Nashat Nawafleh^*, Faris M. Al-Oqla

CMC-Computers, Materials & Continua, Vol.89, No.2, 2026, DOI:10.32604/cmc.2026.087255 - 15 September 2026

Abstract In order to mimic the thermal properties of various natural fibers, this research presents a novel prediction framework that combines Fuzzy Logic (FL) with Grey Wolf Optimization (GWO). While the GWO technique ensures mathematical correctness by fine-tuning membership function parameters, this research uses a hybrid fuzzy model to outline nonlinear relationships between fiber components and thermal performance, which significantly reduces the need for extensive, trial-and-error laboratory testing. In this study, moisture, cellulose, and hemicellulose levels are predicted to be used to identify the finest natural fibers for biomaterial uses. An optimization methodology is seen by More >

Mohammad Alshinwan^1,*, Walaa Alayed^2,*, Fatma A. Hashim³, Arar Al Tawil⁴

CMC-Computers, Materials & Continua, Vol.89, No.2, 2026, DOI:10.32604/cmc.2026.086257 - 15 September 2026

Abstract The increasing trend of phishing sites is among the important threats against the Internet security, associated with monetary loss, data leakage, and identity swindle. In response to this urgent problem, this paper proposes a new phishing website detection framework based on the Modified Differential Evolution (mDE) algorithm in conjunction with state-of-the-art machine learning classifiers. The proposed mDE integrates with dynamic mutation and crossover strategies to improve the global search capability and the convergence speed, which is superior to traditional single optimization methods. We conduct experiments on two benchmark datasets: the UCI Phishing Websites dataset and… More >

Jianwei Zhang^1,2,*, Ran Shen¹, Qianqi Zhang¹, Yuanxin Li^1,*, Shengchao Chen^3,4,*, Minghao Zhao^2,3, Lubing Shi⁴, Bing Wang⁵

CMC-Computers, Materials & Continua, Vol.89, No.2, 2026, DOI:10.32604/cmc.2026.084790 - 15 September 2026

Abstract Non-equibiaxial residual stresses are prevalent in engineering components such as welding, additive manufacturing, and surface strengthening, making their accurate detection critical for ensuring structural integrity. This paper proposes a novel method capable of simultaneously identifying two principal stress components (${\sigma }_{\mathrm{x}}^{\mathrm{R}}$, ${\sigma }_{\mathrm{z}}^{\mathrm{R}}$) using only an individual instrumented indentation. First, the normalized total indentation work variation W_norm and the residual indentation ellipticity λ are extracted as sensitive features from the indentation responses through dimensional analysis. Subsequently, a finite element (FE) simulation database comprising 2400 datasets was established to train three types of neural networks: the… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.10, 2026, DOI:10.32604/or.2026.092122 - 14 September 2026

Abstract This article has no abstract. More >

Zhen Li^1,2, Xinya Yu¹, Boning Wu³, Jialin Zhang¹, Xinyu Ju¹, Yajun Wang¹, Jieli Song¹, Qiao Liu⁴, Peng Huang^4,5,*, Qi Ding^6,*, Yupeng Wu^1,7,8,*

Oncology Research, Vol.34, No.10, 2026, DOI:10.32604/or.2026.084987 - 14 September 2026

Abstract Background: Fascin actin-bundling protein 1 (FSCN1) modulates the expression of key lipogenic enzymes fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD1) in colorectal cancer (CRC), but the underlying mechanisms remain elusive. Methods: Bioinformatics analyses were performed to evaluate FSCN1 expression and its prognostic value in CRC. Intracellular lipid levels following FSCN1 knockdown were assessed by Nile Red/DAPI co-staining and triglyceride quantification, and further validated by Oil Red O staining of xenograft tumors. Expression levels of key metabolic enzymes were measured by qRT-PCR and Western blotting. RNA sequencing identified FSCN1-associated pathways, which were functionally investigated using pharmacological inhibitors. Results: FSCN1… More > Graphic Abstract

Iseult M. Browne^1,2, Monica Esteban Garcia^1,2, Alicia F. C. Okines^1,2,*

Oncology Research, Vol.34, No.10, 2026, DOI:10.32604/or.2026.082829 - 14 September 2026

