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  • Open Access

    ARTICLE

    An Effective Runge-Kutta Optimizer Based on Adaptive Population Size and Search Step Size

    Ala Kana, Imtiaz Ahmad*

    CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3443-3464, 2023, DOI:10.32604/cmc.2023.040775

    Abstract A newly proposed competent population-based optimization algorithm called RUN, which uses the principle of slope variations calculated by applying the Runge Kutta method as the key search mechanism, has gained wider interest in solving optimization problems. However, in high-dimensional problems, the search capabilities, convergence speed, and runtime of RUN deteriorate. This work aims at filling this gap by proposing an improved variant of the RUN algorithm called the Adaptive-RUN. Population size plays a vital role in both runtime efficiency and optimization effectiveness of metaheuristic algorithms. Unlike the original RUN where population size is fixed throughout… More >

  • Open Access

    REVIEW

    Molecular dynamics-driven exploration of peptides targeting SARS-CoV-2, with special attention on ACE2, S protein, Mpro, and PLpro: A review

    MOHAMAD ZULKEFLEE SABRI1, JOANNA BOJARSKA2, FAI-CHU WONG3,4, TSUN-THAI CHAI3,4,*

    BIOCELL, Vol.47, No.8, pp. 1727-1742, 2023, DOI:10.32604/biocell.2023.029272

    Abstract Molecular dynamics (MD) simulation is a computational technique that analyzes the movement of a system of particles over a given period. MD can provide detailed information about the fluctuations and conformational changes of biomolecules at the atomic level over time. In recent years, MD has been widely applied to the discovery of peptides and peptide-like molecules that may serve as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibitors. This review summarizes recent advances in such explorations, focusing on four protein targets: angiotensin-converting enzyme 2 (ACE2), spike protein (S protein), main protease (Mpro), and papain-like protease (PLpro).… More > Graphic Abstract

    Molecular dynamics-driven exploration of peptides targeting SARS-CoV-2, with special attention on ACE2, S protein, M<sup>pro</sup>, and PL<sup>pro</sup>: A review

  • Open Access

    ARTICLE

    Physicochemical Properties of Combustion Ashes of Some Trees (Urban Pruning) Present in the Neotropical Region

    John Freddy Gelves-Díaz1,*, Ludovic Dorkis2, Richard Monroy-Sepúlveda1, Sandra Rozo-Rincón1, Yebrail Alexis Romero-Arcos1

    Journal of Renewable Materials, Vol.11, No.10, pp. 3769-3787, 2023, DOI:10.32604/jrm.2023.029270

    Abstract Secondary lignocellulosic biomass has proved to be useful as an energy source through its oxidation by means of combustion processes. In accordance with the above, in this paper, we wanted to study the ash from urban pruning residues that are generated in cities in the Neotropics. Species such as Licania tomentosa, Azadirachta indica, Ficus benjamina, Terminalia catappa, Leucaena leucocephala, Prosopis juliflora and Pithecellobium dulce were selected because they have been previously studied and showed potential for thermal energy generation. These materials were calcined in an oxidizing atmosphere and characterized by X-ray diffraction and fluorescence, scanning electron microscopy with microchemistry, BET surface area,… More > Graphic Abstract

    Physicochemical Properties of Combustion Ashes of Some Trees (Urban Pruning) Present in the Neotropical Region

  • Open Access

    ARTICLE

    Urban Plant Biomass Residues from the Neotropics and Their Potential for Thermal Energy Generation

    John Freddy Gelves Díaz1,*, Ludovic Dorkis2, Richard Monroy-Sepúlveda1, Sandra Rozo-Rincón1, Gabriel de Jesús Camargo Vargas3

    Journal of Renewable Materials, Vol.11, No.9, pp. 3547-3566, 2023, DOI:10.32604/jrm.2023.029267

    Abstract The material associated with tree pruning in a city in the Colombian neotropics was characterized in order to determine its energy potential. The species studied for their relevance in the territory were Prosopis juliflora, Licania tomentosa, Terminalia catappa, Azadirachta indica, Pithecellobium dulce, Ficus benjamina and Leucaena leucocephala. Moisture content, bulk density, hygroscopic response, elemental chemical analysis, proximal analysis, calorific value, ease of ignition and combustion, thermogravimetric and heat flow analysis, steam generation capacity, and qualitative analysis of gases (mass spectrometry) were determined. The results that were obtained show high initial moisture contents that vary between 37% and 67% and a variable density… More > Graphic Abstract

    Urban Plant Biomass Residues from the Neotropics and Their Potential for Thermal Energy Generation

  • Open Access

    ARTICLE

    Scolarité des élèves atteints de cancer et rôle des enseignants : une étude exploratoire en Suisse romande

