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  • Open Access


    The Interface of Cancer, Their Microenvironment and Nanotechnology

    Natalia Roque1,#, Diana Matias2,#, Joana Balça-Silva3, Valéria Pereira Ferrer4, Luciana Santos Pessoa1, Tania Cristina Leite de Sampaio e Spohr1,5,*

    Oncologie, Vol.24, No.3, pp. 371-411, 2022, DOI:10.32604/oncologie.2022.024035

    Abstract Cancer is one of the deadliest diseases with a cure far from being found. Despite the extraordinary advances in the therapy approaches, only a few patients respond to treatments. The tumor microenvironment (TME) plays a crucial role in cancer progression by contributing to the chemoresistance. Thus, emerging efforts are being made in nanotechnology research focusing on nanoparticles’ potential role and their application in immune system modulation. Moreover, the omics have contributed to bioengineering and nanotechnology development by elucidating the mechanisms of cancer and specific biomarkers that could be used as new therapeutic targets. Furthermore, the non-coding microRNA as a target… More >

  • Open Access


    Chinese Herbal Prescription QYSL Prevents Progression of Lung Cancer by Targeting Tumor Microenvironment

    Yang Chen1,#, Huan Wu2,#, Annan Jiao3, Jiabing Tong4, Jie Zhu5, Mei Zhang1, Zegeng Li4,*, Ping Li1,*

    Oncologie, Vol.24, No.2, pp. 295-307, 2022, DOI:10.32604/oncologie.2022.022116

    Abstract Objectives: Lung cancer is a common and malignant tumor in adults and ranks first in the incidence and mortality of the top five malignant tumors in China. Our previous studies have shown that QYSL prescription can balance lung cancer mice Th1/Th2 and inhibit tumor cell immune escape. Here, we examined the effects of QYSL on lung cancer associated macrophage and the potential associated mechanism. Methods: C57BL/6 mice were injected with Lewis lung cancer cells and treated with QYSL. FACS, RT-PCR, and western blot were used to examined the effect of QYSL on tumor immune microenvironment. Results: We found QYSL inhibited… More >

  • Open Access


    Progression of Exosome-Mediated Chemotherapy Resistance in Cancer

    Haojie Zhang1, Xiaohong Wang2,*, Yue Yu2, Zhenlin Yang3,*

    Oncologie, Vol.24, No.2, pp. 247-259, 2022, DOI:10.32604/oncologie.2022.020993

    Abstract Chemotherapy plays an important role in controlling cancer progression, but the long-term use of chemotherapeutic agents can lead to drug resistance and eventually treatment failure. Therefore, elucidation of the mechanism of drug resistance is the key to solve the problem of chemotherapy resistance. In recent years, exosomes derived from tumor cells have received extensive attention from researchers. In this paper, we reviewed the role and mechanism of exosome-mediated tumor drug resistance in recent years, summarized the related studies of exosome and chemotherapy drug resistance, and focused on several different ways by which exosomes participate in tumor drug resistance. It includes… More >

  • Open Access


    Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts

    Yosuke Mitsui*†, Nahoko Tomonobu*, Masami Watanabe, Rie Kinoshita*, I Wayan Sumardika*‡, Chen Youyi*, Hitoshi Murata*, Ken-ichi Yamamoto*, Takuya Sadahira, Acosta Gonzalez Herik Rodrigo*†, Hitoshi Takamatsu*, Kota Araki, Akira Yamauchi, Masahiro Yamamura#, Hideyo Fujiwara**, Yusuke Inoue††, Junichiro Futami‡‡, Ken Saito§§, Hidekazu Iioka§§, Eisaku Kondo§§, Masahiro Nishibori¶¶, Shinichi Toyooka§, Yasuhiko Yamamoto##, Yasutomo Nasu, Masakiyo Sakaguchi*

    Oncology Research, Vol.27, No.8, pp. 945-956, 2019, DOI:10.3727/096504019X15555408784978

    Abstract S100A11, a member of the S100 family of proteins, is actively secreted from pancreatic ductal adenocarcinoma (PDAC) cells. However, the role of the extracellular S100A11 in PDAC progression remains unclear. In the present study, we investigated the extracellular role of S100A11 in crosstalking between PDAC cells and surrounding fibroblasts in PDAC progression. An abundant S100A11 secreted from pancreatic cancer cells stimulated neighboring fibroblasts through receptor for advanced glycation end products (RAGE) upon S100A11 binding and was followed by not only an enhanced cancer cell motility in vitro but also an increased number of the PDAC-derived circulating tumor cells (CTCs) in… More >

  • Open Access


    Extracellular S100A11 Plays a Critical Role in Spread of the Fibroblast Population in Pancreatic Cancers

    Hitoshi Takamatsu*1, Ken-ichi Yamamoto*1, Nahoko Tomonobu*, Hitoshi Murata*, Yusuke Inoue, Akira Yamauchi, I Wayan Sumardika, Youyi Chen*, Rie Kinoshita*, Masahiro Yamamura, Hideyo Fujiwara#, Yosuke Mitsui*, **, Kota Araki*††, Junichiro Futami‡‡, Ken Saito§§, Hidekazu Iioka§§, I Made Winarsa Ruma§, Endy Widya Putranto¶¶, Masahiro Nishibori##, Eisaku Kondo§§, Yasuhiko Yamamoto***, Shinichi Toyooka††, Masakiyo Sakaguchi*

