Xuelian Du^1,#, Hao Shi^2,#, Haiyan Liu¹, Linghua Zhou¹, Anqun Xie¹, Jufang Guo^1,*

Oncologie, Vol.24, No.4, pp. 769-787, 2022, DOI:10.32604/oncologie.2022.026248

Abstract Background: Gestational diabetes mellitus (GDM) affects the health of numerous women around the world. A recent study has shown that GDM is associated with an increased incidence of cancer. In this study, we aimed to explore the possible shared mechanisms and potential common therapeutic targets between GDM and cancer. Methods: The limma package was used to identify differentially expressed genes (DEGs) in GDM. The Cytoscape plugin cytoHubba was used to screen hub genes. The CIBERSORT algorithm was used to explore the correlation between hub genes and immunity. Cox regression analysis was used to assess the relationship between protein tyrosine kinase… More >

YAO LU^1,2,*, QIUYUE WANG¹, CAIHUI ZHANG¹

BIOCELL, Vol.47, No.2, pp. 393-400, 2023, DOI:10.32604/biocell.2023.024944

Abstract Myocardial fibrosis is an important manifestation of diabetic cardiomyopathy. This study investigated the potential mechanism of diabetic myocardial fibrosis. Male C57BL/6J and db/db mice aged 8 weeks were randomly divided into the diabetic (DB) and control groups. At 20 weeks, the mouse heart was harvested and subjected to hematoxylin-eosin staining (HE) and Masson staining to investigate the degree of fibrosis. The expressions of transforming growth factor-beta 1 (TGF-β1), collagen-III, B-cell lymphoma-2 (Bcl2), Bcl2-associated X protein (Bax), cleaved gasdermin D (GSDMD), cysteinyl aspartate specific proteinase-1 (caspase-1), apoptosis-associated speck-like protein containing a CARD (ASC), and nucleotide-binding oligomerization domain (NOD)-like receptor 3 (NLRP3)… More >

G. Geetha^1,2,*, K. Mohana Prasad¹

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 703-718, 2023, DOI:10.32604/iasc.2023.032530

Abstract Diabetes mellitus is a metabolic disease in which blood glucose levels rise as a result of pancreatic insulin production failure. It causes hyperglycemia and chronic multiorgan dysfunction, including blindness, renal failure, and cardiovascular disease, if left untreated. One of the essential checks that are needed to be performed frequently in Type 1 Diabetes Mellitus is a blood test, this procedure involves extracting blood quite frequently, which leads to subject discomfort increasing the possibility of infection when the procedure is often recurring. Existing methods used for diabetes classification have less classification accuracy and suffer from vanishing gradient problems, to overcome these… More >

YUEHUA SHI^1,#, QIUYING YAN^2,#, QIN LI³, WEI QIAN¹, DONGYAN QIAO¹, DONGDONG SUN², HONG YU^1,*

BIOCELL, Vol.47, No.1, pp. 165-173, 2023, DOI:10.32604/biocell.2022.023043

Abstract The placenta plays an important role in nutrient transport to maintain the growth and development of the embryo. Gestational diabetes mellitus (GDM), the most common complication during pregnancy, highly affects placental function in late gestation. Advanced glycation end-products (AGEs), a complex and heterogeneous group of compounds engaged by the receptor for AGEs (RAGE), are closely associated with diabetes-related complications. In this study, AGEs induced a decrease in the expression of tight junction (TJ) proteins in BeWo cells and increased the paracellular permeability of trophoblast cells by regulating RAGE/NF-κB. Sprague-Dawley (SD) rats injected with 100 mg/kg AGEs-rat serum albumin (RSA) via… More >

Praveen Talari^1,*, A. Suresh², M. G. Kavitha³

Intelligent Automation & Soft Computing, Vol.35, No.1, pp. 1053-1067, 2023, DOI:10.32604/iasc.2023.027024

Abstract As per World Health Organization report which was released in the year of 2019, Diabetes claimed the lives of approximately 1.5 million individuals globally in 2019 and around 450 million people are affected by diabetes all over the world. Hence it is inferred that diabetes is rampant across the world with the majority of the world population being affected by it. Among the diabetics, it can be observed that a large number of people had failed to identify their disease in the initial stage itself and hence the disease level moved from Type-1 to Type-2. To avoid this situation, we… More >

