Jordan L. Mendelson^1,*, Jordan Kassab¹, Phillip Westbrook¹, Katie Yang², Anthony Corcoran¹

Canadian Journal of Urology, Vol.32, No.6, pp. 673-676, 2025, DOI:10.32604/cju.2025.063770 - 30 December 2025

Abstract Stereotactic body radiotherapy (SBRT) for prostate cancer is a generally well-tolerated treatment but can rarely lead to complications such as fistula formation. We report a 69-year-old male on maintenance ibrutinib for chronic lymphocytic leukemia who developed a fistula between his bladder and vas deferens in the setting of ascending scrotal infection. Despite his prior history of SBRT, the fistula was successfully treated with minimally invasive measures. A combination of abscess debridement, urinary diversion, and broad-spectrum antibiotics helped to achieve fistula resolution. The unique presentation described herein highlights the importance of early aggressive intervention for source More >

Khanh Toan Nguyen^1,*, Thi Huong Pham^1,2, Van Lam Ngo¹, Thi Thuy My Nguyen¹, Thi Dao Nguyen¹, Khanh Hung Truong¹, Van Nhat Nguyen¹, Van Thanh Le¹, Ba Duc Ho¹, Thi Phuong Thao Nguyen¹, Thi Ha Phuong Nguyen¹, Thi My Linh Dinh¹, Thi Hong Anh Vo¹, Thi Thuy Phan¹, Thi Hai Yen Le¹, Thi Nhung Ngo¹, Khanh Ha Nguyen¹

Oncology Research, Vol.33, No.12, pp. 4013-4028, 2025, DOI:10.32604/or.2025.069281 - 27 November 2025

Abstract Objective: Patients with stage III non-small cell lung cancer (NSCLC) present with a heterogeneous disease profile and often require multifaceted treatment strategies. This research aimed to investigate the demographic features, therapeutic patterns, and survival outcomes of such patients in Vietnam. Methods: A retrospective descriptive study was conducted on 731 patients diagnosed with stage III NSCLC American Joint Committee on Cancer (AJCC) 8th edition, at Nghe An Oncology Hospital from January 2018 to August 2024. Descriptive statistics summarized baseline and treatment characteristics. We calculated progression-free survival (PFS) and overall survival (OS) through the Kaplan–Meier approach and… More >

Si Qin, Shu Tang, Lijiao Xie, Jianbo Zhu, Jianguo Sun^*

Oncology Research, Vol.33, No.12, pp. 4145-4154, 2025, DOI:10.32604/or.2025.068300 - 27 November 2025

Abstract Background: Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of primary non-small cell lung cancer (NSCLC), with no established treatment guidelines. We present a case of a young female with PPLELC who achieved a pathological complete response (pCR) in both primary and metastatic lesions after receiving combined immunotherapy and radiotherapy. Case description: We present a 33-year-old female patient with stage IVa (cT2bN0M1b) PPLELC. As a first-line treatment, the patient received seven cycles of nab-paclitaxel combined with toripalimab (a PD-1 inhibitor) and achieved stable disease. This was followed by toripalimab maintenance therapy for nearly 30 months.… More >

Aysenur Elmali¹, Birhan Demirhan², Caglayan Selenge Beduk Esen³, Ozan Cem Guler⁴, Pervin Hurmuz⁵, Cem Onal^1,4,*

Canadian Journal of Urology, Vol.32, No.4, pp. 243-254, 2025, DOI:10.32604/cju.2025.066700 - 29 August 2025

Abstract Background: Intermediate-risk prostate cancer (IR-PC) represents a heterogeneous group requiring nuanced treatment approaches, and recent advancements in radiotherapy (RT), androgen deprivation therapy (ADT), and prostate-specific membrane antigen positron emission tomography (PSMA-PET/CT) imaging have prompted growing interest in personalized, risk-adapted management strategies. This study by the Turkish Society for Radiation Oncology aims to examine radiation oncologists’ practices in managing IR-PC, focusing on RT and imaging modalities to identify trends for personalized treatments. Methods: A cross-sectional survey was conducted among Turkish radiation oncologists treating at least 50 prostate cancer (PC) cases annually. The 22-item questionnaire covered IR-PC… More >

Brian Gilmartin^*, Sorcha O’Meara, Michelle Horan, Frank T. D’Arcy, Catherine M. Dowling

Canadian Journal of Urology, Vol.32, No.4, pp. 293-298, 2025, DOI:10.32604/cju.2025.065805 - 29 August 2025

