Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (345)
  • Open Access

    ARTICLE

    PKHD1L1 blocks the malignant behavior of lung adenocarcinoma cells and restricts tumor growth by regulating CBX7

    KEWEI CHENG1, LEI SHI1, CAIWEN SHI1, SHUANSHUAN XIE2, CHANGHUI WANG2,*

    BIOCELL, Vol.48, No.8, pp. 1209-1221, 2024, DOI:10.32604/biocell.2024.049626 - 02 August 2024

    Abstract Objective: To explore the role of polycystic kidney and hepatic disease 1-like 1 (PKHD1L1) in lung adenocarcinoma (LUAD). Methods: Bioinformatics tools were utilized to examine the clinical profile of PKHD1L1 and chromobox protein homolog 7 (CBX7) in LUAD. The Cell Counting Kit-8, colony formation, terminal deoxynucleotidyl transferase dUTP nick end labeling, Transwell, and wound-healing assays were carried out to assess the proliferative, apoptotic, invasive, and migrative capacities of the cells. Furthermore, the interrelation between PKHD1L1 and CBX7 was validated using a co-immunoprecipitation assay. A LUAD mice model was constructed by subcutaneous injection of A549 cells.… More >

  • Open Access

    ARTICLE

    Cloning, Characterization and Transformation of Methyltransferase 2a Gene (Zmet2a) in Maize (Zea mays L.)

    Xin Qi1,#, Yu Wang1,#, Xing Zhang1, Xiaoshuang Wei1, Xinyang Liu1, Zhennan Wang1, Zhenhui Wang1,*, Fenglou Ling2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.7, pp. 1767-1779, 2024, DOI:10.32604/phyton.2024.052844 - 30 July 2024

    Abstract DNA methylation is an important epigenetic regulatory mechanism, it regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of transcription factor(s) to DNA. In this study, a novel methyltransferase 2a gene (Zmet2a) was cloned in maize and identified by polymerase chain reaction-base (PCR-base) using a bioinformatics strategy. The Zmet2a cDNA sequence is 2739 bp long and translates to 912 amino acid peptides. The Zmet2a protein revealed that it contains BAH and CHROMO structural domains, is a non-transmembrane protein that is hydrophilically unstable, and has no signal peptide structure. Meanwhile, we verified More >

  • Open Access

    ARTICLE

    Exploring Capillary Fringe Flow: Quasilinear Modeling with Kirchhoff Transforms and Gardner Model

    Rachid Karra1,*, Abdelatif Maslouhi2

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.7, pp. 1611-1631, 2024, DOI:10.32604/fdmp.2024.048447 - 23 July 2024

    Abstract Recent studies have underscored the significance of the capillary fringe in hydrological and biochemical processes. Moreover, its role in shallow waters is expected to be considerable. Traditionally, the study of groundwater flow has centered on unsaturated-saturated zones, often overlooking the impact of the capillary fringe. In this study, we introduce a steady-state two-dimensional model that integrates the capillary fringe into a 2-D numerical solution. Our novel approach employs the potential form of the Richards equation, facilitating the determination of boundaries, pressures, and velocities across different ground surface zones. We utilized a two-dimensional Freefem++ finite element model… More >

  • Open Access

    REVIEW

    Caching Strategies in NDN Based Wireless Ad Hoc Network: A Survey

    Ahmed Khalid1, Rana Asif Rehman1, Byung-Seo Kim2,*

    CMC-Computers, Materials & Continua, Vol.80, No.1, pp. 61-103, 2024, DOI:10.32604/cmc.2024.049981 - 18 July 2024

    Abstract Wireless Ad Hoc Networks consist of devices that are wirelessly connected. Mobile Ad Hoc Networks (MANETs), Internet of Things (IoT), and Vehicular Ad Hoc Networks (VANETs) are the main domains of wireless ad hoc network. Internet is used in wireless ad hoc network. Internet is based on Transmission Control Protocol (TCP)/Internet Protocol (IP) network where clients and servers interact with each other with the help of IP in a pre-defined environment. Internet fetches data from a fixed location. Data redundancy, mobility, and location dependency are the main issues of the IP network paradigm. All these… More >

  • Open Access

    REVIEW

    Open-Source Software Defined Networking Controllers: State-of-the-Art, Challenges and Solutions for Future Network Providers

    Johari Abdul Rahim1, Rosdiadee Nordin2,*, Oluwatosin Ahmed Amodu3,4

    CMC-Computers, Materials & Continua, Vol.80, No.1, pp. 747-800, 2024, DOI:10.32604/cmc.2024.047009 - 18 July 2024

