Sha Luo¹, Shuang Wu¹, Junyan Song¹, Xuena Yu¹, Kehao Liang¹, Zhi Huang¹, Yi Tang¹, Huanxiu Li¹, Victor Hugo Escalona², Zhifeng Chen³, Fen Zhang^1,*, Bo Sun^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.2, pp. 521-538, 2025, DOI:10.32604/phyton.2025.061099 - 06 March 2025

Abstract This study conducted karyotype analysis on 56 Chinese kale varieties from Guangdong and Fujian provinces using conventional chromosome analysis methods. The varieties were categorized into four groups based on their origin and flower color: white-flower Chinese kale originating from Guangdong (GW), yellow-flower Chinese kale originating from Guangdong (GY), white-flower Chinese kale originating from Fujian (FW), and yellow-flower Chinese kale originating from Fujian (FY). Karyotype differences among the four groups of Chinese kale were analyzed, and the evolutionary relationship between yellow-flower and white-flower Chinese kale from the two regions was inferred based on karyotype parameters. The… More >

Sally Negm¹, Badwy Mohdly², Motrih Al-Mutiry³, Wael Shehata⁴, Karima Ahmed⁵, Mohamed Abou-Zeid^2,*, Rana Elessawy⁶, Ashgan Abdel-Azim⁵, Amr Abdel-Fattah², Amani Omar Abuzaid⁷, Enas A. Almanzalawi⁷, Tahani M. Alqahtani⁷, Shouaa A. Alrobaish⁸, Diaa Abd El Moneim⁹, Ahmed M. Abbas^10,11, Mohammed O. Alshaharni¹⁰, Huda Alghamdi¹⁰, Shaimaa G. Salama¹², Kairy Amer⁵

Phyton-International Journal of Experimental Botany, Vol.94, No.2, pp. 347-377, 2025, DOI:10.32604/phyton.2025.057448 - 06 March 2025

Abstract Barley (Hordeum vulgare L.) is a significant global crop that thrives in various climatic and drought-stress conditions. Furthermore, increased drought intervals and more significant weather variability resulting from climate change can affect the severity of plant diseases. Therefore, two primary objectives of integrated disease management regarding climate change are identifying cultivars resistant to foliar diseases and understanding disease progression under abiotic stress. In the current study, we assessed the quantitative foliar disease resistance of 17 commercial barley cultivars under both normal and water stress conditions over two growing seasons (from 2020/21 to 2021/22). The findings demonstrated… More >

Mian Xia^1,2, Baoguo Xie^3,4, Lijun He^5,*, Jingru Chen⁶

International Journal of Mental Health Promotion, Vol.27, No.2, pp. 231-240, 2025, DOI:10.32604/ijmhp.2025.058878 - 03 March 2025

Abstract Objectives: Recently, how family-related factors influence employees’ mental health has garnered increasing attention from researchers and practitioners. Drawing on the cognitive appraisal theory of stress, this study aims to examine how and when family financial stress affects the employees’ mental health and investigate the mediating role of performance stress and the moderating role of workplace competition. Methods: A cross-sectional survey was conducted with 23,520 Chinese employees by using a voluntary and anonymous structured questionnaire, which included family financial stress, performance stress, symptom checklist 90 (SCL-90) scale, and workplace competition. The data were analyzed using SPSS… More >

Muhammad Armghan Latif¹, Zohaib Mushtaq^2,*, Saifur Rahman³, Saad Arif⁴, Salim Nasar Faraj Mursal³, Muhammad Irfan³, Haris Aziz⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1667-1695, 2025, DOI:10.32604/cmes.2024.056850 - 27 January 2025

Abstract Ransomware attacks pose a significant threat to critical infrastructures, demanding robust detection mechanisms. This study introduces a hybrid model that combines vision transformer (ViT) and one-dimensional convolutional neural network (1DCNN) architectures to enhance ransomware detection capabilities. Addressing common challenges in ransomware detection, particularly dataset class imbalance, the synthetic minority oversampling technique (SMOTE) is employed to generate synthetic samples for minority class, thereby improving detection accuracy. The integration of ViT and 1DCNN through feature fusion enables the model to capture both global contextual and local sequential features, resulting in comprehensive ransomware classification. Tested on the UNSW-NB15 More >

Fei Li^1,2, Meili Ding¹, Hui Yuan¹, Siping Wang¹, Bin Liang^2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.1, pp. 243-250, 2025, DOI:10.32604/phyton.2025.059499 - 24 January 2025

Abstract This study investigated the effects of chlorine-based fertilizers under varying nitrogen solution concentrations in a soilless culture system. The experiment included four nitrogen solution concentration levels, with nitrogen concentrations of 6 mmol/L (C1), 12 mmol/L (C2), 18 mmol/L (C3), and 24 mmol/L (C4). Each nutrient concentration level was further divided into four chloride ion treatments (R1, R2, R3, and R4), where 100%, 60%, 33%, and 0% of the NH₄⁺ and K⁺ ions were derived from NH₄Cl and KCl, respectively. The length, surface area and volume of root were significantly higher by 25.3%~136.9%, 40.1%~173.1%, 27.9%~178.0%, respectively, in the… More >

