EFFAT ALEMZADEH¹, LEILA ALLAHQOLI², AFROOZ MAZIDIMORADI³, ESMAT ALEMZADEH^1,4, FAHIMEH GHASEMI^4,5, HAMID SALEHINIYA⁶, IBRAHIM ALKATOUT^7,*

Oncology Research, Vol.32, No.5, pp. 831-847, 2024, DOI:10.32604/or.2024.031006

Abstract Ovarian cancer is among the most lethal gynecological cancers, primarily due to the lack of specific symptoms leading to an advanced-stage diagnosis and resistance to chemotherapy. Drug resistance (DR) poses the most significant challenge in treating patients with existing drugs. The Food and Drug Administration (FDA) has recently approved three new therapeutic drugs, including two poly (ADP-ribose) polymerase (PARP) inhibitors (olaparib and niraparib) and one vascular endothelial growth factor (VEGF) inhibitor (bevacizumab) for maintenance therapy. However, resistance to these new drugs has emerged. Therefore, understanding the mechanisms of DR and exploring new approaches to overcome them is crucial for effective… More >

Tao Yi^1,3, Xingshu Chen^1,2,*, Mingdong Yang³, Qindong Li¹, Yi Zhu¹

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 929-955, 2024, DOI:10.32604/cmes.2024.048793

Abstract Due to the rapid evolution of Advanced Persistent Threats (APTs) attacks, the emergence of new and rare attack samples, and even those never seen before, make it challenging for traditional rule-based detection methods to extract universal rules for effective detection. With the progress in techniques such as transfer learning and meta-learning, few-shot network attack detection has progressed. However, challenges in few-shot network attack detection arise from the inability of time sequence flow features to adapt to the fixed length input requirement of deep learning, difficulties in capturing rich information from original flow in the case of insufficient samples, and the… More >

Tianyi Li^1,2, Xin Gu², Qing Zhang^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 339-361, 2024, DOI:10.32604/cmes.2024.047566

Abstract This study proposes a comprehensive, coupled thermomechanical model that replaces local spatial derivatives in classical differential thermomechanical equations with nonlocal integral forms derived from the peridynamic differential operator (PDDO), eliminating the need for calibration procedures. The model employs a multi-rate explicit time integration scheme to handle varying time scales in multi-physics systems. Through simulations conducted on granite and ceramic materials, this model demonstrates its effectiveness. It successfully simulates thermal damage behavior in granite arising from incompatible mineral expansion and accurately calculates thermal crack propagation in ceramic slabs during quenching. To account for material heterogeneity, the model utilizes the Shuffle algorithm… More >

Lyuchao Liao^1,2, Hankun Xiao^2,*, Pengqi Xing², Zhenhua Gan^1,2, Youpeng He², Jiajun Wang²

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 557-576, 2024, DOI:10.32604/cmes.2024.047452

Abstract Autonomous driving has witnessed rapid advancement; however, ensuring safe and efficient driving in intricate scenarios remains a critical challenge. In particular, traffic roundabouts bring a set of challenges to autonomous driving due to the unpredictable entry and exit of vehicles, susceptibility to traffic flow bottlenecks, and imperfect data in perceiving environmental information, rendering them a vital issue in the practical application of autonomous driving. To address the traffic challenges, this work focused on complex roundabouts with multi-lane and proposed a Perception Enhanced Deep Deterministic Policy Gradient (PE-DDPG) for Autonomous Driving in the Roundabouts. Specifically, the model incorporates an enhanced variational… More >

Dongsheng Jia, Yingjie Xu^*, Liangdi Wang, Jihong Zhu, Weihong Zhang

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 171-199, 2024, DOI:10.32604/cmes.2024.046703

Abstract The abalone shell, a composite material whose cross-section is composed of inorganic and organic layers, has high strength and toughness. Inspired by the abalone shell, several multi-layer composite plates with different layer sequences and thicknesses are studied as bullet-proof material in this paper. To investigate the ballistic performance of this multi-layer structure, the complete characterization model and related material parameters of large deformation, failure and fracture of Al₂O₃ ceramics and Carbon Fiber Reinforced Polymer (CFRP) are studied. Then, 3D finite element models of the proposed composite plates with different layer sequences and thicknesses impacted by a 12.7 mm armor-piercing incendiary… More >

