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  • Open Access

    ARTICLE

    Chaos-Based Novel Watermarked Satellite Image Encryption Scheme

    Mohamed Medani1, Yahia Said2, Nashwan Adnan Othman3,4, Farrukh Yuldashev5, Mohamed Kchaou6, Faisal Khaled Aldawood6, Bacha Rehman7,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.1, pp. 1049-1070, 2025, DOI:10.32604/cmes.2025.063405 - 11 April 2025

    Abstract Satellite images are widely used for remote sensing and defence applications, however, they are subject to a variety of threats. To ensure the security and privacy of these images, they must be watermarked and encrypted before communication. Therefore, this paper proposes a novel watermarked satellite image encryption scheme based on chaos, Deoxyribonucleic Acid (DNA) sequence, and hash algorithm. The watermark image, DNA sequence, and plaintext image are passed through the Secure Hash Algorithm (SHA-512) to compute the initial condition (keys) for the Tangent-Delay Ellipse Reflecting Cavity Map (TD-ERCS), Henon, and Duffing chaotic maps, respectively. Through More >

  • Open Access

    ARTICLE

    Total Phenolic and Flavonoid Contents of Cymbocarpum widemannii and Their Antioxidant, Antimicrobial, DNA Damaging Activities

    Mehmet Fidan1, Behcet Inal2,*, Mesut Sırrı3, Bülent Hallaç4, Ulutas Mehmet Sefa1

    Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 781-791, 2025, DOI:10.32604/phyton.2025.062171 - 31 March 2025

    Abstract The use of conventional herbal medicines is a rapidly expanding phenomenon in developed nations. For instance, 30%–50% of all drug use in China is attributed to traditional herbal preparations. Current study evaluated the antioxidant (DPPH, FRAP), total phenolic and flavonoid content, antibacterial activity, and DNA damage protective potential of aqueous and methanolic extracts obtained from the aerial parts and roots of Cymbocarpum wiedemannii Boiss., an endemic plant in Turkey. In antioxidant analyses, the methanolic extract of the aerial parts showed the highest %DPPH (73.38) and IC50 (3.46 mg/mL) values. The FRAP analysis revealed the highest iron-reducing… More > Graphic Abstract

    Total Phenolic and Flavonoid Contents of <i>Cymbocarpum widemannii</i> and Their Antioxidant, Antimicrobial, DNA Damaging Activities

  • Open Access

    REVIEW

    Use of DNA methylation patterns for early detection and management of lung cancer: Are we there yet?

    KONTIC MILICA1,2,*, MARKOVIC FILIP1

    Oncology Research, Vol.33, No.4, pp. 781-793, 2025, DOI:10.32604/or.2024.057231 - 19 March 2025

    Abstract Detecting lung cancer early is crucial for improving survival rates, yet it remains a significant challenge due to many cases being diagnosed at advanced stages. This review aims to provide advances in epigenetics which have highlighted DNA methylation patterns as promising biomarkers for early detection, prognosis, and treatment response in lung cancer. Techniques like bisulfite conversion followed by PCR, digital droplet polymerase chain reaction, and next-generation sequencing are commonly used for detecting these methylation patterns, which occur early in the cancer development process and can be detected in non-invasive samples like blood and sputum. Key… More >

  • Open Access

    ARTICLE

    Protective Effects of Probiotics against Methotrexate-Induced Intestinal Toxicity in the Mice Model

    KSENIA S. STAFEEVA1, NATALIA A. SAMOYLOVA1, OLGA A. KARANDEEVA1, VERONIKA V. NESTEROVA1, KIRILL A. STARODUBTSEV1, EVGENY V. MIKHAILOV2, ILYA O. KRUTOV2, EVGENY S. POPOV3, NATALIA S. RODIONOVA4, ANASTASIA V. KOKINA1,5, ARTEM P. GUREEV1,5,*

    BIOCELL, Vol.49, No.1, pp. 7-20, 2025, DOI:10.32604/biocell.2024.058339 - 24 January 2025

    Abstract Objective: The objective of this study was to determine the level of methotrexate (MTX) toxicity in the intestines of mice and to evaluate the protective effect of probiotics composed of Streptococcus, Bifidobacterium, and Lactobacillus species on intestinal cells during MTX treatment. Methods: Mice were divided into three groups: control, MTX group (received MTX injections), and MTX + probiotics group (received MTX injections along with a diet containing probiotics). Morphological and histological changes, the level of mitochondrial DNA (mtDNA) damage, the level of lipid peroxidation products, and gene expression in the mice’s small intestine were assessed. Results: We… More > Graphic Abstract

    Protective Effects of Probiotics against Methotrexate-Induced Intestinal Toxicity in the Mice Model

  • Open Access

    REVIEW

    Renal cell carcinoma: entering the age of biomarkers

    Andrew S. Iskandar, Kevin K. Zarrabi, William J. Tester

    Canadian Journal of Urology, Vol.31, No.4, pp. 11921-11930, 2024

    Abstract Introduction: Renal cell carcinoma is as the most prevalent form of kidney cancer, with the clear cell subtype comprising approximately 75% of cases. The identification of predictive and prognostic biomarkers has emerged as a crucial area of research within the field. Despite advancements in treatment, metastatic renal cell carcinoma presents formidable challenges, with survival rates heavily dependent upon the optimal choice of treatment.
    Materials and methods: This review summarizes the current literature regarding the prognostic and predictive value of biomarkers in patients with renal cell carcinoma. We conducted a comprehensive literature search to identify studies that reference… More >

