WEILAN LIU, XIAOYAN DUAN, KAIYUN QIN, YAN JIANG, CAIFU ZHAO, CONGWEI DAI^*

BIOCELL, Vol.47, No.11, pp. 2471-2484, 2023, DOI:10.32604/biocell.2023.029617 - 27 November 2023

Abstract Introduction: Structural maintenance of chromosome 1A (SMC1A) is a crucial compound of the cohesin complex. It has been reported to regulate the epithelial-mesenchymal transition (EMT) process in multiple cancers. Objectives: The present study aims to further clarify the role of SMC1A in cervical cancer. Methods: We analyzed data from four datasets and confirmed that SMC1A showed high expression in cervical cancer samples and was related to poor prognosis of patients with cervical cancer. Cell proliferation of SiHa and C-33A with knockdown of SMC1A was assessed using CCK-8 and colony formation assay. The migration and invasion were… More > Graphic Abstract

FENGXIANG TANG, YANSHI LI, MIN PAN, ZHIHAI WANG, TAO LU, CHUAN LIU, XIN ZHOU, GUOHUA HU^*

Oncology Research, Vol.31, No.5, pp. 787-803, 2023, DOI:10.32604/or.2023.030081 - 21 July 2023

Abstract Background: Lymphatic metastasis (LM) emerges as an independent prognostic marker for hypopharyngeal squamous cell carcinoma (HSPSCC), chiefly contributing to treatment inefficacy. This study aimed to scrutinize the prognostic relevance of HSP90AA1 and its potential regulatory mechanism of concerning LM in HPSCC. Methods: In a preceding investigation, HSP90AA1, a differential gene, was discovered through transcriptome sequencing of HPSCC tissues, considering both the presence and absence of LM. Validation of HSP90AA1 expression was accomplished via qRT-PCR, western-blotting(WB), and immunohistochemistry(IHC), while its prognostic significance was assessed employing Kaplan–Meier survival analysis(KMSA), log-rank test(LR), and Cox’s regression analysis(CRA). Bioinformatics techniques… More > Graphic Abstract

TABEA GEWALT^1,2, KA-WON NOH³, LYDIA MEDER^1,2,4,*

Oncology Research, Vol.31, No.2, pp. 101-115, 2023, DOI:10.32604/or.2023.028105 - 10 April 2023

Abstract LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity. Under normal conditions, LIN28B is exclusively expressed in embryogenic stem cells, blocking differentiation and promoting proliferation. In addition, it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 microRNAs. In malignancies, LIN28B is frequently overexpressed, which is associated with increased tumor aggressiveness and metastatic properties. In this review, we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic More >

K. Rajesh Kumar^1,*, M. Vijayakumar²

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 819-832, 2023, DOI:10.32604/iasc.2023.030961 - 29 September 2022

Abstract In past decades, cellular networks have raised the usage of spectrum resources due to the victory of mobile broadband services. Mobile devices create massive data than ever before, facing the way cellular networks are installed presently for satisfying the increased traffic requirements. The development of a new exclusive spectrum offered to meet up the traffic requirements is challenging as spectrum resources are limited, hence costly. Cognitive radio technology is presented to increase the pool of existing spectrum resources for mobile users via Femtocells, placed on the top of the available macrocell network for sharing the… More >

TAMARA FERNÁNDEZ-CALERO^1,2,3,#, IGNACIO LÓPEZ^1,#, MARCOS DAVYT¹, CORA CHALAR¹, RICARDO EHRLICH^1,4, MÓNICA MARÍN^1,*

BIOCELL, Vol.46, No.11, pp. 2353-2356, 2022, DOI:10.32604/biocell.2022.020966 - 07 July 2022

Abstract The epithelial to mesenchymal transition (EMT) is a cellular program that drives de-differentiation of cells in both physiological and pathological processes. One of the characteristics of cells describing an EMT is the (re)acquisition of a motility capacity that allows them to migrate through the original tissue as well as to other sites in the organism. The molecular mechanisms that control the EMT are rapidly emerging and here we add to the idea that the adaptation required for cells to commit to the EMT includes adjustments of the translation machinery and metabolic pathways to cope with More >

MENGMENG LIU^1,#, YUE PAN^1,2,#, XUFENG TAO¹, WENLI KANG¹, YINGJIE LIU¹, YONGJIE YANG^3,4,*, GARY GUISHAN XIAO^1,*

BIOCELL, Vol.46, No.10, pp. 2257-2265, 2022, DOI:10.32604/biocell.2022.020325 - 13 June 2022

