Muyi Guo¹, Yan Cai¹, Zhiyong Li^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 49-49, 2019, DOI:10.32604/mcb.2019.05727

Abstract Observational studies have identified angiogenesis from the adventitial vasa vasorum and intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and destabilization. Here we propose a mathematical model incorporating intraplaque neovascularization and hemodynamic calculation for the quantitative evaluation of atherosclerotic plaque hemorrhage. An angiogenic microvasculature based on histology of a patient’s carotid plaque is generated by two-dimensional nine-point model of endothelial cell migration. Three key cells (endothelial cells, smooth muscle cells and macrophages) and three key chemicals (vascular endothelial growth factors, extracellular matrix and matrix metalloproteinase) are involved in the intraplaque angiogenesis model, and… More >

Zhiyong Li^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 29-30, 2019, DOI:10.32604/mcb.2019.06308

Abstract In this article, we summarize our previous work in imaging-based computational modelling and simulation of the interaction between blood flow and atherosclerotic plaque. We also discussed our recent developments in multiphysical modelling of plaque progression and destabilization. Significance and translation of the modelling study to clinical practice are discussed in order to better assess plaque vulnerability and accurately predict a possible rupture. More >

Masaki Izawa¹, Ryota Araki¹, Tatsuro Suzuki¹, Kaito Watanabe², Kazuhito Misaji^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.118, No.3, pp. 493-507, 2019, DOI:10.31614/cmes.2019.04470

Abstract Primary purpose of this research is to create a three-dimensional musculoskeletal mathematical model of a driver of a car using a motion capture system. The model is then used in an analysis of drive torque around joints and attached muscles as a vehicle travels in different travel modes and damping force settings to examine ‘burdens’ for the driver. Previous studies proposed a method of quantifying the degree of musculoskeletal load in simple human motion from the changes in drive torque around joints and attached muscles. However, examination of the level of burdens for the driver More >

Kaito Watanabe¹, Masaki Izawa¹, Ayumi Takahashi¹, Kazuhito Misaji^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.114, No.2, pp. 191-207, 2018, DOI:10.3970/cmes.2018.114.191

Abstract Under the aim of finding effective rehabilitation solutions, the difference between the extents of fatigue of each muscle used in different motions are compared. Previous research suggested methods for estimating muscle torque and muscle tension on the basis of a musculoskeletal model. As a result, it has become possible to quantitatively identify the extent of fatigue in each muscle during motion. Therefore, to evaluate muscle fatigue more quantitatively, driving power and angular momentum are focused on. Based on the driving torque of joints and the muscle torque calculated by using a three-dimensional musculoskeletal model, a More >

Marziyeh Eftekhari¹, Omid Vahidi^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.114, No.2, pp. 153-171, 2018, DOI:10.3970/cmes.2018.114.153

Abstract Various drugs are used to maintain normoglycemia in subjects with type 2 diabetes mellitus. The combination of the drugs from different classes in one single tablet may enhance the effectiveness of the anti-diabetic drugs. To investigate the impact of combining drugs on the glucose regulation of subjects with type 2 diabetes, we propose a pharmacokinetic/pharmacodynamics (PK/PD) mathematical modeling approach for a combination of metformin and vildagliptin drugs. In the proposed modeling approach, two separate PK models representing oral administration of metformin and vildagliptin for diabetic subjects are interconnected to a PD model comprising a detailed More >

K. Venkatadri^a,*, S. Gouse Mohiddin^a , M. Suryanarayana Reddy^b

Frontiers in Heat and Mass Transfer, Vol.9, pp. 1-9, 2017, DOI:10.5098/hmt.9.33

Abstract Two-dimensional unsteady laminar double-diffusive free convective flow of a conducting fluid in a thermally insulated square enclosure except the left wall has been numerically studied in presence of heat generation/absorption. The Marker and Cell (MAC) method is employed for solving nonlinear momentum, energy and concentration equations and the numerical MATLAB code is validated with the previous study. The computed results are depicted graphically and discussed for various values of Rayleigh number (Ra), Hartmann number (Ha), Buoyancy ratio parameter (N), Lewis number (Le) and heat absorption/generation parameter (γ). It is observed that the rate of heat More >

Yan Cai^1,1, Zhiyong Li^1,2,*

Molecular & Cellular Biomechanics, Vol.14, No.2, pp. 59-81, 2017, DOI:10.3970/mcb.2017.014.057

Abstract To investigate the dynamic changes of solid tumor and neo-vasculature in response to chemotherapeutic agent, we proposed a multi-discipline three-dimensional mathematical model by coupling tumor growth, angiogenesis, vessel remodelling, microcirculation and drug delivery. The tumor growth is described by the cell automaton model, in which three cell phenotypes (proliferating cell, quiescent cell and necrotic cell) are assumed to reflect the dynamics of tumor progress. A 3D tree-like architecture network with different orders for vessel diameter is generated as pre-existing vasculature in host tissue. The chemical substances including oxygen, vascular endothelial growth factor, extra-cellular matrix and… More >

Arzu Turan Dincel¹, Surkay D. Akbarov^2,3

CMC-Computers, Materials & Continua, Vol.53, No.3, pp. 249-270, 2017, DOI:10.32604/cmc.2017.053.265

Abstract This paper deals with the mathematical modelling and 3D FEM study of the energy release rate (ERR) in the band crack’s front contained in the orthotropic thick rectangular plate which is stretched or compressed initially before the loading of the crack's edge planes. The initial stretching or compressing of the plate causes uniformly distributed normal stress to appear acting in the direction which is parallel to the plane on which the band crack is located. After the appearance of the initial stress in the plate it is assumed that the crack's edge planes are loaded… More >

Anupam Bhandari¹

FDMP-Fluid Dynamics & Materials Processing, Vol.12, No.4, pp. 155-171, 2016, DOI:10.3970/fdmp.2016.012.155

Abstract The present problem addresses a thermally driven two-dimensional, buoyant flow in a vessel with the application of magnetic field directed in the radial and tangential direction. In the present study, a trough filled with ferrofluid is heated along the center strip by an applied heat flux. Thereby the convection pattern along with the heat distribution is observed. The half of the trough dynamics is calculated with the symmetric plane in the center. On the surface of the bowl, penalty function is applied to enforce the no-slip boundary condition. This problem is then modelled and the More >

Yan Cai^1,2,3, Jie Wu⁴, Zhiyong Li^1,2

Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 231-248, 2015, DOI:10.3970/mcb.2015.012.231

Abstract We propose a coupled mathematical model for the detailed quantitative analyses of initial microtumour and micrometastases formation by including cancer cell migration, host vessel cooption and changes in microenvironment. Migrating cells are included as a new phenotype to describe the migration behaviour of malignant tumour cells. Migration probability of a migrating cell is assumed to be influenced by local chemical microenvironment. Pre-existing vessel cooption and remodelling are introduced according to the local haemodynamical microenvironment, such as interstitial pressure and vessel wall permeability. After the tumour cells and tumour vessels distribution are updated, the chemical substances… More >