Fenglan Wang^#, Zhenyuan Cai^#, Zhimei Li, Shilong Zhang, Honghui Luo, Qing Wu, Hanhan Xia, Yanhong Guo^*

Phyton-International Journal of Experimental Botany, Vol.93, No.4, pp. 819-830, 2024, DOI:10.32604/phyton.2024.049150

Abstract FLOWERING LOCUS T (FT) is an important factor for integrating flowering signals through the photoperiod pathway, which significantly promotes flowering. Most chrysanthemum varieties are short-day plants, sensitive to the photoperiod, which limits their ornamental and annual production supply. In this study, we aim to analyze the nutrients and flowering-related genes of chrysanthemums with different photoperiod types and to clone and verify the function of the flowering-related gene CmFT. We found that the formation of floral buds requires the accumulation of starch while consuming soluble sugars and the expression patterns of flowering-related genes GIGANTEA (GI), CONSTANS (CO), and FT in C.morifolium… More >

XUHUI ZHAO^1,2, XIAOMIN HUANG¹, CHUNYAN DANG², XIA WANG¹, YUJIAO QI³, HONGLING LI^2,*

Oncology Research, Vol.32, No.5, pp. 999-1009, 2024, DOI:10.32604/or.2024.046679

Abstract Background: EBV-miR-BARTs exhibit significant relevance in epithelial tumors, particularly in EBV-associated gastric and nasopharyngeal cancers. However, their specific mechanisms in the initiation and progression of gastric cancer remain insufficiently explored. Material and Methods: Initially, EBV-miRNA-BART6-5p and its target gene SMAD4 expression were assessed in EBV-associated gastric cancer tissues and cell lines. Subsequent transfection induced overexpression of EBV-miRNA-BART6-5p in AGS and MKN-45, and downregulation in EBV-positive cells (SUN-719). The subsequent evaluation aimed to observe their impact on gastric cancer cell proliferation, migration, and glycolytic processes, with the TGF-β/SMAD4 signaling pathway value clarified using a TGF-β inhibitor. Results: EBV-miRNA-BART6-5p exhibits pronounced upregulation… More >

XIAOXI WANG¹, YANFEI JIA², QIANG LI², QIANG YANG², YINGFENG LIU¹, BEIFENG WEI¹, XIANG NIU¹, YINJIE ZHANG¹, XIAODONG LUO², ZIYU ZHAO^1,*, PENG WANG^1,*

Oncology Research, Vol.32, No.5, pp. 933-941, 2024, DOI:10.32604/or.2023.042581

Abstract MicroRNA (miR)-200b-3p has been associated with many tumors, but its involvement in pituitary adenoma is unclear. This study investigated the molecular mechanism underlying miR-200b-3p regulation in pituitary adenomas to provide a theoretical basis for treatment. Bioinformatics was used to analyze pituitary adenoma-related genes and screen new targets related to RECK and miRNA. As well, the relationship between miR-200b-3p and RECK protein was verified using a double-luciferase reporter gene assay. The expression of miR-200b-3p in clinical samples was analyzed by in situ hybridization. Transfection of the miR-200b-3p inhibitor and small interfering-RECK (si-RECK) was verified by qPCR. GH3 cell viability and proliferation… More >

Fatma Nese Efil¹, Sania Qureshi^1,2,3, Nezihal Gokbulut^1,4, Kamyar Hosseini^1,3, Evren Hincal^1,4,*, Amanullah Soomro²

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 485-512, 2024, DOI:10.32604/cmes.2024.047907

Abstract The global population has been and will continue to be severely impacted by the COVID-19 epidemic. The primary objective of this research is to demonstrate the future impact of COVID-19 on those who suffer from other fatal conditions such as cancer, heart disease, and diabetes. Here, using ordinary differential equations (ODEs), two mathematical models are developed to explain the association between COVID-19 and cancer and between COVID-19 and diabetes and heart disease. After that, we highlight the stability assessments that can be applied to these models. Sensitivity analysis is used to examine how changes in certain factors impact different aspects… More >

Guogang Gao¹, Lei Xu¹, Tianpeng Huang^2,*, Xuliang Zhao¹, Lihua Huang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 305-323, 2024, DOI:10.32604/cmes.2024.047899

Abstract The Rotary Inverted Pendulum (RIP) is a widely used underactuated mechanical system in various applications such as bipedal robots and skyscraper stabilization where attitude control presents a significant challenge. Despite the implementation of various control strategies to maintain equilibrium, optimally tuning control gains to effectively mitigate uncertain nonlinearities in system dynamics remains elusive. Existing methods frequently rely on extensive experimental data or the designer’s expertise, presenting a notable drawback. This paper proposes a novel tracking control approach for RIP, utilizing a Linear Quadratic Regulator (LQR) in combination with a reduced-order observer. Initially, the RIP system is mathematically modeled using the… More >