Abstract Pancreatic ductal adenocarcinoma (PDAC) is universally acknowledged as the cancer with the highest mortality rate. Berberine has high medicinal value and has been used as an anti-cancer agent. Hence the purpose of this study was to investigate the anti-cancer effect of berberine in PDAC. Berberine was shown to have a selective anti-cancer effect on PDAC by MTT assay in vitro. Pancreatic cancer stem cells (PCSCs), regulated by epithelial–mesenchymal transition (EMT), could promote the proliferation of PDAC cells. However, berberine suppressed the proliferation and stemness of PCSCs through immunofluorescence staining, stem cell sphere assays and so forth in More >

NING LI^1,#, YANG CHEN^2,#, YONGJIE YANG^3,4, SHUHAN LYU¹, YUE PAN^1,5,*

BIOCELL, Vol.46, No.6, pp. 1473-1482, 2022, DOI:10.32604/biocell.2022.018278 - 07 February 2022

Abstract Breast cancer is a highly aggressive cancer in females. Metastasis is a major obstacle to the efficient and successful treatment of breast cancer. Cetyltrimethylammonium bromide (CTAB) has anti-tumor effects on a variety of tumors. We showed that CTAB inhibits the metastasis of breast cancer to the lungs both in vitro and in vivo. Epithelial-mesenchymal transition (EMT) is thought to be one of the major processes mediating breast cancer metastasis. We found that CTAB suppressed EMT and regulated the levels of the classical EMT markers E-cadherin, N-cadherin, vimentin, Snail and Twist1. Moreover, as a candidate anti-tumor agent, CTAB More >

Kazuhiro Yamamoto^*, Takeshi Ioroi^*, Kazuaki Shinomiya^†, Ayaka Yoshida^*, Kenichi Harada^‡, Masato Fujisawa^‡, Tomohiro Omura^*, Yasuaki Ikemi^§, Shunsaku Nakagawa^§, Atsushi Yonezawa^§, Osamu Ogawa^¶, Kazuo Matsubara^§, Takuya Iwamoto^#, Kohei Nishikawa^**, Sayaka Hayashi^††, Daichi Tohara^††, Yoji Murakami^‡‡, Takanobu Motoshima^‡‡, Hirofumi Jono^††, Ikuko Yano^*§

Oncology Research, Vol.29, No.1, pp. 11-23, 2021, DOI:10.3727/096504022X16418911579334

Abstract We evaluated the association of signal transducer and activator of transcription 3 (STAT3) polymorphisms with the incidence of mammalian target of rapamycin (mTOR) inhibitor-induced interstitial lung disease (ILD) in patients with renal cell carcinoma (RCC). We also used lung-derived cell lines to investigate the mechanisms of this association. Japanese patients with metastatic RCC who were treated with mTOR inhibitors were genotyped for the STAT3 polymorphism, rs4796793 (−1697C/G). We evaluated the association of the STAT3 genotype with the incidence of ILD and therapeutic outcome. In the 57 patients included in the primary analysis, the ILD rate… More >

Shahzaib Anwar¹, Sardar Muhammad Gulfam^1,*, Bilal Muhammad², Syed Junaid Nawaz¹, Khursheed Aurangzeb³, Mohammad Kaleem¹

CMC-Computers, Materials & Continua, Vol.69, No.1, pp. 1021-1037, 2021, DOI:10.32604/cmc.2021.018248 - 04 June 2021

Abstract High electron mobility transistor (HEMT) based on gallium nitride (GaN) is one of the most promising candidates for the future generation of high frequencies and high-power electronic applications. This research work aims at designing and characterization of enhancement-mode or normally-off GaN HEMT. The impact of variations in gate length, mole concentration, barrier variations and other important design parameters on the performance of normally-off GaN HEMT is thoroughly investigated. An increase in the gate length causes a decrease in the drain current and transconductance, while an increase in drain current and transconductance can be achieved by… More >

Jing Li^*†, Lian-mei Zhao^‡, Cong Zhang^‡, Meng Li^§, Bo Gao^†, Xu-hua Hu^†, Jian Cao^†, Gui-ying Wang^†

Oncology Research, Vol.28, No.1, pp. 51-63, 2020, DOI:10.3727/096504019X15619783964700

Abstract Long noncoding RNAs (lncRNAs) participate in and regulate the biological process of colorectal cancer (CRC) progression. Our previous research identified differentially expressed lncRNAs in 10 CRC tissues and 10 matched nontumor tissues by next-generation sequencing (NGS). In this study, we identified an lncRNA, FEZF1 antisense RNA 1 (FEZF1-AS1), and further explored its function and mechanism in CRC. We verified that FEZF1-AS1 is highly expressed in CRC tissues and cell lines. Through functional experiments, we found that reduced levels of FEZF1-AS1 significantly suppressed CRC cell migration, invasion, and proliferation and inhibited tumor growth in vivo. Mechanistically,… More >