RYAN STARK^*

BIOCELL, Vol.47, No.6, pp. 1191-1198, 2023, DOI:10.32604/biocell.2023.027838

Abstract Protein-mediated interactions are the fundamental mechanism through which cells regulate health and disease. These interactions require physical contact between proteins and their respective targets of interest. These targets include not only other proteins but also nucleic acids and other important molecules as well. These proteins are often involved in multibody complexes that work dynamically to regulate cellular health and function. Various techniques have been adapted to study these important interactions, such as affinity-based assays, mass spectrometry, and fluorescent detection. The application of these techniques has led to a greater understanding of how protein interactions are responsible for both the instigation… More >

Walid El-Shafai^1,2,*, Fatma Khallaf^2,3, El-Sayed M. El-Rabaie², Fathi E. Abd El-Samie², Iman Almomani^1,4

Computer Systems Science and Engineering, Vol.46, No.3, pp. 3599-3618, 2023, DOI:10.32604/csse.2023.037655

Abstract This paper presents a robust multi-stage security solution based on fusion, encryption, and watermarking processes to transmit color healthcare images, efficiently. The presented solution depends on the features of discrete cosine transform (DCT), lifting wavelet transform (LWT), and singular value decomposition (SVD). The primary objective of this proposed solution is to ensure robustness for the color medical watermarked images against transmission attacks. During watermark embedding, the host color medical image is transformed into four sub-bands by employing three stages of LWT. The resulting low-frequency sub-band is then transformed by employing three stages of DCT followed by SVD operation. Furthermore, a… More >

Khaled M. Suwais^*

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 2685-2704, 2023, DOI:10.32604/cmc.2023.036161

Abstract Data encryption is essential in securing exchanged data between connected parties. Encryption is the process of transforming readable text into scrambled, unreadable text using secure keys. Stream ciphers are one type of an encryption algorithm that relies on only one key for decryption and as well as encryption. Many existing encryption algorithms are developed based on either a mathematical foundation or on other biological, social or physical behaviours. One technique is to utilise the behavioural aspects of game theory in a stream cipher. In this paper, we introduce an enhanced Deoxyribonucleic acid (DNA)-coded stream cipher based on an iterated n-player… More >

Ghofran Kh. Shraida¹, Hameed A. Younis¹, Taief Alaa Al-Amiedy², Mohammed Anbar^2,*, Hussain A. Younis^3,4, Iznan H. Hasbullah²

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 2641-2654, 2023, DOI:10.32604/cmc.2023.035793

Abstract Nowadays, high-resolution images pose several challenges in the context of image encryption. The encryption of huge images’ file sizes requires high computational resources. Traditional encryption techniques like, Data Encryption Standard (DES), and Advanced Encryption Standard (AES) are not only inefficient, but also less secure. Due to characteristics of chaos theory, such as periodicity, sensitivity to initial conditions and control parameters, and unpredictability. Hence, the characteristics of deoxyribonucleic acid (DNA), such as vast parallelism and large storage capacity, make it a promising field. This paper presents an efficient color image encryption method utilizing DNA encoding with two types of hyper-chaotic maps.… More >

QIAO ZHOU^1,2,3, JIAN LIU^2,4, LING XIN⁴, YANYAN FANG^2,4, LEI WAN^2,4, DAN HUANG^2,4, JINCHEN GUO¹, JIANTING WEN^2,4

BIOCELL, Vol.47, No.4, pp. 761-772, 2023, DOI:10.32604/biocell.2023.026698

Abstract The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being obesity, age, environmental variables, and genetic predisposition. The available evidence suggests that genetic diversity does not adequately account for all clinical characteristics and heterogeneity of OA. Genetics has emerged as a nascent and crucial area of research in OA. The epigenetic module presents a potential link between genetic and environmental risk factors and the susceptibility and pathogenesis of OA. As a critical epigenetic alteration, DNA methylation has been shown to have an important role in the etiology of OA and is a viable biomarker for predicting disease… More >

