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  • Open Access


    Chitosan-based Semi-permeable Nerve Conduits Support Periphereal Nerve Regeneration in Goats and Nonhuman Primates

    A-J. Wang1, Q. Ao1, 2, K. Gong1, Z-H. Zheng1, G-Y. Lu1, G. Wang1, Q. He1, L-J. Kong1, Y-D. Gong1, N-M. Zhao1, X-F. Zhang1

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 143-144, 2006, DOI:10.32604/mcb.2006.003.143

    Abstract This article has no abstract. More >

  • Open Access


    Adipose-derived mesenchymal stem/stromal cells: from the lab bench to the basic concepts for clinical translation

    Yesica Romina FRONTINI-LÓPEZ1, Aldana Daniela GOJANOVICH1, Diego MASONE1,2, Diego Martín BUSTOS1,3, Marina UHART1

    BIOCELL, Vol.42, No.3, pp. 67-78, 2018, DOI:10.32604/biocell.2018.07013

    Abstract In the last years, much work has shown that the most effective repair system of the body is represented by stem cells, which are defined as undifferentiated precursors that own unlimited or prolonged self-renewal ability, which also have the potential to transform themselves into various cell types through differentiation.All tissues that form the body contain many different types of somatic cells, along with stem cells that are called ‘mesenchymal stem (or stromal) cells’ (MSC). In certain circumstances, some of these MSC migrate to injured tissues to replace dead cells or to undergo differentiation to repair… More >

  • Open Access


    Elaboration of Materials with Functionality Gradients by Assembly of Chitosan-Collagen Microspheres Produced by Microfluidics

    David Azria1,2, Raluca Guermache1,2, Sophie Raisin1, Sébastien Blanquer1, Frédéric Gobeaux3, Marie Morille1, Emmanuel Belamie1,2,*

    Journal of Renewable Materials, Vol.6, No.3, pp. 314-324, 2018, DOI:10.7569/JRM.2017.634186

    Abstract Biopolymers extracted from renewable resources like chitosan and collagen exhibit interesting properties for the elaboration of materials designed for tissue engineering applications, among which are their hydrophilicity, biocompatibility and biodegradability. In many cases, functional recovery of an injured tissue or organ requires oriented cell outgrowth, which is particularly critical for nerve regeneration. Therefore, there is a growing interest for the elaboration of materials exhibiting functionalization gradients able to guide cells. Here, we explore an original way of elaborating such gradients by assembling particles from a library of functionalized microspheres. We propose a simple process to More >

  • Open Access


    Combining Smaller Patch, RV Remodeling and Tissue Regeneration in Pulmonary Valve Replacement Surgery Design May Lead to Better Post-Surgery RV Cardiac Function for Patients with Tetralogy of Fallot

    Zhedian Zhou1, Tal Geva2, Rahul H. Rathod2, Alexander Tang2, Chun Yang3, Kristen L. Billiar4, Dalin Tang1,*,3, Pedro del Nido5

    Molecular & Cellular Biomechanics, Vol.15, No.2, pp. 99-115, 2018, DOI:10.3970/mcb.2018.00558

    Abstract Patients with repaired Tetralogy of Fallot (ToF), a congenital heart defect which includes a ventricular septal defect and severe right ventricular outflow obstruction, account for the majority of cases with late onset right ventricle (RV) failure. The current surgical approach, which includes pulmonary valve replacement/insertion (PVR), has yielded mixed results. A computational parametric study using 7 patient-specific RV/LV models based on cardiac magnetic resonance (CMR) data as "virtual surgery" was performed to investigate the impact of patch size, RV remodeling and tissue regeneration in PVR surgery design on RV cardiac functions. Two patch sizes, three… More >

  • Open Access


    Theoretical Prediction and Experimental Testing of Mechanical Properties for 3D Printed Silk Fibroin-Type II Collagen Scaffolds for Cartilage Regeneration

    Lilan Gao1,2,*, Qingxian Yuan1,2, Ruixin Li3,*, Lei Chen1,2, Chunqiu Zhang1,2, Xizheng Zhang1,2

    Molecular & Cellular Biomechanics, Vol.15, No.2, pp. 85-98, 2018, DOI:10.3970/mcb.2018.00329

