CONGCHEN BAI¹, QIHANG KONG², HAO TANG², SHUWEN ZHANG², JUNTENG ZHOU^3,*, XIAOJING LIU^2,4,*

BIOCELL, Vol.47, No.11, pp. 2517-2533, 2023, DOI:10.32604/biocell.2023.043864 - 27 November 2023

Abstract Background: Various physiological mechanisms are linked to dilated cardiomyopathy (DCM) development, including oxidative stress, immune irregularities, inflammation, fibrosis, and genetic changes. However, precise molecular drivers of DCM, especially regarding abnormal immune responses, remain unclear. This study investigates immune-related long non-coding RNAs (lncRNAs) in DCM’s diagnostic and therapeutic potential. Methods: GSE141910, GSE135055, and GSE165303 datasets were acquired from the GEO database. LASSO, SVM-RFE, and random forest algorithms identified DCM-associated immune-related lncRNAs. Diagnostic capabilities were assessed by Nomogram and receiver operating characteristic (ROC) curves. Multivariate linear regression explored lncRNA correlations with ejection fraction. Single-sample gene set enrichment analysis… More > Graphic Abstract

MENGQIN ZHU^1,2,3,4,#, TIANYI XU^5,#, HAN ZHANG^3,4, XIN FAN^3,4, YULAN WANG⁶, JIAJIA ZHANG^3,4, FEI YU^1,2,3,4,*

BIOCELL, Vol.47, No.9, pp. 1931-1945, 2023, DOI:10.32604/biocell.2023.028968 - 28 September 2023

Abstract Glutamine metabolism (GM) plays an important role in tumor growth and proliferation. Skin cutaneous melanoma (SKCM) is a glutamine-dependent cancer. However, the molecular characteristics and action mechanism of GM on SKCM remain unclear. Therefore, we aimed to explore the effects of GM-related genes on survival, clinicopathological characteristics, and the tumor microenvironment in SKCM. In this study, 682 SKCM samples were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Consensus clustering was used to classify SKCM samples into distinct subtypes based on 41 GM-related genes. Differences in survival, immune infiltration, clinical… More > Graphic Abstract

PENGCHENG ZHANG^1,#,*, XINGLONG ZHANG^2,#, YONGFU ZHU³, YIYI CUI¹, JING XU⁴, WEIPING ZHANG^1,*

Oncology Research, Vol.31, No.6, pp. 937-953, 2023, DOI:10.32604/or.2023.030933 - 15 September 2023

Abstract Polo-like kinase 1 (PLK1) plays a crucial role in cell mitosis and has been associated with necroptosis. However, the role of PLK1 and necroptosis in lung adenocarcinoma (LA) remains unclear. In this study, we analyzed The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression databases to evaluate the prognostic value and mechanistic role of PLK1 in LA. PLK1 was found to be highly expressed in LA and was positively associated with advanced disease staging and poor survival outcomes. Functional enrichment analysis showed that PLK1 was involved in cell mitosis, neurotransmitter transmission, and drug metabolism. Further analysis… More > Graphic Abstract

XINRUI SHI¹, XIA GAO¹, WENCONG LIU², XUEJIAO TANG¹, JIAYI LIU¹, DONGCHEN PAN¹, XUEQING DUAN¹, YUQING JIN¹, WEIYAN REN¹, LEI YANG^1,*, WENXUAN LIU^1,*

Oncology Research, Vol.31, No.4, pp. 569-590, 2023, DOI:10.32604/or.2023.028964 - 25 June 2023

Abstract Hepatocellular carcinoma (HCC) is the most common fatal cancer worldwide, patients with HCC have a high mortality rate and poor prognosis. PANoptosis is a novel discovery of programmed cell death associated with cancer development. However, the role of PANoptosis in HCC remains obscure. In this study, we enrolled 274 PANoptosisrelated genes (PANRGs) and screened 8 genes to set up a prognostic model. A previous scoring system calculated PANscore was utilized to quantify the individual risk level of each HCC patient, and the reliability of the prognostic model has been validated in an external cohort. Nomogram More >

YANGQING HUANG^1,2, XINLAN ZHOU¹, XIUFEN LI¹, DAN HUANG¹, ZHONG FANG^3,*, RONGRONG DING^1,*

Oncology Research, Vol.31, No.2, pp. 193-205, 2023, DOI:10.32604/or.2023.027112 - 10 April 2023

Abstract Sterol o-acyltransferase1 (SOAT1) is an enzyme that regulates lipid metabolism. Nevertheless, the predictive value of SOAT1 regarding immune responses in cancer is not fully understood. Herein, we aimed to expound the predictive value and the potential biological functions of SOAT1 in pan-cancer. Raw data related to SOAT1 expression in 33 different types of cancer were acquired from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. SOAT1 expression was significantly increased in most cancers and showed a distinct correlation with prognosis. This enhanced expression of the SOAT1 gene was confirmed by evaluating SOAT1 protein More >

