Lidia M. Lopez*, Marta Dubin**, Patricia H. Carrizo**, Mario H. Burgos***, Amanda Pellegrino De Iraldi*, Andrés O. M. Stoppani**

BIOCELL, Vol.27, No.2, pp. 213-224, 2003, DOI:10.32604/biocell.2003.27.213

Abstract CG 10-248 (3,4-dihydro-2,2-dimethyl-9-chloro-2H-naphtho[1,2b]pyran- 5,6-dione; CG-NQ), a β-lapachone analogue, modified the ultrastructure of rat hepatocytes, as demonstrated by light and electron microscopy. After 4 h incubation with 100 µM CG-NQ, the following effects were observed: (a) nuclear chromatin condensation; (b) chromatin fragmentation; (c) displacement of mitochondria, concentrated around the nucleus; (d) disruption or expansion of mitochondrial outer or inner membranes, respectively; (e) displacement and alteration of endoplasmic reticulum (rough and smooth); (f) decrease of microvilli; (g) blebbing of plasma membrane and production of apoptotic bodies formed by folding of plasma membrane fragments around mitochondria or peroxysomes; and (h) production of hydrogen… More >

Bing Hu¹, Feng Xiang², Fan Wu³, Jian Liu⁴, Zhe Sun¹, Zhixin Sun^1,*

CMC-Computers, Materials & Continua, Vol.61, No.3, pp. 1323-1344, 2019, DOI:10.32604/cmc.2019.06414

Abstract To cope with the arbitrariness of the network delays, a novel method, referred to as the composite particle filter approach based on variational Bayesian (VB-CPF), is proposed herein to estimate the clock skew and clock offset in wireless sensor networks. VB-CPF is an improvement of the Gaussian mixture kalman particle filter (GMKPF) algorithm. In GMKPF, Expectation-Maximization (EM) algorithm needs to determine the number of mixture components in advance, and it is easy to generate overfitting and underfitting. Variational Bayesian EM (VB-EM) algorithm is introduced in this paper to determine the number of mixture components adaptively according to the observations. Moreover,… More >

S. R. Vij^1,*, D. Mukhopadhyay², A. J. Agrawal³

CMC-Computers, Materials & Continua, Vol.61, No.3, pp. 1009-1024, 2019, DOI:10.32604/cmc.2019.08417

Abstract We all negotiate, formally or informally, in jobs, in day today lives and outcomes of negotiations affect those processes of life. Although negotiation is an intrinsic nature of human psyche, it is very complex phenomenon to implement using computing and internet for the various purposes in E Commerce. Automation of negotiation process poses unique challenges for computer scientists and researchers, so here we study how negotiation can be modeled and analyzed mathematically, what can be different techniques and strategies or set of rules/protocols to be implemented and how they can be relevantly implemented. We are in a quest to find… More >

Na Liu¹, Xiaoyun Zhang², Yuzhen Ding², Hong Li², Xiumei Guan², Min Cheng^2,*, Xiaodong Cui^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 87-87, 2019, DOI:10.32604/mcb.2019.05751

Abstract Objective: Endothelial progenitor cells (EPCs) play a vital role in postnatal vascular injury and repair, especially vasculogenesis and angiogenesis. The purpose of this study was to investigate the effect of laminar shear stress in attenuating the decreased-expression of complement regulatory protein CD59 and the mechanism of cytoskeleton F-actin. Methods: EPCs were isolated from human umbilical vein blood and planted on glass slides, which applied to the laminar shear stress force (12 dyne/cm2) in a high glucose (20 mM) culture environment. The gene and protein expression of CD59 were detected by SYBGreen quantitative PCR and fluorescence activated cell sorter (FACS) respectively.… More >

Ju Huang¹, Cuiru Sun^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 67-68, 2019, DOI:10.32604/mcb.2019.05738

