MENGSHU ZHAO¹, PINGSHI GAO¹, LIANG TAO¹, JINGJING WEN¹, LEI WANG¹, YUGUO YI¹, YUXIN CHEN², JUNSONG WANG¹, XI XU¹, JIANFA ZHANG¹, DAN WENG^1,*

BIOCELL, Vol.44, No.3, pp. 353-361, 2020, DOI:10.32604/biocell.2020.08955

Abstract As a natural analog of resveratrol, piceatannol (Pic) exhibits good antioxidant and anti-inflammatory activities in different disease models. However, the role of Pic in type 1 diabetes mouse model has not been reported yet. In this study, we investigated the in vivo effect of Pic in streptozotocin (STZ)-induced type 1 diabetic mice. Mice were injected with STZ to establish the type 1 diabetes mellitus (T1DM) model. After stable hyperglycemia was achieved, mice were then orally treated with Pic (40 mg/kg b.w., i.g.) for 30 days. The results indicated that Pic supplementation efficiently alleviated the typical symptoms associated with T1DM, including… More >

Md. Shakhawat Hossain¹, Md. Daud Hossain¹, Abdul Hannan², Mirza Hasanuzzaman³, Md. Motiar Rohman^4,*

Phyton-International Journal of Experimental Botany, Vol.89, No.3, pp. 541-559, 2020, DOI:10.32604/phyton.2020.010279

Abstract Salinity stress is a major factor limiting plant growth and productivity of many crops including oilseed. The present study investigated the identification of salt tolerant mustard genotypes and better understanding the mechanism of salinity tolerance. Salt stresses significantly reduced relative water content (RWC), chlorophyll (Chl) content, K⁺ and K⁺ /Na⁺ ratio, photosynthetic rate (P_N), transpiration rate (Tr), stomatal conductance (gs), intercellular CO₂ concentration (Ci) and increased the levels of proline (Pro) and lipid peroxidation (MDA) contents, Na⁺ , superoxide (O₂^•− ) and hydrogen peroxide (H₂O₂) in both tolerant and sensitive mustard genotypes. The tolerant genotypes maintained higher Pro and lower… More >

Mahmuda Binte Monsur¹, Nasrin Akter Ivy¹, M. Moynul Haque², Mirza Hasanuzzaman³, Ayman EL Sabagh^4,5,*, Md. Motiar Rohman^6,*

Phyton-International Journal of Experimental Botany, Vol.89, No.3, pp. 497-517, 2020, DOI:10.32604/phyton.2020.09144

Abstract The research was conducted to investigate comparative oxidative damage including probable protective roles of antioxidant and glyoxalase systems in rice (Oryza sativa L.) seedlings under salinity stress. Seedlings of two rice genotypes: Pokkali (tolerant) and BRRI dhan28 (sensitive) were subjected to 8 dSm⁻¹ salinity stress for seven days in a hydroponic system. We observed significant variation between Pokkali and BRRI dhan28 in phenotypic, biochemical and molecular level under salinity stress. Carotenoid content, ion homeostasis, antioxidant enzymes, ascorbate and glutathione redox system and proline accumulation may help Pokkali to develop defense system during salinity stress. However, the activity antioxidant enzymes particularly… More >

Nicola Maschietto¹, Luca Semplicini², Giulio Ceolotto², Arianna Cattelan², Helen Poser³, Ilaria Iacopetti³, Gabriele Gerardi³, Giulia Maria De Benedictis³, Tommaso Pilla³, Daniele Bernardini³, Luca Aresu⁴, Stefania Rizzo⁵, Cristina Basso⁵, Andrea Semplicini², Ornella Milanesi¹

Congenital Heart Disease, Vol.12, No.1, pp. 74-83, 2017

Abstract Background: Stent implantation is the treatment of choice for adolescents and adults with aortic coarctation (CoAo). Despite excellent short-term results, 20%–40% of the patients develop arterial hypertension later in life, which was attributed to inappropriate response of the aortic baroreceptors to increased stiffness of the ascending aorta (ASAO), either congenital or induced by CoAo repair. In particular, it has been hypothesized that stent itself may cause or sustain hypertension. Therefore, we aimed to study the hemodynamic and structural impact following stent implantation in the normal aorta of a growing animal.
Methods: Eight female sheep completed the study and a stent… More >

Osama M. AHMED^1,*, Sanaa R. GALALY², Mai RASLAN³, Mennah-Allah M. A. MOSTAFA^1,*

