Yizhen Zhang^1,2,#, Juan Li^1,3,#, Huanqing Liu^1,4,#, Hong Xia¹, Jian Su^1,5, Fang Liu¹, Bo Su^6,*, Qi Su^1,*

Oncology Research, Vol.33, No.12, pp. 3869-3886, 2025, DOI:10.32604/or.2025.068689 - 27 November 2025

Abstract Objectives: Gastric cancer (GC) is often associated with high invasiveness, epithelial-mesenchymal transition (EMT), and resistance to 5-fluorouracil (5-FU), highlighting the need for novel therapeutic targets. This study explored whether diallyl disulfide (DADS) upregulates retinoic acid-related orphan receptor alpha (ROR) to weaken the protein kinase C alpha (PKC)/RORα-mediated RORα/β-catenin pathway, thereby inhibiting GC cell invasion, epithelial-mesenchymal transition (EMT), and enhancing 5-FU sensitivity. Methods: Human GC cell lines MGC-803 and SGC7901 were treated with DADS, RORα agonist SR1078/antagonist T0901317, and PKCα agonist TPA/antagonist GO6976. Cell proliferation (MTT), migration (scratch assay), invasion (Transwell), protein expression (Western blot), protein… More >

Jiayin Peng^1,2,#, Yijun Xue^2,#, Zhiren Cai², Zhaoguan Li², Kangyan Han², Xiaoqi Lin², Yutong Li^1,*, Yumin Zhuo^1,*

Oncology Research, Vol.33, No.10, pp. 3127-3154, 2025, DOI:10.32604/or.2025.067340 - 26 September 2025

Abstract Background: Clear cell renal cell carcinoma (ccRCC) is an aggressive malignancy associated with limited treatment options and poor prognosis. Emerging studies suggest that the actin-regulating protein actin-related protein 2/3 complex subunit 1B (ARPC1B), a key regulatory protein within the actin cytoskeleton, could play a pivotal role in ccRCC progression. The current study aimed to uncover the biological functions of ARPC1B and the molecular mechanisms driving its effects in ccRCC. Methods: ARPC1B expression and prognostic implications were analyzed using data sourced from the Gene Expression Profiling Interactive Analysis (GEPIA) platform, immunohistochemical (IHC) staining on 150 tumor… More >

Yuhang Jiang^#, Yijun Xu^#, Qi Zhu, Yingxia Wu, Zhe Wang, Shuang He, Shiyong Yu^*, Honggang Xiang^*

Oncology Research, Vol.33, No.9, pp. 2379-2398, 2025, DOI:10.32604/or.2025.063501 - 28 August 2025

Abstract Background: Colorectal cancer (CRC) is common and deadly, often leading to metastasis, challenging treatment, and poor outcomes. Understanding its molecular basis is crucial for developing effective therapies. Aims: This study aimed to investigate the role of Myosin Heavy Chain 11 (MYH11) in CRC progression, especially its effects on epithelial-mesenchymal transition (EMT) and cell behavior, and to explore its potential regulation by the EMT transcription factor zinc finger E-box binding homeobox 1 (ZEB1). Methods: Differential expression analysis was performed in the GSE123390 and TCGA-READ datasets, and 317 intersection genes were identified. The hub gene MYH11 was identified… More >

Li Yu^1,2,3, Xiaoyan Zhang^1,2, Yan Feng^1,4, Xinyue Liao^1,4, Tiejun Zhou⁵, Hang Si^1,4, Yun Feng^1,4, Decai Wang^6,*, Yongxian Lai^1,7,*

Oncology Research, Vol.33, No.8, pp. 2037-2053, 2025, DOI:10.32604/or.2025.064276 - 18 July 2025

Abstract Background: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy with a low five-year survival rate. ATP-binding cassette subfamily B member 5 (ABCB5) has been linked to tumorigenesis. However, its role in inducing OSCC remains unclear. Methods: Quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blot, and immunocytochemistry (ICC) were performed to examine the level of ABCB5 in OSCC (CAL27 and HSC-3) and human oral keratinocyte (HOK). ABCB5 was knocked down in CAL27 cells using ABCB5-specific small interfering RNA (ABCB5 siRNA), and its contribution to migration, invasion, and epithelial-mesenchymal transition (EMT),… More >

LIBO LIANG¹, XINYI WANG^2,3,4, YUPING ZENG^2,3,4, HAO CHEN^2,3,4, WEN ZHOU¹, HONGYING MU^2,3,4, GA LIAO^5,6,*

Oncology Research, Vol.33, No.6, pp. 1405-1421, 2025, DOI:10.32604/or.2024.056708 - 29 May 2025

