HYEON JI KIM^1,#, BO KYUNG JOO^1,#, JIN-SEOK BYUN^2,3,*, DO-YEON KIM^1,3,*

Oncology Research, Vol.33, No.6, pp. 1271-1282, 2025, DOI:10.32604/or.2025.062207 - 29 May 2025

Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive and devastating disease arising primarily from the mucosal epithelium of the oral cavity, pharynx, and larynx. HNSCC ranks as the sixth most common cancer worldwide, carrying significant morbidity and mortality. HPV-positive HNSCC can be partially prevented with the FDA-approved HPV vaccine and generally exhibits a more favorable prognosis compared to HPV-negative cases. However, effective screening and treatment approaches remain elusive for HPV-negative HNSCC. While precancerous lesions may precede invasive cancer in certain situations, most patients present with advanced disease without prior indication of precancerous More >

Chieh-Jen Wu^1,#, Yu-He Li^2,#, Hsin-Hung Chen^3,*

BIOCELL, Vol.49, No.5, pp. 857-872, 2025, DOI:10.32604/biocell.2025.064071 - 27 May 2025

Abstract Background: Serum- and glucocorticoid-induced kinase 1 (SGK1) is a member of the serine/threonine kinase family, playing a crucial role in regulating ion channel function, hormone secretion, cellular growth, survival mechanisms, and neuronal activity. SGK1 is implicated in kidney diseases, hypertension, and metabolic syndromes, influencing salt intake, renal growth, and renal potassium (K⁺) excretion during mineralocorticoid overdose. Although SGK1’s renal functions have been explored, comprehensive identification of SGK1-related genes and signaling cascades remains limited. Objectives: This research sought to explore the cellular mechanisms and signaling pathways influenced by SGK1 in rat kidney cells. Methods: NRK-52E cells, derived… More >

Abdullah M. Alnajim^1,*, Faisal Mohammed Alotaibi^2,#, Sheroz Khan^3,#

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 4515-4535, 2025, DOI:10.32604/cmc.2025.063139 - 19 May 2025

Abstract Distributed denial of service (DDoS) attacks are common network attacks that primarily target Internet of Things (IoT) devices. They are critical for emerging wireless services, especially for applications with limited latency. DDoS attacks pose significant risks to entrepreneurial businesses, preventing legitimate customers from accessing their websites. These attacks require intelligent analytics before processing service requests. Distributed denial of service (DDoS) attacks exploit vulnerabilities in IoT devices by launching multi-point distributed attacks. These attacks generate massive traffic that overwhelms the victim’s network, disrupting normal operations. The consequences of distributed denial of service (DDoS) attacks are typically… More >

Shuqin Zhang¹, Zihao Wang^1,*, Xinyu Su²

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 5781-5809, 2025, DOI:10.32604/cmc.2025.062080 - 19 May 2025

Abstract The methods of network attacks have become increasingly sophisticated, rendering traditional cybersecurity defense mechanisms insufficient to address novel and complex threats effectively. In recent years, artificial intelligence has achieved significant progress in the field of network security. However, many challenges and issues remain, particularly regarding the interpretability of deep learning and ensemble learning algorithms. To address the challenge of enhancing the interpretability of network attack prediction models, this paper proposes a method that combines Light Gradient Boosting Machine (LGBM) and SHapley Additive exPlanations (SHAP). LGBM is employed to model anomalous fluctuations in various network indicators,… More >

Daoming Wei¹, Fangyan Ge², Bopeng Zhang¹, Zhiqiang Zhao³, Dequan Li^3,*, Lizong Xi⁴, Jinrong Hu^5,*, Xin Wang⁶

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 5729-5746, 2025, DOI:10.32604/cmc.2025.061402 - 19 May 2025

Abstract Accurate cloud classification plays a crucial role in aviation safety, climate monitoring, and localized weather forecasting. Current research has been focusing on machine learning techniques, particularly deep learning based model, for the types identification. However, traditional approaches such as convolutional neural networks (CNNs) encounter difficulties in capturing global contextual information. In addition, they are computationally expensive, which restricts their usability in resource-limited environments. To tackle these issues, we present the Cloud Vision Transformer (CloudViT), a lightweight model that integrates CNNs with Transformers. The integration enables an effective balance between local and global feature extraction. To… More >

