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  • Open Access

    ARTICLE

    A Vanillin-Derived, DOPO-Contained Bisphenol as a Reactive Flame Retardant for High-Performance Epoxy Thermosets

    Li Wang1,2,#, Rongbai Tong3,#, Juanli Wang1,2,*, Jintao Wan1,2,*, Yuhu Li1,2, Pujun Jin1,2, Daodao Hu1,2

    Journal of Renewable Materials, Vol.10, No.5, pp. 1349-1364, 2022, DOI:10.32604/jrm.2022.019372 - 22 December 2021

    Abstract Quest for bio-based halogen-free green flame retardant has attracted many concerns in recent years. Herein a reactive functional flame retardant containing phosphorus VDP is synthesized from vanillin, 9,10-dihydro-9-oxa-10-phosphophene-10-oxide (DOPO) and phenol via a facile way. VDP is characterized with 1H NMR, 31P NMR, FTIR and Time of Flight Mass Spectrometry, and used as a new reactive flame retardant for bisphenol epoxy thermosets. Thermogravimetry analysis shows that when the VDP loading is only 0.5P% (based on phosphorus content), the residue increases from 14.2% to 21.1% at 750°C in N2 compare with neat DGEBA. Correspondingly, the limit oxygen index… More >

  • Open Access

    ARTICLE

    Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach

    KATARINA BARALIć1,*, KATARINA ŽIVANčEVIć1, DRAGICA BoŽIĆ1, DANYEL JENNEN2, ALEKSANDRA BUHA DJORDJEVIC1, EVICA ANTONIJEVIć MILJAKOVIć1, DANIJELA ĐUKIć-ĆOSIć1

    BIOCELL, Vol.46, No.2, pp. 519-533, 2022, DOI:10.32604/biocell.2022.018271 - 20 October 2021

    Abstract This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure and obesity, as well as its comorbid conditions, in order to construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used as the main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.cchmc.org) and DisGeNET (http://www.disgenet.org). Among the phthalates, bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) were chosen as the most frequently curated phthalates in CTD, which also share similar mechanisms of toxicity. DEHP, DBP and BPA interacted with 84, 90 and 194… More >

  • Open Access

    VIEWPOINT

    New evidence for a role of Bisphenol A in cell integrity. Implications in the human population

    RAFAEL MORENO-GÓMEZ-TOLEDANO1,*, MARíA I. ARENAS2, ESPERANZA VÉLEZ-VÉLEZ3, RICARDO J. BOSCH1

    BIOCELL, Vol.46, No.2, pp. 305-308, 2022, DOI:10.32604/biocell.2022.017894 - 20 October 2021

    Abstract Bisphenol A (BPA) is a xenoestrogen known for its implications for the endocrine systems and several other organs, including the kidneys. Recent renal studies have shown that BPA can induce alterations of the cytoskeleton and cell adhesion mechanisms such as a podocytopathy with proteinuria and hypertension, alterations involved in the progression of renal diseases. These data and the fact that BPA is known to be present in the urine of almost the entire population strongly suggest the critical need to reevaluate BPA exposures considered safe. More >

  • Open Access

    ARTICLE

    Glass/Biofibers/Epoxy Methacrylate of Bisphenol-C Sandwich Composites: Comparative Mechanical and Electrical Properties and Chemical Resistance

    RITESH D. BHATT, JIGNESH P. PATEL, P. H. PARSANIA*

    Journal of Polymer Materials, Vol.38, No.1-2, pp. 71-87, 2021, DOI:10.32381/JPM.2021.38.1-2.7

