Lu Chen^1,2,#, Zhijie Ren^2,#, Guangmin Zhao², Xuan He², Legong Li², Sheng Teng^1,*, Yikun He^2,*, Fang Bao^2,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2025.073817 - 30 January 2026

Abstract ERD4 proteins, members of the early responsive-to-dehydration family, act as plasma membrane ion channels that contribute to ion homeostasis and modulate plant response to abiotic stresses. However, the functions of ERD4 homologs in non-vascular species remain largely unexplored. Here, we characterized an ERD4 family homolog in Physcomitrium patens (Hedw.) Mitt., PpCSC1 (Calcium-permeable Stress-responsive Cation Channel 1), and investigated its role in salt stress response. PpCSC1 localized to the plasma membrane and functioned as a non-selective cation channel permeable to Na⁺, K⁺, Ca²⁺, and Mg²⁺. Under salt treatment, PpCSC1 transcripts were markedly downregulated, whereas overexpression lines exhibited enhanced salt sensitivity.… More >

Luyao Liu^*, Xiao Liao, Yiqian Li, Shaofeng Zhang

Energy Engineering, Vol.123, No.2, 2026, DOI:10.32604/ee.2025.072631 - 27 January 2026

Abstract Data center industries have been facing huge energy challenges due to escalating power consumption and associated carbon emissions. In the context of carbon neutrality, the integration of data centers with renewable energy has become a prevailing trend. To advance the renewable energy integration in data centers, it is imperative to thoroughly explore the data centers’ operational flexibility. Computing workloads and refrigeration systems are recognized as two promising flexible resources for power regulation within data center micro-grids. This paper identifies and categorizes delay-tolerant computing workloads into three types (long-running non-interruptible, long-running interruptible, and short-running) and develops… More >

Junxian Ma¹, Haonan Zhao^2,*, Zhibing Hu³, Yaru Shen³, Fan Ding³, Shouqi Jiang²

Energy Engineering, Vol.123, No.2, 2026, DOI:10.32604/ee.2025.070530 - 27 January 2026

Abstract Energy storage-equipped photovoltaic (PV-storage) systems can meet frequency regulation requirements under various operating conditions, and their coordinated support for grid frequency has become a future trend. To address frequency stability issues caused by low inertia and weak damping, this paper proposes a multi-timescale frequency regulation coordinated control strategy for PV-storage integrated systems. First, a self-synchronizing control strategy for grid-connected inverters is designed based on DC voltage dynamics, enabling active inertia support while transmitting frequency variation information. Next, an energy storage inertia support control strategy is developed to enhance the frequency nadir, and an active frequency… More >

Zhitao Yang^1,#, Huanyu Cheng^1,#, Xinli Liu¹, Jie Li¹, Xin Ming¹, Beibei Li¹, Luyao Zhang¹, Chunqing MA¹, Yi Jiao¹, Shenjia Wu¹, Ibrar Muhammad Khan², Guanghua Xiong¹, Hongcheng Wang^1,*, Yong Liu^1,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.072736 - 23 January 2026

Abstract Objectives: Postmenopausal osteoporosis is the most common form of osteoporosis in clinical practice, affecting millions of postmenopausal women worldwide. Postmenopausal osteoporosis demands safe and effective therapies. This study aimed to evaluate the potential of hederagenin (Hed) for treating osteoporosis and to elucidate its underlying mechanisms of action. Methods: The anti-osteoporotic potential of Hed was assessed by investigating its effects on ovariectomy (OVX)-induced bone loss in mice and on receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation in RAW264.7 cells. Network pharmacology analysis and molecular docking were employed to identify key targets, which were subsequently validated experimentally. Results:… More >

Dongchi Cai^1,2,#, Jialin Ji^3,#, Chunhui Yang^1,*, Hong Cai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.071152 - 30 December 2025

Abstract Metabolic reprogramming involving branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—is increasingly recognized as pivotal in cancer progression, metastasis, and immune modulation. This review comprehensively explores how cancer cells rewire BCAA metabolism to enhance proliferation, survival, and therapy resistance. Tumors manipulate BCAA uptake and catabolism via high expression of transporters like L-type amino acid transporter 1 (LAT1) and enzymes including branched chain amino acid transaminase 1(BCAT1), branched chain amino acid transaminase 2 (BCAT2), branched-chain alpha-keto acid dehydrogenase (BCKDH), and branched chain alpha-keto acid dehydrogenase kinase (BCKDK). These alterations sustain energy production, biosynthesis, redox homeostasis, and oncogenic… More >