Qing Zhu^1,*, Linlin Gu^1,2, Huijie Lin^1,2

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 577-591, 2024, DOI:10.32604/cmes.2023.043307

Abstract With the rapid development of electric power systems, load estimation plays an important role in system operation and planning. Usually, load estimation techniques contain traditional, time series, regression analysis-based, and machine learning-based estimation. Since the machine learning-based method can lead to better performance, in this paper, a deep learning-based load estimation algorithm using image fingerprint and attention mechanism is proposed. First, an image fingerprint construction is proposed for training data. After the data preprocessing, the training data matrix is constructed by the cyclic shift and cubic spline interpolation. Then, the linear mapping and the gray-color transformation method are proposed to… More >

Zhuoqun Xia¹, Hangyu Hu¹, Wenjing Li^2,3, Qisheng Jiang¹, Lan Pu¹, Yicong Shu¹, Arun Kumar Sangaiah^4,5,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 409-430, 2024, DOI:10.32604/cmes.2024.030052

Abstract Early screening of diabetes retinopathy (DR) plays an important role in preventing irreversible blindness. Existing research has failed to fully explore effective DR lesion information in fundus maps. Besides, traditional attention schemes have not considered the impact of lesion type differences on grading, resulting in unreasonable extraction of important lesion features. Therefore, this paper proposes a DR diagnosis scheme that integrates a multi-level patch attention generator (MPAG) and a lesion localization module (LLM). Firstly, MPAG is used to predict patches of different sizes and generate a weighted attention map based on the prediction score and the types of lesions contained… More >

FREDERICK H. SILVER^1,2,*, TANMAY DESHMUKH²

BIOCELL, Vol.48, No.4, pp. 525-540, 2024, DOI:10.32604/biocell.2024.047965

Abstract All tissues in the body are subjected externally to gravity and internally by collagen fibril and cellular retractive forces that create stress and energy equilibrium required for homeostasis. Mechanotransduction involves mechanical work (force through a distance) and energy storage as kinetic and potential energy. This leads to changes in cell mitosis or apoptosis and the synthesis or loss of tissue components. It involves the application of energy directly to cells through integrin-mediated processes, cell-cell connections, stretching of the cell cytoplasm, and activation of the cell nucleus via yes-associated protein (YAP) and transcriptional coactivator with PDZ-motif (TAZ). These processes involve numerous… More >

Liliane Nga¹, Benoit Ndiwe^1,2, Achille Bernard Biwolé¹, Antonio Pizzi^3,*, Jean Jalin Eyinga Biwole¹, Joseph Zobo Mfomo¹

Journal of Renewable Materials, Vol.12, No.3, pp. 553-568, 2024, DOI:10.32604/jrm.2023.046568

Abstract Extracts of plant origin, particularly tannins, are attracting growing interest for the sustainable development of materials in the industrial sector. The discovery of new tannins is therefore necessary. The aim of this work was to contribute to the understanding of the properties of Paraberlinia bifoliolata tannin by Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectroscopy MALDI-TOF/MS and Carbon 13 Nuclear Magnetic Resonance (¹³C NMR). The chemical composition of tannin extracted from Paraberlinia bifoliolata bark was determined, as was the mechanical strength of the resin hardened with Acacia nilotica extracts. Yield by successive water extraction was 35%. MALDI-TOF/MS analysis… More >

Joseph O. Dirisu^1,*, Imhade P. Okokpujie^2,3,*, Olufunmilayo O. Joseph¹, Sunday O. Oyedepo¹, Oluwasegun Falodun⁴, Lagouge K. Tartibu³, Firdaussi D. Shehu¹

Journal of Renewable Materials, Vol.12, No.3, pp. 485-511, 2024, DOI:10.32604/jrm.2024.045188

Abstract Research into converting waste into viable eco-friendly products has gained global concern. Using natural fibres and pulverized metallic waste becomes necessary to reduce noxious environmental emissions due to indiscriminately occupying the land. This study reviews the literature in the broad area of green composites in search of materials that can be used in automotive brake pads. Materials made by biocomposite, rather than fossil fuels, will be favoured. A database containing the tribo-mechanical performance of numerous potential components for the future green composite was established using the technical details of bio-polymers and natural reinforcements. The development of materials with diverse compositions… More > Graphic Abstract