Chengkan Xu^1,2,4, Xiaofei Wang³, Yixuan Li², Guannan Wang^2,*, He Zhang^2,4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 957-974, 2024, DOI:10.32604/cmes.2024.047327

Abstract Structural damage in heterogeneous materials typically originates from microstructures where stress concentration occurs. Therefore, evaluating the magnitude and location of localized stress distributions within microstructures under external loading is crucial. Repeating unit cells (RUCs) are commonly used to represent microstructural details and homogenize the effective response of composites. This work develops a machine learning-based micromechanics tool to accurately predict the stress distributions of extracted RUCs. The locally exact homogenization theory efficiently generates the microstructural stresses of RUCs with a wide range of parameters, including volume fraction, fiber/matrix property ratio, fiber shapes, and loading direction. Subsequently, the conditional generative adversarial network… More > Graphic Abstract

Yanmei Shi¹, Wei Yu^2,*, Yanxia Zhao^3,*, Yungang Jia⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 887-906, 2024, DOI:10.32604/cmes.2024.046140

Abstract Web application fingerprint recognition is an effective security technology designed to identify and classify web applications, thereby enhancing the detection of potential threats and attacks. Traditional fingerprint recognition methods, which rely on preannotated feature matching, face inherent limitations due to the ever-evolving nature and diverse landscape of web applications. In response to these challenges, this work proposes an innovative web application fingerprint recognition method founded on clustering techniques. The method involves extensive data collection from the Tranco List, employing adjusted feature selection built upon Wappalyzer and noise reduction through truncated SVD dimensionality reduction. The core of the methodology lies in… More >

YARA ALZGHOUL, HALA J. BANI ISSA, AHMAD K. SANAJLEH, TAQWA ALABDUH, FATIMAH RABABAH, MAHA AL-SHDAIFAT, EJLAL ABU-EL-RUB^*, FATIMAH ALMAHASNEH, RAMADA R. KHASAWNEH, AYMAN ALZU’BI, HUTHAIFA MAGABLEH

BIOCELL, Vol.48, No.4, pp. 559-569, 2024, DOI:10.32604/biocell.2024.048056

Abstract Mesenchymal stem cells (MSCs) are ideal candidates for treating many cardiovascular diseases. MSCs can modify the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities, which are essential to restore heart function. MSCs can be easily isolated from different sources, including bone marrow, adipose tissues, umbilical cord, and dental pulp. MSCs from various sources differ in their regenerative and therapeutic abilities for cardiovascular disorders. In this review, we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function. More >

LIJUAN ZHANG^1,#, QINGYIN MENG^2,#, LI ZHUANG¹, QUAN GONG¹, XIANDA HUANG³, XUEQIN LI¹, SHIJUAN LI¹, GUOQIN WANG⁴, XICAI WANG^5,*

BIOCELL, Vol.48, No.4, pp. 581-590, 2024, DOI:10.32604/biocell.2024.047260

Abstract Background: Lung adenocarcinoma is a very pervasive histological form of lung cancers, and inhibiting metastasis is crucial for effective treatment. In this investigation, we explored the functional interaction of miR-30a-5p and the putative transcription factor 2 of the homeodomain (PHTF2) in dictating the aggressiveness and metastasis of lung adenocarcinoma. Method: We collected clinical samples to evaluate the expression patterns of miR-30a-5p and PHTF2 in lung adenocarcinoma along with normal tissues. Cellular experiments including cell count kit (CCK)-8 growth assay, apoptosis analysis, migration and invasion examinations were performed to assess the aggressiveness of lung adenocarcinoma cells. Furthermore, we examined tumorigenesis and… More > Graphic Abstract

DANPING ZHU^1,#, GUANGMING LIU^1,#, KUAN FENG¹, SUYUN LI¹, DANDAN HU², SIDA YANG^3,*, PEIQING LI^1,*

BIOCELL, Vol.48, No.4, pp. 653-664, 2024, DOI:10.32604/biocell.2024.044856

Abstract Background: During Enterovirus type 71 (EV71) infection, the structural viral protein 1 (VP1) activates endoplasmic reticulum (ER) stress associated with peripheral myelin protein 22 (PMP22) accumulation and induces autophagy. However, the specific mechanism behind this process remains elusive. Methods: In this research, we used the VP1-overexpressing mouse Schwann cells (SCs) models co-transfected with a PMP22 silencing or Autocrine motility factor receptor (AMFR/gp78) overexpressing vector to explore the regulation of gp78 on PMP22 and its relationship with autophagy and apoptosis. Results: The activity of gp78 could be influenced by EV71-VP1, leading to a decrease in the ubiquitination and degradation of PMP22,… More >