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  • Open Access

    ARTICLE

    A comparative in vitro study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells

    SHAHID KARIM1,*, ALANOUD NAHER ALGHANMI1, MAHA JAMAL1, HUDA ALKREATHY1, ALAM JAMAL2, HIND A. ALKHATABI3, MOHAMMED BAZUHAIR1, AFTAB AHMAD4,5

    Oncology Research, Vol.32, No.5, pp. 817-830, 2024, DOI:10.32604/or.2024.048988

    Abstract Cancer frequently develops resistance to the majority of chemotherapy treatments. This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), and Doxorubicin (DOX), using in vitro experimentation. The precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin (DOX) in MCF-7 cells. Interestingly, it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their growth. Notably, when these medications were combined with DOX, there was a considerable inhibition of glucose consumption, as well as reductions in… More > Graphic Abstract

    A comparative <i>in vitro</i> study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells

  • Open Access

    ARTICLE

    VOC Sensing Studies on Electrically Conductive Polyaniline@MoS2 Nanocomposites

    RUBY AHMED1, MOHAMMAD OMAISH ANSARI2, FARMAN ALI1, SHAHID PERVEZ ANSARI1,*

    Journal of Polymer Materials, Vol.36, No.3, pp. 243-251, 2019, DOI:10.32381/JPM.2019.36.03.4

    Abstract Polyaniline (PANI) and molybdenum disulphide (MoS2 ) were used to prepare nanocomposites by in-situ oxidative polymerization of acidified aniline in presence of dispersed MoS2 in the reaction mixture. Electron Microscopy (SEM & TEM), Fourier Transform Infrared (FTIR) spectroscopy, Ultraviolet-Visible (UV-Vis) spectroscopy, and X-ray diffraction (XRD) were used to characterize these nanocomposites. SEM micrographs showed that PANI is present on the layers of MoS2 which were exfoliated during the preparation and the presence of MoS2 is also confirmed by XRD peaks. The nanocomposites were studied for their electrical conductivity and stability of electrical conductivity in terms of d.c. electrical conductivity retention.… More >

  • Open Access

    ARTICLE

    Improved Corrosion Resistance of Carbon Reinforced Aluminium Laminates in Atmospheric Environment: Role of Environment Friendly Jute Fibre/ Alumina nano Coating

    M. VASUMATHI1,a,*, VELA MURALI2,b, S. RASHIA BEGUM1,c, N. RAJENDRAN2,d

    Journal of Polymer Materials, Vol.36, No.1, pp. 1-11, 2019, DOI:10.32381/JPM.2019.36.01.1

    Abstract In the Fibre Metal Laminate (FML), Carbon Reinforced Aluminium laminate (CARALL), aluminium is placed next to carbon fibres. The potential difference between the aluminium and carbon is larger, leads to galvanic corrosion, which tries to bring down the durability of the FML. To bring down the effect of corrosion, a material layer is introduced between fibres and aluminium so as to separate them thus lowering the possibility of occurrence of corrosion. Another approach is to coat the surfaces of aluminium with different proportions of aluminium oxide nano particles prior to fabrication of the FML. For both the cases, corrosion rates… More >

  • Open Access

    ARTICLE

    Performance Enhancement of Bio-fouling Resistant Cellulose triacetate-based Osmosis Membranes using Functionalized Multiwalled Carbon Nanotube & Graphene Oxide

    A.K. GHOSH1, RUTUJA S. BHOJE2, R.C. BINDAL1

    Journal of Polymer Materials, Vol.37, No.1-2, pp. 109-120, 2020, DOI:10.32381/JPM.2020.37.1-2.8

    Abstract In this study, cellulose triacetate (CTA) based nanocomposite membranes were developed by incorporation of carboxylic acid functionalized multiwalled carbon-nanotube (cMWCNT) and graphene oxide (GO) which have enhancement of both flux and fouling resistance properties of the membranes. Membranes were casted at room temperature and annealed at 90o C hot water for 10 minutes. The incorporation level of both the nanomaterials is 1.5% of the CTA polymer weight in the nanocomposite membranes. Prepared membranes were characterized in terms of water contact angle, surface morphology and mechanical strength. The performance of the membranes was evaluated both in reverse osmosis (RO) and forward… More >

  • Open Access

    ARTICLE

    Preparation of Polysulfone Capillary Ultrafiltration Membranes for Pre-treatment of Sea Water Reverse Osmosis and Studies on its Fouling behavior after Turbidity Removal from Sea Water

    V. S. MAMTANI, A. K. GHOSH*, R. C. BINDAL

    Journal of Polymer Materials, Vol.39, No.1-2, pp. 137-149, 2022, DOI:10.32381/JPM.2022.39.1-2.9

