Girish Hariharan¹, Vinyas¹, Gowrishankar Mandya Chennegowda¹, Nitesh Kumar¹, Shiva Kumar¹, Deepak Doreswamy², Subraya Krishna Bhat^1,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.073772 - 12 January 2026

Abstract This study presents a framework involving statistical modeling and machine learning to accurately predict and optimize the mechanical and damping properties of hybrid granite–epoxy (G–E) composites reinforced with cast iron (CI) filler particles. Hybrid G–E composite with added cast iron (CI) filler particles enhances stiffness, strength, and vibration damping, offering enhanced performance for vibration-sensitive engineering applications. Unlike conventional approaches, this work simultaneously employs Artificial Neural Networks (ANN) for high-accuracy property prediction and Response Surface Methodology (RSM) for in-depth analysis of factor interactions and optimization. A total of 24 experimental test data sets of varying input… More >

Sarra B. Shakartalla^1,2,3, Iman M. Talaat^1,2,4,*, Nival Ali¹, Shahenaz S. Salih^1,5, Zainab M. Al Shareef^1,2, Noura Alkhayyal⁶, Riyad Bendardaf^2,7,*, Sameh S. M. Soliman^1,8,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070808 - 30 December 2025

Abstract Objectives: Breast cancer (BC) is the leading cause of cancer-related mortality in women, largely due to metastasis. This study aims to explore the role of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism, in the aggressiveness and metastatic behavior of BC. Methods: A comprehensive analysis was performed using in silico transcriptomic data (n = 2509 patients), immunohistochemical profiling of BC tissues (n = 103), and validation through western blotting in multiple BC cell lines. Gene expression and survival analyses were conducted using Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and… More >

Md Salah Uddin^*

Journal of Polymer Materials, Vol.42, No.4, pp. 1051-1073, 2025, DOI:10.32604/jpm.2025.070688 - 26 December 2025

Abstract Carbon fiber-reinforced composites (CFRCs) have a wide range of applications in the aerospace, automotive, and energy sectors. A higher specific strength-to-weight ratio is desired in high-performance applications. The failure mechanism of CFRCs involves multiscale phenomena, such as failure that can occur at the matrix, fibers, interface, layers, lamina, and laminates. When an impactor hits the CFRCs, the design involves analyzing each of these stages to prevent failure and optimize the properties of CFRCs under various loading conditions. A numerical model was employed to predict the fracture toughness of CFRCs with varying weight fractions and orientations.… More >

Oncology Research Editorial Offfce

Oncology Research, Vol.33, No.12, pp. 4155-4155, 2025, DOI:10.32604/or.2025.075990 - 27 November 2025

Abstract This article has no abstract. More >

Minjie Li¹, Wanhao Shi¹, Dingqian Yang², Manman Yuan², Jiabao Du², Xuandong Liu^1,*

Energy Engineering, Vol.122, No.10, pp. 4297-4312, 2025, DOI:10.32604/ee.2025.066337 - 30 September 2025

Abstract In Xinjiang, China, Oil-immersed paper bushings used in reactors are highly susceptible to discharge breakdown faults due to drastic fluctuations in environmental and oil temperatures. To mitigate this problem, oil-free and explosion-proof epoxy resin-impregnated paper (ERIP) bushings are recommended as replacements. This study develops a multi-physics(electric-thermal-fluid) coupling model for 750 kV high voltage reactors ERIP bushings. The model aims to comprehensively assess their thermal and electrical performance under extreme ambient temperatures ranging from −40°C to 90°C and oil temperatures varying from −10°C to 90°C. The results demonstrate that the bushing temperature rises consistently with increases… More >

Ashwini Bhat¹, Nagaraj N. Katagi¹, M. C. Gowrishankar², Manjunath Shettar^2,*

CMC-Computers, Materials & Continua, Vol.85, No.2, pp. 2715-2728, 2025, DOI:10.32604/cmc.2025.069842 - 23 September 2025

