YUZHI LIU^1,#, EVELYNE BISCHOF^2,#, ZHIQIN CHEN¹, JIAHUAN ZHOU³, BEI ZHANG⁴, DING ZHANG⁴, YONG GAO^1,*, MING QUAN^1,*

Oncology Research, Vol.32, No.9, pp. 1429-1438, 2024, DOI:10.32604/or.2024.047309 - 23 August 2024

Abstract Objectives: Human epidermal growth factor receptor 2 (HER2)-targeted therapies have demonstrated potential benefits for metastatic colorectal cancer (mCRC) patients with HER2 amplification, but are not satisfactory in cases of HER2 mutant CRCs. Methods: Consequently, further elucidation of amplifications and somatic mutations in erythroblastic oncogene B-2 (ERBB2) is imperative. Comprehensive genomic profiling was conducted on 2454 Chinese CRC cases to evaluate genomic alterations in 733 cancer-related genes, tumor mutational burden, microsatellite instability, and programmed death ligand 1 (PD-L1) expression. Results: Among 2454 CRC patients, 85 cases (3.46%) exhibited ERBB2 amplification, and 55 cases (2.24%) carried ERBB2 mutation.… More > Graphic Abstract

Miljenko Lapaine^*

Revue Internationale de Géomatique, Vol.33, pp. 155-165, 2024, DOI:10.32604/rig.2024.052258 - 10 June 2024

Abstract The short communication discusses the interrelationships of loxodromes, isometric latitudes and the normal aspect of Mercator projection. It is shown that by applying the isometric latitude, a very simple equation of the loxodrome on the sphere is reached. The consequence of this is that the isometric latitude can be defined using the generalized longitude, and not only using the latitude, as was common until now. Generalized longitude is the longitude defined for every real number; modulo 2π of generalized and usual longitude are congruent. Since the image of the loxodrome in the plane of the… More > Graphic Abstract

Jili Chen^1,2, Hailan Wang², Xiaolan Xie^1,2,*

Computer Systems Science and Engineering, Vol.48, No.3, pp. 645-663, 2024, DOI:10.32604/csse.2023.037957 - 20 May 2024

Abstract Fuzzy C-Means (FCM) is an effective and widely used clustering algorithm, but there are still some problems. considering the number of clusters must be determined manually, the local optimal solutions is easily influenced by the random selection of initial cluster centers, and the performance of Euclid distance in complex high-dimensional data is poor. To solve the above problems, the improved FCM clustering algorithm based on density Canopy and Manifold learning (DM-FCM) is proposed. First, a density Canopy algorithm based on improved local density is proposed to automatically deter-mine the number of clusters and initial cluster… More >

Camden L. Hebson^1,*, Kyle Bliton², Amr Y. Hammouda¹, Kaitlyn Barr³, W. Hampton Gray⁴, Mohini Gunnett², Waldemar F. Carlo¹

Congenital Heart Disease, Vol.19, No.2, pp. 185-195, 2024, DOI:10.32604/chd.2024.048871 - 16 May 2024

Abstract D-transposition of the great arteries (d-TGA) is surgically repaired with the arterial switch operation (ASO) with excellent results, however short and long-term morbidities still develop including neurocognitive delay. Clinically significant central sleep apnea is uncommon in non-premature infants, but when present indicates immature autonomic control of respiration likely due to a neurologic disorder. We report the unanticipated finding of central sleep apnea in four-term neonates with d-TGA after uncomplicated ASO, with the short-term complication of delayed hospital discharge and long-term concerns regarding this early marker of brain immaturity and its hindrance to normal development. Within More >

ALEKSANDRA GORNOSTAEVA, LUDMILA BURAVKOVA, MARGARITA LOBANOVA, ELENA ANDREEVA^*

BIOCELL, Vol.48, No.5, pp. 677-692, 2024, DOI:10.32604/biocell.2024.048873 - 06 May 2024

