FU-MING TSAI¹, PING-HSUN LU^2,3, LU-KAI WANG⁴, CHAN-YEN KUO¹, MAO-LIANG CHEN¹, CHUN-HUA WANG^5,6,*

BIOCELL, Vol.47, No.8, pp. 1793-1802, 2023, DOI:10.32604/biocell.2023.030093

Abstract Background: Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human cancers. Patients often reduce the use of cisplatin due to its side effects, which in turn affects its treatment. This study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for chemotherapy. Methods: Primary human follicle dermal papilla cells (HFDPCs) were used as target cells for cisplatin-induced damage to hair cells. Western blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs damage. Cell survival and cell cycle were analyzed by mitochondrial staining reagent… More >

TONG WANG^1,4,#, JINHUAN HONG^1,5,#, JIAJIE XIE^1,5, QIAN LIU⁴, JINRUI YUE^1,5, XUTING HE^1,5, SHIYU GE⁴, TAO LI⁴, GUOXIN LIU⁴, BENZHI CAI^1,3,5, LINQIANG LI^2,*, YE YUAN^1,3,5,*

BIOCELL, Vol.47, No.8, pp. 1811-1820, 2023, DOI:10.32604/biocell.2023.029120

Abstract Background: Phototherapies based on sunlight, infrared, ultraviolet, visible, and laser-based treatments present advantages like high curative effects, small invasion, and negligible adverse reactions in cancer treatment. We aimed to explore the potential therapeutic effects of blue light emitting diode (LED) in human hepatoma cells and decipher the underlying cellular and molecular mechanisms. Methods: Wound healing and transwell assays were employed to probe the inhibition of the invasion and migration of hepatocellular carcinoma cells in the presence of blue LED. The sphere-forming test was used to evaluate the effect of LED blue light irradiation on cancer stem cell properties. Immunofluorescence and… More > Graphic Abstract

EFFAT ALEMZADEH¹, LEILA ALLAHQOLI², HAMIDEH DEHGHAN³, AFROOZ MAZIDIMORADI⁴, ALIREZA GHASEMPOUR³, HAMID SALEHINIYA^5,*

Oncology Research, Vol.31, No.5, pp. 667-675, 2023, DOI:10.32604/or.2023.028406

Abstract Liquid biopsy, including both circulating tumor cells and circulating tumor DNA, is becoming more popular as a diagnostic tool in the clinical management of breast cancer. Elevated concentrations of these biomarkers during cancer treatment may be used as markers for cancer progression as well as to understand the mechanisms underlying metastasis and treatment resistance. Thus, these circulating markers serve as tools for cancer assessing and monitoring through a simple, non-invasive blood draw. However, despite several study results currently noting a potential clinical impact of ctDNA mutation tracking, the method is not used clinically in cancer diagnosis among patients and more… More > Graphic Abstract

Nashat Salih Abdulkarim Alsandi¹, Dilovan Asaad Zebari^2,*, Adel Al-Zebari³, Falah Y. H. Ahmed⁴, Mazin Abed Mohammed⁵, Marwan Albahar⁶, Abdulaziz Ali Albahr^7,8

Computer Systems Science and Engineering, Vol.47, No.2, pp. 1321-1347, 2023, DOI:10.32604/csse.2023.038089

Abstract Information security has emerged as a key problem in encryption because of the rapid evolution of the internet and networks. Thus, the progress of image encryption techniques is becoming an increasingly serious issue and considerable problem. Small space of the key, encryption-based low confidentiality, low key sensitivity, and easily exploitable existing image encryption techniques integrating chaotic system and DNA computing are purposing the main problems to propose a new encryption technique in this study. In our proposed scheme, a three-dimensional Chen’s map and a one-dimensional Logistic map are employed to construct a double-layer image encryption scheme. In the confusion stage,… More >

CHIWEN BU^1,2, LIGANG ZHAO¹, LISHAN WANG¹, ZEQIAN YU¹, JIAHUA ZHOU^1,*

Oncology Research, Vol.31, No.4, pp. 495-503, 2023, DOI:10.32604/or.2023.029309

Abstract Pancreatic cancer is one of the most aggressive cancers with a median survival time of less than 5 months, and conventional chemotherapeutics are the main treatment strategy. Poly(ADP-ribose) polymerase (PARP) inhibitors have been recently approved for BRCA1/2-mutant pancreatic cancer, opening a new era for targeted therapy for this disease. However, most pancreatic cancer patients carry wild-type BRCA1/2 with resistance to PARP inhibitors. Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. Moreover, we found that knockdown of the mTORC2 obligate subunit Rictor sensitized… More > Graphic Abstract