    M. Diezi, C. Fawer Caputo, F. Naef

    Psycho-Oncologie, Vol.17, No.2, pp. 65-70, 2023, DOI:10.3166/pson-2022-0234

    Abstract S’il reste rare, un diagnostic de cancer chez un élève a souvent un impact majeur non seulement sur l’enfant malade, sa famille et son entourage, mais également sur sa scolarité. L’absentéisme lié aux traitements, les possibles effets secondaires et les divers troubles cognitifs que la maladie peut engendrer amènent parfois à des décrochages scolaires. Pourtant, une réintégration dans une vie la plus normale possible est souhaitable et participe à la stabilité du jeune. Elle nécessite toutefois la collaboration de multiples intervenants, dont les enseignants qui jouent un rôle essentiel dans ce retour à la normalité.… More >

  • Open Access

    ARTICLE

    Migration Algorithm: A New Human-Based Metaheuristic Approach for Solving Optimization Problems

    Pavel Trojovský*, Mohammad Dehghani

    CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.2, pp. 1695-1730, 2023, DOI:10.32604/cmes.2023.028314

    Abstract This paper introduces a new metaheuristic algorithm called Migration Algorithm (MA), which is helpful in solving optimization problems. The fundamental inspiration of MA is the process of human migration, which aims to improve job, educational, economic, and living conditions, and so on. The mathematical modeling of the proposed MA is presented in two phases to empower the proposed approach in exploration and exploitation during the search process. In the exploration phase, the algorithm population is updated based on the simulation of choosing the migration destination among the available options. In the exploitation phase, the algorithm… More >

  • Open Access

    ARTICLE

    Exploration of the oxidative-inflammatory potential targets of Coicis Semen in osteoarthritis: Data mining and systematic pharmacology

    QIAO ZHOU2,3,4, JIAN LIU1,2,*, LING XIN1, YANYAN FANG1,2, LEI WAN1,2, DAN HUANG1,2, JIANTING WEN1,2

    BIOCELL, Vol.47, No.7, pp. 1623-1643, 2023, DOI:10.32604/biocell.2023.028331

    Abstract Objective: On the basis of data mining, systematic pharmacology, molecular docking, and experiment validation, the oxidative-inflammatory molecular targets of Coicis Semen in the therapy of osteoarthritis (OA) were explored. Methods: The association rule analysis was effectively applied to highlight the correlation between Coicis Semen and oxidative inflammation indices. The random walk model was subsequently used to evaluate the clinical efficacy of Coicis Semen. Network pharmacology was used to predict network targets. The binding affinity of the active ingredient in Coicis Semen to the key target of OA was also successfully predicted. Results: Coicis Semen showed a significant reduction in oxidative-inflammatory indicators… More >

  • Open Access

    ARTICLE

    DRUG RELEASE IN TRANSDERMAL DEVICES: A BRIEF PARAMETRIC STUDY

    F.C.C. Almeidaa , P.M. da Silvab,c, M.N.C. Coelho Pinheiroa,d,*

    Frontiers in Heat and Mass Transfer, Vol.12, pp. 1-9, 2019, DOI:10.5098/hmt.12.16

    Abstract In the last decades, polymeric systems were essayed and applied successfully as vehicles for transdermal delivery devices of active principles. Applications in contraception, pain control, and smoking cessation are already frequent. A crucial aspect in the development of new formulations is the maintenance of the therapeutic drug concentration range for long periods. Recognizing this topic as interesting and challenging, simple models to describe drug release from a transdermal device were developed with the purpose to perform a parametric sensitivity analysis. Assuming drug diffusion within the polymeric delivery system as the dominant mechanism the models were More >

  • Open Access

    ARTICLE

    Comparative Analysis for Evaluating Wind Energy Resources Using Intelligent Optimization Algorithms and Numerical Methods

    Musaed Alrashidi*

    Computer Systems Science and Engineering, Vol.47, No.1, pp. 491-513, 2023, DOI:10.32604/csse.2023.038628

    Abstract Statistical distributions are used to model wind speed, and the two-parameters Weibull distribution has proven its effectiveness at characterizing wind speed. Accurate estimation of Weibull parameters, the scale (c) and shape (k), is crucial in describing the actual wind speed data and evaluating the wind energy potential. Therefore, this study compares the most common conventional numerical (CN) estimation methods and the recent intelligent optimization algorithms (IOA) to show how precise estimation of c and k affects the wind energy resource assessments. In addition, this study conducts technical and economic feasibility studies for five sites in the northern… More >

  • Open Access

    ARTICLE

    Champs et objets pour mieux représenter les phénomènes dans leur contexte géographique

    Anne Ruas, Ha Pham, Laura Pinson

    Revue Internationale de Géomatique, Vol.29, No.2, pp. 185-205, 2019, DOI:10.3166/rig.2019.00081

    Abstract De nombreuses études et recherches visent à mieux connaitre les phénomènes de type pollution ou météo. Les champs de valeur représentant ces phénomènes peuvent être visualisés sur des outils de visualisation scientifiques qui ne disposent pas de la richesse de symbolisation propre aux SIGs, notamment pour le géoréférencement et pour la représentation des objets vectoriels décrivant l’espace support. La représentation sous forme raster sur SIG est possible mais limitée. Pourtant au niveau scientifique il est important de pouvoir co-visualiser les champs dans leur contexte géographique pour mieux les analyser et faire des hypothèses sur les… More >

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