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  • Open Access

    REVIEW

    Overview of genetic causes of recurrent miscarriage and the diagnostic approach

    Tarek A ATIA

    BIOCELL, Vol.43, No.4, pp. 253-262, 2019, DOI:10.32604/biocell.2019.08180

    Abstract Recurring miscarriage (RM) is a frustrating reproductive complication with variable etiology. Numerous genetic defects have been known to play a crucial role in the etiology of RM. Chromosomal abnormalities are frequently detected, while other genetic defects cannot be diagnosed through routine research, such as cryptic chromosomal anomalies, single nucleotide polymorphism, single-gene defect, and gene copy number variation. Diagnostic laboratories have recently used variable advanced techniques to detect potential genetic abnormalities in couples with RM and/or in products of conception. Here we aim to summarize the known genetic causes of RM, with a focus on the More >

  • Open Access

    ARTICLE

    Some Remarks on the Method of Fundamental Solutions for Two Dimensional Elasticity

    M. R. Hematiyan1,*, M. Arezou1, N. Koochak Dezfouli1, M. Khoshroo1

    CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.2, pp. 661-686, 2019, DOI:10.32604/cmes.2019.08275

    Abstract In this paper, some remarks for more efficient analysis of two-dimensional elastostatic problems using the method of fundamental solutions are made. First, the effects of the distance between pseudo and main boundaries on the solution are investigated and by a numerical study a lower bound for the distance of each source point to the main boundary is suggested. In some cases, the resulting system of equations becomes ill-conditioned for which, the truncated singular value decomposition with a criterion based on the accuracy of the imposition of boundary conditions is used. Moreover, a procedure for normalizing More >

  • Open Access

    ABSTRACT

    Role of NFAT5 in Hypertonic Stress-Induced Atherosclerosis in Endothelium

    Pingping Ma1, Wanqian Liu1,*, Li Yang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 95-95, 2019, DOI:10.32604/mcb.2019.07363

    Abstract Globally, consumption of sodium (5.8 g per day) was far above the optimal levels (2.3 g per day). High intake of sodium was the leading dietary risk factor for deaths, which caused by cardiovascular disease [1]. Nevertheless, how high-salt intake leads to the occurrence of many cardiovascular diseases such as atherosclerosis is still not very clear. Dmitrieva has reported that elevated sodium concentration promoted thrombogenesis by activating the signal pathway of NFAT5 (nuclear factor of activated T cells 5), a transcription factor which orchestrates cellular defense against osmotic stress [2]. Inflammatory is accompanied with the… More >

  • Open Access

    ABSTRACT

    Some Aspects in Mechano-Biology of Platelet and Leukocyte in Blood Flows

    Ying Fang1, Jianhua Wu1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 5-6, 2019, DOI:10.32604/mcb.2019.05695

    Abstract For hemostasis and thrombosis, some proteins, such as Von Willebrand Factor (VWF, a multimeric plasma glycoprotein synthesized in endothelial cells and megakaryocytes and secreted to circulation or attached to endothelial cells), the metalloprotease ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13), P-selectin (one of three selectin family members with a N-terminal C-type lectin domain, an epidermal growth factor (EGF)-like module, a series of consensus repeat (CR) units, a transmembrane segment and a short cyto-plasmic domain) and β2 integrin. In adhesion and aggregation of circulating platelets towards to the sites of… More >

  • Open Access

    ARTICLE

    Study of phylogenic relationships of some wild and crop species of Iranian Crocus by ITS nuclear loci

    Farshid GOLSHANI1, Barat Ali FAKHERI1, Mahmood SOLOUKI1, Nafiseh MAHDINEZHAD1, Majid Reza KIANI FERIZ2

    BIOCELL, Vol.43, No.3, pp. 225-232, 2019, DOI:10.32604/biocell.2019.07547

    Abstract ITS (Internal Transcription Spacer of nuclear ribosomal DNA) regions method was applied to identify and study the phylogenetic relationships existing between 41 individuals of Crocus, including 8 species collected in Iran (4 crop and 8 wild individuals) and 16 species (2 crop and 27 wild individuals) already registered in GenBank (NCBI). PCR amplifications were performed using the primer designed on the nucleotide sequence of nuclear region (ITS). A total of 12 sequences were obtained and registered in NCBI database. In particular, 4 of these sequences were not already present in the scientific library. Nucleotide… More >

  • Open Access

    ARTICLE

    Trypanosoma rangeli: growth in mammalian cells in vitro and action of a repositioned drug (17-AAG) and a natural extract (Artemisia sp. essential oil)