Abstract This research explores the water uptake behavior of glass fiber/epoxy composites filled with nanoclay and establishes an Artificial Neural Network (ANN) to predict water uptake percentage from experimental parameters. Composite laminates are fabricated with varying glass fiber and nanoclay contents. Water absorption is evaluated for 70 days of immersion following ASTM D570-98 standards. The inclusion of nanoclay reduces water uptake by creating a tortuous path for moisture diffusion due to its high aspect ratio and platelet morphology, thereby enhancing the composite’s barrier properties. The ANN model is developed with a 3–4–1 feedforward structure and learned… More >

EDUARDO ALVARADO-ORTIZ^1,2, MIGUEL ANGEL SARABIA-SáNCHEZ^3,*

Oncology Research, Vol.33, No.8, pp. 1803-1818, 2025, DOI:10.32604/or.2025.065953 - 18 July 2025

Abstract The tumor microenvironment (TME) is characterized by a symbiosis between cancer cells and the immune cells. The scarcity of oxygen generates hostility that forces cancer cells to alter their biological features in solid tumors. In response to low oxygen availability, the Hypoxia Inducible Factors (HIF-1/2/3α) act as metabolic mediators, producing extracellular metabolites in the tumor microenvironment that influence the immune cells. The modulation of lactate and adenosine on immune evasion has been widely described; however, under hypoxic conditions, it has been barely addressed. Evidence has demonstrated an interplay between cancer and the immune cells, and More > Graphic Abstract

Fei Ren^1,#, Yansen Cai^2,#, Yang Song^1,*

Oncology Research, Vol.33, No.8, pp. 2055-2074, 2025, DOI:10.32604/or.2025.061301 - 18 July 2025

Abstract Objectives: Epigenetic changes, particularly N6-methyladenosine (m6A) modifications, play a pivotal role in cancer development. This study explored the role of ovarian tumor deubiquitinase 7B (OTUD7B) in esophageal squamous cell carcinoma (ESCC) in the context of m6A methylation and the hypoxia-inducible factor-1α (HIF-1α) pathway. Methods: The GSE179267 dataset was used to conduct differential gene expression analysis to identify key m6A-enriched genes. The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), and Sequence-based RNA Adenosine Methylation Site Predictor (SRAMP) databases were used to evaluate the expression of OTUD7B in ESCC and its correlation with methyltransferase-like 14… More >

Kartikey Shahi, Velmurugan Ramachandran^*, Ranjith Mohan, Boomurugan Ramachandran

Journal of Polymer Materials, Vol.42, No.2, pp. 477-496, 2025, DOI:10.32604/jpm.2025.062481 - 14 July 2025

Abstract A Shape Memory Polymer Composite (SMPC) is developed by reinforcing an epoxy-based polymer with randomly oriented short glass fibers. Diverging from previous research, which primarily focused on the hot programming of short glass fiber-based SMPCs, this work explores the potential for programming below the glass transition temperature (Tg) for epoxy-based SMPCs. To mitigate the inherent brittleness of the SMPC during deformation, a linear polymer is incorporated, and a temperature between room temperature and Tg is chosen as the deformation temperature to study the shape memory properties. The findings demonstrate an enhancement in shape fixity and More >

Rajagopalan Ramaswamy^1,*, Gunaseelan Mani², Deepak Kumar³, Ozgur Ege^4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.2, pp. 1843-1894, 2025, DOI:10.32604/cmes.2025.063672 - 30 May 2025

Abstract The Department of Economic and Social Affairs of the United Nations has released seventeen goals for sustainable development and SDG No. 3 is “Good Health and Well-being”, which mainly emphasizes the strategies to be adopted for maintaining a healthy life. The Monkeypox Virus disease was first reported in 1970. Since then, various health initiatives have been taken, including by the WHO. In the present work, we attempt a fractional model of Monkeypox virus disease, which we feel is crucial for a better understanding of this disease. We use the recently introduced fractional derivative to closely… More >