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  • Open Access

    ARTICLE

    Ligand Based Virtual Screening of Molecular Compounds in Drug Discovery Using GCAN Fingerprint and Ensemble Machine Learning Algorithm

    R. Ani1,*, O. S. Deepa2, B. R. Manju1

    Computer Systems Science and Engineering, Vol.47, No.3, pp. 3033-3048, 2023, DOI:10.32604/csse.2023.033807

    Abstract The drug development process takes a long time since it requires sorting through a large number of inactive compounds from a large collection of compounds chosen for study and choosing just the most pertinent compounds that can bind to a disease protein. The use of virtual screening in pharmaceutical research is growing in popularity. During the early phases of medication research and development, it is crucial. Chemical compound searches are now more narrowly targeted. Because the databases contain more and more ligands, this method needs to be quick and exact. Neural network fingerprints were created more effectively than the well-known… More >

  • Open Access

    REVIEW

    Cellular and molecular insights into microbiota-mitochondria interplay, therapeutic biomarkers and interventional approaches in COVID-19: A review

    VIBHAV VARSHNEY1,*, PRASHANT SINGH KUSHWAH2, NEETU AGRAWAL1, AHSAS GOYAL1,*, GOVIND SINGH2

    BIOCELL, Vol.47, No.10, pp. 2141-2149, 2023, DOI:10.32604/biocell.2023.030853

    Abstract The persistent global pandemic, COVID-19, stems from the pathogenic influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yielding an unprecedented worldwide crisis. With reference to a WHO report, the count of COVID-19 cases had exceeded 754 million by February 03, 2023. Intriguingly, emerging research has spotlighted the intricate interplay of gut microbiota and mitochondrial entities, acting as potent immunomodulatory factors at the cellular and molecular levels. This interconnection operates through a series of dynamic mechanisms. SARS-CoV-2 infection perturbs the delicate equilibrium of gut microbiota, leading to dysbiosis—a signature biomarker. This imbalance is intrinsically linked to exacerbated COVID-19 progression. Mechanistically,… More >

  • Open Access

    ARTICLE

    Research and Application of Log Defect Detection and Visualization System Based on Dry Coupling Ultrasonic Method

    Yongning Yuan1, Dong Zhang2, Usama Sayed3, Hao Zhu1, Jun Wang4, Xiaojun Yang2, Zheng Wang2,*

    Journal of Renewable Materials, Vol.11, No.11, pp. 3917-3932, 2023, DOI:10.32604/jrm.2023.028764

    Abstract In order to optimize the wood internal quality detection and evaluation system and improve the comprehensive utilization rate of wood, this paper invented a set of log internal defect detection and visualization system by using the ultrasonic dry coupling agent method. The detection and visualization analysis of internal log defects were realized through log specimen test. The main conclusions show that the accuracy, reliability and practicability of the system for detecting the internal defects of log specimens have been effectively verified. The system can make the edge of the detected image smooth by interpolation algorithm, and the edge detection algorithm… More >

  • Open Access

    ARTICLE

    K-Hyperparameter Tuning in High-Dimensional Space Clustering: Solving Smooth Elbow Challenges Using an Ensemble Based Technique of a Self-Adapting Autoencoder and Internal Validation Indexes

    Rufus Gikera1,*, Jonathan Mwaura2, Elizaphan Muuro3, Shadrack Mambo3

    Journal on Artificial Intelligence, Vol.5, pp. 75-112, 2023, DOI:10.32604/jai.2023.043229

    Abstract k-means is a popular clustering algorithm because of its simplicity and scalability to handle large datasets. However, one of its setbacks is the challenge of identifying the correct k-hyperparameter value. Tuning this value correctly is critical for building effective k-means models. The use of the traditional elbow method to help identify this value has a long-standing literature. However, when using this method with certain datasets, smooth curves may appear, making it challenging to identify the k-value due to its unclear nature. On the other hand, various internal validation indexes, which are proposed as a solution to this issue, may be… More >

  • Open Access

    ARTICLE

    An Interpolation Method for Karhunen–Loève Expansion of Random Field Discretization

    Zi Han1,*, Zhentian Huang2

    CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.1, pp. 245-272, 2024, DOI:10.32604/cmes.2023.029708

    Abstract In the context of global mean square error concerning the number of random variables in the representation, the Karhunen–Loève (KL) expansion is the optimal series expansion method for random field discretization. The computational efficiency and accuracy of the KL expansion are contingent upon the accurate resolution of the Fredholm integral eigenvalue problem (IEVP). The paper proposes an interpolation method based on different interpolation basis functions such as moving least squares (MLS), least squares (LS), and finite element method (FEM) to solve the IEVP. Compared with the Galerkin method based on finite element or Legendre polynomials, the main advantage of the… More > Graphic Abstract