Wenli Lei^1,2,*, Xinghao Wu^1,2, Kun Jia^1,2, Jinping Han^1,2

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 5679-5698, 2025, DOI:10.32604/cmc.2025.061268 - 19 May 2025

Abstract Aiming to address the limitations of the standard Chimp Optimization Algorithm (ChOA), such as inadequate search ability and susceptibility to local optima in Unmanned Aerial Vehicle (UAV) path planning, this paper proposes a three-dimensional path planning method for UAVs based on the Improved Chimp Optimization Algorithm (IChOA). First, this paper models the terrain and obstacle environments spatially and formulates the total UAV flight cost function according to the constraints, transforming the path planning problem into an optimization problem with multiple constraints. Second, this paper enhances the diversity of the chimpanzee population by applying the Sine… More >

Hongliang Tian, Meiruo Li^*

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 5539-5559, 2025, DOI:10.32604/cmc.2025.060297 - 19 May 2025

Abstract The accelerated advancement of the Internet of Things (IoT) has generated substantial data, including sensitive and private information. Consequently, it is imperative to guarantee the security of data sharing. While facilitating fine-grained access control, Ciphertext Policy Attribute-Based Encryption (CP-ABE) can effectively ensure the confidentiality of shared data. Nevertheless, the conventional centralized CP-ABE scheme is plagued by the issues of key misuse, key escrow, and large computation, which will result in security risks. This paper suggests a lightweight IoT data security sharing scheme that integrates blockchain technology and CP-ABE to address the abovementioned issues. The integrity… More >

Jiawei Shi^1,2,3,#, Zhen Wang^1,2,3,#, Ying Bai^1,2,3, Shiying Li^1,2,3, Xin Zhang^1,2,3, Tianshu Liu^1,2,3, Liu Hong^1,2,3, Li Cui^1,2,3, Yi Zhang^1,2,3, Jing Ma^1,2,3, Juanjuan Liu^1,2,3, Jing Zhang^1,2,3, Haiyan Cao^1,2,3,*, Jing Wang^1,2,3,*

Congenital Heart Disease, Vol.20, No.2, pp. 213-229, 2025, DOI:10.32604/chd.2025.064950 - 30 April 2025

Abstract Background: Tetralogy of Fallot (TOF), the predominant cyanotic congenital heart defect, arises from multifactorial gene-environment interactions disrupting cardiac developmental networks. This study investigated TOF-specific transcriptional alterations and identified high-confidence candidate genes. Methods: Based on GSE36761 transcriptome data, a weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) network were conducted to identify TOF-related sub-network and Hub genes. The potential biological functions among these genes were revealed by enrichment analysis. Genetic, epigenetic and transcriptional alteration in the Hub genes were analyzed with leveraged public resources: a methylation dataset (GSE62629) and two single-cell datasets (EGAS00001003996 and GSE126128). Results:… More >

Dina Anggraini¹, Kurnia Wahyudi², Melawati Hasan³, Sri Endah Rahayuningsih^4,*, Charlotte Johanna Cool³

Congenital Heart Disease, Vol.20, No.2, pp. 133-141, 2025, DOI:10.32604/chd.2025.064164 - 30 April 2025

Abstract Background: Congenital heart disease (CHD) occurs in 9 out of 100 births and is the leading cause of birth defects, with acyanotic CHD being more common. The incidence of adult CHD is rising faster than pediatric CHD. Pulmonary hypertension is the most common complication in untreated CHD patients. Methods: This study is retrospective descriptive research based on medical record data and the results of right heart catheterization examinations in adult acyanotic CHD aged ≥18 years and free from other organ disorders. Results: A total of 103 patients met the inclusion criteria, the majority were young… More >

Dandan Wang^*, Jiaxin Chen, Yanwen Zhang

Phyton-International Journal of Experimental Botany, Vol.94, No.4, pp. 1137-1158, 2025, DOI:10.32604/phyton.2025.063894 - 30 April 2025

Abstract Taxus cuspidata, a rare species of the Taxus genus, and its wild resources are under severe threat. The development of cultivated species has become an important strategy to replace wild species. The objective of this work was to elucidate the differences in secondary metabolite accumulation, particularly in the paclitaxel biosynthesis pathway, between wild and cultivated species. This study employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) and RNA sequencing (RNA-Seq) technologies to conduct integrated metabolomic and transcriptomic analyses of wild and cultivated species of T. cuspidata. The results showed that the content of paclitaxel in cultivated species was significantly higher… More >