    Abstract Silk fibroin-typeⅡcollagen scaffold was made by 3D printing technique and freeze-drying method, and its mechanical properties were studied by experiments and theoretical prediction. The results show that the three-dimensional silk fibroin-typeⅡ collagen scaffold has good porosity and water absorption, which is (89.3%+3.26%) and (824.09%+93.05%), respectively. With the given strain value, the stress of scaffold decreases rapidly firstly and then tends to be stable during the stress relaxation. Both initial and instantaneous stresses increase with increase of applied strain value. The creep strains of scaffold with different stress levels show the two stages: the rapidly increasing… More >

  • Open Access


    3D Bio-Plotted Composite Scaffold Made of Collagen Treated Hydroxyapatite-Tricalciumphosphate for Rabbit Tibia Bone Regeneration

    Pranav S. Sapkal1*, Abhaykumar M. Kuthe1, Divya Ganapathy2, Shantanu C. Mathankar3, Sudhanshu Kuthe4

    Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 115-136, 2016, DOI:10.3970/mcb.2016.013.131

    Abstract Biphasic calcium phosphate scaffolds with 20/80 HA/TCP ratio were fabricated using the 3D-Bioplotting system to heal critical size defects in rabbit tibia bone. Four different architectures were printed in a layer by layer fashion with lay down patterns viz. (a) 0°– 90°, (b) 0°– 45°– 90°– 135°, (c) 0°–108°– 216° and (d) 0°– 60°– 120°. After high-temperature sintering scaffolds were coated with collagen and were further characterized by (FTIR) Fourier Transform Infrared Spectroscopy, (SEM) Scanning Electron Microscopy, (XRD) X-Ray diffraction, Porosity analysis and Mechanical testing. Scaffold samples were tested for its ability to induce cytotoxicity… More >

  • Open Access


    3D Fluid-Structure Interaction Canine Heart Model with Patch to Quantify Mechanical Conditions for Optimal Myocardium Stem Cell Growth and Tissue Regeneration

    Heng Zuo*, Dalin Tang*,†,‡, Chun Yang*,§, Glenn Gaudette, Kristen L. Billiar, Pedro J. del NidokII

    Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 67-85, 2015, DOI:10.3970/mcb.2015.012.067

    Abstract Right ventricular (RV) dysfunction is a common cause of heart failure in patients with congenital heart defects and often leads to impaired functional capacity and premature death. Myocardial tissue regeneration techniques are being developed for the potential that viable myocardium may be regenerated to replace scar tissues in the heart or used as patch material in heart surgery. 3D computational RV/LV/Patch models with fluid-structure interactions (FSI) were constructed based on data from a healthy dog heart to obtain local fluid dynamics and structural stress/strain information and identify optimal conditions under which tissue regeneration techniques could… More >

  • Open Access


    Effect of Cartilage Endplate on Cell Based Disc Regeneration: A Finite Element Analysis

    Yongren Wu, Sarah Cisewski, Barton L. Sachs, Hai Yao∗,†,‡

    Molecular & Cellular Biomechanics, Vol.10, No.2, pp. 159-182, 2013, DOI:10.3970/mcb.2013.010.159

    Abstract This study examines the effects of cartilage endplate (CEP) calcification and the injection of intervertebral disc (IVD) cells on the nutrition distributions inside the human IVD under physiological loading conditions using multiphasic finite element modeling. The human disc was modeled as an inhomogeneous mixture consisting of a charged elastic solid, water, ions (Na+ and Cl), and nutrient solute(oxygen,glucose and lactate) phases. The effect of the endplate calcification was simulated by a reduction of the tissue porosity (i.e., water volume faction) from 0.60 to 0.48. The effect of cell injection was simulated by increasing the cell density… More >

  • Open Access


    Bone Tissue Formation under Ideal Conditions in a Scaffold Generated by a Reaction-Diffusion System

    Marco A.Velasco, Diego A. Garzón-Alvarado

    Molecular & Cellular Biomechanics, Vol.10, No.2, pp. 137-157, 2013, DOI:10.3970/mcb.2013.010.137

    Abstract The design of porous scaffolds for tissue engineering requires methods to generate geometries in order to control the stiffness and the permeability of the implant among others characteristics. This article studied the potential of the reaction-diffusion systems to design porous scaffolds for bone regeneration. We simulate the degradation of the scaffold material and the formation of new bone tissue over canal-like, spherical and ellipsoid structures obtained by this approach. The simulations show that the degradation and growth rates are affected by the form of porous structures. The results have indicated that the proposed method has More >

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