R. Coriat

Oncologie, Vol.21, No.2, pp. 75-81, 2019, DOI:10.3166/onco-2019-0046

Abstract Pancreatic neuroendocrine tumours are the tumours developed at the expense of pancreas and require a specific diagnostic assessment. The imaging assessment of a pancreatic neuroendocrine tumour is useful for diagnosis as well as for surgical/medical treatment. Recently, a number of advances have been made in the field of imaging pancreatic neuroendocrine tumours, in particular in functional imaging using radiolabelled somatostatin analogues. In this review, we approach diagnostic progress by focusing on the advances of recent years. Thus, the interest of conventional imaging (scanner, abdominal ultrasound, and magnetic resonance imaging), ultrasound endoscopy and the place of functional imaging mainly with radiolabelled… More >

V. Rohmer

Oncologie, Vol.21, No.2, pp. 73-73, 2019, DOI:10.3166/onco-2019-0045

Abstract This article has no abstract. More >

V. Massard, A. Harlé, L. Uwer, J.-L. Merlin

Oncologie, Vol.21, No.1, pp. 29-32, 2019, DOI:10.3166/onco-2019-0027

Abstract Acquired endocrine resistance remains one of the main obstacles in the treatment of estrogen receptor (ER) positive, HER2 negative advanced breast cancer. Recently, activating ESR1 gene mutations affecting the ligand-binding domain have been identified as a key mechanism in aromatase inhibitor (AI) resistance. These mutations can be detected on histological samples or circulating tumour DNA, using PCRbased assays or next-generation sequencing. They induce a constitutive activation of ER, leading to acquired resistance to AI; tamoxifen, fulvestrant and targeted therapies against mTOR or CDK4/6 retain their efficacy. The use of monitoring ESR1 mutations in clinical practice is still to be defined.… More >

Ewa Szefer^*, Agnieszka Leszczyńska, Edyta Hebda, Krzysztof Pielichowski

Journal of Renewable Materials, Vol.9, No.6, pp. 1127-1142, 2021, DOI:10.32604/jrm.2021.014584

Abstract The aim of this work was to use cellulose nanocrystals that were obtained by hydrolysis in phosphoric acid solution and further modified with succinic anhydride in the microwave field for PLA reinforcement. A series of all-bionanocomposites containing unmodified and surface modified cellulose nanocrystals with CNC content in the range of 1–3 %_w.t. were obtained by melt blending and tested by XRD, SEM, DSC and DMA to investigate the effect of surface esterification of CNCs on the structure, morphology, dynamic mechanical properties of bionanocomposites, as well as phase transitions of PLA in the presence of cellulosic nanofiller. DMA investigations showed the… More > Graphic Abstract

Dexby de Guzman, Rizalinda de Leon^*

Journal of Renewable Materials, Vol.9, No.1, pp. 145-162, 2021, DOI:10.32604/jrm.2021.011646

Abstract Levulinic acid (LA) is a platform biorefinery chemical from biomass which can be converted to green solvents, plasticizers, polymer precursors, bio-based cleaning agents, fuels and fuel additives. This study assessed the potential of SnCl₂-based mixed acid systems as catalyst in the hydrothermal conversion of microcrystalline cellulose to levulinic acid. Maximum LA yield of 36.2 mol% was achieved using 0.2 M SnCl₂ concentration at test conditions of 3 h, 180°C and 1% w/v cellulose loading. To reduce precipitate formation and further improve LA yield, the strategy employed was to combine SnCl₂ (a Lewis acid) with conventional mineral acids (Bronsted acids). Evaluation… More >