Abstract Intravascular optical coherence tomography (OCT) has the characteristics of high resolution and fast imaging speed. Continuous images of the same section of the same vessel can reflect the deformation characteristics of the vessel wall under different blood pressure. Digital image processing may be used to segment various structures on the vascular wall and extract the deformation incorporating with biomechanical analysis. Image filtering plays a very important role in image processing. Median filter was used to filter salt and pepper noise in OCT images. Fuzzy function gray processing method was used to suppress irrelevant information and improve image clarity. Dividing point… More >

Lu Huang¹, Juhui Qiu^1,*, Guixue Wang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 33-34, 2019, DOI:10.32604/mcb.2019.05714

Abstract Oscillatory shear stress (OSS) is one of the major risk factors related to endothelial (EC) dysfunction, which contributes to atherosclerosis. Our previous study indicated that inhibitor of DNA binding 1 (Id1) plays vital role in the regulation of OSS mediated EC function related to atherosclerosis. However, the initiation mechanism during this process remains to be elucidated. Ten-eleven Translocation protein 1 alternative isoform (Tet1s) is a newly reported protein that may have function in adult tissue. Here, we investigate the role of Tet1s in regulating OSS mediated endothelial dysfunction and its underlying mechanism. First, physical interaction between Tet1s and Id1 was… More >

R. Jegadeeshwaran¹, V. Sugumaran², K.P. Soman³

Structural Durability & Health Monitoring, Vol.10, No.1, pp. 81-97, 2014, DOI:10.3970/sdhm.2014.010.081

Abstract In automobile, brake system is an essential part responsible for control of the vehicle. Vibration signals of a rotating machine contain the dynamic information about its health condition. Many research papers have reported the suitability of vibration signals for fault diagnosis applications. Many of them are based on (Fast Fourier Transform) FFT, which have their own drawback with nonstationary signals. Hence, there is a need for development of new methodologies to infer diagnostic information from such non stationary signals. This paper uses vibration signals acquired from a hydraulic brake system under good and simulated faulty conditions for the purpose of… More >

Akhil Muralidharan^1,2, V. Sugumaran¹, K.P Soman³, M. Amarnath⁴

Structural Durability & Health Monitoring, Vol.10, No.1, pp. 55-80, 2014, DOI:10.3970/sdhm.2014.010.055

Abstract Gears are machine elements that transmit motion by means of successively engaging teeth. In purely scientific terms, gears are used to transmit motion. A faulty gear is a matter of serious concern as it affects the functionality of a machine to a great extent. Thus it is essential to diagnose the faults at an initial stage so as to reduce the losses that might be incurred. This necessitates the need for continuous monitoring of the gears. The vibrations produced by gears from good and simulated faulty conditions can be effectively used to detect the faults in these gears. The introduction… More >

F. Caputo, G. Lamanna, A. Soprano¹

Structural Durability & Health Monitoring, Vol.7, No.4, pp. 283-296, 2011, DOI:10.3970/sdhm.2011.007.283

Abstract The present paper deals with a numerical investigation on hybrid bolted joints between unidirectional, quasi isotropic Carbon Fiber Reinforced Polymer (CFRP) composite and aluminium alloy plates, subjected to traction loads. CFRP composite materials are widely used in aerospace applications, where requirements of weight reduction and structural high performances are very compelling. Composite materials generally present high resistance to fatigue and corrosion but the presence of joints in the structure can cause structural problems and then decrease the structural reliability of jointed component.
A hybrid bolted joint constituted of a metal plate, made of aluminium alloy, and a carbon fiber reinforced… More >

G. Davì¹, A. Milazzo¹

Structural Durability & Health Monitoring, Vol.3, No.4, pp. 229-238, 2007, DOI:10.3970/sdhm.2007.003.229

Abstract An original and alternative single domain boundary element formulation and its numerical implementation are presented for the analysis of orthotropic two-dimensional cracked bodies. The problem is formulated employing the classical displacement boundary integral representation and an alternative integral equation deduced on the basis of the stress function theory. This integral equation written on the crack provides the relations needed to determine the problem solution in the framework of linear elastic fracture mechanics. Numerical examples are reported and discussed to demonstrate the accuracy of the proposed approach. More >