Ana Luisa Arantes Chaves^1,*, Marco Tulio Mendes Ferreira²

Phyton-International Journal of Experimental Botany, Vol.95, No.3, 2026, DOI:10.32604/phyton.2026.077185 - 31 March 2026

Abstract Holocentric chromosomes, characterized by kinetochore activity distributed along almost their entire length, have attracted growing interest in cytogenetics and evolutionary biology, particularly because of their adaptive significance. This review provides a historical overview of research on holocentricity, from the earliest microscopic observations to recent advances made possible by modern molecular and cytogenetic techniques. We discuss the main hypotheses concerning the origin and evolution of holocentric chromosomes, emphasizing their multiple independent origins across diverse lineages, as well as the potential selective pressures underlying their maintenance and diversification. In addition, we examine the principal methods used for More >

Laura Lacomba-Trejo^1,*, Francisco González-Sala¹, Sandra Simó², Florencia Talmón-Knuser³

International Journal of Mental Health Promotion, Vol.28, No.3, 2026, DOI:10.32604/ijmhp.2026.077053 - 31 March 2026

Abstract Backgrounds: Somatization and eating-related problems in adolescents living in residential care may be shaped by the interplay of risk and protective factors, including gender, relational trauma, attachment patterns, emotional intelligence, and perceived social support. This study examined how gender, relational trauma, attachment dimensions, resilience, and emotional intelligence contribute to the presence of somatic and eating difficulties in this population. Methods: The sample included 46 adolescents (63% female; ages 12–17, Mean = 14.85, Standard Deviation (SD) = 1.49) residing in child protection institutions in Uruguay. Participants completed self-report measures assessing childhood relational trauma (CaMir), attachment dimensions (anxiety… More > Graphic Abstract

Abdullah Alattar¹, Reem Alshaman¹, Fawaz E. Alanazi¹, Yusuf S. Althobaiti², Ghareb M. Soliman³, Waleed Salman Khubrni¹, Howaida S. Ali⁴, Fawad Ali Shah^5,6,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2026.074865 - 23 March 2026

Abstract Objectives: Permanent middle cerebral artery occlusion (pMCAO) can lead to hippocampal damage through multiple linked pathways such as reactive oxidative stress (ROS), neuroinflammation mediated by NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3), tumour necrosis factor-alpha (TNF-α), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and glutamate excitotoxicity involving N-methyl-D-aspartate receptor subunits 2a and 2b (NR2a/NR2b) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR/GluR1). The hippocampus, which is essential for memory and cognition, is at a substantial risk of ischemic degeneration. The aim of this study was to investigate the neuroprotective potential of melatonin in regulating these… More > Graphic Abstract

Ye Ri Han^1,*, Sang Bong Lee^2,3,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.075923 - 23 March 2026

Abstract Radiopharmaceuticals deliver diagnostic or therapeutic radionuclides to disease sites with molecular precision. Over the past five years, clinical adoption has accelerated, led by U.S. Food and Drug Administration approvals of ¹⁷⁷Lu-DOTA-TATE and ¹⁷⁷Lu-PSMA-617 and their complementary Positron Emission Tomography agents (⁶⁸Ga-DOTA-TATE, ⁶⁸Ga-PSMA-11), which have established radiotheranostics as a pillar of oncology care. The new generation of agents couples optimized radionuclides (β⁻, α, and Auger emitters) to antibodies, peptides, and small-molecule vectors that improve tumor uptake, residence time, and clearance profiles, thereby enhancing efficacy and safety. Beyond neuroendocrine tumors and prostate cancer, radiotheranostic strategies are advancing for diverse malignancies… More >

Chang He^#, An Wang^#, Youbo Wang^#, Qinyun Ma^*, Xiaofeng Chen^*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074880 - 23 March 2026

Abstract Objectives: Combined chemotherapy and photothermal therapy (PTT) represents a promising approach for enhancing cancer treatment efficacy. This study aimed to develop arsenic trioxide (ATO) and poly(cyclopentadithiophene-alt-benzothiadiazole) (PCPDTBT)-loaded nanoparticles (ATO/PCPDTBT@NPs) to evaluate their synergistic efficacy in inhibiting lung cancer growth and metastasis. Methods: Nanovesicles were synthesized via a streamlined protocol and subjected to 808 nm NIR irradiation to assess their photothermal conversion capabilities. The therapeutic efficacy was evaluated in vitro using A549 lung carcinoma cells to assess apoptosis, invasion, and migration, and in vivo to monitor tumor volume reduction. Results: The nanoparticles exhibited excellent hemocompatibility and low cytotoxicity while More >

