Jung-Yeon Kim^#, Min Hui Park^#, Kiryeong Kim, Jaechan Leem^*

BIOCELL, Vol.49, No.11, pp. 2147-2166, 2025, DOI:10.32604/biocell.2025.070188 - 24 November 2025

Abstract Background: Cisplatin (CDDP) is a cornerstone chemotherapeutic agent for many solid tumors, but its clinical use is severely limited by dose-dependent nephrotoxicity, which results in acute kidney injury (AKI) in a significant proportion of patients. CDDP-induced AKI involves interconnected mechanisms, including inflammation, oxidative stress, and tubular cell death. In this study, we aimed to investigate the renoprotective effects of esculetin (ES), a natural antioxidant coumarin, in a murine model of CDDP-induced AKI. Methods: Male C57BL/6 mice (8–10 weeks) received a single intraperitoneal injection of CDDP (20 mg/kg) with or without ES (40 mg/kg/day, oral gavage).… More >

Haoquan Xue¹, Yujie Zhang¹, Zhuang Zhao¹, Haoran Gao¹, Wanlin Bao¹, Jiaxuan Li², Zhiheng Zhang², Qi Wang¹, Qiang He^1,*

Journal of Polymer Materials, Vol.42, No.2, pp. 379-409, 2025, DOI:10.32604/jpm.2025.066695 - 14 July 2025

Abstract Nanocellulose, derived from abundant lignocellulosic biomass, has emerged as a transformative material with unparalleled versatility across industries. This review systematically analyzes its sources, extraction methods, and multidimensional applications. Key findings include: (1) Plant fiber hierarchy dictates nanocellulose properties, with wood-derived cellulose offering high crystallinity and agricultural waste enabling cost-effective production. (2) Acid hydrolysis remains dominant for cellulose nanocrystals (CNCs), while mechanical methods yield high-aspect-ratio cellulose nanofibrils (CNFs). (3) Nanocellulose’s mechanical strength, biocompatibility, and tunable surface chemistry drive innovations in energy storage (e.g., supercapacitors), biosensors (e.g., glucose monitoring), and biomedical engineering (e.g., 3D-printed scaffolds). Challenges in More >

MIAO YAN¹, DONGXUAN CHI², WEN WANG³, PEI PEI⁴, MIN XIE¹, SHUANGLING LI^1,*

BIOCELL, Vol.49, No.5, pp. 893-906, 2025, DOI:10.32604/biocell.2025.063622 - 27 May 2025

Abstract Background: Transcription factor Krüppel-like factor 3 (KLF3) may be involved in regulating inflammation and lymphocyte function. Immune dysfunction in sepsis involves both hyper-inflammation and immunosuppression. However, studies on T-lymphocyte KLF3 expression in sepsis are lacking. Methods: We induced sepsis in mice via cecal ligation and puncture (CLP), and their survival rate over 7 days was evaluated. To identify the immune status of these mice, we assessed their cytokine levels, organ damage scores, and splenic T-lymphocyte phenotype. Finally, T-lymphocyte KLF3 expression was detected through flow cytometry. Results: Over the 7 days of observation, septic mice demonstrated 64.7%… More >

María Belén Rocco, Clara Requena D’Alessio, Valeria Giselle Sánchez, Horacio Eduardo Romeo, María Laura Barreiro Arcos^*

BIOCELL, Vol.49, No.4, pp. 629-646, 2025, DOI:10.32604/biocell.2025.062525 - 30 April 2025

Abstract Introduction: Hyperthyroidism is known to affect various physiological systems, including the immune system. Thyroid hormones (THs) play a crucial role in regulating immune function, and alterations in THs levels can lead to immune dysregulation. Objective: Currently, we aimed to elucidate the effects of hyperthyroidism on immune function in BALB/c mice, with a focus on anatomical and histological changes in lymphoid organs, the immune response to mitogenic stimulation, mitochondrial dynamics, and reactive oxygen species (ROS) production. Methods: Hyperthyroidism was induced in BALB/c mice by administering thyroxine (T4; 14 mg/L) in their drinking water for 30 days. Thyroid… More >

Kuo-Yang Huang¹, Sheng-Chien Lin^2,3, Chun-Hung Su^4,5,6, Sheng-Wen Wu^4,7, Ching-Chi Tseng^8,9, Wei-Chin Hung¹⁰, Shih-Pin Chen^4,5, Yu-Hsiang Kuan^2,3,*

BIOCELL, Vol.49, No.2, pp. 315-334, 2025, DOI:10.32604/biocell.2025.061073 - 28 February 2025

Abstract ABSTRACT: Background: Acute respiratory distress syndrome (ARDS) is the major therapeutic dilemma associated with significant inflammation and severe pulmonary dysfunction. Liriodendrin is a bioactive compound extract from traditional Chinese medicine, historically utilized for modulating inflammatory responses and alleviating symptoms in multiple disease models. Methods: At present, BALB/c mice were used to explore the effects of liriodendrin on lipopolysaccharide (LPS)-induced ARDS. Before LPS was administered, the mice were treated with either liriodendrin or dexamethasone. Leukocyte infiltration, lung edema, and alveolar-capillary barrier integrity were evaluated in the bronchoalveolar lavage fluid (BALF) and pulmonary parenchyma. The expression of adhesion… More >