    Abstract Glass/Biofibers/Epoxy methacrylate of bisphenol-C (G/BF/EBCMAS) sandwich composites was prepared by compression molding. G/BF/EBCMAS showed good mechanical and good to excellent electrical properties and excellent chemical resistance. Studied properties are compared with EBCMAS and G/EBCMAS. In comparison with G/EBCMAS, G/BF/EBCMAS showed considerable decline of tensile strength (18-63.4%), flexural strength (18.8-38.7%), flexural modulus (12.8-50.7%), Izod impact strength (17.4-43.5%), Barcol hardness (2.1-16.7%) and dielectric strength (23.8-76.8%) except flexural strength of G/BM/EBCMAS. G/WC/EBCMAS (96.7%), G/B/EBCMAS (79.2%), G/GN/EBCMAS (83.3%) and G/RH/EBCMAS (97.9%) showed decline of volume resistivity, whereas other sandwich composites showed 1150-58233% improvement. The decrease in mechanical properties and More >

  • Open Access

    ARTICLE

    Natural Convection in an H-Shaped Porous Enclosure Filled with a Nanofluid

    Zehba A. S. Raizah1, Abdelraheem M. Aly1,2,*

    CMC-Computers, Materials & Continua, Vol.66, No.3, pp. 3233-3251, 2021, DOI:10.32604/cmc.2021.012402 - 28 December 2020

    Abstract This study simulates natural convection flow resulting from heat partitions in an H-shaped enclosure filled with a nanofluid using an incompressible smoothed particle hydrodynamics (ISPH) method. The right area of the H-shaped enclosure is saturated with non-Darcy porous media. The center variable partitions of the H-shaped enclosure walls are kept at a high-temperature Th. The left and right walls of the H-shaped enclosure are positioned at a low temperature Tc and the other walls are adiabatic. In ISPH method, the source term in pressure Poisson equation (PPE) is modified. The influences of the controlling parameters on… More >

  • Open Access

    ARTICLE

    Efficacy and Safety of Drug-Eluting Beads Transarterial Chemoembolization by CalliSpheres® in 275 Hepatocellular Carcinoma Patients: Results From the Chinese CalliSpheres® Transarterial Chemoembolization in Liver Cancer (CTILC) Study

    Junhui Sun*1, Guanhui Zhou*1, Xiaoxi Xie, Wenjiang Gu, Jing Huang§, Dedong Zhu, Wenhao Hu#, Qinming Hou**, Changsheng Shi††, Tiefeng Li‡‡ , Xin Zhang§§, Wenbin Ji¶¶, Shihong Ying§§, Zhiyi Peng§§, Jian Zhou##, Zhihai Yu***, Jiansong Ji†††, Haijun Du‡‡‡, Xiaohua Guo§§§, Jian Fang¶¶¶, Jun Han###, Huanhai Xu****, Zhichao Sun††††, Wenqiang Yu‡‡‡‡, Guoliang Shao§§§§, Xia Wu¶¶¶¶ ,Hongjie Hu¶¶¶¶ , Ling Li#, Jiaping Zheng§§§§, Jun Luo§§§§, Yutang Chen§§§§, Guohong Cao####, Tingyang Hu‡‡‡‡

    Oncology Research, Vol.28, No.1, pp. 75-94, 2020, DOI:10.3727/096504019X15662966719585

    Abstract The purpose of this study was to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Chinese hepatocellular carcinoma (HCC) patients and the prognostic factors for treatment response as well as survival. A total of 275 HCC patients were included in this prospective study. Treatment response was assessed by modified Response Evaluation Criteria in Solid Tumors (mRECIST), and progression-free survival (PFS) as well as overall survival (OS) were determined. Liver function and adverse events (AEs) were assessed before and after DEB-TACE operation. Complete response (CR), partial response (PR), and objective response… More >

  • Open Access

    ARTICLE

    The Comprehensive Analysis of Efficacy and Safety of CalliSpheres® Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study

    Zhiyi Peng*1, Guohong Cao†1, Qinming Hou, Ling Li§, Shihong Ying*, Junhui Sun, Guanhui Zhou, Jian Zhou#, Xin Zhang*, Wenbin Ji**, Zhihai Yu††, Tiefeng Li‡‡, Dedong Zhu§, Wenhao Hu§§, Jiansong Ji¶¶, Haijun Du##, Changsheng Shi***, Xiaohua Guo†††, Jian Fang‡‡‡, Jun Han§§§, Wenjiang Gu¶¶¶, Xiaoxi Xie###, Zhichao Sun****, Huanhai Xu††††, Xia Wu‡‡‡‡, Tingyang Hu§§§§, Jing Huang¶¶¶¶, Hongjie Hu‡‡‡‡, Jiaping Zheng####, Jun Luo####, Yutang Chen####, Wenqiang Yu§§§§, Guoliang Shao####

