Wu Feng^1,2,*, Tengku Anita Raja Hussin¹, Xu Yang³

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071664 - 08 January 2026

Abstract This study investigates the thermo–mechanical behavior of C40 concrete and reinforced concrete subjected to elevated temperatures up to 700°C by integrating experimental testing and advanced numerical modeling. A temperature-indexed Concrete Damage Plasticity (CDP) framework incorporating bond–slip effects was developed in Abaqus to capture both global stress–strain responses and localized damage evolution. Uniaxial compression tests on thermally exposed cylinders provided residual strength data and failure observations for model calibration and validation. Results demonstrated a distinct two-stage degradation regime: moderate stiffness and strength reduction up to ~400°C, followed by sharp deterioration beyond 500°C–600°C, with residual capacity at… More >

Zezhi Wen¹, Kai Zhang¹, Shanlin Liang², Liqiong Chen^1,*, Zijian Xiong¹

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.066408 - 08 January 2026

Abstract Maintaining the structural integrity of parallel natural gas pipelines during leakage-induced jet fires remains a critical engineering challenge. Existing methods often fail to account for the complex interactions among heat transfer, material behavior, and pipeline geometry, which can lead to overly simplified and potentially unsafe assessments. To address these limitations, this study develops a multiphysics approach that integrates small-orifice leakage theory with detailed thermo-fluid-structural simulations. The proposed framework contributes to a more accurate failure analysis through three main components: (1) coupled modeling that tracks transient heat flow and stress development as fire conditions evolve; (2)… More >

Jing Shan¹, Catherine King^2,3, Harunor Rashid^3,4, Veysel Kayser^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070851 - 30 December 2025

Abstract Objectives: B-cell maturation antigen (BCMA)-targeted antibody–drug conjugates (ADCs) have emerged as promising therapies for relapsed/refractory multiple myeloma (RRMM), but the overall efficacy and safety profile is unclear. This study aimed to synthesize the available evidence on the safety and efficacy of BCMA-ADCs in development for RRMM. Methods: A systematic search was conducted using six bibliographic databases and ClinicalTrials.gov up to November 2024. Studies were eligible if they were human clinical trials or animal studies evaluating BCMA-ADCs and reported efficacy and safety outcomes. Data extraction and quality assessments were conducted using validated tools, including ROBINS-I… More >

Giacomo Iovane^1,*, Luca Traman², Michele Maffezzoli^1,3, Giuseppe Fornarini², Domenico Corradi⁴, Debora Guareschi⁴, Matteo Santoni^5,#, Sebastiano Buti^1,#

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070523 - 30 December 2025

Abstract Background: While the treatment of metastatic renal cell carcinoma (mRCC) is evolving due to immune checkpoint inhibitors (ICIs), optimal strategies for later lines of therapy have yet to be defined. The combination of lenvatinib and everolimus represents a viable option, and the present review aimed to summarize its activity, effectiveness, and safety. Methods: A systematic review of the literature was conducted using PubMed, targeting studies published between 2018 and 2025. Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen. Results:… More > Graphic Abstract

Gengan Wu^1,#, Anqi Jiang^1,#, Zihan Chen², Xinwei Su^3,4,*

Journal of Psychology in Africa, Vol.35, No.6, pp. 853-861, 2025, DOI:10.32604/jpa.2025.073822 - 30 December 2025

Abstract This study examined the role of role clarity and safety cognition in shaping mountain climbers’ participation motivation and safety behavior. The study sample comprised 454 participants (males = 58.8%, mean age = 32 years, SD = 9.31). They completed measures on five participation motivation dimensions (achievement, interest, knowledge, socialization, and health) and safety participation. The results from structural equation modelling indicated that participant motivations in achievement, health, and knowledge significantly predicted safety participation behavior, such as risk avoidance, self-protection, and mutual assistance, more so than the motivations of interest and socialization. Role clarity moderated the More >

Fan Deng^*

Journal of Psychology in Africa, Vol.35, No.6, pp. 797-805, 2025, DOI:10.32604/jpa.2025.068735 - 30 December 2025

