JIAYU ZHANG^1,2,3,#, RUOYAN CAO^1,2,3,#, JIANMIN PENG^1,2,3, QINCHAO HU^1,2,3, JUAN XIA^1,2,3,*, BIN CHENG^1,2,3,*

BIOCELL, Vol.46, No.1, pp. 111-125, 2022, DOI:10.32604/biocell.2022.016612

Abstract Metabolic reprogramming and immunologic suppression are two critical characteristics promoting the progression of head and neck squamous cell carcinoma (HNSCC). The integrative analysis of all the metabolism-related genes (MRGs) in HNSCC is lacking and the interaction between the metabolism and the immune characteristics also requires more exploration to uncover the potential mechanisms. Therefore, this study was designed to establish a prognostic signature based on all the MRGs in HNSCC. Genes of HNSCC samples were available from the TCGA and GEO databases while the MRGs were retrieved from a previous study. Ultimately 4 prognostic MRGs were selected to construct a model… More >

Siddhant Banyal¹, Rinky Dwivedi², Koyel Datta Gupta², Deepak Kumar Sharma^3,*, Fadi Al-Turjman⁴, Leonardo Mostarda⁵

CMC-Computers, Materials & Continua, Vol.67, No.2, pp. 1679-1696, 2021, DOI:10.32604/cmc.2021.014387

Abstract The COVID-19 outbreak initiated from the Chinese city of Wuhan and eventually affected almost every nation around the globe. From China, the disease started spreading to the rest of the world. After China, Italy became the next epicentre of the virus and witnessed a very high death toll. Soon nations like the USA became severely hit by SARS-CoV-2 virus. The World Health Organisation, on 11th March 2020, declared COVID-19 a pandemic. To combat the epidemic, the nations from every corner of the world has instituted various policies like physical distancing, isolation of infected population and researching on the potential vaccine… More >

Silvana Molossi^1,2, Hitesh Agrawal^1,2

Congenital Heart Disease, Vol.12, No.5, pp. 596-596, 2017, DOI:10.1111/chd.12490

Abstract Coronary artery anomalies, particularly anomalous aortic origin of a coronary artery with an interarterial course, are associated with sudden cardiac arrest or death in the young. There is paucity of data on risk stratification and longitudinal follow up is lacking in these patients. Collaboration and sharing of data among specialized centers might shed much needed light in this complex problem. More >

Dinesh Balgude, Anagha Sabnis^*

Journal of Renewable Materials, Vol.4, No.2, pp. 146-157, 2016, DOI:10.7569/JRM.2015.634117

Abstract The performance properties of conventional polymeric material have been investigated by modifying it with cashew nut shell liquid (CNSL) derived hybrid precursor. The synthesis of hybrid material involved formation of maleic anhydride adduct of CNSL followed by silane modifi cation and subsequent hydrolysis and condensation with tetra ethyl orthosilicate. The developed hybrid material was characterized by a number of instrumental techniques like FT-IR, 1H-NMR and 13C-NMR, as reported in our earlier work. In the present work, we have investigated the effect of CNSL-based hybrid material on the performance properties of conventional alkyd-melamine formaldehyde-based stoving system. The synthesized material was used… More >

Zahra Niki Boroujeni¹, Atefeh Shirkav¹, Seyed Ahmad Aleyasin^1,*

Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 41-58, 2019, DOI:10.32604/mcb.2019.04366

Abstract Today, prognosis, diagnosis and treatment of cancers are progressing with non-invasive methods, including investigation and modification of the DNA methylation profile in cancer cells. One of the effective factors in regulating gene expression in mammals is DNA methylation. Methylation alterations of genes by external factors can change the expression of genes and inhibit the cancer. In the present study, we investigated the effect of Down syndrome critical region 1 gene (DSCR1) ectopic expression on the methylation status of the BCL-XL, ITGA6, TCF3, RASSF1A, DOK7, VIM and CXCR4 genes in breast cancer cell lines. The effect of DSCR1 ectopic expression on… More >

Zahra Niki Boroujeni¹, Atefeh Shirkav¹, Seyed Ahmad Aleyasin^1,*

Molecular & Cellular Biomechanics, Vol.15, No.4, pp. 215-227, 2018, DOI:10.32604/mcb.2018.01813

Abstract Down syndrome critical region 1 gene (DSCR1) is an anti-angiogenesis gene that inhibits the growth of tumor cells. In this study, the role of autophagy and apoptosis in DSCR1-induced cytotoxicity were investigated in MDA-MB-468 breast cancer cells. Lentivirus vector harboring DSCR1 (LV-DSCR1⁺) was constructed in HEK 293 cells and the optimal dosage of lentivirus vector for infection was determined by the MTT assay. After infection of cells using LV-DSCR1⁺, acridine orange and ethidium bromide staining was performed to investigation of apoptosis and autophagy. Expression of DSCR1 and marker genes for angiogenesis (VEGF), apoptosis (Bax and Bcl2) and autophagy (LC3 and… More >

Hong Qian^∗, Hao Ge^†

Molecular & Cellular Biomechanics, Vol.9, No.1, pp. 1-30, 2012, DOI:10.3970/mcb.2012.009.001

Abstract Biochemical reaction systems in mesoscopic volume, under sustained environmental chemical gradient(s), can have multiple stochastic attractors. Two distinct mechanisms are known for their origins: (a) Stochastic single-molecule events, such as gene expression, with slow gene on-off dynamics; and (b) nonlinear networks with feedbacks. These two mechanisms yield different volume dependence for the sojourn time of an attractor. As in the classic Arrhenius theory for temperature dependent transition rates, a landscape perspective provides a natural framework for the system's behavior. However, due to the nonequilibrium nature of the open chemical systems, the landscape, and the attractors it represents, are all themselves… More >

Mohamed Rady¹, Eric Arquis²

FDMP-Fluid Dynamics & Materials Processing, Vol.6, No.2, pp. 137-152, 2010, DOI:10.3970/fdmp.2010.006.137

Abstract In the present article, differential scanning calorimetry (DSC) and a modified T-history method have been used to study the phase changing behavior of granular composites. Further modifications and improvements of the two methods are employed to handle granular materials undergoing phase change over a temperature range. A simple procedure has been advised to obtain accurate results from the DSC measurements based on the estimation of the thermal resistance between the sample and its enclosure. The concept of enthalpy and its relationship with temperature has been employed in the T-history analysis to obtain enthalpy-temperature and apparent heat capacity curves similar to… More >