Qingqing Liu1,2,#, Lei Li3,4,#, Kumar Ganesan1,2, Yang Jiang5, Kewu Zeng6, Yue Sui1,2, Xinyuan Guan2,7, Rongfang He3,*, Jianping Chen1,2,*
Oncology Research, Vol.34, No.10, 2026, DOI:10.32604/or.2026.082536
- 14 September 2026
Abstract Objectives: Sorting nexin 9 (SNX9) participates in endocytic trafficking and has been connected to several malignancies, but its involvement in breast cancer (BC) remains incompletely resolved. This work was designed to examine whether SNX9 supports BC progression and investigate signaling and cytoskeletal processes associated with its activity. Methods: The clinical relevance of SNX9 was assessed using bioinformatics analysis of publicly available cancer databases. Lentiviral vectors were used to establish BC cell models with stable SNX9 overexpression or knockdown. Both cellular (proliferation and motility) and murine (tumor growth and metastatic colonization) experiments were implemented to functionally characterize… More >