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  • Open Access

    ARTICLE

    Effects of Forest Types on Soil Available Nutrients and Carbon Contents in Coastal Areas, China

    Zirui Chen1,2, Jiale Liu1,2, Haijun Sun1,2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.10, pp. 2557-2569, 2024, DOI:10.32604/phyton.2024.056868 - 30 October 2024

    Abstract Clarifying the soil nutrient dynamics caused by forest type variations in the coastal region helps scientifically to apply fertilizer to forest plantations and enhance the carbon (C) sink capacity. Pure forests of Ligustrum and Metasequoia, as well as their mixed forests, in a coastal region of China were investigated by collecting 0–20 and 20–40 cm soil samples and analyzing their differences in bulk density, water content, pH, soil organic matter (SOM), ammonium (NH4+–N), nitrate (NO3–N) and total nitrogen (TN), available phosphorus (AP) and potassium (AK), microbial biomass C (MBC) and N (MBN), and enzyme activity. The results… More >

  • Open Access

    ARTICLE

    MiR-150-5p inhibits cell proliferation and metastasis by targeting FTO in osteosarcoma

    LICHEN XU1,2, PAN ZHANG3,*, GUIQI ZHANG2, ZHAOLIANG SHEN4, XIZHUANG BAI1,3,*

    Oncology Research, Vol.32, No.11, pp. 1777-1789, 2024, DOI:10.32604/or.2024.047704 - 16 October 2024

    Abstract Background: Osteosarcoma (OS), recognized as the predominant malignant tumor originating from bones, necessitates an in-depth comprehension of its intrinsic mechanisms to pinpoint novel therapeutic targets and enhance treatment methodologies. The role of fat mass and obesity-associated (FTO) in OS, particularly its correlation with malignant traits, and the fundamental mechanism, remains to be elucidated. Materials and Methods: 1. The FTO expression and survival rate in tumors were analyzed. 2. FTO in OS cell lines was quantified utilizing western blot and PCR. 3. FTO was upregulated and downregulated separately in MG63. 4. The impact of FTO on the… More >

  • Open Access

    ARTICLE

    Remodeling tumor microenvironment using pH-sensitive biomimetic co-delivery of TRAIL/R848 liposomes against colorectal cancer

    YONGJIAN HUANG, JINZHOU WANG, JIUHUA XU, NING RUAN*

    Oncology Research, Vol.32, No.11, pp. 1765-1776, 2024, DOI:10.32604/or.2024.045564 - 16 October 2024

    Abstract Background: Despite significant advancements in the development of anticancer therapies over the past few decades, the clinical management of colorectal cancer remains a challenging task. This study aims to investigate the inhibitory effects of cancer-targeting liposomes against colorectal cancer. Materials and Methods: Liposomes consisting of 3β-[N-(N′, N′-dimethylamino ethane)carbamoyl]-cholesterol (DC-CHOL), cholesterol (CHOL), and dioleoylphosphatidylethanolamine (DOPE) at a molar ratio of 1:1:0.5 were created and used as carriers to deliver an apoptosis-inducing plasmid encoding the tumor necrosis factor-related apoptosis-inducing ligand (pTRAIL) gene, along with the toll-like receptor (TLR7) agonist Rsiquimod (R848). The rationale behind this design is that More > Graphic Abstract

    Remodeling tumor microenvironment using pH-sensitive biomimetic co-delivery of TRAIL/R848 liposomes against colorectal cancer

  • Open Access

    COMMENTARY

    A commentary: harnessing vesicles power with new scenes of membrane-based devices for drug delivery

    NOELIA L. D´ELĺA1,2, A. NOEL GRAVINA1,2, LUCIANO A. BENEDINI2,3,*, PAULA V. MESSINA1,2

    BIOCELL, Vol.48, No.10, pp. 1401-1403, 2024, DOI:10.32604/biocell.2024.055512 - 02 October 2024

    Abstract This work shows relevant interactions between cells and drug-delivery systems based on vesicles crucial for therapeutic activity. This interplay drives strategies for the design of new drug-carry. Among the described systems are found liposomes, extracellular vesicles, and hybrid systems. The text details their properties, advantages, and constraints, and eventually, a perspective about the future of these formulations is proposed. More >

  • Open Access

    REVIEW

    Spliceosome-mediated RNA trans-splicing: a strategy for Huntington’s disease gene therapy

    QINGYANG ZHANG, SHUXIAN HUANG, DAN WENG*

    BIOCELL, Vol.48, No.10, pp. 1443-1453, 2024, DOI:10.32604/biocell.2024.053794 - 02 October 2024

    Abstract Huntington’s disease (HD) is a debilitating neurodegenerative disorder caused by an abnormal expansion of CAG repeats (Cytosine, Adenine, Guanine) in the huntingtin gene (HTT). This mutation leads to the production of a mutant huntingtin protein, resulting in neuronal dysfunction and cell death. Current treatments primarily focus on symptomatic relief and do not address the underlying genetic cause. This review explores spliceosome-mediated RNA trans-splicing (SMaRT) therapy as an innovative and potential approach for HD treatment. SMaRT leverages the cell’s natural splicing machinery to correct mutant mRNA, thereby reducing toxic protein levels while restoring functional protein production. We More >

  • Open Access

    REVIEW

    Neural stem cell-derived exosomes: a cell-free transplant for potential cure of neurological diseases

