KAREL H. M. VAN WELY^*

BIOCELL, Vol.46, No.6, pp. 1453-1457, 2022, DOI:10.32604/biocell.2022.018939

Abstract Transcription termination of nearly all protein-coding genes in mammals requires 3’ end processing by a multiprotein complex that will cleave and polyadenylate the messenger RNA precursor. Because a variety of enzyme complexes intervene, 3’ end processing was thought to be fundamentally complex and subject to a multitude of regulatory effects. The possibility to select just one out of several polyadenylation sites, in particular, has caused much questioning and speculation. What appear to be separate mechanisms however can be combined into a defined set of rules, allowing for a relatively simple interpretation of 3’ end processing. Ultimately, readiness of the terminal… More >

Amira Baumy¹, Abeer D. Algarni^2,*, Mahmoud Abdalla³, Walid El-Shafai^4,5, Fathi E. Abd El-Samie^3,4, Naglaa F. Soliman^2,3

CMC-Computers, Materials & Continua, Vol.71, No.2, pp. 3257-3276, 2022, DOI:10.32604/cmc.2022.021047

Abstract This paper is concerned with a vital topic in image processing: color image forgery detection. The development of computing capabilities has led to a breakthrough in hacking and forgery attacks on signal, image, and data communicated over networks. Hence, there is an urgent need for developing efficient image forgery detection algorithms. Two main types of forgery are considered in this paper: splicing and copy-move. Splicing is performed by inserting a part of an image into another image. On the other hand, copy-move forgery is performed by copying a part of the image into another position in the same image. The… More >

LIUCHENG WU^1,3,#, YI WANG^2,#, LILI DU¹, GUIQING JI¹, RUI ZHOU², ZEYI ZHAO², JUN CHEN², SHUNXING ZHU^1,*

BIOCELL, Vol.45, No.6, pp. 1501-1507, 2021, DOI:10.32604/biocell.2021.09528

Abstract Spinal muscular atrophy (SMA) is an autosomal recessive hereditary neuromuscular disease. Exon 7 and 8 of survival of motor neuron 1 (SMN1) gene or only exon 7 homology deletion leads to the failure to produce a full-length SMN gene. The copy number of SMN2 gene with high homology of SMN1 affects the degree of disease and was the target gene for targeting therapy, in which splicing silencer in intron 7 was the key to suppress the inclusion of exon 7. In this study, we projected to use CRISPR/Case 9 for the targeted editing of intronic-splicing silencer (ISS) sequence to promote… More >

Razi J. Al-Azawi¹, Nadia M. G. Al-Saidi², Hamid A. Jalab^3,*, Rabha W. Ibrahim⁴, Dumitru Baleanu^5,6,7

CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 3903-3915, 2021, DOI:10.32604/cmc.2021.020368

Abstract Over the past years, image manipulation tools have become widely accessible and easier to use, which made the issue of image tampering far more severe. As a direct result to the development of sophisticated image-editing applications, it has become near impossible to recognize tampered images with naked eyes. Thus, to overcome this issue, computer techniques and algorithms have been developed to help with the identification of tampered images. Research on detection of tampered images still carries great challenges. In the present study, we particularly focus on image splicing forgery, a type of manipulation where a region of an image is… More >

YONG LIU^1,2,#, ZHIHUA JU^1,#, QIANG JIANG¹, WENHAO LIU¹, CHUNHONG YANG¹, YARAN ZHANG¹, XIUGE WANG¹, YAPING GAO¹, XIAOCHAO WEI¹, YAN SUN¹, JINPENG WANG¹, MINGHAI HOU¹, LING YANG², JINMING HUANG^1,*

BIOCELL, Vol.45, No.1, pp. 79-87, 2021, DOI:10.32604/biocell.2021.013583

Abstract F-box and WD-40 domain protein 11 (FBXW11) is an important component of the E3 ubiquitin-ligase enzyme that plays a key role in the ubiquitin-dependent regulation of spermatogenesis. In our previous research, the mRNA expression of FBXW11 in bull sperm with high motility is significantly higher than that with low motility. In the present study, the protein expression levels of FBXW11 in bull testicular tissues with low-performance sperm quality groups were significantly higher than those in normal performance groups. The immunohistochemistry result demonstrated that FBXW11 protein was located in the periphery of Leydig cells and seminiferous tubules. Three splice variants of… More >

REN FANG^#, WEIXIONG HUANG^#, JINYAN YAO, XING LONG, JI ZHANG, SHUANGYUN ZHOU, BIAO DENG, WENZHONG TANG, ZHENYU AN^*

BIOCELL, Vol.44, No.4, pp. 737-750, 2020, DOI:10.32604/biocell.2020.012933

Abstract Annona squamosa is a multipurpose fruit tree employed in nutritional, medicinal, and industrial fields. Its fruit is significantly enriched in sugars, making it an excellent species to study sugar accumulation in fruit. However, the scarcity of genomic resources hinders genetic studies in this species. This study aimed at generating large-scale genomic resources in A. squamosa and deciphering the molecular basis of its high sugar content. Herein, we sequenced and characterized the full-length transcriptome of A. squamosa fruit using PacBio Iso-seq. In addition, we analyzed the changes in sugar content over five fruit growth and ripening stages, and we applied RNA-sequencing… More >

Jinwei Wang^1,*, Yangyang Li²

Journal of Information Hiding and Privacy Protection, Vol.1, No.2, pp. 77-86, 2019, DOI:10.32604/jihpp.2019.07186

Abstract With the rapid development of information technology, digital images have become an important medium for information transmission. However, manipulating images is becoming a common task with the powerful image editing tools and software, and people can tamper the images content without leaving any visible traces of splicing in order to gain personal goal. Images are easily spliced and distributed, and the situation will be a great threat to social security. The survey covers splicing image and its localization. The present status of splicing image localization approaches is discussed along with a recommendation for future research. More >

Jiwei Zhang¹, Yueying Li², Shaozhang Niu^1,*, Zhiyi Cao¹, Xinyi Wang¹

CMC-Computers, Materials & Continua, Vol.60, No.1, pp. 287-303, 2019, DOI:10.32604/cmc.2019.05353

Abstract With the rapid development of image editing techniques, the image splicing behavior, typically for those that involve copying a portion from one original image into another targeted image, has become one of the most prevalent challenges in our society. The existing algorithms relying on hand-crafted features can be used to detect image splicing but unfortunately lack precise location information of the tampered region. On the basis of changing the classifications of fully convolutional network (FCN), here we proposed an improved FCN that enables locating the spliced region. Specifically, we first insert the original images into the training dataset that contains… More >