    Oncology Research, Vol.28, No.3, pp. 249-271, 2020, DOI:10.3727/096504019X15766663541105

    Abstract This study aimed to investigate the efficacy, safety, and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. A total of 367 liver cancer patients from 24 medical centers were consecutively enrolled in this multiple-center, prospective cohort study, including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) cases, and 55 secondary liver cancer cases. All the patients received CalliSpheres® DEB-TACE treatment. Treatment response, overall survival (OS), change of liver function, and adverse events (AEs) were assessed. DEB-TACE treatment achieved 19.9% complete response (CR) and 79.6% objective response rate (ORR),… More >

  • Open Access

    ARTICLE

    Simulation of Water-Soil-Structure Interactions Using Incompressible Smoothed Particle Hydrodynamics

    Abdelraheem M. Aly1, 2, *, Mitsuteru Asai3, Ehab Mahmoud Mohamed4, 5

    CMC-Computers, Materials & Continua, Vol.65, No.1, pp. 205-224, 2020, DOI:10.32604/cmc.2020.09227 - 23 July 2020

    Abstract In the present work, an incompressible smoothed particle hydrodynamic (SPH) method is introduced to simulate water-soil-structure interactions. In the current calculation, the water is modelled as a Newtonian fluid. The soil is modelled in two different cases. In the first case, the granular material is considered as a fluid where a Bingham type constitutive model is proposed based on Mohr-Coulomb yield-stress criterion, and the viscosity is derived from the cohesion and friction angle. In addition, the fictitious suspension layers between water and soil depending on the concentration of soil are introduced. In the second case,… More >

  • Open Access

    ARTICLE

    Efficacy and Safety of CalliSpheres® Drug-Eluting Beads Transarterial Chemoembolization in Barcelona Clinic Liver Cancer Stage C Patients

    Yaohong Liu, Wensou Huang, Mingji He, Hui Lian, Yongjian Guo, Jingjun Huang, Jingwen Zhou, Kangshun Zhu

    Oncology Research, Vol.27, No.5, pp. 565-573, 2019, DOI:10.3727/096504018X15313896322888

    Abstract This study aimed to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Barcelona Clinic Liver Cancer (BCLC) stage C liver cancer patients. In 39 patients with BCLC stage C liver cancer, after the first cycle of DEB-TACE, 2 (5.1%) and 24 (61.5%) patients achieved complete response (CR) and partial response (PR) to give an overall objective response rate (ORR) of 66.7%. With respect to the second cycle of therapy, the ORR was higher in patients receiving DEB-TACE compared with those receiving cTACE (57.1% vs. 11.1%). After the first cycle of… More >

  • Open Access

    ARTICLE

    NUMERICAL SIMULATION OF METAL-PLASTIC COMPOSITE HEAT RADIATOR WITH HEMISPHERICAL MICROSTRUCTURE ARRAY

    Hui Jianga,b, Daming Wua,b,c, Jian Zhuanga,b,*, Ying Liua,b,c, Changqing Huanga,b

    Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-6, 2015, DOI:10.5098/hmt.6.14

    Abstract A new type of metal-plastic composite heat radiator with hemispherical microstructure array was proposed in this paper. The influence of the geometrical parameters of the microstructure array, including size of the hemisphere, configuration of hemisphere, tilt angle of the radiator, thermal conductivity and radiation emissivity of the plastic, on the process of heat transfer under natural convection were numerically simulated. It was concluded that the metal-plastic composite heat radiator with hemispherical microstructure array had comparable heat transfer behaviors with those of metal heat radiator. So it is possible to replace metal heat radiator by such More >

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