Abstract The structural and associated molecules of the extracellular matrix (ECM) complex is an important component of the local milieu of cells, both for maintaining their functions and homeostasis. It is a dynamic structure that is finely tuned to changes in the microenvironment. One of these factors is hypoxia, which can arise in tissues due to physiological or pathological effects. As a result of the hypoxic effect, the properties of the ECM are significantly modified, stiffness increases, the balance between degradation and synthesis of structural proteins shifts, and the deposition of biologically active mediators’ changes. Hypoxia-inducible… More >

QIN LIU^1,#, CHUNYAN NIU^2,#,*, QIANG ZHANG³, SHIQIN SUN⁴, YUE CHEN², YONGQIANG SHI²

BIOCELL, Vol.48, No.5, pp. 759-769, 2024, DOI:10.32604/biocell.2024.048551 - 06 May 2024

Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is a global health concern with the acid sphingomyelinase (ASM)/ceramide (CE) pathway and the NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) inflammasome identified as pivotal players in lipid disorders and inflammation. This study explores the interaction mechanism between the ASM/CE pathway and NLRP3 in NAFLD cell models, aiming to understand the impact of amitriptyline (Ami), an ASM inhibitor, on lipid deposition and hepatocyte injury by regulating the ASM/CE-NLRP3 pathway. Methods: HepG2 and HL-7702 cells were exposed to free fatty acids (FFAs) to establish the NAFLD model. The cells… More >

Amardeep Singh¹, Hamad Ali Abosaq², Saad Arif³, Zohaib Mushtaq^4,*, Muhammad Irfan⁵, Ghulam Abbas⁶, Arshad Ali⁷, Alanoud Al Mazroa⁸

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 857-873, 2024, DOI:10.32604/cmc.2024.048036 - 25 April 2024

Abstract Data security assurance is crucial due to the increasing prevalence of cloud computing and its widespread use across different industries, especially in light of the growing number of cybersecurity threats. A major and ever-present threat is Ransomware-as-a-Service (RaaS) assaults, which enable even individuals with minimal technical knowledge to conduct ransomware operations. This study provides a new approach for RaaS attack detection which uses an ensemble of deep learning models. For this purpose, the network intrusion detection dataset “UNSW-NB15” from the Intelligent Security Group of the University of New South Wales, Australia is analyzed. In the… More >

KARAN WADHWA¹, PAYAL CHAUHAN¹, SHOBHIT KUMAR², RAKESH PAHWA^3,*, RAVINDER VERMA⁴, RAJAT GOYAL⁵, GOVIND SINGH¹, ARCHANA SHARMA⁶, NEHA RAO³, DEEPAK KAUSHIK^1,*

Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278 - 23 April 2024

Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive More > Graphic Abstract

SHAN OU^#, YUN XU^#, QINGLAN LIU, TIANWEN YANG, WEI CHEN, XIU YUAN, XIN ZUO, PENG SHI^*, JIE YAO^*

BIOCELL, Vol.48, No.3, pp. 415-429, 2024, DOI:10.32604/biocell.2024.046178 - 15 March 2024

Abstract Background: The interrelation between intestinal polyps, metabolic syndrome (MetS), and colorectal cancer (CRC) is a critical area of study. This research focuses on pinpointing potential molecular targets to understand the link between intestinal polyp formation, metabolic irregularities, and CRC progression. Methods: We examined clinical samples from patients with intestinal polyps coexisting with MetS and compared them with samples from patients with standard intestinal polyps. Transcriptome sequencing and public database analysis were employed to identify significant pathways and genes. These targets were then validated through immunohistochemistry (IHC). Following the RNA interference of key target expression, a… More > Graphic Abstract

Xiaodan Wang^1,*, Zheng Xie², Guiping Du³

International Journal of Mental Health Promotion, Vol.26, No.2, pp. 149-160, 2024, DOI:10.32604/ijmhp.2023.030755 - 08 March 2024

Abstract Research purpose: This study implemented somatosensory music therapy on patients with depressive disorders, and explored the effects of somatosensory music therapy on the degree of depression, positive and negative emotions, intuitive stress and autonomic nervous function of patients. Research method: We collected 66 patients diagnosed with depression from the Department of Psychological Medicine of Henan Provincial People’s Hospital, and divided them into a control group and an intervention group according to the random number table, with 33 people in each group. The control group received routine psychiatric treatment and nursing. On the basis of the control… More >