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  • Open Access

    ARTICLE

    Mesenchymal stem cells are more effective than captopril in reverting cisplatin-induced nephropathy

    Entsar A. SAAD1, Reda S. EL-DEMERDASH2, Eman M. ABD EI-FATTAH1

    BIOCELL, Vol.43, No.2, pp. 73-80, 2019, DOI:10.32604/biocell.2019.07020

    Abstract Cisplatin is a powerful anticancer drug but its nephrotoxic effects limit its clinical use. We aimed to evaluate the effect of mesenchymal stem cells (MSCs) injection or of captopril to counteract the cisplatin-induction of nephropathy. MSCs isolation, preparation and tracking, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) expressions, kidney function tests, oxidative stress state, and histological examinations were done. Cisplatininduced nephropathy was indicated biochemically and confirmed histopathologically. MSCs treatment showed normal kidney architecture, and significantly decreased oxidative stress and TGF-β while increased IL-10 and improved kidney function tests. Rats treated with cisplatin + captopril More >

  • Open Access

    REVIEW

    Active compounds of medicinal plants, mechanism for antioxidant and beneficial effects

    Orozco Montes F1, A Vázquez-Hernández2, B Fenton-Navarro1

    Phyton-International Journal of Experimental Botany, Vol.88, No.1, pp. 1-10, 2019, DOI:10.32604/phyton.2019.04525

    Abstract An increased interest in the antioxidant effects of medicinal plants has developed in recent years. Identifying antioxidant compounds present in medicinal plants and elucidating the mechanism by which they prevent oxidation have been the focus of the research community. We performed a systematic and exhaustive review aimed at analyzing the available data regarding the beneficial effects of secondary metabolites in plants. The result of this review is presented as a description of free radicals, as well as cellular and physiological oxidative stress, is provided. The origin and source of antioxidant compounds, and the cellular and More >

  • Open Access

    ARTICLE

    Prenatal exposure to the fluoride containing psychiatric drug fluoxetine and anti-oxidative alterations in the neonatal rat brain

    Ramesa Shafi BHAT1, Amina El GEZEERY2, Abir Ben BACHAN1, Mona Awad ALONAZI1, Leena Saleh ALSUHAIBANI1, Afaf El-ANSARY3,4

    BIOCELL, Vol.43, No.2, pp. 65-71, 2019, DOI:10.32604/biocell.2019.07012

    Abstract Fluoride is a key ingredient of many psychiatric drugs like fluoxetine (Prozac®, Fluoxetine®). Pregnant women frequently use this drug as they suffer from depression and anxiety disorders during this period. Fluoxetine is able to reach the fetus through the placenta and passes to the newborn through milk. In the present study, female Wistar rats were treated with 5, 10, and 20 mg/L fluoxetine (containing 94% fluorides) from pregnancy day 10 to day 20. After delivery, the levels of the enzymatic antioxidants in the brain of their offspring at postnatal day 2 were measured. The results More >

  • Open Access

    REVIEW

    Oxidative effects of the harmful algal blooms on primary organisms of the food web

    Joaquin Cabrera1,2, Paula Mariela González1,2, Susana Puntarulo1,2

    BIOCELL, Vol.43, No.2, pp. 41-50, 2019, DOI:10.32604/biocell.2019.06163

    Abstract Degraded water quality from nutrient pollution, physical, biological, and other chemical factors contributes to the development and persistence of many harmful algal blooms (HABs). The complex dynamics of the HABs is a challenge to marine ecosystems for the toxic effects reported. The consequences include fish, bird, and mammal mortality, respiratory or digestive tract problems, memory loss, seizures, lesions and skin irritation in many organisms. This review is intended to briefly summarize the recent reported information on harmful marine toxin deleterious effects over the primary organisms of the food web, namely algae, zooplankton and invertebrates.… More >

  • Open Access

    ARTICLE

    Photo-Activatable Akt Probe: A New Tool to Study the Akt-Dependent Physiopathology of Cancer Cells

    Sanae Haga*, Takeaki Ozawa, Naoki Morita, Mami Asano§, Shigeki Jin, Yimin#, Michitaka Ozaki*§¶

    Oncology Research, Vol.26, No.3, pp. 467-472, 2018, DOI:10.3727/096504017X15040166233313

    Abstract Akt is commonly overexpressed and activated in cancer cells and plays a pivotal role in cell survival, protection, and chemoresistance. Therefore, Akt is one of the target molecules in understanding characters of cancer cells and developing anticancer drugs. Here we examined whether a newly developed photo-activatable Akt (PA-Akt) probe, based on a light-inducible protein interaction module of plant cryptochrome2 (CRY2) and cryptochrome-interacting basic helix–loop–helix (CIB1), can regulate Akt-associated cell functions. By illuminating blue light to the cells stably transfected with PA-Akt probe, CRY2-Akt (a fusion protein of CRY2 and Akt) underwent a structural change and… More >

  • Open Access

    ARTICLE

    Association between preterm birth risk and polymorphism and expression of the DNA repair genes OGG1 and APE1 in Saudi women

