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  • Open Access

    ARTICLE

    Zein Membrane Barrier for Bone Guided Regeneration

    Cristiane Michele Alves de Oliveira1, Bruna Carolina Dorm1, Antonio José Felix Carvalho2, Deliane da Silva Cabral2, Flávia Aparecida Resende Nogueira1, Nádia Andrade Aleixo1, Mônica Rosas Costa Iemma1, Eliane Trovatti1,*

    Journal of Renewable Materials, Vol.14, No.3, 2026, DOI:10.32604/jrm.2025.02025-0166 - 25 March 2026

    Abstract Materials from natural sources have been studied to replace the conventional synthetic or animal-derived products as a safer alternative to be used in the healthcare field. In dentistry, guided bone regeneration (GBR) relies on barrier membranes, predominantly from animals or synthetic materials, to improve osteogenesis by avoiding undesired soft tissue cells from defect sites. In this study, membranes were prepared from zein, a corn-derived protein, using a simple extraction and casting method, followed by optional formaldehyde cross-linking to evaluate their behavior for application in GBR. The membranes were characterised by FTIR, DSC, TGA, tensile strength… More > Graphic Abstract

    Zein Membrane Barrier for Bone Guided Regeneration

  • Open Access

    ARTICLE

    A Data-Driven Framework for Lithium-Ion Battery SOH Estimation Using VMD-GRU Hybrid Approach with Multi-Scale Feature Analysis

    Min Liu1,*, Zhengxiong Lu2,*

    Energy Engineering, Vol.123, No.3, 2026, DOI:10.32604/ee.2025.071144 - 27 February 2026

    Abstract The accurate state of health (SOH) estimation in lithium-ion batteries represents a critical technological challenge with profound implications for electric vehicle performance and user experience. Precise SOH assessment not only enables reliable mileage prediction but also ensures operational safety. However, the complex and non-linear capacity fading process during battery cycling poses a challenge to obtaining accurate SOH. To address this issue, this study proposes an effective health factor derived from the local voltage range during the battery charging phase. First, the battery charging phase is divided evenly with reference to voltage intervals, and an importance… More >

  • Open Access

    REVIEW

    The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease

    Douglas M. Ruden*

    BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.072273 - 23 January 2026

    Abstract Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs: the integrated stress response (ISR) and the senescence-associated secretory phenotype (SASP). These pathways act as a Yin–Yang system, balancing beneficial and detrimental outcomes across development, tissue homeostasis, and disease. On the yin (protective) side, transient ISR activation and acute SASP signaling foster adaptation, embryonic patterning, wound healing, and regeneration. On the yang (maladaptive) side, chronic ISR signaling and unresolved SASP output drive stem cell exhaustion, fibrosis, inflammation, and tumorigenesis. This duality highlights their roles as both guardians and disruptors More > Graphic Abstract

    The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease

  • Open Access

    REVIEW

    Polymeric Nanofiber Scaffolds for Diabetic Wound Healing: A Review

    Rafl M. Kamil1, Shaik Nyamathulla1,*, Syed Mahmood1,2,3,4,*

    Journal of Polymer Materials, Vol.42, No.4, pp. 959-992, 2025, DOI:10.32604/jpm.2025.072005 - 26 December 2025

    Abstract With the global diabetes epidemic, diabetic foot ulcers (DFUs) have become a major health burden, affecting approximately 18 million people worldwide each year, and account for about 80% of diabetes-related amputations. Five-year mortality among DFU patients approaches 30%, which is comparable to that of many malignancies. Yet despite standard wound care, only about 30%–40% of chronic DFUs achieve complete healing within 12 weeks. This persistent failure shows that conventional dressings remain passive supports. They do not counteract underlying pathologies such as ischemia, prolonged inflammation, and infection. Recent advances in polymeric nanofiber scaffolds, particularly electrospun matrices,… More > Graphic Abstract

    Polymeric Nanofiber Scaffolds for Diabetic Wound Healing: A Review

  • Open Access

    PROCEEDINGS

    Grayscale Digital Light Processing of Graded Porous Materials for Bone Regeneration

    Guanghai Fei*, Yue Zhang

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.3, pp. 1-1, 2025, DOI:10.32604/icces.2025.011869

    Abstract The regeneration of large-segment bone defects remains a significant challenge in orthopedics. Synthetic bone implants offer a promising solution; however, existing implants struggle to accurately replicate the heterogeneity and graded porosity of natural bone tissue while also failing to meet patients' individualized needs. Leveraging stereolithography-based 3D printing, we developed a halftoning grayscale 3D printing strategy for the precise fabrication of bone scaffolds with complex structures and graded porosity, closely mimicking natural bone tissue. This research focuses on optimizing both the 3D printing process and the performance of graded porous biomimetic bone scaffolds. More >

  • Open Access

    ARTICLE

    Optimizing Silver Nanoparticle Concentrations to Improve the In Vitro Regeneration and Growth of Phalaenopsis Orchids

    Hay Mon Aung1, Aung Htay Naing2,*, Chang Kil Kim2, Kyeung II Park1,*

    Phyton-International Journal of Experimental Botany, Vol.94, No.9, pp. 2719-2727, 2025, DOI:10.32604/phyton.2025.068713 - 30 September 2025