XI YANG^1,5,#, HUIXIAN WU^2,3,#, CHAO XIONG^4,#, BO ZHAO¹, MEILIAN LIU¹, JIE QIN⁶, MEI DENG^1,2,3,*

BIOCELL, Vol.47, No.5, pp. 1021-1037, 2023, DOI:10.32604/biocell.2023.027103 - 10 April 2023

Abstract Background: Cytochrome b561 (CYB561) plays a critical role in neuroendocrine function, cardiovascular regulation, and tumor growth; however, the prognostic value of CYB561 in patients with breast cancer and the relationship between CYB561 expression and immune infiltration in breast cancer remain unclear. Methods: The mRNA expression and clinical data of patients with breast cancer were obtained from The Cancer Genome Atlas database. Functional enrichment analysis was used to explore underlying biological functions associated with CYB561. The methylation status of CYB561 was analyzed using the MethSurv database. The enrichment score of immune cell infiltration for CYB561 in breast… More >

HAOTONG SUN^1,2, HEYING WANG^1,3, XIN LI^1,2, YANJIE HAO^1,2, JUN LING^1,2, HUAN WANG^1,2, FEIMIAO WANG^1,2, FANG XU^1,2,*

BIOCELL, Vol.47, No.3, pp. 607-618, 2023, DOI:10.32604/biocell.2023.026445 - 03 January 2023

Abstract Background: Colon adenocarcinoma (COAD) is the second leading cause of cancer death worldwide thus, identification of COAD biomarkers is critical. Mitotic Arrest Deficient 2 Like 2 (MAD2L2) is a key factor in mammalian DNA damage repair and is highly expressed in many malignant tumors. This is a comprehensive study of MAD2L2 expression, its diagnostic value, prognostic analysis, potential biological function, and impact on the immune system of patients with COAD. Methods: Gene expression, clinical relevance, prognostic analysis, diagnostic value, GO/KEGG cluster analysis, data obtained from TCGA, and bioinformatics statistical analysis were performed using the R package. Immune… More >

Xuelian Du^1,#, Hao Shi^2,#, Haiyan Liu¹, Linghua Zhou¹, Anqun Xie¹, Jufang Guo^1,*

Oncologie, Vol.24, No.4, pp. 769-787, 2022, DOI:10.32604/oncologie.2022.026248 - 31 December 2022

Abstract Background: Gestational diabetes mellitus (GDM) affects the health of numerous women around the world. A recent study has shown that GDM is associated with an increased incidence of cancer. In this study, we aimed to explore the possible shared mechanisms and potential common therapeutic targets between GDM and cancer. Methods: The limma package was used to identify differentially expressed genes (DEGs) in GDM. The Cytoscape plugin cytoHubba was used to screen hub genes. The CIBERSORT algorithm was used to explore the correlation between hub genes and immunity. Cox regression analysis was used to assess the relationship… More >

JIAMING ZHAN, WEIHUA WANG, YANLEI TANG, NING ZHOU, DAOWEN JIANG^*

BIOCELL, Vol.46, No.12, pp. 2601-2613, 2022, DOI:10.32604/biocell.2022.021300 - 10 August 2022

Abstract Esophageal cancer (EC) was an aggressive malignant neoplasm characterized by high morbidity and poor prognosis. Identifying the changes in DNA damage repair genes helps to better understand the mechanisms of carcinoma progression. In this study, by comparing EC samples and normal samples, we found a total of 132 DDR expression with a significant difference. Moreover, we revealed higher expression of POLN, PALB2, ATM, PER1, TOP3B and lower expression of HMGB1, UBE2B were correlated to longer OS in EC. In addition, a prognostic risk score based on 7 DDR gene expression (POLN, HMGB1, TOP3B, PER1, UBE2B,… More >

WEI LIANG^1,2,*, QIANG LUO^1,2,#, ZONGWEI ZHANG^1,2,#, KEJU YANG^1,2,3, ANKANG YANG^1,2, QINGJIA CHI⁴, HUAN HU⁵

BIOCELL, Vol.46, No.8, pp. 1989-2002, 2022, DOI:10.32604/biocell.2022.019300 - 22 April 2022

Abstract Diabetic nephropathy (DN) is a common microvascular complication that easily leads to end-stage renal disease. It is important to explore the key biomarkers and molecular mechanisms relevant to diabetic nephropathy (DN). We used highthroughput RNA sequencing to obtain the genes related to DN glomerular tissues and healthy glomerular tissues of mice. Then we used LIMMA to analyze differentially expressed genes (DEGs) between DN and non-diabetic glomerular samples. And we performed KEGG, gene ontology functional (GO) enrichment, and gene set enrichment analysis to reveal the signaling pathway of the disease. The CIBERSORT algorithm based on support… More >