JUNPING LIU^1,2, FEIRAN GAO¹, DANTING WANG², RUIXUE ZHOU², CHUNYAN HUANG^2,*

Oncology Research, Vol.33, No.6, pp. 1323-1334, 2025, DOI:10.32604/or.2024.059113 - 29 May 2025

Abstract Exosomes (EXOs) play an important role in the progression of breast cancer. EXOs, with a diameter of approximately 100 nm, have a simple structure but diverse functions, and can affect the development of breast cancer through signal transduction and molecular transfer, etc. Angiogenesis provides nutrients for the growth and metastasis of breast cancer and is a crucial part of tumor progression. The mechanism of tumor angiogenesis is complex. The VEGF/VEGFR pathway promotes angiogenesis by regulating the activities of ECs. Hypoxia, a common feature in the tumor microenvironment, as a key regulator, can affect angiogenesis… More > Graphic Abstract

LIBO LIANG¹, XINYI WANG^2,3,4, YUPING ZENG^2,3,4, HAO CHEN^2,3,4, WEN ZHOU¹, HONGYING MU^2,3,4, GA LIAO^5,6,*

Oncology Research, Vol.33, No.6, pp. 1405-1421, 2025, DOI:10.32604/or.2024.056708 - 29 May 2025

Abstract Objectives: Exosomal long noncoding RNAs (lncRNAs) might facilitate epithelial–mesenchymal transition (EMT) in liver cancer after transarterial chemoembolization (TACE), thereby enhancing tumor cell invasiveness and migration. This study investigated the prognostic role of plasma exosomal long noncoding RNA-plasmacytoma variant translocation 1 (lncRNA-PVT1) in TACE treated hepatocellular carcinoma (HCC). Methods: Plasma exosomal lncRNA-PVT1 was evaluated via qPCR before and after TACE. Hepatoma cell behavior was investigated in different HCC cell lines. A lncRNA-PVT1 plasmid was synthesized and overexpressed, and si-lncRNA PVT1 was transfected into poorly invasive cells to reveal its influence on cell characteristics. The lncRNA-PVT1–FoxM1 interaction… More > Graphic Abstract

MING YANG^1,#, LIANGZHAO CHU^1,#, SHUKAI LIN², HAN PENG¹, NIYA LONG¹, KAYA XU¹, HUA YANG¹, FENG HAN^1,*, JIAN LIU^1,*

Oncology Research, Vol.33, No.5, pp. 1189-1198, 2025, DOI:10.32604/or.2024.055102 - 18 April 2025

Abstract Background: Glioblastoma (GBM) is one of the most malignant types of central nervous system tumors. Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression. However, the mechanisms of hypoxia-promoted tumor progression remain elusive. Methods: Alternative splicing of diacylglycerol kinase gamma (DGKG)-Δ exon13 was amplified and verified by PCR-Sanger sequencing. The functions of DGKG and DGKG-Δ exon13 were analyzed by Cell counting kit-8 (CCK-8), Transwell, Matrigel-transwell experiments, and in vivo orthotropic GBM animal models. Transcriptome analyses were done to find out the regulated genes. Results: In this study, we found… More > Graphic Abstract

Poonam Sharma¹, Bhisham Sharma^2,*, Dhirendra Prasad Yadav³, Surbhi Bhatia Khan^4,5,6,*, Ahlam Almusharraf⁷

CMC-Computers, Materials & Continua, Vol.83, No.2, pp. 3227-3245, 2025, DOI:10.32604/cmc.2025.062376 - 16 April 2025

Abstract Rapid and precise diagnostic tools for Monkeypox (Mpox) lesions are crucial for effective treatment because their symptoms are similar to those of other pox-related illnesses, like smallpox and chickenpox. The morphological similarities between smallpox, chickenpox, and monkeypox, particularly in how they appear as rashes and skin lesions, which can sometimes make diagnosis challenging. Chickenpox lesions appear in many simultaneous phases and are more diffuse, often beginning on the trunk. In contrast, monkeypox lesions emerge progressively and are typically centralized on the face, palms, and soles. To provide accessible diagnostics, this study introduces a novel method… More >

Yongming Li, Dingyuan Zhang^*, Yadong Chen, Jiandu Ye

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.2, pp. 261-277, 2025, DOI:10.32604/fdmp.2025.060033 - 06 March 2025

Abstract Resin plugging agents play a pivotal role in addressing casing damage in oil and gas fields. However, the widespread use of epoxy resin is constrained by its high cost and non-renewable origin, while plant-based resins often suffer from inadequate mechanical properties, which limit their effectiveness in such applications. This study introduces BEOPA, an innovative, renewable, high-strength resin plugging agent derived from epoxidized soybean oil (ESO) and enhanced with bisphenol A-type benzoxazine (BZ). In this study, the synthesis process, reaction mechanism, and application performance of this novel material are systematically presented, explored and optimized. It is… More >