MAGDALENA WILCZAK^1,2,#, MAGDALENA SURMAN^1,#,*, MAłGORZATA PRZYBYłO^1,*

Oncology Research, Vol.33, No.2, pp. 245-262, 2025, DOI:10.32604/or.2024.055449 - 16 January 2025

Abstract Angiogenesis, the expansion of pre-existing vascular networks, is crucial for normal organ growth and tissue repair, but is also involved in various pathologies, including inflammation, ischemia, diabetes, and cancer. In solid tumors, angiogenesis supports growth, nutrient delivery, waste removal, and metastasis. Tumors can induce angiogenesis through proangiogenic factors including VEGF, FGF-2, PDGF, angiopoietins, HGF, TNF, IL-6, SCF, tryptase, and chymase. This balance is disrupted in tumors, and extracellular vesicles (EVs) contribute to this by transferring proangiogenic factors and increasing their expression in endothelial cells (ECs). Malignant melanoma, a particular type of skin cancer, accounts for More >

JUNWEI DU, QIANG ZHANG, JING ZHANG, MAIERDANJIANG MAIHEMUTI, HAIYANG HE, RENBING JIANG^*

Oncology Research, Vol.33, No.2, pp. 357-367, 2025, DOI:10.32604/or.2024.050878 - 16 January 2025

Abstract Objectives: Melanoma is a highly aggressive and metastatic form of cancer, and the role of exosomal microRNAs (miRNAs) in its progression remains largely unexplored. This study aimed to investigate the effects of melanoma cell-derived exosomal miR-424-5p on angiogenesis and its underlying mechanisms. Methods: Exosomes were isolated from melanoma cell lines A375 and A2058, and their effects on the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells (HUVECs) were examined. The interaction between miR-424-5p and its target gene, large tumor suppressor kinase 2 (LATS2), was analyzed using luciferase reporter assays and functional experiments. In vivo,… More >

ZHENGYANG ZHOU^1,#, LEI QIAO^1,#, TONGTONG WANG¹, WEN PAN¹, JINGJING DUAN¹, HAIYANG ZHANG², TING DENG¹, YI BA^1,*, YI HE^1,*

Oncology Research, Vol.33, No.2, pp. 327-345, 2025, DOI:10.32604/or.2024.050431 - 16 January 2025

Abstract Background: Patients with gastric cancer (GC) are prone to lymph node metastasis (LNM), which is an important factor for recurrence and poor prognosis of GC. Nowadays, more and more studies have confirmed that exosomes can participate in tumor lymphangiogenesis. An in-depth exploration of the pathological mechanism in the process of LNM in GC may provide effective targets and improve the diagnosis and treatment effect. Materials and Methods: We used sequencing analysis of collected serum to screen out exo-miRNA related to LNM in GC. ELISA, qRT-PCR, Western Blot, RNA pull-down assay, Transwell assay, animal experiments, and other… More > Graphic Abstract

MERYEM A. ABDESSALEM, SIRIN A. ADHAM^*

Oncology Research, Vol.33, No.1, pp. 27-44, 2025, DOI:10.32604/or.2024.056955 - 20 December 2024

Abstract Nanotechnology in cancer therapy has significantly advanced treatment precision, effectiveness, and safety, improving patient outcomes and personalized care. Engineered smart nanoparticles and cell-based therapies are designed to target tumor cells, precisely sensing the tumor microenvironment (TME) and sparing normal cells. These nanoparticles enhance drug accumulation in tumors by solubilizing insoluble compounds or preventing their degradation, and they can also overcome therapy resistance and deliver multiple drugs simultaneously. Despite these benefits, challenges remain in patient-specific responses and regulatory approvals for cell-based or nanoparticle therapies. Cell-based drug delivery systems (DDSs) that primarily utilize the immune-recognition principle between… More > Graphic Abstract

TAO SUN^1,2, QINGHUA SONG³, HUA LIU^1,*

Oncology Research, Vol.33, No.1, pp. 133-148, 2025, DOI:10.32604/or.2024.054141 - 20 December 2024

Abstract Background: Lung cancer is a life-threatening disease that occurs worldwide, but is especially common in China. The crucial role of the tumour microenvironment (TME) in non-small cell lung cancer (NSCLC) has attracted recent attention. Cancer-associated fibroblasts (CAFs) are the main factors that contribute to the TME function, and CAF exosomes are closely linked to NSCLC. Methods: The expression levels of miR-3124-5p and Toll-interacting protein (TOLLIP) were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot detection. Fibroblasts were isolated and identified from clinical NSCLC tissues. Transmission electron microscopy and Western Blot were used to identify exosomes… More >