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  • Open Access

    ARTICLE

    Boundedness and Positivity Preserving Numerical Analysis of a Fuzzy-Parameterized Delayed Model for Foot and Mouth Disease Dynamics

    Muhammad Tashfeen1, Fazal Dayan1, Muhammad Aziz ur Rehman1, Thabet Abdeljawad2,3,4,5,*, Aiman Mukheimer2

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.3, pp. 2527-2554, 2024, DOI:10.32604/cmes.2024.056269 - 31 October 2024

    Abstract Foot-and-mouth disease (FMD) is a viral disease that affects cloven-hoofed animals including cattle, pigs, and sheep, hence causing export bans among others, causing high economic losses due to reduced productivity. The global effect of FMD is most felt where livestock rearing forms an important source of income. It is therefore important to understand the modes of transmission of FMD to control its spread and prevent its occurrence. This work intends to address these dynamics by including the efficacy of active migrant animals transporting the disease from one area to another in a fuzzy mathematical modeling… More >

  • Open Access

    ARTICLE

    Effect of Liquid Temperature on Surface and Mechanical Characteristics of Al-Mg Alloy Treated with a Cavitating Waterjet

    Can Kang1,*, Shifeng Yan1, Haixia Liu2, Jie Chen2, Kejin Ding3

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.11, pp. 2431-2442, 2024, DOI:10.32604/fdmp.2024.055688 - 28 October 2024

    Abstract The presented study aims to reveal the effect of liquid temperature on cavitation-induced erosion of an Al-Mg alloy. An experimental work was conducted using a submerged cavitating waterjet to impact the specimen surface. For a certain cavitation number and a given standoff distance, different liquid temperatures were considered. Accordingly, a comprehensive comparison was implemented by inspecting the mass loss and surface morphology of the tested specimens. The results show that the cumulative mass loss increases continuously with the liquid temperature. A cavitation zone with an irregular profile becomes evident as the cavitation treatment proceeds. Increasing More > Graphic Abstract

    Effect of Liquid Temperature on Surface and Mechanical Characteristics of Al-Mg Alloy Treated with a Cavitating Waterjet

  • Open Access

    ARTICLE

    Integrative bioinformatics and in vitro exploration of EVI2A expression: unraveling its immunological and prognostic implications in kidney renal clear cell carcinoma

    RONG LIU1,#, SHENG LI2,#, SITU XIONG2, FUCUN ZHENG2, XIANGPENG ZHAN2, JIN ZENG2, BIN FU2, SONGHUI XU2, SHAOXING ZHU1,*, RU CHEN1,*

    Oncology Research, Vol.32, No.11, pp. 1733-1746, 2024, DOI:10.32604/or.2024.050851 - 16 October 2024

    Abstract EVI2A has emerged as a significant biomarker in various diseases; however, its biological role and mechanism in kidney renal clear cell carcinoma (KIRC) remains unexplored. We used TCGA and GEO databases to analyze EVI2A gene expression comprehensively and performed pan-cancer assessments. Clinical relevance was evaluated through Kaplan-Meier analysis and ROC curves. The gene’s immune relevance was explored through analyses of the tumor microenvironment (TME), Tumor Immune Single-cell Hub (TISCH), immune checkpoints, and immunotherapy sensitivity. Our results indicate that EVI2A expression is upregulated in KIRC, showing correlations with tumor grade and T/N/M stage. EVI2A demonstrates high… More >

  • Open Access

    ARTICLE

    DNAJA4, DNAJB11 and DNAJC10 induce cell transformation by inhibiting p53 and oncogene-induced senescence

    HYEON JU LEE1, CHANG SEOP LEE1, SI HOON KIM1, SOOKYUNG KIM1, JEONG MI KIM1, SUN-WHA IM1, YU-JIN JUNG2, SEUNG-PYO HONG3, HYUNJUNG LEE3, JONG-IL KIM3,4,5, JEONG A. HAN1,*

    BIOCELL, Vol.48, No.10, pp. 1455-1464, 2024, DOI:10.32604/biocell.2024.054538 - 02 October 2024

    Abstract Objective: Transformation from normal cells to malignant cells is the basis for tumorigenesis. While this cell transformation is known to result from aberrant activation or inactivation of associated genes, these genes have not yet been fully identified. In addition, DNAJs, proteins with a J domain, are known to be molecular co-chaperones, but their cellular functions remain largely unexplored. In this context, we here identified DNAJA4, DNAJB11, and DNAJC10 as pro-transforming genes and elucidated their action mechanisms. Methods: Senescence-associated (SA)-β-galactosidase staining and western blotting were used to analyze cellular senescence and protein expression. Soft agar assay was used… More >

  • Open Access

    ARTICLE

    Diosgenin inhibited podocyte pyroptosis in diabetic kidney disease by regulating the Nrf2/NLRP3 pathway

    YU TANG1, WENXIAO HU2,*, YAJUN PENG1, XIANGDONG LING2

    BIOCELL, Vol.48, No.10, pp. 1503-1516, 2024, DOI:10.32604/biocell.2024.052692 - 02 October 2024

    Abstract Background: Podocyte injury is crucial in diabetic kidney disease (DKD) progression, and the mechanism remains unclear. The previous studies indicated Diosgenin played a key role in inhibiting podocyte injury progression. However, more research is needed to explore Diosgenin in inhibiting-molecular mechanisms in the process of podocyte injury. Methods: The content of Diosgenin in HeShenwan was detected by High-Performance Liquid Chromatography-mass spectrometry (HPLC-MS) method. The podocyte injury model was constructed by high glucose (HG)-induced mpc5 cells. The Cell Counting Kit-8 (CCK-8) assay was utilized to evaluate the activity of mpc5 cells. Pyroptosis in mpc5 cells was… More > Graphic Abstract