    Abstract In this study, polysulfone based capillary ultrafiltration membranes with desired characteristics were indigenously developed and their performance was evaluated with respect to turbidity removal from raw sea water. Capillary membranes were spun with in-house fabricated spinneret using polymer casting solution (dope solution) of different compositions having different viscosity using polyvinyl pyrrolidone (PVP) as pore-forming agent. Different experimental conditions namely dope pressure, bore fluid flow rate and air gap distance are optimized to get membranes of desired properties. Test results of individual capillaries in terms of pure water permeability (PWP), separation of single uncharged solutes like polyethylene glycol (PEG) and mechanical… More >

  • Open Access

    ARTICLE

    Influence of Bottom Inclination on the Flow Structure in a Rotating Convective Layer

    Andrei Vasiliev, Andrei Sukhanovskii*, Elena Popova

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.4, pp. 739-748, 2024, DOI:10.32604/fdmp.2024.048092

    Abstract The formation of convective flows in a rotating cylindrical layer with an inclined bottom and free surface is studied. Convection is driven by localized cooling at the center of the upper free surface and by rim heating at the bottom near the sidewall. The horizontal temperature difference in a rotating layer leads to the formation of a convective flow with a complex structure. The mean meridional circulation, consisting of three cells, provides a strongly non-uniform differential rotation. As a result of the instability of the main cyclonic zonal flow, the train of baroclinic waves appears in the upper layer. The… More >

  • Open Access

    ARTICLE

    A Hybrid Machine Learning Approach for Improvised QoE in Video Services over 5G Wireless Networks

    K. B. Ajeyprasaath, P. Vetrivelan*

    CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3195-3213, 2024, DOI:10.32604/cmc.2023.046911

    Abstract Video streaming applications have grown considerably in recent years. As a result, this becomes one of the most significant contributors to global internet traffic. According to recent studies, the telecommunications industry loses millions of dollars due to poor video Quality of Experience (QoE) for users. Among the standard proposals for standardizing the quality of video streaming over internet service providers (ISPs) is the Mean Opinion Score (MOS). However, the accurate finding of QoE by MOS is subjective and laborious, and it varies depending on the user. A fully automated data analytics framework is required to reduce the inter-operator variability characteristic… More >

  • Open Access

    ARTICLE

    Heat Recovery from Automotive Exhaust Using Heat Pipes with Limited Fluid Charge

    Bin Xiao*

    Frontiers in Heat and Mass Transfer, Vol.22, No.1, pp. 35-48, 2024, DOI:10.32604/fhmt.2024.048039

    Abstract Experiments were conducted in this study to examine the thermal performance of a thermosyphon, made from Inconel alloy 625, could recover waste heat from automobile exhaust using a limited amount of fluid. The thermosyphon has an outer diameter of 27 mm, a thickness of 2.6 mm, and an overall length of 483 mm. The study involved directing exhaust gas onto the evaporator. This length includes a 180-mm evaporator, a 70-mm adiabatic section, a 223-mm condenser, and a 97-mm finned exchanger. The study examined the thermal performance of the thermosyphon under exhaust flow rates ranging from 0–10 g/sec and temperatures varying… More >

  • Open Access

    EDITORIAL

    Femoral Access with Ultrasound-Guided Puncture and Z-Stitch Hemostasis for Adults with Congenital Heart Diseases Undergoing Electrophysiological Procedures

    Fu Guan1,*, Matthias Gass2, Florian Berger2, Heiko Schneider1, Firat Duru1,3, Thomas Wolber1,3,*

    Congenital Heart Disease, Vol.19, No.1, pp. 85-92, 2024, DOI:10.32604/chd.2024.047266

    Abstract Aims: Although the application of ultrasound-guided vascular puncture and Z-stitch hemostasis to manage femoral access has been widely utilized, there is limited data on this combined application in adult congenital heart disease (ACHD) patients undergoing electrophysiological (EP) procedures. We sought to evaluate the safety and efficacy of ultrasound-guided puncture and postprocedural Z-stitch hemostasis for ACHD patients undergoing EP procedures. Methods and Results: The population of ACHD patients undergoing transfemoral EP procedures at the University of Zurich Heart Center between January 2019 and December 2022 was observed and analyzed. During the study period, femoral access (left/right, arterial/venous) was performed under real-time… More >

  • Open Access

    ARTICLE

    Hydrogen Permeation Characteristics of Pd-Cu Membrane in Plasma Membrane Reactor

    Muhd Hadi Iskandar Abd Razak*, Motoki Tsuda, Yukio Hayakawa, Shinji Kambara

    Energy Engineering, Vol.121, No.2, pp. 259-272, 2024, DOI:10.32604/ee.2023.043615

    Abstract Hydrogen is an alternative energy source that has the potential to replace fossil fuels. One of the hydrogen applications is as a material for Polymer Electrolyte Membrane Fuel Cells (PEMFC) in fuel cell vehicles. High-purity hydrogen can be obtained using a hydrogen separation membrane to prevent unwanted contaminants from potentially harming the PEMFC components. In this study, we fabricated a plasma membrane reactor and investigated the permeation performance of a hydrogen separation membrane in a plasma membrane reactor utilizing atmospheric pressure plasma. The result showed the hydrogen permeation rate increasing with time as reactor temperature is increased through joule heating.… More >

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