Roshana Mukhtar¹, Chuan-Yu Chang², Muhammad Asif Zahoor Raja^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.2, 2026, DOI:10.32604/cmes.2026.079390 - 27 May 2026

Abstract Parkinson’s disease (PD) is a complex neurodegenerative disease associated with the accumulation of α-synuclein, which is linked to the dysfunctional ubiquitin–proteasome system. Fractional calculus has emerged as a powerful tool for modeling complex disease dynamics due to its promising features that inherently capture memory and hereditary effects. This paper presents a fractional-order Proteasome-Fibril interaction model (F-PFIM) for the dynamics of PD, represented by three fractional differential classes, showing concentrations of fibrils (F), proteasomes (P), and proteasome fibril complex (C). The three classes of the F-PFIM collectively make a controlling system that works for the clearance… More > Graphic Abstract

Amjad Hussain^1,*, Ayesha Saadia^2,*, Chihhsiong Shih³, Nazish Nawaz², Amir H. Gandomi^4,*, Khursheed Aurangzeb⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.2, 2026, DOI:10.32604/cmes.2026.078451 - 27 May 2026

Abstract Malware has evolved from the early Creeper virus into highly sophisticated and organized cyber threats. Over time, it grew in sophistication, adopting advanced techniques, stealth tactics, and autonomous propagation. Modern malware leverages encryption, obfuscation, zero-day exploits, and AI-assisted techniques to conduct stealthy and persistent attacks. Classification of its exact family is the end goal to defend and mitigate the latest attacks. Researchers have contributed significantly and introduced many techniques to tackle malware threats. Binary detection is performed at a large scale, but very little in multi-class classification. In this research, a hybrid technique is proposed… More >

Weixiang Song^1,#, Yanbo Zhang^2,#, Xubo Shen¹, Qin Yu¹, Yujin Liu¹, Yongchun Yu³, Rui Chen^1,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078665 - 21 May 2026

Abstract Objective: Osimertinib can selectively inhibit both epidermal growth factor receptor (EGFR) sensitizing and T790M gatekeeper mutations, and has shown remarkable therapeutic effects in patients with lung adenocarcinoma. However, almost all patients inevitably develop drug resistance. Herein, we sought to clarify the roles of exosomal lncRNA H19 in modulating osimertinib resistance, focusing on the PI3K-PTEN-Akt signaling axis. Methods: Functional assays, including cell viability assay, colony formation, cell apoptosis and xenograft mouse, employed in evaluate the effects of exosomal lncRNA H19 on cell growth and apoptosis. RNA quantitation and western blot were adopted to demonstrate the regulatory roles of… More >

Wei Jiang¹, You Zheng¹, Zhouhong Jing², Xiangling Yu¹, Huiying Fang^2,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078278 - 21 May 2026

Abstract Background: Breast cancer treatment is often hampered by the immunosuppressive tumor microenvironment (TME). To improve therapeutic efficacy, this study developed a folic acid-chitosan (FA-CS)-modified liposomal formulation co-delivering doxorubicin (DOX) and resiquimod (R848) for combined chemotherapy and immune modulation. Methods: The FA-CS-R848/DOX@Lip liposomes were prepared by rotary evaporation and characterized for morphology, particle size, zeta potential, drug encapsulation efficiency (EE), drug loading (DL) capacity, and drug release profiles. Cellular uptake and cytotoxicity were determined to assess the biological effects of the formulation. Antitumor efficacy and biosafety were assessed in an EO771 tumor-bearing mouse model. The macrophage phenotype,… More >

Fang-Ying Chiu^1,2,3,*, Yun Yen^2,4,5,6

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.077076 - 21 May 2026

Abstract Objective: Glioblastoma (GBM) is the most common primary malignant brain tumor and is characterized by significant intratumoral heterogeneity. This study aimed to investigate the clinical and genomic landscapes of GBM across diverse ethnic populations to identify potential prognostic markers. Methods: Leveraging The Cancer Imaging Archive (TCIA) and bioinformatics modeling, White, African, and Asian American cohorts were analyzed. Patients were stratified according to the 2021 WHO classification of central nervous system (CNS) tumors. Population-specific genomic drivers and phenotypic markers were evaluated for their impact on outcomes. Survival rates across age, sex, and ethnicity were estimated using the… More >