ZEINAB KLAAB¹, AZIZA HASSAN², JAWAHER ALBAQAMI¹, FAIZAH A. ALMALKI^1,*

BIOCELL, Vol.47, No.4, pp. 891-904, 2023, DOI:10.32604/biocell.2023.026556

Abstract Cancer remains to be one of the most severe sicknesses globally. Cases have kept rising over the years. Breast cancer (BC), which is among the leading types of cancers and predominantly affects women, is the second leading cause of cancer mortality. Researchers have developed interventions over the years; however, the BC survival rate has not improved since the 1980s. This has created the need for novel drug interventions that would manage and treat BC more effectively. This study focused on using a combination of natural product extracts such as phytoestrogen (Ziziphus jujube) and Tannin nanoparticles (NP99) together, which we have… More >

MERAN KESHAWA EDIRIWEERA^*

BIOCELL, Vol.47, No.3, pp. 441-444, 2023, DOI: 10.32604/biocell.2023.025747

Abstract Irregularities in the DNA repair pathways are frequently observed in cancer. Dysregulated DNA repair pathways support growth advantages to tumor cells. DNA polymerase-theta (POLQ) is an error-prone DNA polymerase involved in double-strand break repair through microhomology-mediated end joining (MMEJ). POLQ also mediates translesion DNA synthesis and it is largely not expressed in normal cells. POLQ is overexpressed in a range of cancer cells, including homologous recombination (HR) deficient cancer cells. In HR deficient cells, MMEJ is crucial as a backup DNA repair pathway, indicating the indispensable role of POLQ-mediated MMEJ in HR deficient cancer cells. In addition, POLQ is synthetic… More >

A. Arokiaraj Jovith¹, S. Rama Sree², Gudikandhula Narasimha Rao³, K. Vijaya Kumar⁴, Woong Cho⁵, Gyanendra Prasad Joshi⁶, Sung Won Kim^7,*

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 6429-6444, 2023, DOI:10.32604/cmc.2023.031817

Abstract The exponential growth of data necessitates an effective data storage scheme, which helps to effectively manage the large quantity of data. To accomplish this, Deoxyribonucleic Acid (DNA) digital data storage process can be employed, which encodes and decodes binary data to and from synthesized strands of DNA. Vector quantization (VQ) is a commonly employed scheme for image compression and the optimal codebook generation is an effective process to reach maximum compression efficiency. This article introduces a new DNA Computing with Water Strider Algorithm based Vector Quantization (DNAC-WSAVQ) technique for Data Storage Systems. The proposed DNAC-WSAVQ technique enables encoding data using… More >

Ahmed Zohair Ibrahim^1,*, P. Prakash², V. Sakthivel², P. Prabu³

Computer Systems Science and Engineering, Vol.45, No.3, pp. 2447-2460, 2023, DOI:10.32604/csse.2023.030134

Abstract In order to research brain problems using MRI, PET, and CT neuroimaging, a correct understanding of brainfunction is required. This has been considered in earlier times with the support of traditional algorithms. Deep learning process has also been widely considered in these genomics data processing system. In this research, brain disorder illness incliding Alzheimer’s disease, Schizophrenia and Parkinson’s diseaseis is analyzed owing to misdetection of disorders in neuroimaging data examined by means fo traditional methods. Moeover, deep learning approach is incorporated here for classification purpose of brain disorder with the aid of Deep Belief Networks (DBN). Images are stored in… More >

Noureldin Eissa^1,2,*, Uswah Khairuddin^1,3, Rubiyah Yusof¹, Ahmed Madani²

CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 2817-2838, 2023, DOI:10.32604/cmc.2023.033632

Abstract Epigenetics is the study of phenotypic variations that do not alter DNA sequences. Cancer epigenetics has grown rapidly over the past few years as epigenetic alterations exist in all human cancers. One of these alterations is DNA methylation; an epigenetic process that regulates gene expression and often occurs at tumor suppressor gene loci in cancer. Therefore, studying this methylation process may shed light on different gene functions that cannot otherwise be interpreted using the changes that occur in DNA sequences. Currently, microarray technologies; such as Illumina Infinium BeadChip assays; are used to study DNA methylation at an extremely large number… More >