Jiunn-Wei Wang^1,2,3, Wen-Hung Hsu^2,3,4, Fang-Jung Yu^2,3, Fu-Chen Kuo⁵, Chung-Jung Liu^3,6, Chao-Hung Kuo^1,2,3, Jaw-Yuan Wang^7,8, Ming-Hong Lin^9,*, Deng-Chyang Wu^1,2,3,*

Oncology Research, Vol.33, No.12, pp. 3907-3922, 2025, DOI:10.32604/or.2025.070432 - 27 November 2025

Abstract Objectives: Colorectal adenomatous polyps frequently recur after removal and are precursors to colorectal cancer, highlighting the need for effective preventive strategies. This study evaluated the efficacy of probiotic Clostridium butyricum MIYAIRI 588 (CBM588) in preventing colorectal adenoma recurrence in high-risk patients. Methods: We conducted a randomized, single-blind, two-year crossover trial in patients with a history of adenomatous polyps. Participants received CBM588 in either the first or second year, with the alternate year as observation, and underwent annual surveillance colonoscopies. Outcomes (adenoma recurrence and polyp counts) were analyzed by intention-to-treat (ITT) and per-protocol (PP) approaches. Results: A total… More >

Mikhail Syromyatnikov^1,2,*, Mariya Gladkikh¹, Ekaterina Nesterova¹, Shima Kazemzadeh¹, Polina Morozova¹, Olga Korneeva¹

BIOCELL, Vol.49, No.9, pp. 1573-1603, 2025, DOI:10.32604/biocell.2025.065311 - 25 September 2025

Abstract The gut microbiome is a complex community of microorganisms that plays a direct role in the health of both the gastrointestinal tract and the entire body. Numerous factors influence the abundance and diversity of gut microbiota. Microbial imbalance can contribute to disease development. Probiotics are biologically active supplements with promising properties that have high therapeutic potential. Currently, there is a tendency to switch from classic probiotic microorganisms represented by lactic acid bacteria to next-generation probiotics due to their unique ability to influence the human immune system. New-generation probiotics include bacteria such as Akkermansia muciniphila, Faecalibacterium prausnitzii, Bacteroides sp., More >

Nu Ri Song^1,#, Seo Yeon Shin^1,#, Ki Min Kim¹, Sa Rang Choi¹, Doo Sang Park², Sun Oh Kim³, Dai Hyun Jung⁴, Kyung Mok Park^1,*

BIOCELL, Vol.49, No.7, pp. 1291-1310, 2025, DOI:10.32604/biocell.2025.065467 - 25 July 2025

Abstract Objectives: Limosilactobacillus reuteri is a beneficial Lactobacillus widely used in foods and supplements to promote overall health. Some studies also suggest it supports skin health and prevents allergies and cardiovascular disease. However, research on its skin-protective effects against photoaging has not been conducted. This study evaluated the potential of culture broths from three L. reuteri strains (DS0333, DS0384, and DS0385) to inhibit skin photoaging. Methods: To assess their anti-photoaging potential, the culture broths were examined for antioxidant capacity, melanin inhibition, and collagen synthesis promotion. Radical scavenging activity was tested using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2^′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays.… More > Graphic Abstract

KSENIA S. STAFEEVA¹, NATALIA A. SAMOYLOVA¹, OLGA A. KARANDEEVA¹, VERONIKA V. NESTEROVA¹, KIRILL A. STARODUBTSEV¹, EVGENY V. MIKHAILOV², ILYA O. KRUTOV², EVGENY S. POPOV³, NATALIA S. RODIONOVA⁴, ANASTASIA V. KOKINA^1,5, ARTEM P. GUREEV^1,5,*

BIOCELL, Vol.49, No.1, pp. 7-20, 2025, DOI:10.32604/biocell.2024.058339 - 24 January 2025

Abstract Objective: The objective of this study was to determine the level of methotrexate (MTX) toxicity in the intestines of mice and to evaluate the protective effect of probiotics composed of Streptococcus, Bifidobacterium, and Lactobacillus species on intestinal cells during MTX treatment. Methods: Mice were divided into three groups: control, MTX group (received MTX injections), and MTX + probiotics group (received MTX injections along with a diet containing probiotics). Morphological and histological changes, the level of mitochondrial DNA (mtDNA) damage, the level of lipid peroxidation products, and gene expression in the mice’s small intestine were assessed. Results: We… More > Graphic Abstract

FARIHA NUSRAT¹, MOHAMMAD TARIQUR RAHMAN², MUHAMMAD MANJURUL KARIM^3,*

BIOCELL, Vol.47, No.1, pp. 81-89, 2023, DOI:10.32604/biocell.2023.024635 - 26 September 2022