Abstract Triple negative breast cancer (TNBC) is defined by the absence of oestrogen receptor, progesterone receptor, and HER2 expression, and carries a disproportionate burden of breast cancer-related mortality due to its aggressive biology and historically limited therapeutic options. The treatment landscape of metastatic TNBC has undergone a fundamental transformation over the past decade, driven by immune checkpoint inhibitors, antibody-drug conjugates (ADCs), and the identification of actionable genomic alterations. This review provides a comprehensive, clinically oriented appraisal of the current and emerging therapeutic landscape of metastatic TNBC, encompassing its molecular underpinnings and tumour microenvironment biology. We critically More >

Qingqing Liu^1,2,#, Lei Li^3,4,#, Kumar Ganesan^1,2, Yang Jiang⁵, Kewu Zeng⁶, Yue Sui^1,2, Xinyuan Guan^2,7, Rongfang He^3,*, Jianping Chen^1,2,*

Oncology Research, Vol.34, No.10, 2026, DOI:10.32604/or.2026.082536 - 14 September 2026

Abstract Objectives: Sorting nexin 9 (SNX9) participates in endocytic trafficking and has been connected to several malignancies, but its involvement in breast cancer (BC) remains incompletely resolved. This work was designed to examine whether SNX9 supports BC progression and investigate signaling and cytoskeletal processes associated with its activity. Methods: The clinical relevance of SNX9 was assessed using bioinformatics analysis of publicly available cancer databases. Lentiviral vectors were used to establish BC cell models with stable SNX9 overexpression or knockdown. Both cellular (proliferation and motility) and murine (tumor growth and metastatic colonization) experiments were implemented to functionally characterize… More >

Yawan Zi^1,#, Huilin Yu^1,#, Xiaohui Wang¹, Yuezhou Zhang¹, Shengxin Fan¹, Jiukang Li², Jian Wang³, Ke Liao^1,*, Hong Chen^1,*

Oncology Research, Vol.34, No.10, 2026, DOI:10.32604/or.2026.082400 - 14 September 2026

Abstract Background: Although epidermal growth factor receptor (EGFR)-directed tyrosine kinase inhibition produces substantial initial benefit in EGFR-mutant non-small cell lung cancer, durable disease control is frequently compromised by the emergence of drug-resistant tumor cells. We therefore examined whether loss of cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) supports the resistant phenotype by altering redox control and the cellular threshold for ferroptotic injury. Methods: The Gene Expression Omnibus (GEO) datasets GSE172002 and GSE236654 were analyzed to identify resistance-associated pathways. cGAS was depleted in parental cells and restored in resistant derivatives, followed by phenotypic, redox, mitochondrial, and signaling assessments in… More >

Fiona Tsui-Fen Cheng^1,2,#, Kung-Ju Chen^3,#, Jing-Quan Zheng^3,4,5, Hui-Wen Chiu^3,6,7, Hui-Yu Lin^2,3,8,*, Yuan-Feng Lin^3,9,*

Oncology Research, Vol.34, No.10, 2026, DOI:10.32604/or.2026.081093 - 14 September 2026

Abstract Background: Metastatic dissemination of triple-negative breast cancer (TNBC) to distant organs, such as the lungs and brain, poses a significant threat to patient survival. Nevertheless, the molecular basis driving TNBC metastasis remains largely elusive. In the present study, we elucidated the role and underlying mechanism of OTU deubiquitinase 7B (OTUD7B) in promoting TNBC metastasis. Methods: The Cancer Genome Atlas (TCGA)/K-M Plotter databases were used for determining the prognostic significance of OTUD7B in TNBC patients. Cell migration and lung colony-forming assays were performed to evaluate the metastatic potential of TNBC cells. A cycloheximide-chase assay was employed to… More > Graphic Abstract

Shangjian Li¹, Qipeng Han², Xinying Sun³, Rongrong Yu^1,*

Oncology Research, Vol.34, No.10, 2026, DOI:10.32604/or.2026.080228 - 14 September 2026

Abstract Objective: Renal cell carcinoma is a common malignancy of the urinary system. In this study, we analyzed a public clear cell renal cell carcinoma (ccRCC) dataset and identified Nephrosis 2, idiopathic, steroid-resistant (NPHS2) as a candidate gene to investigate whether epigenetic dysregulation of NPHS2 is associated with tumor microenvironment remodeling. Methods: Differential expression analysis was first performed on GSE68417 using GEO2R. In addition, clinical samples and cell-based assays were used to evaluate changes in NPHS2 expression and promoter methylation following 5′-Aza-CdR treatment. Subsequently, 786-O and A498 cells were obtained, and sunitinib-resistant 786-O/R and A498/R sublines were… More >