R. Rajkamal^1,*, Anitha Karthi², Xiao-Zhi Gao³

CMC-Computers, Materials & Continua, Vol.73, No.1, pp. 2013-2033, 2022, DOI:10.32604/cmc.2022.027142

Abstract Diabetes is increasing commonly in people’s daily life and represents an extraordinary threat to human well-being. Machine Learning (ML) in the healthcare industry has recently made headlines. Several ML models are developed around different datasets for diabetic prediction. It is essential for ML models to predict diabetes accurately. Highly informative features of the dataset are vital to determine the capability factors of the model in the prediction of diabetes. Feature engineering (FE) is the way of taking forward in yielding highly informative features. Pima Indian Diabetes Dataset (PIDD) is used in this work, and the impact of informative features in… More >

Elias Hossain¹, Mohammed Alshehri², Sultan Almakdi^2,*, Hanan Halawani², Md. Mizanur Rahman³, Wahidur Rahman⁴, Sabila Al Jannat⁵, Nadim Kaysar⁶, Shishir Mia⁴

CMC-Computers, Materials & Continua, Vol.72, No.1, pp. 1713-1746, 2022, DOI:10.32604/cmc.2022.024822

Abstract Diabetes Mellitus is one of the most severe diseases, and many studies have been conducted to anticipate diabetes. This research aimed to develop an intelligent mobile application based on machine learning to determine the diabetic, pre-diabetic, or non-diabetic without the assistance of any physician or medical tests. This study's methodology was classified into two the Diabetes Prediction Approach and the Proposed System Architecture Design. The Diabetes Prediction Approach uses a novel approach, Light Gradient Boosting Machine (LightGBM), to ensure a faster diagnosis. The Proposed System Architecture Design has been combined into seven modules; the Answering Question Module is a natural… More >

Saleh Albahli^1,2,*, Ghulam Nabi Ahmad Hassan Yar³

Intelligent Automation & Soft Computing, Vol.33, No.2, pp. 837-853, 2022, DOI:10.32604/iasc.2022.024427

Abstract Diabetic retinopathy is an eye deficiency that affects the retina as a result of the patient having Diabetes Mellitus caused by high sugar levels. This condition causes the blood vessels that nourish the retina to swell and become distorted and eventually become blocked. In recent times, images have played a vital role in using convolutional neural networks to automatically detect medical conditions, retinopathy takes this to another level because there is need not for just a system that could determine is a patient has retinopathy, but also a system that could tell the severity of the procession and if it… More >

YANQIU LI^#,*, CHENJUN HAO^#, WEIYI CHEN, QINGJU MENG

BIOCELL, Vol.46, No.6, pp. 1565-1573, 2022, DOI:10.32604/biocell.2022.018347

Abstract This work aimed to clarify the interaction between the fetus and pregnant patients with gestational diabetes mellitus (GDM), the lipid metabolomics analysis of the fetal umbilical cord blood of GDM patients and normal pregnant women were performed to screen out the specific lipid metabolites for pathogenesis of GDM. From 2019–2020, 21 patients with GDM and 22 normal pregnant women were enrolled in Hexian Memorial Hospital, Panyu District, Guangzhou. The general information such as weight, height, age, body mass index (BMI) before pregnancy were analyzed. Non-targeted metabonomic detection and analysis were performed in umbilical cord plasma using LC-MS method. The age,… More >

Altyeb Altaher Taha^*, Sharaf Jameel Malebary

CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 6089-6105, 2022, DOI:10.32604/cmc.2022.023848

Abstract Diabetes is a chronic health condition that impairs the body's ability to convert food to energy, recognized by persistently high levels of blood glucose. Undiagnosed diabetes can cause many complications, including retinopathy, nephropathy, neuropathy, and other vascular disorders. Machine learning methods can be very useful for disease identification, prediction, and treatment. This paper proposes a new ensemble learning approach for type 2 diabetes prediction based on a hybrid meta-classifier of fuzzy clustering and logistic regression. The proposed approach consists of two levels. First, a base-learner comprising six machine learning algorithms is utilized for predicting diabetes. Second, a hybrid meta-learner that… More >