Annemarie E. M. Post^*†, Johan Bussink^*, Fred C. G. J. Sweep^†, Paul N. Span^*

Oncology Research, Vol.28, No.1, pp. 33-40, 2020, DOI:10.3727/096504019X15555794826018

Abstract Tamoxifen-induced radioresistance, reported in vitro, might pose a problem for patients who receive neoadjuvant tamoxifen treatment and subsequently receive radiotherapy after surgery. Previous studies suggested that DNA damage repair or cell cycle genes are involved, and could therefore be targeted to preclude the occurrence of cross-resistance. We aimed to characterize the observed cross-resistance by investigating gene expression of DNA damage repair genes and cell cycle genes in estrogen receptor-positive MCF-7 breast cancer cells that were cultured to tamoxifen resistance. RNA sequencing was performed, and expression of genes characteristic for several DNA damage repair pathways was investigated, as well as expression… More >

Nahathai Dukaew^*†, Teruaki Konishi^‡§, Kongthawat Chairatvit^¶, Narongchai Autsavapromporn^#, Noppamas Soonthornchareonnon^**, Ariyaphong Wongnoppavich^†

Oncology Research, Vol.28, No.2, pp. 161-175, 2020, DOI:10.3727/096504019X15736439848765

Abstract Radiotherapy (RT) is an important treatment for non-small cell lung cancer (NSCLC). However, the major obstacles to successful RT include the low radiosensitivity of cancer cells and the restricted radiation dose, which is given without damaging normal tissues. Therefore, the sensitizer that increases RT efficacy without dose escalation will be beneficial for NSCLC treatment. Eurycomalactone (ECL), an active quassinoid isolated from Eurycoma longifolia Jack, has been demonstrated to possess anticancer activity. In this study, we aimed to investigate the effect of ECL on sensitizing NSCLC cells to X-radiation (X-ray) as well as the underlying mechanisms. The results showed that ECL… More >

Chao Jiang^*, Xueyan Liu^†, Meng Wang^*, Guoyue Lv^*, Guangyi Wang^*

Oncology Research, Vol.28, No.7-8, pp. 833-833, 2020, DOI:10.3727/096504018X16233193839045

Abstract This article has no abstract. More >

FEIFEI TIAN¹, HUAN HU¹, DI WANG¹, HUAN DING¹, QINGJIA CHI², HUAPING LIANG³, WENLI ZENG^4,*

BIOCELL, Vol.46, No.10, pp. 2291-2301, 2022, DOI:10.32604/biocell.2022.020198

Abstract This study used transcriptome and epigenetic data to predict the prognosis of immune-related genes (IRGs) Apelin (APLN) in patients with hepatocellular carcinoma (HCC). The TCGA database has gene expression and clinical data for HCC. And DNA methylation 450 k data for HCC was download from the University of California Santa Cruz (UCSC) Xena browser. Performing clinical and prognostic analysis of APLN expression, results show that APLN is highly expressed in tumor samples. And it has an increasing trend with the development of clinical stage and T stage. To explore the prognostic role of APLN, the Immune-related DNA methylation (DNAm) sites… More >

Muhammad Zubair Rehman¹, Muhammad Aamir^2,*, Nazri Mohd. Nawi³, Abdullah Khan⁴, Saima Anwar Lashari⁵, Siyab Khan⁴

CMC-Computers, Materials & Continua, Vol.73, No.1, pp. 493-511, 2022, DOI:10.32604/cmc.2022.021787

Abstract

Recently, many researchers have used nature inspired metaheuristic algorithms due to their ability to perform optimally on complex problems. To solve problems in a simple way, in the recent era bat algorithm has become famous due to its high tendency towards convergence to the global optimum most of the time. But, still the standard bat with random walk has a problem of getting stuck in local minima. In order to solve this problem, this research proposed bat algorithm with levy flight random walk. Then, the proposed Bat with Levy flight algorithm is further hybridized with three different variants of ANN.… More >