Abstract This study investigated the relationship between customer-employee exchange (CEX) and employee work engagement (vigor, dedication, absorption), and the role of psychological safety and self-efficacy mediate that relationship. Survey data were collected from 329 Chinese hotel employees (females = 52.9%, tenure: 1–3 years = 50.5%). The results following ordinary least squares regression and the SPSS PROCESS macro indicate that higher customer-employee exchange is associated with employee vigor, dedication, and absorption. Psychological safety and self-efficacy mediate the relationship between customer-employee exchange and vigor and dedication to be stronger, while the work absorption mediating effect is not significant. More >

Mirza Murad Baig¹, Muhammad Rehan Faheem^2,*, Lal Khan^3,*, Hannan Adeel², Syed Asim Ali Shah⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 2895-2935, 2025, DOI:10.32604/cmes.2025.073172 - 23 December 2025

Abstract With growing urban areas, the climate continues to change as a result of growing populations, and hence, the demand for better emergency response systems has become more important than ever. Human Behaviour Classification (HBC) systems have started to play a vital role by analysing data from different sources to detect signs of emergencies. These systems are being used in many critical areas like healthcare, public safety, and disaster management to improve response time and to prepare ahead of time. But detecting human behaviour in such stressful conditions is not simple; it often comes with noisy… More > Graphic Abstract

Miah A. Robinson, Abdulghani M. Abdulghani, Mokhles M. Abdulghani, Khalid H. Abed^*

Journal on Artificial Intelligence, Vol.7, pp. 615-632, 2025, DOI:10.32604/jai.2025.073535 - 01 December 2025

Abstract Ensuring the safety of Artificial Intelligence (AI) is essential for providing dependable services, especially in various sectors such as the military, education, healthcare, and automotive industries. A highly effective method to boost the precision and performance of an AI agent involves multi-configuration training, followed by thorough evaluation in a specific setting to gauge performance outcomes. This research thoroughly investigates the design of three AI agents, each configured with a different number of hidden units. The first agent is equipped with 128 hidden units, the second with 256, and the third with 512, all utilizing the… More >

Yi Feng^1,#, Haoxin Yang², Guicai Liang¹, Jun Chen³, Tao Li¹, Yingjuan Wang⁴, Jilin Chang¹, Yan Li³, Meng Yang¹, Xilong Zhou¹, Zhiqiang Wang^5,*, Chunlei Ge^1,*

Oncology Research, Vol.33, No.12, pp. 3801-3836, 2025, DOI:10.32604/or.2025.067824 - 27 November 2025

Abstract Immune checkpoint inhibitor (ICI) has limited efficacy in the treatment of immune “cold” tumors. Due to insufficient T cell infiltration and heterogeneous programmed death ligand 1 (PD-L1) expression, the ORR is only 5%–8% compared with 30%–40% of “hot” tumors. This article reviews the synergistic mechanism, clinical efficacy and optimization strategy of oncolytic virus (OVs) combined with ICIs in the treatment of refractory malignant tumors. Systematic analysis of mechanistic interactions across tumor types and clinical trial data demonstrates that OVs transform the immunosuppressive microenvironment by inducing immunogenic cell death and activating innate immunity. Concurrently, ICIs enhance… More >

Lucila M. Curi^*, Maria C. Area, Maria E. Vallejos

Journal of Renewable Materials, Vol.13, No.11, pp. 2109-2137, 2025, DOI:10.32604/jrm.2025.02025-0069 - 24 November 2025

Abstract The global demand for renewable and sustainable non-petroleum-based resources is rapidly increasing. Lignocellulosic biomass is a valuable resource with broad potential for nanocellulose (NC) production. However, limited studies are available regarding the potential toxicological impact of NC. We provide an overview of the nanosafety implications associated mainly with nanofibrillated cellulose (CNF) and identify knowledge gaps. For this purpose, we present an analysis of the studies published from 2014 to 2025 in which the authors mention aspects related to toxicity in the context of packaging. We also analyze the main methods used for toxicity evaluations and… More > Graphic Abstract