Jun-Hui Chen¹, Si-Run Du¹, Chang Liu¹, Bei-Bei Liu¹, Hai-Ying Xu², Xin-Ying Ji², Bo Feng³, Chun-Zheng Ma³, Jun-Hui Guo^3,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.073484 - 22 April 2026

Abstract Esophageal cancer (EC) ranks among the most lethal gastrointestinal malignancies. Due to challenges in early diagnosis, molecular heterogeneity, and therapeutic resistance, patient prognosis remains extremely poor, necessitating the development of novel biomarkers and therapeutic targets. As a core effector of the Hippo signaling pathway, the potential significance of Yes-associated protein 1 (YAP1) has garnered increasing attention. This paper aims to systematically summarize the multi-omics research, molecular mechanisms, and preclinical/translational evidence for YAP1, covering its activation pathways, biological functions, clinical significance, and therapeutic strategies. We elucidated YAP1’s multidimensional regulatory network in EC, including Hippo-dependent and -independent mechanisms, cross-regulation… More >

Abdullah Alattar¹, Reem Alshaman¹, Fawaz E. Alanazi¹, Yusuf S. Althobaiti², Ghareb M. Soliman³, Waleed Salman Khubrni¹, Howaida S. Ali⁴, Fawad Ali Shah^5,6,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2026.074865 - 23 March 2026

Abstract Objectives: Permanent middle cerebral artery occlusion (pMCAO) can lead to hippocampal damage through multiple linked pathways such as reactive oxidative stress (ROS), neuroinflammation mediated by NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3), tumour necrosis factor-alpha (TNF-α), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and glutamate excitotoxicity involving N-methyl-D-aspartate receptor subunits 2a and 2b (NR2a/NR2b) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR/GluR1). The hippocampus, which is essential for memory and cognition, is at a substantial risk of ischemic degeneration. The aim of this study was to investigate the neuroprotective potential of melatonin in regulating these… More > Graphic Abstract

Joongbum Moon¹, Ji Hyeon Ahn², Moo-Ho Won^3,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2025.072635 - 23 March 2026

Abstract Ischemia-reperfusion (I/R) injury induces region-specific neuronal vulnerability within the hippocampus, with the cornu ammonis 1 (CA1) subfield particularly prone to delayed neuronal death. While intrinsic neuronal factors have been implicated, emerging evidence highlights the decisive contribution of astrocyte endfeet (AEF)—specialized perivascular structures that regulate ion and water homeostasis, glutamate clearance, and blood–brain barrier (BBB) stability. This review synthesizes structural and molecular alterations of AEF across the CA1–CA3 subfields following I/R and their correlation with neuronal fate. In CA1, AEF undergo early-onset swelling and detachment from the vascular basal lamina due to dysfunction of critical proteins… More >

Roland Mangold, Timea Teglas^*

BIOCELL, Vol.49, No.12, pp. 2239-2244, 2025, DOI:10.32604/biocell.2025.069925 - 24 December 2025

Abstract The quality of life in older adulthood is greatly influenced by cognitive aging, which in turn is affected by nutrition, especially as it relates to hippocampal function. Although the link between hippocampal function and nutrition is defined, the exact mechanics are still unknown. The commentary addresses how docosahexaenoic acid (DHA) contributes to age-related cognitive decline and may play a role in promoting neurogenesis and neuroplasticity on the molecular level. The current challenge to our understanding is to investigate how DHA influences hippocampal function and cognitive aging, which would be possible and even more detailed with More >

Myoung Cheol Shin¹, Tae-Kyeong Lee², Dae Won Kim³, Joon Ha Park⁴, Moo-Ho Won¹, Choong-Hyun Lee^5,*, Ji Hyeon Ahn^6,*

BIOCELL, Vol.49, No.6, pp. 1071-1083, 2025, DOI:10.32604/biocell.2025.065506 - 24 June 2025

Abstract Background: Astrocyte endfeet (AEF) serves as a key element of the blood-brain barrier and is important for the survival and maintenance of neuronal function. However, the immunohistochemical and ultrastructural changes of AEF in the CA1 and CA3 areas of the hippocampus over time following cerebral ischemia-reperfusion (IR) injury have not been well elucidated. Objectives: We investigated chronological changes in AEF in the gerbil hippocampal CA1 area from 3 h to 10 days following transient forebrain ischemia (TFI), and examined their association with neuronal death and tissue repair following IR injury. Changes in the CA3 area… More >