Abstract Background: Radiation cystitis is a well-known complication resulting from radiotherapy for pelvic malignancies. It remains a challenging condition to treat and is associated with significant morbidity for patients. We aimed to establish the economic cost burden of presentations and investigations associated with radiation cystitis over a two-year period to a tertiary referral hospital in Ireland. Materials and Methods: A retrospective review of patient charts was performed for radiation cystitis-related presentations and investigations over 24 months. Costs were estimated in consultation with the hospital finance department and using Health Service Executive data on diagnostic-related groups and average More >

KOSEI NAKAJIMA^1,2,3,*, YOSHINORI INO¹

Oncology Research, Vol.33, No.7, pp. 1769-1779, 2025, DOI:10.32604/or.2025.063419 - 26 June 2025

Abstract Background: Neoadjuvant/preoperative therapy (NAT) involves the administration of chemotherapy, with or without radiation, prior to surgical resection. This approach is commonly used for locally advanced tumors to reduce tumor volume, improve resectability, and minimize the need for extensive surgical procedures. While NAT has been shown to be effective in inducing local anti-tumor immunity in potentially resectable solid tumors, the underlying molecular mechanisms remain poorly understood. Methods: Cohort samples from pancreatic cancer patients who underwent NAT (n = 26) and those who did not (n = 20) were analyzed. Changes in the immune microenvironment induced by… More >

YU HONG^1,#, YUNXIANG TANG^1,#, WENYAN ZHOU¹, HANYUE LUO², LINLIN BU², HUI QIU^3,*, QIUJI WU^3,*

Oncology Research, Vol.33, No.6, pp. 1347-1361, 2025, DOI:10.32604/or.2025.059327 - 29 May 2025

Abstract As a rising immune checkpoint on tumor cells, CD24 is closely related to tumorigenesis and progression. CD24 can directly regulate the malignant behavior of tumor cells and indirectly inhibit the function of immune cells in the meantime, which promotes the immune escape of tumor cells, induces cancer invasion and causes poor prognosis. The basic principle of cancer treatment is to induce cell death and inhibit cell survival. Resistance to chemoradiotherapy is a critical challenge in oncology, which limits the effectiveness of anti-cancer treatments. Many studies have shown a strong association between CD24 and chemoradiotherapy More >

JIANMIAO YANG^1,2,#, XIAOYAN SUN^3,#, TIANTIAN WANG¹, HAIQING ZHONG^1,3, MIN HAN^1,3, WUPING SHUAI^4,5,6,*, DONGHANG XU^1,*

Oncology Research, Vol.33, No.6, pp. 1423-1436, 2025, DOI:10.32604/or.2025.058997 - 29 May 2025

Abstract Objectives: Triphenylphosphine (TPP) and Doxorubicin (DOX) were conjugated to obtain Triphenylphosphine-Doxorubicin (TPP-DOX), which was applied in tumor cells for enhancement of DOX in mitochondria targeting. The study focused on investigating the anti-tumor effect of TPP-DOX in combination with radiotherapy throughout in vitro and in vivo studies. Methods: TPP-DOX was synthesized using the carbodiimide method. In vitro experiments were conducted with 4T1 cells (mouse breast cancer cell line) to assess apoptosis induction, mitochondrial targeting, reactive oxygen species (ROS) production, and mitochondrial membrane potential. The research evaluates the effects of TPP-DOX, DOX, and their combinations with radiotherapy. A nude mouse… More > Graphic Abstract

LIZHI WANG¹, HUILIN SUN², GUIZHI YU¹, ZEJING QU¹, YING JI¹, YANPING CUI^1,*

Oncology Research, Vol.33, No.4, pp. 885-894, 2025, DOI:10.32604/or.2024.051586 - 19 March 2025

Abstract Background: Small cell lung cancer (SCLC) is characterized by its aggressive nature and high propensity for brain metastases. This study investigates the clinical efficacy and safety profile of Anlotinib in combination with Stereotactic Radiotherapy (SRT) for treating brain metastases in patients with small cell lung cancer (SCLC). Methods: This research included 98 SCLC brain metastasis patients treated at Chengde Central Hospital from October 2020 to January 2024. The patients were categorized into a combined treatment group (CTG) (n = 45) and a Simple SRT group (SSG)(n = 53). The CTG (58 lesions) received Anlotinib with… More >

Do Nang Toan^1,*, Lam Thanh Hien², Ha Manh Toan¹, Nguyen Trong Vinh², Pham Trung Hieu¹

Intelligent Automation & Soft Computing, Vol.39, No.2, pp. 319-335, 2024, DOI:10.32604/iasc.2024.046925 - 21 May 2024

Abstract Cancer is one of the most dangerous diseases with high mortality. One of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and technicians. In our study, we focused on the 3D dose prediction problem in radiotherapy by applying the deep-learning approach to computed tomography (CT) images of cancer patients. Medical image data has more complex characteristics than normal image data, and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the… More >