Amina Mahreen¹, Fateh Mebarek-Oudina^2,3,4,*, Amna Ashfaq¹, Jawad Raza¹, Sami Ullah Khan⁵, Hanumesh Vaidya⁶

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.11, pp. 2829-2853, 2025, DOI:10.32604/fdmp.2025.072492 - 01 December 2025

Abstract Understanding the complex interaction between heat and mass transfer in non-Newtonian microflows is essential for the development and optimization of efficient microfluidic and thermal management systems. This study investigates the magnetohydrodynamic (MHD) thermosolutal convection of a Casson fluid within an inclined, porous microchannel subjected to convective boundary conditions. The nonlinear, coupled equations governing momentum, energy, and species transport are solved numerically using the MATLAB bvp4c solver, ensuring high numerical accuracy and stability. To identify the dominant parameters influencing flow behavior and to optimize transport performance, a comprehensive hybrid optimization framework—combining a modified Taguchi design, Grey… More >

Rym Akrout¹, Ludovic Leloup², Khouloud Ayed¹, Fabrice Parat², Sami Zekri^3,4, Wassim Y. Almawi¹, Rahma Boughriba¹, Hanen Attia¹, Olfa Masmoudi-Kouki⁴, Hervé Kovacic^2,*, Asma Gati^1,*

Oncology Research, Vol.33, No.12, pp. 3887-3906, 2025, DOI:10.32604/or.2025.070729 - 27 November 2025

Abstract Objectives: Cisplatin (CDDP) therapy for glioblastoma (GBM) is linked with several limitations, which include poor penetration of the blood-brain barrier (BBB), systemic toxicity, and the development of drug resistance mechanisms implicating oxidative stress dysregulation and compromised apoptotic pathways. This study evaluates C-Phycocyanin (C-PC) as a potential adjuvant to enhance CDDP efficacy by modulating redox balance and apoptosis. Methods: GBM cells (U87 and U87-EGFRvIII) were treated with CDDP, C-PC, or their combination. Cell viability was assessed by MTT assay; apoptosis was evaluated by DAPI staining and Western blot analysis of cleaved Caspase-3 and poly (ADP-ribose) polymerase… More > Graphic Abstract

Mohamed Hammad^1,2,*, Mohammed ElAffendi¹, Souham Meshoul^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.1, pp. 1055-1086, 2025, DOI:10.32604/cmes.2025.072650 - 30 October 2025

Abstract Skin cancer is among the most common malignancies worldwide, but its mortality burden is largely driven by aggressive subtypes such as melanoma, with outcomes varying across regions and healthcare settings. These variations emphasize the importance of reliable diagnostic technologies that support clinicians in detecting skin malignancies with higher accuracy. Traditional diagnostic methods often rely on subjective visual assessments, which can lead to misdiagnosis. This study addresses these challenges by developing HybridFusionNet, a novel model that integrates Convolutional Neural Networks (CNN) with 1D feature extraction techniques to enhance diagnostic accuracy. Utilizing two extensive datasets, BCN20000 and… More >

Azhar Iqbal Kashif Butt^1,*, Tariq Ismaeel^2,*, Sara Khan², Muhammad Imran³, Waheed Ahmad², Ismail Abdulrashid⁴, Muhammad Sajid Riaz⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.3, pp. 3463-3492, 2025, DOI:10.32604/cmes.2025.069277 - 30 September 2025

Abstract Malaria is a significant global health challenge. This devastating disease continues to affect millions, especially in tropical regions. It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes. This study introduces a nonlinear mathematical model for examining the transmission dynamics of malaria, incorporating both human and mosquito populations. We aim to identify the key factors driving the endemic spread of malaria, determine feasible solutions, and provide insights that lead to the development of effective prevention and management strategies. We derive the basic reproductive number employing the next-generation matrix approach and identify the disease-free and… More >

Almustafa Abd Elkader Ayek¹, Bilel Zerouali^2,*, Ankur Srivastava³, Mohannad Ali Loho^4,5, Nadjem Bailek^6,7, Celso Augusto Guimarães Santos^8,9

Revue Internationale de Géomatique, Vol.34, pp. 669-689, 2025, DOI:10.32604/rig.2025.067137 - 19 August 2025

Abstract This study investigates the spatial and temporal dynamics of key air pollutants—nitrogen dioxide (NO₂), carbon monoxide (CO), methane (CH₄), formaldehyde (HCHO), and the ultraviolet aerosol index (UVAI)—over the period 2019–2024. Utilizing high-resolution remote sensing data from the Sentinel-5 Precursor satellite and its TROPOspheric Monitoring Instrument (TROPOMI) processed via Google Earth Engine (GEE), pollutant concentrations were analyzed, with spatial visualizations produced using ArcGIS Pro. The results reveal that urban and industrial hotspots—notably in Damascus, Aleppo, Homs, and Hama—exhibit elevated NO₂ and CO levels, strongly correlated with population density, traffic, and industrial emissions. Temporal trends indicate significant pollutant fluctuations More > Graphic Abstract