Abstract Bacterial endotoxins are a major concern in periodontal health and diseases owing to their structure and biological activity. With up-to-date knowledge of endotoxins and the recent findings about the influence of endotoxins in dental health, their probable mode of pathogenesis, and standard detection methods, this review analyzes the potential efficacy and benefits of probiotics in combination with conventional and contemporary treatment measures. In the oral cavity, Gram-negative bacteria are documented to predominate in the pulpal lesions with radiolucent areas and in the root canal with pulp necrosis, where they pose an absolute threat by promoting… More >

XIN MENG^*, XUE LI, LIANRONG YANG, RUI YIN, LEHUI QI, QI GUO

BIOCELL, Vol.47, No.1, pp. 91-107, 2023, DOI:10.32604/biocell.2023.024310 - 26 September 2022

Abstract In recent years, microbial metabolomics, a new field that has attracted wide attention, provides a map of metabolic pathways and clarifies the interaction mechanism between microorganisms and hosts. Many microorganisms are found in the human intestine, oral cavity, vagina, etc. Probiotics could maintain the good health of the host, while pathogens and an imbalance of bacterial flora lead to a series of diseases of the body and mind. Metabolomics is a science for qualitative and quantitative analysis of all metabolites in an organism or biological system, which could provide key information to understand the related… More >

Peter M. Grin^1,2, Paulina M. Kowalewska³, Waleed Alhazzani¹, Alison E. Fox-Robichaud^1,2

Canadian Journal of Urology, Vol.20, No.1, pp. 6607-6614, 2013

Abstract Introduction: Urinary tract infections (UTIs) are the most common infections affecting women, and often recur. Lactobacillus probiotics could potentially replace low dose, long term antibiotics as a safer prophylactic for recurrent UTI (rUTI). This systematic review and meta-analysis was performed to compile the results of existing randomized clinical trials (RCTs) to determine the efficacy of probiotic Lactobacillus species in preventing rUTI.
Materials and methods: MEDLINE and EMBASE were searched from inception to July 2012 for RCTs using a Lactobacillus prophylactic against rUTI in premenopausal adult women. A random-effects model meta-analysis was performed using a pooled risk ratio,… More >

K. C. Hayes, K. Bassett-Spiers, R. Das, K. D. Ethans, C. Kagan, J. L. K. Kramer, T. Linsenmeyer, K. N. Moore, H. Razvi, G. Reid, J. S. Walter, J. W. L. Wilson

Canadian Journal of Urology, Vol.14, No.1, pp. 3416-3423, 2007

Abstract Objective: A multidisciplinary panel of experts from Canada and the United States was convened by the Ontario Neurotrauma Foundation (ONF) to establish research priorities in the area of urological care following spinal cord injury (SCI).
Design: The panel reviewed a synthesis of published literature in five areas of urology, identified emerging opportunities in the private and public sector, and used a modified Delphi approach to reach consensus on priorities for funding.
Results: The panel recommendations included: clinical trials of the safety and efficacy of M3 receptor specific anti-muscarinic agents for bladder hyperactivity in SCI patients; development and… More >

DIANA B. DOCK*, JOSÉ E. AGUILAR-NASCIMENTO**, MARCIA Q. LATORRACA*

BIOCELL, Vol.28, No.2, pp. 143-150, 2004, DOI:10.32604/biocell.2004.28.143

Abstract AIM: The aim of this study was to evaluate the effect of probiotics on the recovery of the bowel atrophy induced by malnutrition in rats. METHODS: Twenty-and-six Wistar rats (200-250g) were fed with either a normoproteic (sham group, n=6) or a free-protein diet (n=20) during 12 days. Twelve malnourished rats were randomized to recover during 15 days with either a hydrolyzed diet (control group, n=6) or the same diet enriched with probiotics (Streptococcus thermophilus and Lactobacillus helveticus; probiotic group, n=6). RESULTS: Probiotic group showed similar gain of body, liver and bowel weight than controls. At the More >

Andrew W. Bruce, Gregor Reid

Canadian Journal of Urology, Vol.10, No.2, pp. 1785-1789, 2003

Abstract Emerging from the stigma of once being referred to as “snake oil”, excellent scientific and clinical evidence now exists to indicate that probiotics do indeed have a role to play in medicine. The proper definition of probiotics is important “Live microorganisms which when administered in adequate amounts confer a health benefit on the host”, for several reasons. It rules out so-called probiotics that have no clinically proven, peer-reviewed data, and it states the need to have viable bacteria present, unlike these pseudo products which are often wrongly labeled, poorly manufactured, with low or no viability… More >