    Diosgenin inhibited podocyte pyroptosis in diabetic kidney disease by regulating the Nrf2/NLRP3 pathway

  • Open Access

    ARTICLE

    Adaptable and Dynamic Access Control Decision-Enforcement Approach Based on Multilayer Hybrid Deep Learning Techniques in BYOD Environment

    Aljuaid Turkea Ayedh M1,2,*, Ainuddin Wahid Abdul Wahab1,*, Mohd Yamani Idna Idris1,3

    CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 4663-4686, 2024, DOI:10.32604/cmc.2024.055287 - 12 September 2024

    Abstract Organizations are adopting the Bring Your Own Device (BYOD) concept to enhance productivity and reduce expenses. However, this trend introduces security challenges, such as unauthorized access. Traditional access control systems, such as Attribute-Based Access Control (ABAC) and Role-Based Access Control (RBAC), are limited in their ability to enforce access decisions due to the variability and dynamism of attributes related to users and resources. This paper proposes a method for enforcing access decisions that is adaptable and dynamic, based on multilayer hybrid deep learning techniques, particularly the Tabular Deep Neural Network TabularDNN method. This technique transforms… More >

  • Open Access

    REVIEW

    The Impact of Domain Name Server (DNS) over Hypertext Transfer Protocol Secure (HTTPS) on Cyber Security: Limitations, Challenges, and Detection Techniques

    Muhammad Dawood1, Shanshan Tu1, Chuangbai Xiao1, Muhammad Haris2, Hisham Alasmary3, Muhammad Waqas4,5,*, Sadaqat Ur Rehman6

    CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 4513-4542, 2024, DOI:10.32604/cmc.2024.050049 - 12 September 2024

    Abstract The DNS over HTTPS (Hypertext Transfer Protocol Secure) (DoH) is a new technology that encrypts DNS traffic, enhancing the privacy and security of end-users. However, the adoption of DoH is still facing several research challenges, such as ensuring security, compatibility, standardization, performance, privacy, and increasing user awareness. DoH significantly impacts network security, including better end-user privacy and security, challenges for network security professionals, increasing usage of encrypted malware communication, and difficulty adapting DNS-based security measures. Therefore, it is important to understand the impact of DoH on network security and develop new privacy-preserving techniques to allow More >

  • Open Access

    ARTICLE

    A Cascading Fault Path Prediction Method for Integrated Energy Distribution Networks Based on the Improved OPA Model under Typhoon Disasters

    Yue He1, Yaxiong You1, Zhian He1, Haiying Lu1, Lei Chen2,*, Yuqi Jiang2, Hongkun Chen2

    Energy Engineering, Vol.121, No.10, pp. 2825-2849, 2024, DOI:10.32604/ee.2024.052371 - 11 September 2024

    Abstract In recent times, the impact of typhoon disasters on integrated energy active distribution networks (IEADNs) has received increasing attention, particularly, in terms of effective cascading fault path prediction and enhanced fault recovery performance. In this study, we propose a modified ORNL-PSerc-Alaska (OPA) model based on optimal power flow (OPF) calculation to forecast IEADN cascading fault paths. We first established the topology and operational model of the IEADNs, and the typical fault scenario was chosen according to the component fault probability and information entropy. The modified OPA model consisted of two layers: An upper-layer model to More >

  • Open Access

    REVIEW

    Security and Privacy Challenges in SDN-Enabled IoT Systems: Causes, Proposed Solutions, and Future Directions

    Ahmad Rahdari1,6, Ahmad Jalili2, Mehdi Esnaashari3, Mehdi Gheisari1,4,7,8,*, Alisa A. Vorobeva5, Zhaoxi Fang1, Panjun Sun1,*, Viktoriia M. Korzhuk5, Ilya Popov5, Zongda Wu1, Hamid Tahaei1

    CMC-Computers, Materials & Continua, Vol.80, No.2, pp. 2511-2533, 2024, DOI:10.32604/cmc.2024.052994 - 15 August 2024

    Abstract Software-Defined Networking (SDN) represents a significant paradigm shift in network architecture, separating network logic from the underlying forwarding devices to enhance flexibility and centralize deployment. Concurrently, the Internet of Things (IoT) connects numerous devices to the Internet, enabling autonomous interactions with minimal human intervention. However, implementing and managing an SDN-IoT system is inherently complex, particularly for those with limited resources, as the dynamic and distributed nature of IoT infrastructures creates security and privacy challenges during SDN integration. The findings of this study underscore the primary security and privacy challenges across application, control, and data planes.… More >

  • Open Access

    ARTICLE

    IGED: Towards Intelligent DDoS Detection Model Using Improved Generalized Entropy and DNN

    Yanhua Liu1,2,3, Yuting Han1,2,3, Hui Chen1,2,3, Baokang Zhao4,*, Xiaofeng Wang4, Ximeng Liu1,2,3

    CMC-Computers, Materials & Continua, Vol.80, No.2, pp. 1851-1866, 2024, DOI:10.32604/cmc.2024.051194 - 15 August 2024

    Abstract As the scale of the networks continually expands, the detection of distributed denial of service (DDoS) attacks has become increasingly vital. We propose an intelligent detection model named IGED by using improved generalized entropy and deep neural network (DNN). The initial detection is based on improved generalized entropy to filter out as much normal traffic as possible, thereby reducing data volume. Then the fine detection is based on DNN to perform precise DDoS detection on the filtered suspicious traffic, enhancing the neural network’s generalization capabilities. Experimental results show that the proposed method can efficiently distinguish More >

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