    JIAJUN HUANG1,#, WEI WANG1,#, WENTONG LIN2, HENGSEN CAI3, ZHIHAN ZHU1, WAQAS AHMED4, QIANKUN ZHANG1, JIALE LIU1, YIFAN ZHANG1, RONG LI1, ZHINUO LI1, AHSAN ALI KHAN5, DENG LU3, YONG HU6, LUKUI CHEN1,*

    BIOCELL, Vol.48, No.10, pp. 1405-1418, 2024, DOI:10.32604/biocell.2024.053148 - 02 October 2024

    Abstract Degeneration and death of nerve cells are inevitable with the occurrence and progression of nervous system disorders. Researchers transplanted neural stem cells into relevant areas, trying to solve the difficulty of neural cell loss by differentiating neural stem cells into various nerve cells. In recent years, however, studies have shown that transplanted neural stem cells help neural tissues regenerate and return to normal through paracrine action rather than just replacing cells. Exosomes are essential paracrine mediators, which can participate in cell communication through substance transmission. In this regard, this review mainly discusses the current research More >

  • Open Access

    ARTICLE

    Exosomal microRNA let-7c-5p enhances cell malignant characteristics by inhibiting TAGLN in oral cancer

    YI LI1, TIANYI WANG1, HAORAN DING1, SHIYONG ZHUANG1, XIAOBO DAI1, BING YAN1,2,*

    Oncology Research, Vol.32, No.10, pp. 1623-1635, 2024, DOI:10.32604/or.2024.048191 - 18 September 2024

    Abstract Background: Oral cancer, a malignancy that is prevalent worldwide, is often diagnosed at an advanced stage. MicroRNAs (miRNAs) in circulating exosomes have emerged as promising cancer biomarkers. The role of miRNA let-7c-5p in oral cancer remains underexplored, and its potential involvement in tumorigenesis warrants comprehensive investigation. Methods: Serum samples from 30 patients with oral cancer and 20 healthy controls were used to isolate exosomes and quantify their RNA content. Isolation of the exosomes was confirmed through transmission electron microscopy. Quantitative PCR was used to assess the miRNA profiles. The effects of let-7c-5p and TAGLN overexpression… More >

  • Open Access

    REVIEW

    Research progress on the role of adipocyte exosomes in cancer progression

    YUN WANG1, XIAOJIANG LI2, DALONG LIU2, ZHIFENG WANG3, JICHEN XIA4, LIJUN WANG5, XUDONG ZHANG6,*

    Oncology Research, Vol.32, No.10, pp. 1649-1660, 2024, DOI:10.32604/or.2024.043482 - 18 September 2024

    Abstract Exosomes, minute vesicles ubiquitously released by diverse cell types, serve as critical mediators in intercellular communication. Their pathophysiological relevance, especially in malignancies, has garnered significant attention. A meticulous exploration of the exosomal impact on cancer development has unveiled avenues for innovative and clinically valuable techniques. The cargo conveyed by exosomes exerts transformative effects on both local and distant microenvironments, thereby influencing a broad spectrum of biological responses in recipient cells. These membrane-bound extracellular vesicles (EVs) play a pivotal role in delivering bioactive molecules among cells and organs. Cellular and biological processes in recipient cells, ranging… More > Graphic Abstract

    Research progress on the role of adipocyte exosomes in cancer progression

  • Open Access

    ARTICLE

    Genomic profiling of colorectal cancer in large-scale Chinese patients: amplification and somatic mutations in ERBB2

    YUZHI LIU1,#, EVELYNE BISCHOF2,#, ZHIQIN CHEN1, JIAHUAN ZHOU3, BEI ZHANG4, DING ZHANG4, YONG GAO1,*, MING QUAN1,*

    Oncology Research, Vol.32, No.9, pp. 1429-1438, 2024, DOI:10.32604/or.2024.047309 - 23 August 2024

    Abstract Objectives: Human epidermal growth factor receptor 2 (HER2)-targeted therapies have demonstrated potential benefits for metastatic colorectal cancer (mCRC) patients with HER2 amplification, but are not satisfactory in cases of HER2 mutant CRCs. Methods: Consequently, further elucidation of amplifications and somatic mutations in erythroblastic oncogene B-2 (ERBB2) is imperative. Comprehensive genomic profiling was conducted on 2454 Chinese CRC cases to evaluate genomic alterations in 733 cancer-related genes, tumor mutational burden, microsatellite instability, and programmed death ligand 1 (PD-L1) expression. Results: Among 2454 CRC patients, 85 cases (3.46%) exhibited ERBB2 amplification, and 55 cases (2.24%) carried ERBB2 mutation.… More > Graphic Abstract

    Genomic profiling of colorectal cancer in large-scale Chinese patients: amplification and somatic mutations in ERBB2

  • Open Access

    SHORT COMMUNICATION

    New Definitions of the Isometric Latitude and the Mercator Projection

    Miljenko Lapaine*

    Revue Internationale de Géomatique, Vol.33, pp. 155-165, 2024, DOI:10.32604/rig.2024.052258 - 10 June 2024

    Abstract The short communication discusses the interrelationships of loxodromes, isometric latitudes and the normal aspect of Mercator projection. It is shown that by applying the isometric latitude, a very simple equation of the loxodrome on the sphere is reached. The consequence of this is that the isometric latitude can be defined using the generalized longitude, and not only using the latitude, as was common until now. Generalized longitude is the longitude defined for every real number; modulo 2π of generalized and usual longitude are congruent. Since the image of the loxodrome in the plane of the… More > Graphic Abstract

    New Definitions of the Isometric Latitude and the Mercator Projection

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