Zenglun Guan^1,2, Murad S. Alfarzaeai^1,3,*, Eryi Hu^1,3,*, Taqiaden Alshmeri⁴, Wang Peng³

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 279-306, 2024, DOI:10.32604/cmc.2024.047159

Abstract In the coal mining industry, the gangue separation phase imposes a key challenge due to the high visual similarity between coal and gangue. Recently, separation methods have become more intelligent and efficient, using new technologies and applying different features for recognition. One such method exploits the difference in substance density, leading to excellent coal/gangue recognition. Therefore, this study uses density differences to distinguish coal from gangue by performing volume prediction on the samples. Our training samples maintain a record of 3-side images as input, volume, and weight as the ground truth for the classification. The prediction process relies on a… More >

Yan Xiang^1,2, Daofeng Li^1,2,*, Xinyi Meng^1,2, Chengfeng Dong^1,2, Guanglin Qin^1,2

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1005-1023, 2024, DOI:10.32604/cmc.2024.047143

Abstract The rapid expansion of Internet of Things (IoT) devices across various sectors is driven by steadily increasing demands for interconnected and smart technologies. Nevertheless, the surge in the number of IoT device has caught the attention of cyber hackers, as it provides them with expanded avenues to access valuable data. This has resulted in a myriad of security challenges, including information leakage, malware propagation, and financial loss, among others. Consequently, developing an intrusion detection system to identify both active and potential intrusion traffic in IoT networks is of paramount importance. In this paper, we propose ResNeSt-biGRU, a practical intrusion detection… More >

Yuejiao Wang, Zhong Ma^*, Chaojie Yang, Yu Yang, Lu Wei

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 819-836, 2024, DOI:10.32604/cmc.2024.047108

Abstract The quantization algorithm compresses the original network by reducing the numerical bit width of the model, which improves the computation speed. Because different layers have different redundancy and sensitivity to data bit width. Reducing the data bit width will result in a loss of accuracy. Therefore, it is difficult to determine the optimal bit width for different parts of the network with guaranteed accuracy. Mixed precision quantization can effectively reduce the amount of computation while keeping the model accuracy basically unchanged. In this paper, a hardware-aware mixed precision quantization strategy optimal assignment algorithm adapted to low bit width is proposed,… More >

Mark Ariel Levin^*

Journal of Quantum Computing, Vol.6, pp. 15-24, 2024, DOI:10.32604/jqc.2024.047423

Abstract Quantum algorithms for unstructured search problems rely on the preparation of a uniform superposition, traditionally achieved through Hadamard gates. However, this incidentally creates an auxiliary search space consisting of nonsensical answers that do not belong in the search space and reduce the efficiency of the algorithm due to the need to neglect, un-compute, or destructively interfere with them. Previous approaches to removing this auxiliary search space yielded large circuit depth and required the use of ancillary qubits. We have developed an optimized general solver for a circuit that prepares a uniform superposition of any N states while minimizing depth and… More >

SHAHID KARIM^1,*, ALANOUD NAHER ALGHANMI¹, MAHA JAMAL¹, HUDA ALKREATHY¹, ALAM JAMAL², HIND A. ALKHATABI³, MOHAMMED BAZUHAIR¹, AFTAB AHMAD^4,5

Oncology Research, Vol.32, No.5, pp. 817-830, 2024, DOI:10.32604/or.2024.048988

Abstract Cancer frequently develops resistance to the majority of chemotherapy treatments. This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), and Doxorubicin (DOX), using in vitro experimentation. The precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin (DOX) in MCF-7 cells. Interestingly, it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their growth. Notably, when these medications were combined with DOX, there was a considerable inhibition of glucose consumption, as well as reductions in… More > Graphic Abstract

XUHUI ZHAO^1,2, XIAOMIN HUANG¹, CHUNYAN DANG², XIA WANG¹, YUJIAO QI³, HONGLING LI^2,*

Oncology Research, Vol.32, No.5, pp. 999-1009, 2024, DOI:10.32604/or.2024.046679

Abstract Background: EBV-miR-BARTs exhibit significant relevance in epithelial tumors, particularly in EBV-associated gastric and nasopharyngeal cancers. However, their specific mechanisms in the initiation and progression of gastric cancer remain insufficiently explored. Material and Methods: Initially, EBV-miRNA-BART6-5p and its target gene SMAD4 expression were assessed in EBV-associated gastric cancer tissues and cell lines. Subsequent transfection induced overexpression of EBV-miRNA-BART6-5p in AGS and MKN-45, and downregulation in EBV-positive cells (SUN-719). The subsequent evaluation aimed to observe their impact on gastric cancer cell proliferation, migration, and glycolytic processes, with the TGF-β/SMAD4 signaling pathway value clarified using a TGF-β inhibitor. Results: EBV-miRNA-BART6-5p exhibits pronounced upregulation… More >