BIOCELL, Vol.44, No.1, pp. 41-53, 2020, DOI:10.32604/biocell.2020.08157

Abstract This study aimed to assess the preventive effects of thyme oil and thymol on doxorubicin (DOX)-induced renotoxicity, cardiotoxicity, and oxidative stress in Wistar rats. Thyme oil was subjected to GC-MS analysis, which indicated that thymol was the major constituent representing 33.896%. Rats intraperitoneally injected with DOX at a dose of 2 mg/kg b.w./one per week for 7 weeks were co-treated with thyme oil and its major constituent, thymol, at doses 250 and 100 mg/kg b.w./every other day, respectively, by oral gavage for the same period. Thyme oil and thymol markedly ameliorated the raised levels of serum urea, uric acid, and… More >

Fuat USLUSOY¹, Mustafa NAZIROĞLU^2,3,*

BIOCELL, Vol.43, No.4, pp. 271-283, 2019, DOI:10.32604/biocell.2019.08333

Abstract The wound is induced by several mechanical and metabolic factors. In the etiology of the wound recovery, excessive oxidative stress, calcium ion (Ca²⁺) influx, and apoptosis have important roles. Ca²⁺-permeable TRPM2 channel is activated by oxidative stress. Protective roles of Hypericum perforatum extract (HP) on the mechanical nerve injury-induced apoptosis and oxidative toxicity through regulation of TRPM2 in the experimental animals were recently reported. The potential protective roles in HP treatment were evaluated on the TRPM2-mediated cellular oxidative toxicity in the renal epithelium (MPK) cells. The cells were divided into three groups as control, wound, and wound + HP treatment… More >

IIZUKA YOKO¹, SAMIN HONG², CHAN YUN KIM², SEUNG KAB KIM², GONG JE SEONG²

BIOCELL, Vol.32, No.3, pp. 245-250, 2008, DOI:10.32604/biocell.2008.32.245

Abstract Agmatine, 2-(4-aminobutyl)guanidine, has been reported to have neuroprotective effects against various neuronal damages. In this study it was investigated whether agmatine pretreatment rescues the retinal ganglion cells from oxidative injury in vitro. After differentiation of transformed rat retinal ganglion cells (RGC-5 cell line) with staurosporine, agmatine (0.0 to 100.0 μM) pretreatment was performed for 2 hours. Subsequently, they were exposed to hydrogen peroxide (0.0 to 2.5 mM) as an oxidative stress. Cell viability was monitored for up to 48 hours with the lactate dehydrogenase (LDH) assay and apoptosis was examined by the terminal deoxynucleotide transferase-mediated terminal uridine deoxynucleotidyl transferase nick… More >

G.C. DALVIT, P.D. CETICA, L.N. PINTOS, M.T. BECONI

BIOCELL, Vol.29, No.2, pp. 209-212, 2005, DOI:10.32604/biocell.2005.29.209

Abstract Oxidative modifications of cell components due to the action of reactive oxygen species (ROS) is one of the most potentially damaging processes for proper cell function. However, in the last few years it has been observed that ROS participate in physiological processes. The aim of this work was to determine ROS generation during in vitro production of bovine embryos. Cumulus-oocyte complexes were recovered by aspiration of antral follicles from ovaries obtained from slaughtered cows and cultured in medium 199 for 22 h at 39ºC in 5% CO₂: 95% humidified air. In vitro fertilization was carried out in IVF-mSOF with frozenthawed… More >

VIJAY L. KUMAR^* AND BISWA M. PADHY

BIOCELL, Vol.35, No.3, pp. 63-70, 2011, DOI:10.32604/biocell.2011.35.063

Abstract Calotropis species have been used in the traditional medicinal system for the treatment of diseases of the liver and abdomen. In view of the antioxidant and anti-hyperglycemic properties of an aqueous suspension obtained from the dried latex of Calotropis procera, the present study was carried out to evaluate its efficacy in affording protection against alloxan induced changes in rat kidney. A single intraperitoneal injection of alloxan (150 mg/kg) in rats produced hyperglycemia within 3 days and altered kidney functions over a period of 90 days. Daily oral administration of the aqueous suspension (100 and 400 mg/kg) in diabetic rats produced… More >

Wang QL, DH Liu, JY Yue

Phyton-International Journal of Experimental Botany, Vol.85, pp. 270-282, 2016, DOI:10.32604/phyton.2016.85.270

Abstract This study aimed to determine the effects of different Cd concentrations (0, 1, 10, 100, and 300 μM CdCl₂) on Allium plantlets. To achieve this goal, we examined the (1) dynamics of Cd²⁺ flux in the rhizosphere, (2) partitioning of Cd between roots and leaves, (3) formation of reactive oxygen species (ROS), (4) levels of H₂O₂ and chlorophyll, and (5) translocation of several macro- and micronutrients. A strong net Cd²⁺ influx was observed in the root apex after exposure to 100 μM Cd for 24 h. Exposure to either 1 or 10 μM Cd for 96 h presented no evident… More >