Thanh Hoa Vo^1,2, Edel McNeela^1,2, Orla O’Donnovan^1,2, Jai Prakash Mehta³, Van Hoa Nguyen⁴, Sweta Rani^1,2,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.075346 - 21 May 2026

Abstract Long non-coding RNAs (lncRNAs) have emerged as key regulators of drug resistance in human epidermal growth factor receptor 2 (HER2)-positive breast cancer, a subtype in which both intrinsic and acquired resistance to HER2-targeted therapies remain major clinical challenges. Although mechanistic studies have begun to reveal how lncRNAs modulate signaling pathways, interact with microRNAs, and influence the tumor microenvironment, dedicated investigations in HER2-positive disease are still limited. This review synthesizes current evidence across epigenetic, transcriptional, and post-transcriptional mechanisms of resistance, including competing endogenous RNA (ceRNA) networks, RNA-binding protein interactions, and exosome-mediated intercellular communication. Particular emphasis is… More >

Yun-Jae Ahn^1,2,3, Moon-Seok Kang², Ki-Byung Lim^2,3,4,*

Phyton-International Journal of Experimental Botany, Vol.95, No.4, 2026, DOI:10.32604/phyton.2026.078884 - 28 April 2026

Abstract Artificial polyploidy induction is widely used in ornamental breeding but can yield aneuploidy derivatives that vary in developmental stability and breeding utility. In Hibiscus syriacus ‘Blue Bird’, in vivo colchicine and oryzalin treatments generated regenerated shoots in which genome-size shifts were detected by flow cytometry; among the candidate lines, a subset reached flowering maturity and was characterized in detail. These flowering aneuploids displayed diverse floral alterations, including reduced corolla size, altered pigmentation, and partial conversion of stamens into petaloid organs. Flow cytometry and somatic chromosome counts indicated aneuploid status (150–182 chromosomes). Pollen morphology was highly variable, with… More >

Omar Badran^1,2,*, Siraj Attarya³

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.075916 - 22 April 2026

Abstract Extrachromosomal DNA (ecDNA) constitutes a principal factor in the amplification of oncogenes and the progression of tumors in solid malignancies. This review synthesizes emerging mechanistic, genomic, and immunologic evidence across multiple tumor types, including glioblastoma, lung, breast, gastrointestinal, hepatobiliary, urothelial, prostate, gynecologic, pediatric, and head-and-neck cancers, with the goal of clarifying the role of ecDNA in immune escape and therapy resistance and outlining its translational implications for precision oncology. ecDNA comprises substantial acentromeric circular elements that serve as transcriptional hubs, modulate enhancer–promoter interactions, and undergo dynamic copy-number cycling, thereby fostering intratumoral heterogeneity and resistance to… More >

Ana Luisa Arantes Chaves^1,*, Marco Tulio Mendes Ferreira²

Phyton-International Journal of Experimental Botany, Vol.95, No.3, 2026, DOI:10.32604/phyton.2026.077185 - 31 March 2026

Abstract Holocentric chromosomes, characterized by kinetochore activity distributed along almost their entire length, have attracted growing interest in cytogenetics and evolutionary biology, particularly because of their adaptive significance. This review provides a historical overview of research on holocentricity, from the earliest microscopic observations to recent advances made possible by modern molecular and cytogenetic techniques. We discuss the main hypotheses concerning the origin and evolution of holocentric chromosomes, emphasizing their multiple independent origins across diverse lineages, as well as the potential selective pressures underlying their maintenance and diversification. In addition, we examine the principal methods used for More >

Laura Lacomba-Trejo^1,*, Francisco González-Sala¹, Sandra Simó², Florencia Talmón-Knuser³

International Journal of Mental Health Promotion, Vol.28, No.3, 2026, DOI:10.32604/ijmhp.2026.077053 - 31 March 2026

Abstract Backgrounds: Somatization and eating-related problems in adolescents living in residential care may be shaped by the interplay of risk and protective factors, including gender, relational trauma, attachment patterns, emotional intelligence, and perceived social support. This study examined how gender, relational trauma, attachment dimensions, resilience, and emotional intelligence contribute to the presence of somatic and eating difficulties in this population. Methods: The sample included 46 adolescents (63% female; ages 12–17, Mean = 14.85, Standard Deviation (SD) = 1.49) residing in child protection institutions in Uruguay. Participants completed self-report measures assessing childhood relational trauma (CaMir), attachment dimensions (anxiety… More > Graphic Abstract