David Azria^1,2, Raluca Guermache^1,2, Sophie Raisin¹, Sébastien Blanquer¹, Frédéric Gobeaux³, Marie Morille¹, Emmanuel Belamie^1,2,*

Journal of Renewable Materials, Vol.6, No.3, pp. 314-324, 2018, DOI:10.7569/JRM.2017.634186

Abstract Biopolymers extracted from renewable resources like chitosan and collagen exhibit interesting properties for the elaboration of materials designed for tissue engineering applications, among which are their hydrophilicity, biocompatibility and biodegradability. In many cases, functional recovery of an injured tissue or organ requires oriented cell outgrowth, which is particularly critical for nerve regeneration. Therefore, there is a growing interest for the elaboration of materials exhibiting functionalization gradients able to guide cells. Here, we explore an original way of elaborating such gradients by assembling particles from a library of functionalized microspheres. We propose a simple process to prepare chitosan-collagen hybrid microspheres by… More >

Zhedian Zhou¹, Tal Geva², Rahul H. Rathod², Alexander Tang², Chun Yang³, Kristen L. Billiar⁴, Dalin Tang^1,*,3, Pedro del Nido⁵

Molecular & Cellular Biomechanics, Vol.15, No.2, pp. 99-115, 2018, DOI: 10.3970/mcb.2018.00558

Abstract Patients with repaired Tetralogy of Fallot (ToF), a congenital heart defect which includes a ventricular septal defect and severe right ventricular outflow obstruction, account for the majority of cases with late onset right ventricle (RV) failure. The current surgical approach, which includes pulmonary valve replacement/insertion (PVR), has yielded mixed results. A computational parametric study using 7 patient-specific RV/LV models based on cardiac magnetic resonance (CMR) data as "virtual surgery" was performed to investigate the impact of patch size, RV remodeling and tissue regeneration in PVR surgery design on RV cardiac functions. Two patch sizes, three degrees of scar trimming (RV… More >

Lilan Gao^1,2,*, Qingxian Yuan^1,2, Ruixin Li^3,*, Lei Chen^1,2, Chunqiu Zhang^1,2, Xizheng Zhang^1,2

Molecular & Cellular Biomechanics, Vol.15, No.2, pp. 85-98, 2018, DOI: 10.3970/mcb.2018.00329

Abstract Silk fibroin-typeⅡcollagen scaffold was made by 3D printing technique and freeze-drying method, and its mechanical properties were studied by experiments and theoretical prediction. The results show that the three-dimensional silk fibroin-typeⅡ collagen scaffold has good porosity and water absorption, which is (89.3%+3.26%) and (824.09%+93.05%), respectively. With the given strain value, the stress of scaffold decreases rapidly firstly and then tends to be stable during the stress relaxation. Both initial and instantaneous stresses increase with increase of applied strain value. The creep strains of scaffold with different stress levels show the two stages: the rapidly increasing stage and the second stable… More >

Pranav S. Sapkal^1*, Abhaykumar M. Kuthe¹, Divya Ganapathy², Shantanu C. Mathankar³, Sudhanshu Kuthe⁴

Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 115-136, 2016, DOI:10.3970/mcb.2016.013.131

Abstract Biphasic calcium phosphate scaffolds with 20/80 HA/TCP ratio were fabricated using the 3D-Bioplotting system to heal critical size defects in rabbit tibia bone. Four different architectures were printed in a layer by layer fashion with lay down patterns viz. (a) 0°– 90°, (b) 0°– 45°– 90°– 135°, (c) 0°–108°– 216° and (d) 0°– 60°– 120°. After high-temperature sintering scaffolds were coated with collagen and were further characterized by (FTIR) Fourier Transform Infrared Spectroscopy, (SEM) Scanning Electron Microscopy, (XRD) X-Ray diffraction, Porosity analysis and Mechanical testing. Scaffold samples were tested for its ability to induce cytotoxicity in Balb/c 3T3 cells at… More >

Heng Zuo^*, Dalin Tang^*,†,‡, Chun Yang^*,§, Glenn Gaudette^¶, Kristen L. Billiar^¶, Pedro J. del Nidok^II

Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 67-85, 2015, DOI:10.3970/mcb.2015.012.067

Abstract Right ventricular (RV) dysfunction is a common cause of heart failure in patients with congenital heart defects and often leads to impaired functional capacity and premature death. Myocardial tissue regeneration techniques are being developed for the potential that viable myocardium may be regenerated to replace scar tissues in the heart or used as patch material in heart surgery. 3D computational RV/LV/Patch models with fluid-structure interactions (FSI) were constructed based on data from a healthy dog heart to obtain local fluid dynamics and structural stress/strain information and identify optimal conditions under which tissue regeneration techniques could achieve best outcome. RV/LV/Patch geometry… More >

Yongren Wu^∗, Sarah Cisewski^∗, Barton L. Sachs^†, Hai Yao^∗,†,‡

Molecular & Cellular Biomechanics, Vol.10, No.2, pp. 159-182, 2013, DOI:10.3970/mcb.2013.010.159

Abstract This study examines the effects of cartilage endplate (CEP) calcification and the injection of intervertebral disc (IVD) cells on the nutrition distributions inside the human IVD under physiological loading conditions using multiphasic finite element modeling. The human disc was modeled as an inhomogeneous mixture consisting of a charged elastic solid, water, ions (Na⁺ and Cl⁻), and nutrient solute(oxygen,glucose and lactate) phases. The effect of the endplate calcification was simulated by a reduction of the tissue porosity (i.e., water volume faction) from 0.60 to 0.48. The effect of cell injection was simulated by increasing the cell density in the nucleus pulposus… More >

Marco A.Velasco^∗, Diego A. Garzón-Alvarado^†

Molecular & Cellular Biomechanics, Vol.10, No.2, pp. 137-157, 2013, DOI:10.3970/mcb.2013.010.137

Abstract The design of porous scaffolds for tissue engineering requires methods to generate geometries in order to control the stiffness and the permeability of the implant among others characteristics. This article studied the potential of the reaction-diffusion systems to design porous scaffolds for bone regeneration. We simulate the degradation of the scaffold material and the formation of new bone tissue over canal-like, spherical and ellipsoid structures obtained by this approach. The simulations show that the degradation and growth rates are affected by the form of porous structures. The results have indicated that the proposed method has potential as a tool to… More >