Tao Zhu¹, Taofeng Wei¹, Mingdong Yang¹, Junjun Xu¹, Huifang Jiang¹, Wei He¹, Juyan Zheng^2,*, Haibin Dai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070180 - 30 December 2025

Abstract Background: Aberrant expression of transcription factors (TFs) is a key mechanism mediating tumor immune escape and therapeutic resistance. The involvement of E26 transformation-specific (ETS) family of TFs in immune regulation is not fully understood. The study aimed to elucidate the function of E-twenty-six variant 4 (ETV4) in tumor immune evasion and its potential as a predictive biomarker for immunotherapy in melanoma. Methods: The expression patterns of ETS family TFs were analyzed in melanoma and hepatocellular carcinoma (HCC). Single-cell RNA sequencing (scRNA-seq) was used to dissect the cellular expression and function of ETV4 in the tumor… More >

Yunhao Yu¹, Boda Zhang¹, Meiling Dizha¹, Ruibin Wen¹, Fuhua Luo¹, Xiang Guo¹, Zhenyong Zhang^2,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-19, 2026, DOI:10.32604/cmc.2025.070577 - 09 December 2025

Abstract Load frequency control (LFC) is a critical function to balance the power consumption and generation. The grid frequency is a crucial indicator for maintaining balance. However, the widely used information and communication infrastructure for LFC increases the risk of being attacked by malicious actors. The dynamic load altering attack (DLAA) is a typical attack that can destabilize the power system, causing the grid frequency to deviate from its nominal value. Therefore, in this paper, we mathematically analyze the impact of DLAA on the stability of the grid frequency and propose the network parameter regulation (NPR)… More >

Himadri Nath Saha¹, Dipanwita Chakraborty Bhattacharya^2,*, Sancharita Dutta³, Arnab Bera³, Srutorshi Basuray⁴, Satyasaran Changdar⁵, Saptarshi Banerjee⁶, Jon Turdiev⁷

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-56, 2026, DOI:10.32604/cmc.2025.070507 - 09 December 2025

Abstract The emergence of Medical Large Language Models has significantly transformed healthcare. Medical Large Language Models (Med-LLMs) serve as transformative tools that enhance clinical practice through applications in decision support, documentation, and diagnostics. This evaluation examines the performance of leading Med-LLMs, including GPT-4Med, Med-PaLM, MEDITRON, PubMedGPT, and MedAlpaca, across diverse medical datasets. It provides graphical comparisons of their effectiveness in distinct healthcare domains. The study introduces a domain-specific categorization system that aligns these models with optimal applications in clinical decision-making, documentation, drug discovery, research, patient interaction, and public health. The paper addresses deployment challenges of Medical-LLMs, More >

YANG-YANG SHUAI^1,2, PEI-PEI WANG¹, HAI-JUN ZHANG², HUI AO^1,*, WEI PENG¹, HONG ZHANG^1,2,*

BIOCELL, Vol.49, No.12, pp. 2299-2333, 2025, DOI:10.32604/biocell.2025.071569 - 24 December 2025

Abstract Breast cancer ranks first among cancer-related fatalities and is the most frequent cancer in women globally. ROS plays an important role in controlling the occurrence and progression of breast cancer. Increasing reports suggest that natural products and their derivatives are beneficial for the management of breast cancer via the regulation of reactive oxygen species (ROS). A summary of the known patterns of natural products that modulate ROS against breast cancer will contribute to the discovery of more natural medicines for clinical applications and the development of new drugs. In this review, the pharmacological effects of More >

Nadia Lamsaadi¹, Oumaima Maarouf², Soukaina Lahmaoui², Hamid Msaad², Omar Farssi², Chaima Hamim², Mohamed Tamoudjout², Hafsa Hirt², Habiba Kamal², Majida El Hassni², Cherki Ghoulam^3,4, Ahmed El Moukhtari^5,*, Mohamed Farissi²

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3585-3610, 2025, DOI:10.32604/phyton.2025.072311 - 01 December 2025

Abstract Abiotic stresses, such as drought, heavy metals, salinity, and extreme temperatures, are among the most common adverse threats that restrict the use of land for agriculture and limit crop growth and productivity. As sessile organisms, plants defend themselves from abiotic stresses by developing various tolerance mechanisms. These mechanisms are governed by several biochemical traits. The biochemical mechanisms are the products of key genes that express under specific conditions. Interestingly, the expression of these genes is regulated by specialized proteins known as transcription factors (TFs). Several TFs, including those from the bZIP, bHLH, MYB, HSF, WRKY,… More >