    Arwa Osama NEMER1, Mohammad Saud AL ANAZI2, Ramesa Shafi BHAT1*, Arjumand S. WARSY3, Zeneb A BABAY4, Mohammad H. ADDAR4, Jilani SHAIK2, Sooad AL-DAIHAN1

    BIOCELL, Vol.42, No.1, pp. 1-6, 2018, DOI:10.32604/biocell.2018.07005

    Abstract Genomic instability and mutations caused by increases in oxidative stress during pregnancy can damage the fetoplacental unit and can upshot preterm birth. Oxidative damage to DNA may possibly be involved in etiology of preterm birth (PTB) which can be repaired by DNA repair gene. In the present study, we assessed the association of base excision repair gene family by analyzing the association of single nucleotide polymorphisms and genes expression in 8-oxoguanine glycosylase-1 (OGG1) and apurinic-apyrimidinic endonuclease 1 (APE1) genes with risk of preterm birth in Saudi women. We analyzed genotypes of four single nucleotide polymorphisms (SNPs) (rs1052133,… More >

  • Open Access

    ARTICLE

    Aortic stenting in the growing sheep causes aortic endothelial dysfunction but not hypertension: Clinical implications for coarctation repair

    Nicola Maschietto1, Luca Semplicini2, Giulio Ceolotto2, Arianna Cattelan2, Helen Poser3, Ilaria Iacopetti3, Gabriele Gerardi3, Giulia Maria De Benedictis3, Tommaso Pilla3, Daniele Bernardini3, Luca Aresu4, Stefania Rizzo5, Cristina Basso5, Andrea Semplicini2, Ornella Milanesi1

    Congenital Heart Disease, Vol.12, No.1, pp. 74-83, 2017

    Abstract Background: Stent implantation is the treatment of choice for adolescents and adults with aortic coarctation (CoAo). Despite excellent short-term results, 20%–40% of the patients develop arterial hypertension later in life, which was attributed to inappropriate response of the aortic baroreceptors to increased stiffness of the ascending aorta (ASAO), either congenital or induced by CoAo repair. In particular, it has been hypothesized that stent itself may cause or sustain hypertension. Therefore, we aimed to study the hemodynamic and structural impact following stent implantation in the normal aorta of a growing animal.
    Methods: Eight female sheep completed the study… More >

  • Open Access

    ARTICLE

    Simvastatin Inhibits the Proliferation and Apoptosis of Macrophages Induced by Mechanical and/or Oxidized Low-Density Lipoprotein

    Kefeng Liu1,2, §, Zhengyu Zhang1,3, §, Ting Pei1, Ziqing Li4, Jingjing Wang1, Hong Wang1, Suning Ping1, Lie Deng1, Linli Wang1, Jintao Huang5, Puyi Sheng4, Shuying Liu1, Chaohong Li1

    Molecular & Cellular Biomechanics, Vol.14, No.2, pp. 101-123, 2017, DOI:10.3970/mcb.2017.014.099

    Abstract This study was designed to investigate the effects of mechanical (MS) and/or oxidized low-density lipoprotein on proliferation and apoptosis of RAW264.7 macrophages and the underlying mechanisms. The cultured quiescent RAW264.7 macrophages were subject to stimulation with MS and/or in the presence or absence of simvastatin and then harvested for Western blot, and immunoflourecence. Either MS or alone could cause increase in cell proliferation and apoptosis, while their combination led to an additive effect. In terms of mechanisms, MS and/or significantly increased phosphorylation levels of MAPKs (ERKs, JNKs and p38MAPK), promoted the reactive oxygen species (ROS) More >

  • Open Access

    ARTICLE

    Physiological responses of Allium cepa var. agrogarum L. plants to Cadmium stress

    Wang QL, DH Liu, JY Yue

    Phyton-International Journal of Experimental Botany, Vol.85, pp. 270-282, 2016, DOI:10.32604/phyton.2016.85.270

    Abstract This study aimed to determine the effects of different Cd concentrations (0, 1, 10, 100, and 300 μM CdCl2) on Allium plantlets. To achieve this goal, we examined the (1) dynamics of Cd2+ flux in the rhizosphere, (2) partitioning of Cd between roots and leaves, (3) formation of reactive oxygen species (ROS), (4) levels of H2O2 and chlorophyll, and (5) translocation of several macro- and micronutrients. A strong net Cd2+ influx was observed in the root apex after exposure to 100 μM Cd for 24 h. Exposure to either 1 or 10 μM Cd for 96 h More >

  • Open Access

    ARTICLE

    Update on Fe-dependent oxidative metabolism in vivo: An integrative view

    Natacha E PILONI, Elizabeth ROBELLO, Julián G BONETTO, Susana PUNTARULO*

    BIOCELL, Vol.40, No.1, pp. 39-42, 2016, DOI:10.32604/biocell.2016.40.039

    Abstract Fe is essential for human life because it constitutes the required cofactor for proteins of diverse biological functions. However, the development of oxidative stress by exposure to excessive Fe, share signaling pathways with other treatments including activation of redox-sensitive factors. This study was focused on the comparison on the effects of Fe in the brain and other organs in vivo. The oxidative effects triggered by Fe overload strongly depend not only on the administration protocol, but also on the Fe-compound used, and the studied organ. In both the liver and the brain, Fe content drastically… More >

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