    Abstract Phalaenopsis orchids are economically important ornamental crops; however, their commercial micropropagation is often limited by poor rooting efficiency and inconsistent growth. In this study, we investigated the effects of silver nanoparticles (Ag-NPs) on the in vitro regeneration and growth of Phalaenopsis cultivar 611B to determine the optimal concentration of Ag-NPs for improved micropropagation outcomes. Shoot tip explants (2–3 mm)—derived from protocorm-like bodies were cultured on a regeneration medium containing Hyponex (20:20:20 and 6.5:6.5:19), 18 g/L sugar, 2 g/L peptone, 0.8 g/L activated charcoal, 12.5 g/L potato extract, 50 mL/L apple juice, and 10 mg/L 6-benzylaminopurine (6-BA), with… More >

  • Open Access

    ARTICLE

    Optimizing In Vitro Regeneration of Wheat via Somatic Embryogenesis Using Endosperm-Supported Mature Embryos

    Sumeyra Ucar1, Muhammed Aldaif 2, Esra Yaprak1, Esma Yigider 2, Murat Aydin2,*, Emre Ilhan1, Abdulkadir Ciltas2, Ertan Yildirim3

    Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2461-2477, 2025, DOI:10.32604/phyton.2025.068383 - 29 August 2025

    Abstract Wheat is a crucial crop for global food security, and effective in vitro plant regeneration techniques are considered a precondition for genetic engineering in wheat breeding programs. A practical approach for in vitro regeneration of the Kırik bread wheat cultivar via somatic embryogenesis was investigated using endosperm-supported mature embryos. Callus cultures were initiated from mature embryos supported by endosperm, cultured on phytagel-based Murashige and Skoog (MS) basal medium containing dicamba (12 mg/L) and indole-3-acetic acid (IAA) (0.5 mg/L) under dark conditions. This research was designed to examine the impact of putrescine (Put) (0.0 and 1.0 mM) on… More >

  • Open Access

    COMMENTARY

    A commentary on the interplay of biomaterials and cell adhesion: new insights in bone tissue regeneration

    A. NOEL GRAVINA1,2, NOELIA D´ELÍA1,2, LUCIANO A. BENEDINI2,3,*, PAULA MESSINA1,2

    BIOCELL, Vol.48, No.11, pp. 1517-1520, 2024, DOI:10.32604/biocell.2024.055513 - 07 November 2024

    Abstract This article navigates the relationship between biomaterials and osteogenic cell adhesion, highlighting the importance of mimicking the physiological response for bone tissue regeneration. Within this spirit is an initial description of the interaction between osteoblasts and osteoprogenitor cells with the extracellular matrix, explaining the leading role of integrins and cadherins in cell adhesion, and the intracellular signaling pathways elicited. Additionally, there is a focus on the strategies of advanced biomaterials that foster osteogenesis by replicating the native environment, taking advantage of these known specific signaling pathways. The final remarks lay on the need for careful More >

  • Open Access

    ARTICLE

    An Efficient Plant Regeneration System for Different Explants of Rare and Endangered Plants in Mussaenda anomala

    Gaoyin Wu1,#, Yundou Pang1,#, Ya Tan1, Zhongcheng Peng1, Shuanggui Geng1, Guanglin Tao2, Qiuying Li1, Shuang Wang1, Lihong Zhang1, Quanyan Tian1, Yingliang Liu1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.10, pp. 2597-2611, 2024, DOI:10.32604/phyton.2024.056875 - 30 October 2024

    Abstract To establish an efficient regeneration method for the rare and endangered plant Mussaenda anomala to address problems regarding its reproductive obstacles and scarce populations. In this study, the terminal buds, axillary buds, stem segments with two axillary buds, stem segments with two axillary buds and one terminal bud, and leaves of M. anomala were used as explants. The effects of different explants and disinfection methods, plant growth regulators and substrates on plant regeneration were explored. The following results were obtained: (1) The terminal bud was a suitable explant for M. anomala tissue culture, and the disinfection method utilized… More >

  • Open Access

    REVIEW

    Neural stem cell-derived exosomes: a cell-free transplant for potential cure of neurological diseases

    JIAJUN HUANG1,#, WEI WANG1,#, WENTONG LIN2, HENGSEN CAI3, ZHIHAN ZHU1, WAQAS AHMED4, QIANKUN ZHANG1, JIALE LIU1, YIFAN ZHANG1, RONG LI1, ZHINUO LI1, AHSAN ALI KHAN5, DENG LU3, YONG HU6, LUKUI CHEN1,*

    BIOCELL, Vol.48, No.10, pp. 1405-1418, 2024, DOI:10.32604/biocell.2024.053148 - 02 October 2024

    Abstract Degeneration and death of nerve cells are inevitable with the occurrence and progression of nervous system disorders. Researchers transplanted neural stem cells into relevant areas, trying to solve the difficulty of neural cell loss by differentiating neural stem cells into various nerve cells. In recent years, however, studies have shown that transplanted neural stem cells help neural tissues regenerate and return to normal through paracrine action rather than just replacing cells. Exosomes are essential paracrine mediators, which can participate in cell communication through substance transmission. In this regard, this review mainly discusses the current research More >

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