KSENIA S. STAFEEVA¹, NATALIA A. SAMOYLOVA¹, OLGA A. KARANDEEVA¹, VERONIKA V. NESTEROVA¹, KIRILL A. STARODUBTSEV¹, EVGENY V. MIKHAILOV², ILYA O. KRUTOV², EVGENY S. POPOV³, NATALIA S. RODIONOVA⁴, ANASTASIA V. KOKINA^1,5, ARTEM P. GUREEV^1,5,*

BIOCELL, Vol.49, No.1, pp. 7-20, 2025, DOI:10.32604/biocell.2024.058339 - 24 January 2025

Abstract Objective: The objective of this study was to determine the level of methotrexate (MTX) toxicity in the intestines of mice and to evaluate the protective effect of probiotics composed of Streptococcus, Bifidobacterium, and Lactobacillus species on intestinal cells during MTX treatment. Methods: Mice were divided into three groups: control, MTX group (received MTX injections), and MTX + probiotics group (received MTX injections along with a diet containing probiotics). Morphological and histological changes, the level of mitochondrial DNA (mtDNA) damage, the level of lipid peroxidation products, and gene expression in the mice’s small intestine were assessed. Results: We… More > Graphic Abstract

MERYEM A. ABDESSALEM, SIRIN A. ADHAM^*

Oncology Research, Vol.33, No.1, pp. 27-44, 2025, DOI:10.32604/or.2024.056955 - 20 December 2024

Abstract Nanotechnology in cancer therapy has significantly advanced treatment precision, effectiveness, and safety, improving patient outcomes and personalized care. Engineered smart nanoparticles and cell-based therapies are designed to target tumor cells, precisely sensing the tumor microenvironment (TME) and sparing normal cells. These nanoparticles enhance drug accumulation in tumors by solubilizing insoluble compounds or preventing their degradation, and they can also overcome therapy resistance and deliver multiple drugs simultaneously. Despite these benefits, challenges remain in patient-specific responses and regulatory approvals for cell-based or nanoparticle therapies. Cell-based drug delivery systems (DDSs) that primarily utilize the immune-recognition principle between… More > Graphic Abstract

MIKHAIL V. DUBININ^1,*, IRINA B. MIKHEEVA², ANASTASIA E. STEPANOVA¹, NATALIA V. MIKINA¹, DANIIL V. SUSHENTSOV¹, VYACHESLAV A. SHARAPOV¹, ALENA A. CHEREPANOVA¹, VALENTIN V. LOSKUTOV¹, KONSTANTIN N. BELOSLUDTSEV^1,2

BIOCELL, Vol.48, No.12, pp. 1815-1825, 2024, DOI:10.32604/biocell.2024.058068 - 30 December 2024

Abstract Objectives: Duchenne muscular dystrophy (DMD) is characterized by the development of cardiac pathology secondarily expressed in mitochondrial dysfunction. DMD treatment includes support for mitochondrial function. The purpose of this work was to evaluate the effects of the lipophilic cation MKT-077, capable of modulating mitochondrial activity, on the structure and function of cardiac mitochondria in mdx and wild-type mice, as well as the state of this organ. Methods: Animals were divided into 4 groups: wild type (WT), WT + 5 mg/kg MKT-077, mdx, mdx + 5 mg/kg MKT-077. MKT-077 was administered intraperitoneally daily for 28 days. Finally, we… More >

AMOURA M. ABOU-EL-NAGA¹, SHAKER A. MOUSA², FAYEZ ALTHOBAITI³, EMAN FAYAD^3,*, ENGY S. FAHIM¹

BIOCELL, Vol.48, No.12, pp. 1835-1837, 2024, DOI:10.32604/biocell.2024.054569 - 30 December 2024

Abstract This article has no abstract. More >

SIYUAN LIU, YUAN ZHAO, YU YU, DOU YE, QIAN WANG, ZHAOYAN WANG, ZUO LUAN^*

BIOCELL, Vol.48, No.7, pp. 1115-1126, 2024, DOI:10.32604/biocell.2024.050493 - 03 July 2024

Abstract Introduction: Transplantation of mesenchymal stromal cells (MSCs) is a promising therapy for type 1 diabetes (T1D). However, whether the infused MSCs affect the endoplasmic reticulum stress or subsequent unfolded protein response in β cells remains unclear. Methods: To investigate this, we induced early-onset T1D in non-obese diabetic mice using streptozotocin. Subsequently, T1D mice were randomly assigned to receive either MSCs or phosphate-buffered saline. We observed the in vivo homing of MSCs and assessed their effectiveness by analyzing blood glucose levels, body weight, histopathology, pancreatic protein expression, and serum levels of cytokines, proinsulin, and C-peptide. Results: Infused MSCs… More > Graphic Abstract