Abdelhakim Lahrech¹, Tahar Tayebi², Mohamed Kallel^3,*, Mehdi Hashemi-Tilehnoee^4,*, Ali J. Chamkha⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.1, pp. 359-385, 2025, DOI:10.32604/cmes.2025.067099 - 31 July 2025

Abstract The study considers numerical findings regarding magneto-thermosolutal-aided natural convective flow of alumina/water-based nanofluid filled in a non-Darcian porous horizontal concentric annulus. Two equations are assumed to evaluate the thermal fields in the porous medium under Local Thermal Non-Equilibrium (LTNE) conditions, along with the Darcy-Brinkman-Forchheimer model for the flow. By imposing distinct and constant temperatures and concentrations on both internal and external cylinders, thermosolutal natural convection is induced in the annulus. We apply the finite volume method to solve the dimensionless governing equations numerically. The thermal conductivity and viscosity of the nanofluid mixture are determined utilizing… More >

Umer Farooq¹, Nabil Kerdid^2,*, Yasir Nawaz³, Muhammad Shoaib Arif ⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.1, pp. 873-898, 2025, DOI:10.32604/cmes.2025.066800 - 31 July 2025

Abstract In this study, we proposed a numerical technique for solving time-dependent partial differential equations that arise in the electro-osmotic flow of Carreau fluid across a stationary plate based on a modified exponential integrator. The scheme is comprised of two explicit stages. One is the exponential integrator type stage, and the second is the Runge-Kutta type stage. The spatial-dependent terms are discretized using the compact technique. The compact scheme can achieve fourth or sixth-order spatial accuracy, while the proposed scheme attains second-order temporal accuracy. Also, a mathematical model for the electro-osmotic flow of Carreau fluid over… More >

Kun Lan¹, Feiyang Gao¹, Xiaoliang Jiang^1,*, Jianzhen Cheng^2,*, Simon Fong³

CMC-Computers, Materials & Continua, Vol.84, No.3, pp. 4805-4824, 2025, DOI:10.32604/cmc.2025.065864 - 30 July 2025

Abstract With the continuous development of artificial intelligence and machine learning techniques, there have been effective methods supporting the work of dermatologist in the field of skin cancer detection. However, object significant challenges have been presented in accurately segmenting melanomas in dermoscopic images due to the objects that could interfere human observations, such as bubbles and scales. To address these challenges, we propose a dual U-Net network framework for skin melanoma segmentation. In our proposed architecture, we introduce several innovative components that aim to enhance the performance and capabilities of the traditional U-Net. First, we establish… More >

Nu Ri Song^1,#, Seo Yeon Shin^1,#, Ki Min Kim¹, Sa Rang Choi¹, Doo Sang Park², Sun Oh Kim³, Dai Hyun Jung⁴, Kyung Mok Park^1,*

BIOCELL, Vol.49, No.7, pp. 1291-1310, 2025, DOI:10.32604/biocell.2025.065467 - 25 July 2025

Abstract Objectives: Limosilactobacillus reuteri is a beneficial Lactobacillus widely used in foods and supplements to promote overall health. Some studies also suggest it supports skin health and prevents allergies and cardiovascular disease. However, research on its skin-protective effects against photoaging has not been conducted. This study evaluated the potential of culture broths from three L. reuteri strains (DS0333, DS0384, and DS0385) to inhibit skin photoaging. Methods: To assess their anti-photoaging potential, the culture broths were examined for antioxidant capacity, melanin inhibition, and collagen synthesis promotion. Radical scavenging activity was tested using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2^′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays.… More > Graphic Abstract

Li Ling^*, Danhao Song, Qianlong Hu, Zihao Xiang, Zeyu Zhang

Energy Engineering, Vol.122, No.8, pp. 3309-3328, 2025, DOI:10.32604/ee.2025.065824 - 24 July 2025

Abstract Rack-level loop thermosyphons have been widely adopted as a solution to data centers’ growing energy demands. While numerous studies have highlighted the heat transfer performance and energy-saving benefits of this system, its economic feasibility, water usage effectiveness (WUE), and carbon usage effectiveness (CUE) remain underexplored. This study introduces a comprehensive evaluation index designed to assess the applicability of the rack-level loop thermosyphon system across various computing hub nodes. The air wet bulb temperature T_a,w was identified as the most significant factor influencing the variability in the combination of PUE, CUE, and WUE values. The results indicate… More >