EUN NA¹, SUN YOUNG LIM^2,*

BIOCELL, Vol.46, No.9, pp. 2101-2109, 2022, DOI:10.32604/biocell.2022.019807

Abstract We investigated the diversity and composition of microflora in feces of Lycopus lucidus Turcz.-fed mice. In addition, we evaluated the production of major cytokines (Interleukin-6 and -10) which are related to inflammation and fatty acid composition of several tissues. 16S ribosomal DNA sequencing-based microbiome taxonomic profiling analysis was performed utilizing the EzBioCloud data base. Male mice fed on L. lucidus showed a significantly reduced number of lactic acid bacteria and coliform in the feces compared with the control group (p < 0.05). 16S rDNA sequencing analysis of fecal samples showed that L. lucidus supplementation decreased the community of harmful microflora… More >

Yanqing Wu^1,2, Jiao Liu¹, Yuhan Tang², Daqiu Zhao², Jun Tao^1,2,*

Phyton-International Journal of Experimental Botany, Vol.91, No.9, pp. 2005-2016, 2022, DOI:10.32604/phyton.2022.021062

Abstract The ornamental and commercial values of herbaceous peony (Paeonia lactiflora Pall.) are directly related to its flower pattern. However, the molecular mechanisms underlying the type formation of P. lactiflora flowers have not been studied in great detail. Previous studies identified, using integrated multipleomics analysis, revealed that APETALA2 (AP2) is an important candidate gene that modulates type formation of P. lactiflora flowers. To further reveal the expression mechanism of AP2 in P. lactiflora petals, we examined the profile of AP2 expression in the inner and outer petals of ‘ZiFengyu’ at various developmental stages using qRT-PCR and BSP+Miseq methylation analysis. Based on… More >

Samirah Alzahrani^1,*, A.I. El-Maghrabi², M.S. Badr³

Intelligent Automation & Soft Computing, Vol.34, No.2, pp. 769-783, 2022, DOI:10.32604/iasc.2022.024682

Abstract The generalized structure of deoxyribonucleic acid (DNA) is based on the rules of topological spaces. DNA recombination is one of the most important processes within DNA, as it is essential in the pharmaceutical industry as well as in gene therapy. In this paper, we are discussing the relationship between rough sets, nano topological spaces (N), nano Z open (N) sets, and DNA recombination. We also created a new recombination mapping using the properties of the DNA recombination process. Further, by using the process of cutting and sticking of a sequence of genes, new topological structures are constructed and some of… More >

Khaled Suwais^*

Intelligent Automation & Soft Computing, Vol.33, No.3, pp. 1815-1834, 2022, DOI:10.32604/iasc.2022.025076

Abstract Securing communication over public communication channels is one of the challenging issues in the field of cryptography and information security. A stream cipher is presented as an approach for securing exchanged data between different parties through encryption. The core of stream cipher relies on its keystream generator, that is responsible for generating random and secure keystream of encrypting streaming data. Thus, the security of the keystream is measured by its randomness and its resistance to statistical and cryptanalytic attacks. As there is always a trade-off between the security and performance while designing new cryptographic primitives, we introduce a game theory-based… More >

K. Sundara Krishnan^1,*, Syed Suhaila¹, S. P. Raja²

Intelligent Automation & Soft Computing, Vol.33, No.2, pp. 1081-1101, 2022, DOI:10.32604/iasc.2022.024023

Abstract The technological advances made possible by the Internet, coupled with the unforeseen critical circumstances set in motion by the Covid-19 pandemic, have greatly increased the generation and transmission of medical images every day. Medical image transmission over an unsecured public network threatens the privacy of sensitive patient information. We have, in this paper, designed a new secure color medical image encryption algorithm based on binary plane decomposition, DNA (deoxyribonucleic acid) computing, and the chaotic Rössler dynamical system. At first, a bit-by-bit swap is performed on twenty four binary planes of the input image and encoded using DNA encoding rules. Thereafter,… More >