Abstract Objectives: Exosomal long noncoding RNAs (lncRNAs) might facilitate epithelial–mesenchymal transition (EMT) in liver cancer after transarterial chemoembolization (TACE), thereby enhancing tumor cell invasiveness and migration. This study investigated the prognostic role of plasma exosomal long noncoding RNA-plasmacytoma variant translocation 1 (lncRNA-PVT1) in TACE treated hepatocellular carcinoma (HCC). Methods: Plasma exosomal lncRNA-PVT1 was evaluated via qPCR before and after TACE. Hepatoma cell behavior was investigated in different HCC cell lines. A lncRNA-PVT1 plasmid was synthesized and overexpressed, and si-lncRNA PVT1 was transfected into poorly invasive cells to reveal its influence on cell characteristics. The lncRNA-PVT1–FoxM1 interaction… More > Graphic Abstract

HYEONG SIM CHOI¹, JEONG-KUI KU¹, SEONG-GYU KO², PIL-YOUNG YUN^1,3,*

Oncology Research, Vol.33, No.5, pp. 1217-1227, 2025, DOI:10.32604/or.2025.059791 - 18 April 2025

Abstract Background: Oral cancer remains a significant global health challenge, as it has high morbidity and mortality rates. Current treatments show limited efficacy and have severe side effects, prompting searches for new therapeutic agents. SH003, a traditional herbal formulation comprising Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii, has demonstrated potential anticancer properties in previous studies. However, its specific efficacy against oral cancer and the role of its key components, particularly Cucurbitacin D, remain underexplored. Methods: The cytotoxic effects of SH003 and its major components—i.e., Cucurbitacin D, Decursin, Formononetin, and Nodakenin—were evaluated using 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT), Trypan Blue exclusion, and… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.5, pp. 1253-1253, 2025, DOI:10.32604/or.2024.056916 - 18 April 2025

Abstract This article has no abstract. More >

Hongjuan Guo¹, Dan Liu^1,2, Ruyu Yan^1,2, Tianjing Zhang³, Kecheng Zhou^1,2,*, Minxia Liu^1,*

BIOCELL, Vol.49, No.3, pp. 483-502, 2025, DOI:10.32604/biocell.2025.062143 - 31 March 2025

Abstract Objectives: Non-small cell lung cancer (NSCLC) represents a formidable malignancy characterized by its marked metastatic potential and intrinsic resistance to therapeutic interventions. The identification of potential biomarkers delineating the progression and metastatic cascade of NSCLC assumes paramount importance in fostering advancements toward enhanced patient outcomes and prognostic stratification. Methods: The expression level of the actin-related protein 2/3 complex; subunit 1A (ARPC1A) in NSCLC was evaluated using The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis (GEPIA) databases; along with the LinkedOmics database for co-expression genes. Further verification of ARPC1A expression in normal lung cells… More >

LUIS MANUEL GONZáLEZ-RODRíGUEZ¹, LUIS MIGUEL JUáREZ-SALCEDO^1,*, JAVIER LOSCERTALES¹, EVA ARRANZ¹, JIMENA CANNATA-ORTIZ¹, JAVIER ORTIZ¹, MARIA JOSé LóPEZ DE LA OSA¹, ADRIáN ALEGRE¹, SAMIR DALIA^2,*

Oncology Research, Vol.33, No.3, pp. 505-517, 2025, DOI:10.32604/or.2025.058175 - 28 February 2025

Abstract T-prolymphocytic leukemia is a rare and aggressive hematological malignancy characterized by the clonal proliferation of mature lymphoid T-cells. The pathogenesis of T-PLL is closely linked to specific chromosomal abnormalities, primarily involving the proto-oncogene T-cell leukemia/lymphoma 1 gene family. Recent advancements in molecular profiling have identified additional genomic aberrations, including those affecting the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. This case report presents a patient with T-prolymphocytic leukemia whose cytogenetic and molecular analysis revealed a t(X;14)(q28;q11.2) translocation and a STAT5B mutation. Here, we aim to review the genetic and molecular underpinnings of T-prolymphocytic More >

DONG JIANG¹, ZHI QI³, ZHIYING XU^2,*, YIRAN LI^1,*

Oncology Research, Vol.33, No.3, pp. 709-722, 2025, DOI:10.32604/or.2024.050125 - 28 February 2025

Abstract Background: Hepatocellular carcinoma (HCC) is a prevalent liver malignancy. This study examined the roles of transforming growth factor beta (TGF-β) and cytochrome b5 domain containing 2 (CYB5D2) in HCC etiology and their prognostic biomarker potential. Methods: Key modules and prognostic genes were identified by analyzing the GSE101685 dataset by weighted gene co-expression network analysis (WGCNA) and Least absolute shrinkage and selection operator (LASSO) Cox regression. The expression levels of CYB5D2 and TGF-β in HCC cell lines were quantified using Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blotting (WB) assays. Effects of CYB5D2 overexpression on cell proliferation,… More >