DHANYA K. NAMBIAR¹, DEEPALI MISHRA², RANA P. SINGH^2,3,*

Oncology Research, Vol.31, No.4, pp. 405-421, 2023, DOI:10.32604/or.2023.028310

Abstract Ionizing radiation is frequently used to treat solid tumors, as it causes DNA damage and kill cancer cells. However, damaged DNA is repaired involving poly-(ADP-ribose) polymerase-1 (PARP-1) causing resistance to radiation therapy. Thus, PARP-1 represents an important target in multiple cancer types, including prostate cancer. PARP is a nuclear enzyme essential for single-strand DNA breaks repair. Inhibiting PARP-1 is lethal in a wide range of cancer cells that lack the homologous recombination repair (HR) pathway. This article provides a concise and simplified overview of the development of PARP inhibitors in the laboratory and their clinical applications. We focused on the… More > Graphic Abstract

E. Srimathi^1,*, S. P. Chokkalingam²

Computer Systems Science and Engineering, Vol.47, No.1, pp. 903-918, 2023, DOI:10.32604/csse.2023.029790

Abstract When it comes to data storage, cloud computing and cloud storage providers play a critical role. The cloud data can be accessed from any location with an internet connection. Additionally, the risk of losing privacy when data is stored in a cloud environment is also increased. A variety of security techniques are employed in the cloud to enhance security. In this paper, we aim at maintaining the privacy of stored data in cloud environment by implementing block-based modelling to boost the privacy level with Anti-Codify Technique (ACoT) and block cipher-based algorithms. Initially, the cipher text is generated using Deoxyribo Nucleic… More >

RYAN STARK^*

BIOCELL, Vol.47, No.6, pp. 1191-1198, 2023, DOI:10.32604/biocell.2023.027838

Abstract Protein-mediated interactions are the fundamental mechanism through which cells regulate health and disease. These interactions require physical contact between proteins and their respective targets of interest. These targets include not only other proteins but also nucleic acids and other important molecules as well. These proteins are often involved in multibody complexes that work dynamically to regulate cellular health and function. Various techniques have been adapted to study these important interactions, such as affinity-based assays, mass spectrometry, and fluorescent detection. The application of these techniques has led to a greater understanding of how protein interactions are responsible for both the instigation… More >

Walid El-Shafai^1,2,*, Fatma Khallaf^2,3, El-Sayed M. El-Rabaie², Fathi E. Abd El-Samie², Iman Almomani^1,4

Computer Systems Science and Engineering, Vol.46, No.3, pp. 3599-3618, 2023, DOI:10.32604/csse.2023.037655

Abstract This paper presents a robust multi-stage security solution based on fusion, encryption, and watermarking processes to transmit color healthcare images, efficiently. The presented solution depends on the features of discrete cosine transform (DCT), lifting wavelet transform (LWT), and singular value decomposition (SVD). The primary objective of this proposed solution is to ensure robustness for the color medical watermarked images against transmission attacks. During watermark embedding, the host color medical image is transformed into four sub-bands by employing three stages of LWT. The resulting low-frequency sub-band is then transformed by employing three stages of DCT followed by SVD operation. Furthermore, a… More >

Khaled M. Suwais^*

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 2685-2704, 2023, DOI:10.32604/cmc.2023.036161

Abstract Data encryption is essential in securing exchanged data between connected parties. Encryption is the process of transforming readable text into scrambled, unreadable text using secure keys. Stream ciphers are one type of an encryption algorithm that relies on only one key for decryption and as well as encryption. Many existing encryption algorithms are developed based on either a mathematical foundation or on other biological, social or physical behaviours. One technique is to utilise the behavioural aspects of game theory in a stream cipher. In this paper, we introduce an enhanced Deoxyribonucleic acid (DNA)-coded stream cipher based on an iterated n-player… More >