Saad Alobid^1,#, Hussam Albassam^1,#, Tebyan O. Mirgany², Faris Almutairi¹, Mohammed Mufadhe Alanazi¹, Ahmed H. Bakheit², Hanadi H. Asiri², Eram Eltahir³, Gamaleldin I. Harisa^3,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2025.073371 - 23 March 2026

Abstract Objective: Glioblastoma (GB) therapy is challenged by tumor heterogeneity and multidrug resistance (MDR), highlighting the need for effective therapies. This study aimed to explore the combined anticancer effects of Sunitinib (SNB) and Fenofibrate (FEN) on U87 cells. Methods: U87 cells were exposed to SNB, FEN, or their combination for 24 h, followed by evaluations of cell viability, migration, and clonogenic survival using MTT, scratch, and colony formation assays. Intracellular reactive oxygen species (ROS) were quantified via the 2^′, 7^′-dichlorofluorescein assay, while mitochondrial membrane potential (MMP) was assessed using JC-1 red/green fluorescence. Molecular docking was performed to… More > Graphic Abstract

Shuwen Sun^1,2,3,4,#, Jingcheng Zhang^1,2,3,#, Zongtai Zheng^5,#, Yajuan Hao^1,3, Tianyuan Xu^1,2,3, Ji Liu^1,3, Liang Sun², Aimin Wang², Yadong Guo^1,3, Shiyu Mao^1,3, Xu Zhang⁶, Yunfei Xu^1,3,*, Yifan Chen^1,2,3,*, Yang Yan^1,2,3,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2025.072373 - 23 March 2026

Abstract Objectives: Bladder cancer (BCa) progression is closely linked to the immune microenvironment. However, the key molecules that regulate this microenvironment and their specific mechanisms remain poorly understood. This study aims to identify a key molecule and elucidate its mechanisms, providing a theoretical basis for identifying novel therapeutic targets. Methods: Immune microenvironment-related genes in BCa were identified using The Cancer Genome Atlas and Shanghai Tenth People’s Hospital datasets. Proteasome 26S subunit non-ATPase 2 (PSMD2) expression was validated via quantitative polymerase chain reaction (qPCR), Western blot (WB) analysis, and immunofluorescence (IF). In vitro and in vivo experiments confirmed the… More > Graphic Abstract

Abdallah Ghourabi^1,*, Hassen Chouaib²

CMC-Computers, Materials & Continua, Vol.87, No.1, 2026, DOI:10.32604/cmc.2026.074505 - 10 February 2026

Abstract In recent years, ransomware attacks have become one of the most common and destructive types of cyberattacks. Their impact is significant on the operations, finances and reputation of affected companies. Despite the efforts of researchers and security experts to protect information systems from these attacks, the threat persists and the proposed solutions are not able to significantly stop the spread of ransomware attacks. The latest remarkable achievements of large language models (LLMs) in NLP tasks have caught the attention of cybersecurity researchers to integrate these models into security threat detection. These models offer high embedding… More >

Kirubavathi Ganapathiyappan¹, Chahana Ravikumar¹, Raghul Alagunachimuthu Ranganayaki¹, Ayman Altameem², Ateeq Ur Rehman^3,*, Ahmad Almogren^4,*

CMC-Computers, Materials & Continua, Vol.87, No.1, 2026, DOI:10.32604/cmc.2025.072840 - 10 February 2026

Abstract Android smartphones have become an integral part of our daily lives, becoming targets for ransomware attacks. Such attacks encrypt user information and ask for payment to recover it. Conventional detection mechanisms, such as signature-based and heuristic techniques, often fail to detect new and polymorphic ransomware samples. To address this challenge, we employed various ensemble classifiers, such as Random Forest, Gradient Boosting, Bagging, and AutoML models. We aimed to showcase how AutoML can automate processes such as model selection, feature engineering, and hyperparameter optimization, to minimize manual effort while ensuring or enhancing performance compared to traditional… More >

Yang Deng^1,#, Tong Su^1,#, Bin Wu¹, Li Peng², Muyu Chen^1,2,*, Liang Zhang^1,*

International Journal of Mental Health Promotion, Vol.28, No.1, 2026, DOI:10.32604/ijmhp.2025.072327 - 28 January 2026

Abstract Background: Submarine personnel often experience insomnia and reduced psychological resilience due to extended deployments in confined, high-stress environments. Effective non-pharmacological interventions are needed to improve sleep quality and resilience in this population. This study aimed to investigate the effect of virtual reality (VR) combined with forest therapy interventions on psychological resilience and sleep quality among submarine personnel with insomnia symptoms. Methods: Using convenience sampling, 92 submarine personnel with insomnia symptoms undergoing recuperation at a PLA sanatorium between July 2023 and May 2025 were randomly allocated to experimental and control groups (n = 46 each). The control group… More >