  • Open Access

    PROCEEDINGS

    Numerical Simulation of In Situ Deformation Behavior of Pt-DNA Hydrogel

    Isamu Riku1,*, Arisa Fukatsu1, Koji Mimura1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.011356

    Abstract Pt-DNA hydrogel is formed by cross-linking the DNA strands with Pt-ions and the resultant three-dimensionally cross-linked DNA strands’ network is expected be used as a biocompatible polymeric carrier, i.e. the drug delivery platform for in situ tissue repair due to its high toughness. On the other hand, as another essential qualification for the drug delivery platform, the stability of the microstructure of the platform is indispensable.
    To evaluate the stability of the microstructure of Pt-DNA hydrogel, in this study, we at first employ the nonaffine molecular chains’ network model to reproduce the experimental results of the More >

  • Open Access

    ARTICLE

    DNAJA4, DNAJB11 and DNAJC10 induce cell transformation by inhibiting p53 and oncogene-induced senescence

    HYEON JU LEE1, CHANG SEOP LEE1, SI HOON KIM1, SOOKYUNG KIM1, JEONG MI KIM1, SUN-WHA IM1, YU-JIN JUNG2, SEUNG-PYO HONG3, HYUNJUNG LEE3, JONG-IL KIM3,4,5, JEONG A. HAN1,*

    BIOCELL, Vol.48, No.10, pp. 1455-1464, 2024, DOI:10.32604/biocell.2024.054538 - 02 October 2024

    Abstract Objective: Transformation from normal cells to malignant cells is the basis for tumorigenesis. While this cell transformation is known to result from aberrant activation or inactivation of associated genes, these genes have not yet been fully identified. In addition, DNAJs, proteins with a J domain, are known to be molecular co-chaperones, but their cellular functions remain largely unexplored. In this context, we here identified DNAJA4, DNAJB11, and DNAJC10 as pro-transforming genes and elucidated their action mechanisms. Methods: Senescence-associated (SA)-β-galactosidase staining and western blotting were used to analyze cellular senescence and protein expression. Soft agar assay was used… More >

  • Open Access

    ARTICLE

    Cloning, Characterization and Transformation of Methyltransferase 2a Gene (Zmet2a) in Maize (Zea mays L.)

    Xin Qi1,#, Yu Wang1,#, Xing Zhang1, Xiaoshuang Wei1, Xinyang Liu1, Zhennan Wang1, Zhenhui Wang1,*, Fenglou Ling2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.7, pp. 1767-1779, 2024, DOI:10.32604/phyton.2024.052844 - 30 July 2024

    Abstract DNA methylation is an important epigenetic regulatory mechanism, it regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of transcription factor(s) to DNA. In this study, a novel methyltransferase 2a gene (Zmet2a) was cloned in maize and identified by polymerase chain reaction-base (PCR-base) using a bioinformatics strategy. The Zmet2a cDNA sequence is 2739 bp long and translates to 912 amino acid peptides. The Zmet2a protein revealed that it contains BAH and CHROMO structural domains, is a non-transmembrane protein that is hydrophilically unstable, and has no signal peptide structure. Meanwhile, we verified More >

  • Open Access

    ARTICLE

    LncRNA HOTAIR promotes DNA damage repair and radioresistance by targeting ATR in colorectal cancer

    HAIQING HU1,#,*, HAO YANG2,#, SHUAISHUAI FAN3, XUE JIA3, YING ZHAO3, HONGRUI LI3

    Oncology Research, Vol.32, No.8, pp. 1335-1346, 2024, DOI:10.32604/or.2024.044174 - 17 July 2024

    Abstract Long non-coding RNAs (lncRNAs) have been implicated in cancer progression and drug resistance development. Moreover, there is evidence that lncRNA HOX transcript antisense intergenic RNA (HOTAIR) is involved in colorectal cancer (CRC) progression. The present study aimed to examine the functional role of lncRNA HOTAIR in conferring radiotherapy resistance in CRC cells, as well as the underlying mechanism. The relative expression levels of HOTAIR were examined in 70 pairs of CRC tumor and para-cancerous tissues, as well as in radiosensitive and radioresistant samples. The correlations between HOTAIR expression levels and clinical features of patients with… More >

  • Open Access

    ARTICLE

    The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory

    MAHER KURDI1,*, ALAA ALKHOTANI2, ABDULRAHMAN SABBAGH3, EYAD FAIZO4, AHMED I. LARY5, AHMED K. BAMAGA6, MAJID ALMANSOURI7, BADR HAFIZ8, THAMER ALSHARIF9, SALEH BAEESA8

    Oncology Research, Vol.32, No.6, pp. 1037-1045, 2024, DOI:10.32604/or.2024.051112 - 23 May 2024

    Abstract Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described. Methods: A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype tumors. Both groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR analysis. Inter-cohort statistical significance was evaluated. Results: Both IDH-mutant WHO grade 4 astrocytomas (n = 22, 64.7%) and IDH-wildtype… More > Graphic Abstract

    The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory

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