Somchai Sriyab¹, Wannapong Triampo²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.13, No.3, pp. 51-52, 2009, DOI:10.3970/icces.2009.013.051

Abstract Understanding of Bacteria cell division is essential for an understanding of microorganism as well as the origin of the life. Particularly, in cell division process of \emph {E. coli}, Min proteins (MinD and MinE) play crucial roles to regulate the dividing dynamics physically via their oscillatory dynamics from pole to pole. In this work, we have developed a numerical scheme based on the mesoscopic Lattice Boltzmann Method (LBM) to simulate the coarse-grained coupled reaction-diffusion equations model used to describe the MinD/MinE interaction in two dimensions. Biologically, we have focused on investigating how the protein copies affect the oscillation patterns as… More >

Waipot Ngamsaad, Wannapong Triampo¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.13, No.2, pp. 49-50, 2009, DOI:10.3970/icces.2009.013.049

Abstract The Min-proteins oscillation in \emph {E. coli} has an essential role in controlling the accuracy placement of cell-division septum at the middle cell zone of the bacteria. This biochemical process has been successfully described by a set of reaction-diffusion equation at the macroscopic level [1]. Recently, a mesoscopic modeling by the lattice Boltzmann method (LBM) has been proposed to simulate the Min-proteins oscillation [2]. However, as pointed out by Zhang et al., the standard boundary conditions are not accuracy for a class of dispersion transport modeled by LBM [3]. In this present work, we investigated the boundary effects in LBM… More >

S.R.K Vedula¹, T.S. Lim², W. Hunziker³, C.T. Lim¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.13, No.1, pp. 29-30, 2009, DOI:10.3970/icces.2009.013.029

Abstract The structural integrity as well as the regulation of paracellular diffusion of solutes across epithelial monolayers is critically regulated by the intercellular adhesion complex. The intercellular adhesion complex consists of a variety of proteins that perform different physiological functions. While proteins localizing at adherens junctions (nectins and e-cadherins) are important for initiating and stabilizing cell adhesion, proteins localizing at the tight junctions (occludin, claudins and junctional adhesion molecules) act as gates to regulate the diffusion of solutes across the epithelial monolayer. Despite significant advancement in the understanding of the biological roles of these cell adhesion proteins in regulating various cellular… More >

Evelien Uitterhaegen^1,2, Quang Hung Nguyen^1,2, Othmane Merah^1,2, Christian V. Stevens³, Thierry Talou^1,2, Luc Rigal^1,2, Philippe Evon^1,2*

Journal of Renewable Materials, Vol.4, No.3, pp. 225-238, 2016, DOI:10.7569/JRM.2015.634120

Abstract New fiberboards were manufactured from a coriander cake through thermo-pressing, and the influence of thermo-pressing conditions (temperature, pressure and time) on the boards’ mechanical properties, their thickness swelling and their water absorption was evaluated. Because the protein glass transition systematically occurred during molding, this resulted in effective wetting of the fibers. Consequently, all boards were cohesive, with proteins and fibers acting as binder and reinforcing fillers, respectively. Flexural properties were influenced by all tested conditions, and the optimal board was molded at 200 °C temperature, 36.8 MPa pressure and 180 s time. Its flexural strength at break and its elastic… More >

Nuria Burgos, Arantzazu Valdés, Alfonso Jiménez^*

Journal of Renewable Materials, Vol.4, No.3, pp. 165-177, 2016, DOI:10.7569/JRM.2016.634108

Abstract In this study we provide an overview of the latest developments on the extraction, production, modification and applications of fruit residues and by-products in the formation of protein-based biopolymers, in particular for the formulation of edible films. Our aim was mainly to demonstrate the highly transdisciplinary character of these topics by giving an overview of the main developments and research topics in the chemistry and engineering aspects of protein-based biopolymers. These innovative raw materials have been evaluated for the production of biomaterials to be used in some key sectors, such as food packaging. More >

Min Zhang^∗, Fa-Ming Chen^†, Yong-Jin Chen^∗,‡, Shun Wu^∗, Xin Lv^∗, Rui-Ni Zhao^∗

Molecular & Cellular Biomechanics, Vol.8, No.1, pp. 43-60, 2011, DOI:10.3970/mcb.2011.008.043

Abstract To investigate the role of mechanical pressure on cartilage thickness and type II collagen synthesis, and the role of G protein in that process, in vitro organ culture of mandibular cartilage was adopted in this study. A hydraulic pressure-controlled cellular strain unit was used to apply hydrostatic pressurization to explant cultures. The explants were compressed by different pressure values (0 kPa, 100 kPa, and 300 kPa) after pretreatment with or without a selective and direct antagonist (NF023) for the G proteins. After 4, 8 and 12 h of cell culture under each pressure condition, histological sections of the explants were… More >

Vedula S.R.K.^*, Lim T.S.^†, Hunziker W.^‡, Lim C.T.^§

Molecular & Cellular Biomechanics, Vol.5, No.3, pp. 169-182, 2008, DOI:10.3970/mcb.2008.005.169

Abstract Intercellular adhesion molecules play an important role in regulating several cellular processes such as a proliferation, migration and differentiation. They also play an important role in regulating solute diffusion across monolayers of cells. The adhesion characteristics of several intercellular adhesion molecules have been studied using various biochemical assays. However, the advent of single molecule force spectroscopy as a powerful tool to analyze the kinetics and strength of protein interactions has provided us with an opportunity to investigate these interactions at the level of a single molecule. The study of interactions involving intercellular adhesion molecules has gained importance because of the… More >

Ankush Aggarwal¹, Jiun-Shyan Chen², William S. Klug³

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.1, pp. 69-99, 2014, DOI:10.3970/cmes.2014.098.069

Abstract Mechanical properties of proteins play an important role in their biological function. For example, microtubules carry large loads to transport organelles inside the cell, and virus shells undergo changes in shape and mechanical properties during maturation which affect their infectivity. Various theoretical models including continuum elasticity have been applied to study these structural properties, and a significant success has been achieved. But, the previous frameworks lack a connection between the atomic and continuum descriptions. Here this is accomplished through the development of a meshfree framework based on reproducing kernel shape functions for the large deformation mechanics of protein structures. The… More >

V. Pletser¹, R. Bosch², L. Potthast², R. Kassel³

FDMP-Fluid Dynamics & Materials Processing, Vol.2, No.1, pp. 65-76, 2006, DOI:10.3970/fdmp.2006.002.065

Abstract Orbital weightless conditions have been shown to yield better and larger crystals. The Solution Crystallization Diagnostics Facility (SCDF) is a third generation instrument developed by ESA and dedicated to the observation and study with advanced diagnostics nucleation and crystallisation processes of molecules from solutions on board the International Space Station. The SCDF is intended to be used for studies of proteins and large biomolecules, and more generally of any kind of molecules growing from solutions, using the powerful set of diagnostics means available in the SCDF platform. Several protein crystallisation reactors have been developed to study protein and macro-biomolecules assembling… More >