    Oncology Research, Vol.27, No.6, pp. 713-727, 2019, DOI:10.3727/096504018X15433161908259

    Abstract The fertile stroma in pancreatic ductal adenocarcinomas (PDACs) has been suspected to greatly contribute to PDAC progression. Since the main cell constituents of the stroma are fibroblasts, there is crosstalking(s) between PDAC cells and surrounding fibroblasts in the stroma, which induces a fibroblast proliferation burst. We have reported that several malignant cancer cells including PDAC cells secrete a pronounced level of S100A11, which in turn stimulates proliferation of cancer cells via the receptor for advanced glycation end products (RAGE) in an autocrine manner. Owing to the RAGE+ expression in fibroblasts, the extracellular abundant S100A11 will affect adjacent fibroblasts. In this… More >

  • Open Access


    Microenvironment Analysis of Prognosis and Molecular Signature of Immune-Related Genes in Lung Adenocarcinoma

    Bo Ling, Zuliang Huang, Suoyi Huang, Li Qian, Genliang Li, Qianli Tang

    Oncology Research, Vol.28, No.6, pp. 561-578, 2020, DOI:10.3727/096504020X15907428281601

    Abstract There is growing evidence on the clinical significance of tumor microenvironment (TME) cells in predicting prognosis and therapeutic effects. However, cell interactions in tumor microenvironments have not been thoroughly studied or systematically analyzed so far. In this study, 22 immune cell components in the lung adenocarcinoma (LUAD) TME were analyzed using gene expression profile from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). The TME-based molecular subtypes of LUAD were defined to evaluate further the relationship between molecular subtypes, prognosis, and clinical characteristics. A TME risk score model was constructed by using the differentially expressed genes (DEGs) of… More >

  • Open Access


    Role of PTX3 and complement modulation in the tumor microenvironment


    BIOCELL, Vol.46, No.10, pp. 2235-2239, 2022, DOI:10.32604/biocell.2022.020209

    Abstract Pentraxin-3 (PTX3), the prototype of long pentraxins, seems to influence complement system (CS) modulation. PTX3 and CS sustain carcinogenesis, enriching tumor microenvironment (TME) with pro-inflammatory molecules promoting angiogenesis in prostate cancer (PC) and renal cell carcinoma (RCC). Furthermore, cancer cells overexpress complement regulatory proteins, such as CD46, CD55 and CD59, which negatively affect complement pathways for support cancer cells survival. This viewpoint aims to elucidate the ambivalent role of PTX3 and the CS in the context of tumor microenvironment (TME). More >

  • Open Access


    Microenvironmental regulation of stem cells injected in the area at risk of neurodegenerative diseases


    BIOCELL, Vol.46, No.10, pp. 2231-2234, 2022, DOI:10.32604/biocell.2022.020179

    Abstract The complex mechanism of degenerative diseases and the non-specific modulation of regenerative targets are topics that need to be elucidated in order to advance the use of stem cells in improvement of neurodegenerative diseases. From pre-transplantation through post-transplantation, there are many changes in the conditions, both inside and outside of the stem cells that have not been carefully considered. This has hindered development in the field of cell therapy and regeneration. This viewpoint highlights the potential implications of intracellular and extracellular alterations of stem cells in transplanted areas at risk of neurodegenerative disease. More >

  • Open Access


    The cellular microenvironment and cytoskeletal actin dynamics in liver fibrogenesis


    BIOCELL, Vol.46, No.9, pp. 2003-2007, 2022, DOI:10.32604/biocell.2022.020171

    Abstract Hepatic stellate cells (HSCs) are the primary effector cells in liver fibrosis. In the normal liver, HSCs serve as the primary vitamin A storage cells in the body and retain a “quiescent” phenotype. However, after liver injury, they transdifferentiate to an “activated” myofibroblast-like phenotype, which is associated with dramatic upregulation of smooth muscle specific actin and extracellular matrix proteins. The result is a fibrotic, stiff, and dysfunctional liver. Therefore, understanding the molecular mechanisms that govern HSC function is essential for the development of anti-fibrotic medications. The actin cytoskeleton has emerged as a key component of the fibrogenic response in wound… More >

  • Open Access


    Microenvironment and cell mechanics


    BIOCELL, Vol.46, No.7, pp. 1629-1632, 2022, DOI:10.32604/biocell.2022.018364

    Abstract Microenvironment contains biophysical and biochemical elements to maintain survival, growth, proliferation, and differentiation of cells. Any change can lead to cell response to the mechanical forces, which can be described by elasticity. It is an indicator of a cell’s state since it plays an important role in many cellular processes. In many cases, cell elasticity is measured by using discontinuous manner, which may not allow elucidating real-time activity of individual live cells in physiological condition or cell response against microenvironmental changes. I argue that measuring cell elasticity using continuously repetitive nanoindentation technique is important that should be considered. As an… More >

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