YAN ZHANG, HEYANG ZHANG, JING WANG, XIN WEI, YI QU, FENG XU, LIJUN ZHANG^*

Oncology Research, Vol.32, No.5, pp. 955-963, 2024, DOI:10.32604/or.2023.043922

Abstract Background: Bortezomib results in peripheral neuropathy (PN) in approximately 50% of patients, during multiple myeloma (MM) treatment, a complication known as Bortezomib-induced peripheral neuropathy (BIPN). The drug response varies among individuals. Genetic factor may play an important role in BIPN. Methods: A next-generation sequencing (NGS) panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib therapy. mRNA expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR (RT-qPCR). Serum homocysteine (Hcy) levels were detected in 40 samples by chemiluminescent microparticle immunoassay… More > Graphic Abstract

XIAOXI WANG¹, YANFEI JIA², QIANG LI², QIANG YANG², YINGFENG LIU¹, BEIFENG WEI¹, XIANG NIU¹, YINJIE ZHANG¹, XIAODONG LUO², ZIYU ZHAO^1,*, PENG WANG^1,*

Oncology Research, Vol.32, No.5, pp. 933-941, 2024, DOI:10.32604/or.2023.042581

Abstract MicroRNA (miR)-200b-3p has been associated with many tumors, but its involvement in pituitary adenoma is unclear. This study investigated the molecular mechanism underlying miR-200b-3p regulation in pituitary adenomas to provide a theoretical basis for treatment. Bioinformatics was used to analyze pituitary adenoma-related genes and screen new targets related to RECK and miRNA. As well, the relationship between miR-200b-3p and RECK protein was verified using a double-luciferase reporter gene assay. The expression of miR-200b-3p in clinical samples was analyzed by in situ hybridization. Transfection of the miR-200b-3p inhibitor and small interfering-RECK (si-RECK) was verified by qPCR. GH3 cell viability and proliferation… More >

JINGJING TIAN^1,*, XIBAO HU², XINRONG ZHANG¹

Oncology Research, Vol.32, No.5, pp. 925-931, 2024, DOI:10.32604/or.2023.042447

Abstract To confirm the relationship between Circ_0003855 and EC, we purchased the Human esophageal carcinoma cell line Eca109 and normal human esophageal epithelial cells HEEC, and the expression levels of Circ_0003855, miR-622, and FLOT1 were detected. The results show that Circ_0003855 and FLOT1 were highly expressed in Eca109 cells, while miR-622 was lowly expressed (p < 0.05). Subsequently, Circ_0003855 small interfering RNA (si-Circ_0003855) and its negative control (si-NC) were used to detect changes in cellular biological behaviors. We found that the activity of Eca109 cells was reduced after interfering with the expression of Circ_0003855, and miR-622 expression was elevated, while FLOT1… More >

EFFAT ALEMZADEH¹, LEILA ALLAHQOLI², AFROOZ MAZIDIMORADI³, ESMAT ALEMZADEH^1,4, FAHIMEH GHASEMI^4,5, HAMID SALEHINIYA⁶, IBRAHIM ALKATOUT^7,*

Oncology Research, Vol.32, No.5, pp. 831-847, 2024, DOI:10.32604/or.2024.031006

Abstract Ovarian cancer is among the most lethal gynecological cancers, primarily due to the lack of specific symptoms leading to an advanced-stage diagnosis and resistance to chemotherapy. Drug resistance (DR) poses the most significant challenge in treating patients with existing drugs. The Food and Drug Administration (FDA) has recently approved three new therapeutic drugs, including two poly (ADP-ribose) polymerase (PARP) inhibitors (olaparib and niraparib) and one vascular endothelial growth factor (VEGF) inhibitor (bevacizumab) for maintenance therapy. However, resistance to these new drugs has emerged. Therefore, understanding the mechanisms of DR and exploring new approaches to overcome them is crucial for effective… More >