Xiaojian Chen^1,2,#, Zhujiang Dai^1,#, Qiang Wang³, Wei Chen¹, Yun Liu^1,*, Zhongchuan Wang^1,*

BIOCELL, Vol.49, No.3, pp. 503-518, 2025, DOI:10.32604/biocell.2025.059286 - 31 March 2025

Abstract Background: Nudix Hydrolase 21 (NUDT21) is crucial for the regulation of alternative polyadenylation, with its reduced expression frequently resulting in a shortened mRNA 3^′ untranslated region (UTR), thereby enhancing the protein levels of downstream genes. Although NUDT21 is widely recognized for its tumor-suppressive function in various cancers, its involvement in colorectal cancer (CRC) remains poorly understood. Methods: The expression of NUDT21 in CRC and adjacent normal tissues was analyzed through qPCR, Western blot, and immunohistochemistry (IHC). Additionally, we investigated the correlation between NUDT21 expression and patient prognosis. With Cell Counting Kit-8 assay and Transwell assay, we… More >

KEWEI CHENG¹, LEI SHI¹, CAIWEN SHI¹, SHUANSHUAN XIE², CHANGHUI WANG^2,*

BIOCELL, Vol.48, No.8, pp. 1209-1221, 2024, DOI:10.32604/biocell.2024.049626 - 02 August 2024

Abstract Objective: To explore the role of polycystic kidney and hepatic disease 1-like 1 (PKHD1L1) in lung adenocarcinoma (LUAD). Methods: Bioinformatics tools were utilized to examine the clinical profile of PKHD1L1 and chromobox protein homolog 7 (CBX7) in LUAD. The Cell Counting Kit-8, colony formation, terminal deoxynucleotidyl transferase dUTP nick end labeling, Transwell, and wound-healing assays were carried out to assess the proliferative, apoptotic, invasive, and migrative capacities of the cells. Furthermore, the interrelation between PKHD1L1 and CBX7 was validated using a co-immunoprecipitation assay. A LUAD mice model was constructed by subcutaneous injection of A549 cells.… More >

FREDERICK H. SILVER^1,2,*, TANMAY DESHMUKH²

BIOCELL, Vol.48, No.4, pp. 525-540, 2024, DOI:10.32604/biocell.2024.047965 - 09 April 2024

Abstract All tissues in the body are subjected externally to gravity and internally by collagen fibril and cellular retractive forces that create stress and energy equilibrium required for homeostasis. Mechanotransduction involves mechanical work (force through a distance) and energy storage as kinetic and potential energy. This leads to changes in cell mitosis or apoptosis and the synthesis or loss of tissue components. It involves the application of energy directly to cells through integrin-mediated processes, cell-cell connections, stretching of the cell cytoplasm, and activation of the cell nucleus via yes-associated protein (YAP) and transcriptional coactivator with PDZ-motif… More >

Ain Raal^1,*, Linda Rusalepp², Tatiana Chiru³, Nicolae Ciobanu³, Kelly Talvistu¹, Michelle Shusta¹, Oleh Koshovyi^1,4, Tõnu Püssa²

Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 2965-2979, 2023, DOI:10.32604/phyton.2023.042723 - 24 October 2023

Abstract The fruits of the Sea buckthorn (Hippophae rhamnoides L.) are a popular plant food and a valuable health product. Cultivating plants produces a lot of leaves with fine branches as an unnecessary residue, which needs valorization. The aim of the study was to estimate (by HPLC-MS/MS) the qualitative and quantitative content of polyphenolic compounds in different parts of H. rhamnoides (HR), and to determine the level of antioxidant activity of leaves and fruits (by DPPH, ABTS methods and ferrozine test). Up to 19 compounds were identified in different parts of HR. The fruits are rich in flavonoids, including… More >

Xinyi Xiao, Dongbo Pan^*, Jianjun Yuan

Intelligent Automation & Soft Computing, Vol.37, No.3, pp. 3179-3191, 2023, DOI:10.32604/iasc.2023.041208 - 11 September 2023

Abstract Neurological disorders like Alzheimer’s disease have a significant impact on the lives and health of the elderly as the aging population continues to grow. Doctors can achieve effective prevention and treatment of Alzheimer’s disease according to the morphological volume of hippocampus. General segmentation techniques frequently fail to produce satisfactory results due to hippocampus’s small size, complex structure, and fuzzy edges. We develop a new SC-Net model using complete brain MRI images to achieve high-precision segmentation of hippocampal structures. The proposed network improves the accuracy of hippocampal structural segmentation by retaining the original location information of More >