Burcu BİTERGE SÜT^1,*, Ayşe İKİNCİ KELE޲

Oncologie, Vol.22, No.3, pp. 147-154, 2020, DOI:10.32604/oncologie.2020.014449

Abstract Components of the protein synthesis machinery are subjected to alterations in cancer cells. eEF1D gene, which lies within the frequently amplified 8q24 locus, is one of the subunits of the human eukaryotic elongation factor complex. This study aimed to evaluate the prognostic and predictive significance of eEF1D in breast cancer using in silico analysis tools. For this purpose, we analyzed genomic alterations of the eEF1D gene using TCGA datasets via cBioPortal. Histopathological analysis was performed on patient tissue images obtained from cBioPortal and the Human Protein Atlas. Survival analysis was carried out using the KM Plotter and the prediction of… More >

Yunxiang Guo¹, Cheng Lu^1,2, Feng Yu¹, Liang Hua¹, Xinsong Zhang^1,*

Energy Engineering, Vol.117, No.6, pp. 429-438, 2020, DOI:10.32604/EE.2020.011673

Abstract Nanocrystalline core is often adopted in high-power medium-frequency transformer, whose excitation voltage is usually a rectangular wave with an adjustable duty ratio. In this paper, several kinds of methods are proposed for core loss calculation under non-sinusoidal voltage excitation by modifying the original Steinmetz equation (OSE). Firstly, these correction methods are compared in theory, and their analytical equations under rectangular voltage with an adjustable duty ratio are deduced. Then, a hysteresis loop measurement system is established to measure the core loss density of a nanocrystalline core. Based on the measured results of the core loss density under sinusoidal voltage excitation,… More >

Xing Zhou^1,*, Xin Zhang¹, Dong Wang¹, Changqing Fang^1,*, Wanqing Lei¹, Zhigang Huang², Yonghua Song¹, Xinyu He¹, Yingwei Huang¹

Journal of Renewable Materials, Vol.8, No.6, pp. 631-645, 2020, DOI:10.32604/jrm.2020.010176

Abstract Cellulose plays a key role in abundant organic natural materials meeting the increasing demand for green and biocompatible products. The highly crystalline nanoscale component of cellulose nanocrystals has recently attracted great attention due to the versatile performance as filler or matrix in producing functional materials. In this work, we prepared the waterborne polyurethane via a prepolymer process, and obtained cellulose and cellulose nanocrystals from waste paper via a facile acid hydrolysis process. After that, the cellulose nanocrystals were assembled into film and mixed with polyurethane to prepare flexible polyurethane/cellulose nanocrystals composite membrane with different soaking time. The correlation between the… More >

Xing Chen, Wu Zhou, Qinghua Hu, Lingjin Huang

Congenital Heart Disease, Vol.14, No.3, pp. 396-402, 2019, DOI:10.1111/chd.12733

Abstract Objective: This study explores the role of the Notch3‐HES5 signal pathway in mono‐ crotaline‐induced pulmonary hypertension (PH) using rat models.
Method: Sprague Dawley rats (n = 45) were randomly grouped into normal group, control group, and model group. Rats in the model group were used to establish the PH rat model. Four weeks after model establishment, right catheterization was used to measure the mean pulmonary arterial pressure (mPAP) and right ventricular sys‐ tolic pressure (RVSP) to analyze hemodynamic changes. The severity of PH was as‐ sessed by the right ventricular hypertrophy index (RVHI) and percentage of media thickness (MT%). The… More >

Xiaozheng Sun^*, Qiang He, Yu Yang

Journal of Renewable Materials, Vol.8, No.4, pp. 447-460, 2020, DOI:10.32604/jrm.2020.09671

Abstract Agricultural waste straw is the renewable resource with the highest annual yield in the world. In value-added applications of agricultural waste, dicarboxyl cellulose nanocrystals (DCCs) are prepared from rice, wheat, and corn straw by sequential periodate-chlorite oxidation. In this study, DCCs from rice, wheat, and corn straw were characterized by transmission electron microscopy (TEM), Fourier transform infrared spectrometer, X-ray diffractometer (XRD), and thermal gravimetric analysis (TGA). The carboxyl content of the DCCs was also investigated. XRD results show that the crystallinity index decreased after sequential periodate-chlorite oxidation; however, the cellulose I structure was maintained. TEM results show that rod-shaped DCCs… More >