    Ana Laura CIMADOR1,#, Emeli Luciana GALANTE1,#, Lucila Ibel MUÑOZ1,#, Patricia Silvia ROMANO2,3, Antonella Denisse LOSINNO1,2, María Cristina VANRELL1,2,3

    BIOCELL, Vol.43, No.1, pp. 13-20, 2019, DOI:10.32604/biocell.2019.07018

    Abstract Trypanosoma rangeli and T. cruzi are both parasitic unicellular species that infect humans. Unlike T. cruzi, the causative agent of Chagas disease, T. rangeli is an infective and non-pathogenic parasite for humans, but pathogenic for vectors from the Rhodnius genus. Because both species can coexist in different hosts and overlap their infective cycles but very little is known about the infection of T. rangeli in mammalian cells, we decided to characterize both the development of this parasite in cell culture and the effect of therapeutic agents with potential trypanocidal action on it. We found that T. rangeli exhibits a cycle of… More >

  • Open Access

    ABSTRACT

    Classification of Crystallographic Groups of Alloy Systems by Isomap and Modularity Methods

    Kuan-Peng Chen1,3, An-Cheng Yang1,3, Wen-Jay Lee1, Yi-Ming Tseng2, Nien-Ti Tsou2, Nan-Yow Chen1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.21, No.3, pp. 54-54, 2019, DOI:10.32604/icces.2019.05401

    Abstract Crystallographic classification of microstructure is a very important issue in material science especially numerous data were generated by experiments or Molecular Dynamic (MD) simulations. Some analysis tools were purposed, such as coordination analysis and Honeycutt-Anderson (HA) pair analysis [1], however, to analyze these huge amounts of data is still quite difficult. Sometimes, crystallography prior knowledge of their structures is also desired in the classification procedures. Not only the task is very labor intensive but also the result is susceptible to errors and is usually lack of objectivity. In this study, we developed a computational workflow… More >

  • Open Access

    ABSTRACT

    Fringe Pattern Analysis: Some Results and Discussions (III)

    Kemao Qian

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.21, No.1, pp. 4-4, 2019, DOI:10.32604/icces.2019.05557

    Abstract Fringe-based measurement techniques provide an accurate, straightforward and convenient means for optical metrology and experimental mechanics [1]. Consequently, fringe pattern analysis is an important issue. We have reported our works in this conference in 2011 [2] and 2014 [3]. In this paper, our recent developments since 2014 are introduced, as listed below:
    1. Among various fringe patterns, carrier fringe is more convenient to use but more difficult to characterize. We unified several prominent carrier fringe analysis techniques for deeper understanding. The background removal and the influence of high-order harmonics are also studied.
    2. Moving fringe analysis… More >

  • Open Access

    ARTICLE

    Equivalence of Ratio and Residual Approaches in the Homotopy Analysis Method and Some Applications in Nonlinear Science and Engineering

    Mustafa Turkyilmazoglu1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.120, No.1, pp. 63-81, 2019, DOI:10.32604/cmes.2019.06858

    Abstract A ratio approach based on the simple ratio test associated with the terms of homotopy series was proposed by the author in the previous publications. It was shown in the latter through various comparative physical models that the ratio approach of identifying the range of the convergence control parameter and also an optimal value for it in the homotopy analysis method is a promising alternative to the classically used h-level curves or to the minimizing the residual (squared) error. A mathematical analysis is targeted here to prove the equivalence of both the ratio approach and the More >

  • Open Access

    ARTICLE

    Some Topological Indices Computing Results If Archimedean Lattices L(4,6,12)

    Kang Qiong1,*, Xinting Li2

    CMC-Computers, Materials & Continua, Vol.58, No.1, pp. 121-133, 2019, DOI:10.32604/cmc.2019.03723

    Abstract The introduction of graph-theoretical structure descriptors represents an important step forward in the research of predictive models in chemistry and falls within the lines of the increasing use of mathematical and computational methods in contemporary chemistry. The basis for these models is the study of the quantitative structure-property and structure-activity relationship. In this paper, we investigate Great rhom-bitrihexagonal which is a kind of dodecagon honeycomb net-work covered by quadrangle and hexagon. Many topological indexes of Great rhom-bitrihexagonal have being investigated, such as sum-connectivity index, atom-bond connectivity index, geometric-arithmetic index, fifth, harmonic index, Randić connectivity index, More >

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