    An Interpolation Method for Karhunen–Loève Expansion of Random Field Discretization

  • Open Access

    ARTICLE

    A Secure Device Management Scheme with Audio-Based Location Distinction in IoT

    Haifeng Lin1,2, Xiangfeng Liu2, Chen Chen2, Zhibo Liu2, Dexin Zhao3, Yiwen Zhang4, Weizhuang Li4, Mingsheng Cao5,6,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.1, pp. 939-956, 2024, DOI:10.32604/cmes.2023.028656

    Abstract Identifying a device and detecting a change in its position is critical for secure devices management in the Internet of Things (IoT). In this paper, a device management system is proposed to track the devices by using audio-based location distinction techniques. In the proposed scheme, traditional cryptographic techniques, such as symmetric encryption algorithm, RSA-based signcryption scheme, and audio-based secure transmission, are utilized to provide authentication, non-repudiation, and confidentiality in the information interaction of the management system. Moreover, an audio-based location distinction method is designed to detect the position change of the devices. Specifically, the audio frequency response (AFR) of several… More >

  • Open Access

    PROCEEDINGS

    TPMS-Based Topology Optimization Design with Multiple Materials via MMC Method

    Sinuo Zhang1, Daicong Da2, Yingjun Wang1,3,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.2, pp. 1-2, 2023, DOI:10.32604/icces.2023.09085

    Abstract Topology optimization (TO) designs involving multiple materials suffer either difficult interface modeling or finding physically meaningful transition domains with an accurate structural representation. Simple interpolation approaches are usually used in multi-material designs to represent the overlapped regions of different materials, which cannot solve either of these problems. In this paper, a moving morphable component (MMC)-based TO is developed to overcome this issue by leveraging the triply periodic minimal surfaces (TPMS). The TMPS-based architecture will serve as the infilling microstructure to accurately represent the overlapped domains of different materials. A TPMS function interpolation scheme is used to generate new microstructures for… More >

  • Open Access

    ARTICLE

    Multi-Model Fusion Framework Using Deep Learning for Visual-Textual Sentiment Classification

    Israa K. Salman Al-Tameemi1,3, Mohammad-Reza Feizi-Derakhshi1,*, Saeed Pashazadeh2, Mohammad Asadpour2

    CMC-Computers, Materials & Continua, Vol.76, No.2, pp. 2145-2177, 2023, DOI:10.32604/cmc.2023.040997

    Abstract Multimodal Sentiment Analysis (SA) is gaining popularity due to its broad application potential. The existing studies have focused on the SA of single modalities, such as texts or photos, posing challenges in effectively handling social media data with multiple modalities. Moreover, most multimodal research has concentrated on merely combining the two modalities rather than exploring their complex correlations, leading to unsatisfactory sentiment classification results. Motivated by this, we propose a new visual-textual sentiment classification model named Multi-Model Fusion (MMF), which uses a mixed fusion framework for SA to effectively capture the essential information and the intrinsic relationship between the visual… More >

  • Open Access

    ARTICLE

    CNN-Based RF Fingerprinting Method for Securing Passive Keyless Entry and Start System

    Hyeon Park1, SeoYeon Kim2, Seok Min Ko1, TaeGuen Kim2,*

    CMC-Computers, Materials & Continua, Vol.76, No.2, pp. 1891-1909, 2023, DOI:10.32604/cmc.2023.039464

    Abstract The rapid growth of modern vehicles with advanced technologies requires strong security to ensure customer safety. One key system that needs protection is the passive key entry system (PKES). To prevent attacks aimed at defeating the PKES, we propose a novel radio frequency (RF) fingerprinting method. Our method extracts the cepstral coefficient feature as a fingerprint of a radio frequency signal. This feature is then analyzed using a convolutional neural network (CNN) for device identification. In evaluation, we conducted experiments to determine the effectiveness of different cepstral coefficient features and the convolutional neural network-based model. Our experimental results revealed that… More >

  • Open Access

    ARTICLE

    Explainable AI and Interpretable Model for Insurance Premium Prediction

    Umar Abdulkadir Isa*, Anil Fernando*

    Journal on Artificial Intelligence, Vol.5, pp. 31-42, 2023, DOI:10.32604/jai.2023.040213

    Abstract Traditional machine learning metrics (TMLMs) are quite useful for the current research work precision, recall, accuracy, MSE and RMSE. Not enough for a practitioner to be confident about the performance and dependability of innovative interpretable model 85%–92%. We included in the prediction process, machine learning models (MLMs) with greater than 99% accuracy with a sensitivity of 95%–98% and specifically in the database. We need to explain the model to domain specialists through the MLMs. Human-understandable explanations in addition to ML professionals must establish trust in the prediction of our model. This is achieved by creating a model-independent, locally accurate explanation… More >

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