Aiga Ivdre^*, Ralfs Pomilovskis, Arnis Abolins

Journal of Renewable Materials, Vol.13, No.2, pp. 349-361, 2025, DOI:10.32604/jrm.2024.056820 - 20 February 2025

Abstract Studies on the use of renewable materials for various applications, including polymers, have gained momentum due to global climate change and the push towards a circular economy. In this study, polymer resins were developed through Michael 1,4-addition. The precursors were synthesized from tall oil-based acetoacetates derived from epoxidized tall oil fatty acids or their methyl esters. Two different epoxidation methods were employed: enzymatic epoxidation of tall oil fatty acids and ion-exchange resin epoxidation of tall oil fatty acid methyl esters. Following oxirane opening and transesterification with trimethylolpropane, further esterification or transesterification was carried out to… More >

Jéssica da Silva Chagas^1,2, José Elson Soares Filho^1,2, Natália Fernanda Inocêncio Silva^1,2, Marcelo Massayoshi Ueki³, Eliton Souto de Medeiros^1,2, Renate Maria Ramos Wellen¹, Mauricio Pinheiro de Oliveira⁴, Gelsoneide da Silva Gois⁵, Yêda Medeiros Bastos de Almeida⁵, Amélia S. F. Santos^1,2,*

Journal of Renewable Materials, Vol.12, No.12, pp. 2079-2094, 2024, DOI:10.32604/jrm.2024.055361 - 20 December 2024

Abstract Poly(3-hydroxybutyrate) (PHB) is a biothechnological and biodegradable thermoplastic polymer from the polyhydroxyalkanoates (PHAs) family, whose chain regularity, high molecular weight, and physical and mechanical properties comparable to polypropylene (PP) are characteristics that have made PHB a prominent commercial bioplastic. Nevertheless, its susceptibility to thermal degradation and hydrolysis has limited many applications. To address the challenges associated with processing, a random copolymer of 95.86 mol% 3-hydroxybutyrate and 4.14 mol% 3-hydroxyvalerate (referred as PHB) was compounded without (neat PHB) and with 0.25, 0.5, 1, and 1.5 wt% of chain extender (Joncryl^®ADR 4368), consisting of multifunctional epoxy groups, and… More >

Subburayan Manickavasagam Suresh Kumar¹, Sundaravel Balachandran², Seong Cheol Kim³, Balamurugan Rathinam^4,*, Vanaraj Ramkumar^3,5,*

Journal of Polymer Materials, Vol.41, No.4, pp. 207-218, 2024, DOI:10.32604/jpm.2024.057901 - 16 December 2024

Abstract The present study focuses on sustainable biopolymer composites created from coconut sheath and basalt fibres, which are biodegradable, environmentally benign, and have low carbon footprints. High specific strength, superior mechanical performance, reduced weight, and improved thermal stability are all displayed by these materials. Four hybrid epoxy composites (C1–C4) were produced utilizing five stacking sequences and compression moulding, demonstrating that hybridization considerably enhances mechanical characteristics. The hybrid and pure basalt fibre composites have larger storage moduli than untreated coconut sheath fibre-reinforced epoxy (2.1 GPa). The greatest glass transition temperature (Tg) for C4 has been determined to More > Graphic Abstract

Aswinraj Anbazhagan¹, Piyali Roy Choudhury¹, Sahila Sambandam², Jayakumari Lakshmanan Saraswathi^1,*

Journal of Polymer Materials, Vol.41, No.4, pp. 299-313, 2024, DOI:10.32604/jpm.2024.056261 - 16 December 2024

Abstract Petroleum-based cured epoxy polymers, used widely in aerospace, marine, and automotive industries, pose environmental threats due to their toxicity. Therefore, developing alternative curing systems for epoxy resin is crucial. This study explores the use of bio-based phenalkamines as curing agents for epoxy resin to enhance the mechanical properties of polymer composites and fiber-reinforced laminates. The functional groups, morphology, and thermal properties of the composites were analyzed using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). Mechanical properties of two epoxy systems—EP-TETA (triethylenetetramine-cured) and EP-PA (phenalkamine-cured)—were evaluated according to ASTM standards. More > Graphic Abstract

Somasundaram Karthiyaini¹, Mohan Sasikumar^2,*, Abraham Jebamalar³, P. A. Prasob²

Journal of Polymer Materials, Vol.41, No.4, pp. 219-237, 2024, DOI:10.32604/jpm.2024.053829 - 16 December 2024

Abstract This manuscript presents the projectile impact behavior of hybrid jute/epoxy composite laminates using an instrumented air gun impact setup with the projectile moving in the vertical direction. An approach based on the stiffness change is used to predict the projectile impact response of hybrid jute epoxy-filled laminates impacted with a stainless-steel projectile. The experimental validation of the parameters like dynamic hardness (Hd) coefficient of restitution (COR), natural frequency, damping factor, and loss factor was used to analyze the impact behavior of jute/epoxy composites strengthened with fillers ZrO₂, ZnO, and TiO₂. The free vibration tests of the More >