    Abstract Software Defined Networking (SDN) is programmable by separation of forwarding control through the centralization of the controller. The controller plays the role of the ‘brain’ that dictates the intelligent part of SDN technology. Various versions of SDN controllers exist as a response to the diverse demands and functions expected of them. There are several SDN controllers available in the open market besides a large number of commercial controllers; some are developed to meet carrier-grade service levels and one of the recent trends in open-source SDN controllers is the Open Network Operating System (ONOS). This paper… More >

  • Open Access

    ARTICLE

    LncRNA HOTAIR promotes DNA damage repair and radioresistance by targeting ATR in colorectal cancer

    HAIQING HU1,#,*, HAO YANG2,#, SHUAISHUAI FAN3, XUE JIA3, YING ZHAO3, HONGRUI LI3

    Oncology Research, Vol.32, No.8, pp. 1335-1346, 2024, DOI:10.32604/or.2024.044174 - 17 July 2024

    Abstract Long non-coding RNAs (lncRNAs) have been implicated in cancer progression and drug resistance development. Moreover, there is evidence that lncRNA HOX transcript antisense intergenic RNA (HOTAIR) is involved in colorectal cancer (CRC) progression. The present study aimed to examine the functional role of lncRNA HOTAIR in conferring radiotherapy resistance in CRC cells, as well as the underlying mechanism. The relative expression levels of HOTAIR were examined in 70 pairs of CRC tumor and para-cancerous tissues, as well as in radiosensitive and radioresistant samples. The correlations between HOTAIR expression levels and clinical features of patients with… More >

  • Open Access

    CORRECTION

    Correction: Applying Customized Convolutional Neural Network to Kidney Image Volumes for Kidney Disease Detection

    Ali Altalbe1,2,*, Abdul Rehman Javed3

    Computer Systems Science and Engineering, Vol.48, No.4, pp. 1075-1081, 2024, DOI:10.32604/csse.2024.054179 - 17 July 2024

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    CoopAI-Route: DRL Empowered Multi-Agent Cooperative System for Efficient QoS-Aware Routing for Network Slicing in Multi-Domain SDN

    Meignanamoorthi Dhandapani*, V. Vetriselvi, R. Aishwarya

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2449-2486, 2024, DOI:10.32604/cmes.2024.050986 - 08 July 2024

    Abstract The emergence of beyond 5G networks has the potential for seamless and intelligent connectivity on a global scale. Network slicing is crucial in delivering services for different, demanding vertical applications in this context. Next-generation applications have time-sensitive requirements and depend on the most efficient routing path to ensure packets reach their intended destinations. However, the existing IP (Internet Protocol) over a multi-domain network faces challenges in enforcing network slicing due to minimal collaboration and information sharing among network operators. Conventional inter-domain routing methods, like Border Gateway Protocol (BGP), cannot make routing decisions based on performance,… More >

  • Open Access

    ARTICLE

    Rapid and Accurate Identification of Concrete Surface Cracks via a Lightweight & Efficient YOLOv3 Algorithm

    Haoan Gu1, Kai Zhu1, Alfred Strauss2, Yehui Shi3,4, Dragoslav Sumarac5, Maosen Cao1,*

    Structural Durability & Health Monitoring, Vol.18, No.4, pp. 363-380, 2024, DOI:10.32604/sdhm.2024.042388 - 05 June 2024

    Abstract Concrete materials and structures are extensively used in transformation infrastructure and they usually bear cracks during their long-term operation. Detecting cracks using deep-learning algorithms like YOLOv3 (You Only Look Once version 3) is a new trend to pursue intelligent detection of concrete surface cracks. YOLOv3 is a typical deep-learning algorithm used for object detection. Owing to its generality, YOLOv3 lacks specific efficiency and accuracy in identifying concrete surface cracks. An improved algorithm based on YOLOv3, specialized in the rapid and accurate identification of concrete surface cracks is worthy of investigation. This study proposes a tailored… More >

  • Open Access

    ARTICLE

    The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory

    MAHER KURDI1,*, ALAA ALKHOTANI2, ABDULRAHMAN SABBAGH3, EYAD FAIZO4, AHMED I. LARY5, AHMED K. BAMAGA6, MAJID ALMANSOURI7, BADR HAFIZ8, THAMER ALSHARIF9, SALEH BAEESA8

    Oncology Research, Vol.32, No.6, pp. 1037-1045, 2024, DOI:10.32604/or.2024.051112 - 23 May 2024

    Abstract Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described. Methods: A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype tumors. Both groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR analysis. Inter-cohort statistical significance was evaluated. Results: Both IDH-mutant WHO grade 4 astrocytomas (n = 22, 64.7%) and IDH-wildtype… More > Graphic Abstract

    The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory

Displaying 21-30 on page 3 of 345. Per Page