways

    Enrico Mini*, Ida Landini*, Laura Lucarini, Andrea Lapucci*, Cristina Napoli, Gabriele Perrone*, Renato Tassi*, Emanuela Masini, Flavio Moroni, Stefania Nobili

    Oncology Research, Vol.25, No.9, pp. 1441-1451, 2017, DOI:10.3727/096504017X14926854178616

    Abstract The poly(ADP-ribose) polymerase (PARP) enzymes play a key role in the regulation of cellular processes (e.g., DNA damage repair, genomic stability). It has been shown that PARP inhibitors (PARPIs) are selectively cytotoxic against cells having dysfunctions in genes involved in DNA repair mechanisms (synthetic lethality). Drug-induced PARP inhibition potentiates the activity of anticancer drugs such as 5-fluorouracil in enhancing DNA damage, whose repair involves PARP-1 activity. The aim of this study was to evaluate the inhibitory effects of a novel PARPI, HYDAMTIQ, on growth in human tumor cell lines characterized by different features with regard… More >

  • Open Access


    Silencing of ATP4B of ATPase H+/K+ Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells

    Shuye Lin*†, Bonan Lin*, Xiaoyue Wang*, Yuanming Pan, Qing Xu*, Jin-Shen He*, Wanghua Gong§, Rui Xing, Yuqi He, Lihua Guo*, Youyong Lu, Ji Ming Wang, Jiaqiang Huang*†

    Oncology Research, Vol.25, No.3, pp. 317-329, 2017, DOI:10.3727/096504016X14734735156265

    Abstract The ATPase H+/K+ Transporting Beta Subunit (ATP4B) encodes the b subunit of the gastric H+, K+ -ATPase, which controls gastric acid secretion and is therefore a target for acid reduction. Downregulation of ATP4B was recently observed in human gastric cancer (GC) without known mechanisms. In the present study, we demonstrated that ATP4B expression was decreased in human GC tissues and cell lines associated with DNA hypermethylation and histone hypoacetylation of histone H3 lysine 9 at its intragenic region close to the transcriptional start site. The expression of ATP4B was restored in GC cell lines by treatment with… More >

  • Open Access


    Silencing of E3 Ubiquitin Ligase RNF8 Enhances Ionizing Radiation Sensitivity of Medulloblastoma Cells by Promoting the Deubiquitination of PCNA

    Fei Li*1, Bin Liu†1, Xiaolan Zhou*, Quan Xu

    Oncology Research, Vol.26, No.9, pp. 1365-1373, 2018, DOI:10.3727/096504018X15154085345907

    Abstract DNA damage response induced by ionizing radiation (IR) is an important event involved in the sensitivity and efficiency of radiotherapy in human medulloblastoma. RNF8 is an E3 ubiquitin ligase and has key roles in the process of DNA damage and repair. Our study aimed to evaluate the effect of RNF8 in the DNA damage repair induced by IR exposure in medulloblastoma cells. We found that the levels of RNF8 were significantly upregulated by γ-ray irradiation in a dose-dependent manner in medulloblastoma cells and colocalized with γ-H2AX, a sensitive marker of DNA double-strand breaks induced by… More >

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