YARU DU^1,2,#, ZHIHUI PEI^1,3,#, SHUQIN HU⁴, CHUANWEN LIAO¹, SHUHAO LIU^1,*

Oncology Research, Vol.33, No.2, pp. 309-325, 2025, DOI:10.32604/or.2024.058273 - 16 January 2025

Abstract Objectives: KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein involved in several cellular processes, including nuclear splicing, mRNA localization, and cytoplasmic degradation. While KHSRP’s role has been studied in other cancers, its specific involvement in gastric cancer remains poorly understood. This study aims to explore KHSRP expression in gastric cancer and its potential effects on tumor progression and immune response. Methods: KHSRP expression in gastric cancer tissues and normal tissues was analyzed using data from The Cancer Genome Atlas (TCGA) database. The correlation between KHSRP expression, patient survival, and immune response was also assessed.… More >

HUNG-WEI LIN¹, PEI YU LEE¹, YU-SHIUAN CHANG¹, MAU-SUN CHANG^1,2,*

Oncology Research, Vol.33, No.2, pp. 493-503, 2025, DOI:10.32604/or.2024.053791 - 16 January 2025

Abstract Background: Rho GTPases are essential regulators for cellular movement and intracellular membrane trafficking. Their enzymatic activities fluctuate between active GTP-bound and inactive GDP-bound states regulated by GTPase activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs). Arhgap39/Vilse/Porf-2 is a newly identified GAP. The role of Arhgap39 in migration and invasion has not been addressed thoroughly. Methods: The Arhgap39 gene was knocked out by Crispr-Cas9 gene editing in mouse Hepa1-6 and Hepa-1c1c7 cells to analyze the impact of Arhgap39 depletion on migration and invasion. Results: Loss of Arhgap39 noticeably increased the migration and invasive potential. Purified Arhgap39… More >

ZHENGYANG ZHOU^1,#, LEI QIAO^1,#, TONGTONG WANG¹, WEN PAN¹, JINGJING DUAN¹, HAIYANG ZHANG², TING DENG¹, YI BA^1,*, YI HE^1,*

Oncology Research, Vol.33, No.2, pp. 327-345, 2025, DOI:10.32604/or.2024.050431 - 16 January 2025

Abstract Background: Patients with gastric cancer (GC) are prone to lymph node metastasis (LNM), which is an important factor for recurrence and poor prognosis of GC. Nowadays, more and more studies have confirmed that exosomes can participate in tumor lymphangiogenesis. An in-depth exploration of the pathological mechanism in the process of LNM in GC may provide effective targets and improve the diagnosis and treatment effect. Materials and Methods: We used sequencing analysis of collected serum to screen out exo-miRNA related to LNM in GC. ELISA, qRT-PCR, Western Blot, RNA pull-down assay, Transwell assay, animal experiments, and other… More > Graphic Abstract

CANCAN HE^1,2,*, TINGTING ZHANG³, WEI XIONG⁴, SHENGYU WANG⁵, XIN SUN⁶

Oncology Research, Vol.33, No.2, pp. 421-429, 2025, DOI:10.32604/or.2024.049757 - 16 January 2025

Abstract Background: The outcomes of pediatric patients with acute lymphoblastic leukemia (ALL) remain far less than favorable. While apigenin is an anti-cancer agent, studies on the mechanism by which it regulates ALL cell cycle progression are inadequate. Ferroptosis and AMP-activated protein kinase (AMPK) signaling are important processes for ALL patients. However, it remains unclear whether apigenin works by affecting AMPK and apoptosis. Materials and Methods: SUP-B15 and T-cell Jurkat ALL cells were treated with apigenin, and cell viability and apoptosis were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays, respectively.… More >

QI LV^1,#, GANGMIN WANG^2,#, YI HONG¹, TIANYI ZHU¹, SHUANG QIN¹, SAIFEI SUN¹, YUTING WANG¹, YAOHUA LIU¹, QING ZHANG¹, CHUNHUI MA^3,*, PEIJUN WANG^1,*

Oncology Research, Vol.33, No.2, pp. 407-420, 2025, DOI:10.32604/or.2024.047698 - 16 January 2025

Abstract Background: Sunitinib resistance is a major challenge in advanced renal cell carcinoma (RCC). Clinically, elucidating the underlying mechanisms and developing practical countermeasures for sunitinib resistance in RCC is desirable. In previous studies, we found that circAGAP1 expression was significantly upregulated in clear cell RCC (ccRCC) and was strongly associated with poor prognosis. However, the role of circAGAP1 in sunitinib resistance in ccRCC remains unclear. Methods: We used public databases for bioinformatics analysis to identify the binding targets of circAGAP1. Additionally, the effects of circAGAP1 on the proliferation, clonogenesis, apoptosis, and migration of ccRCC cells were… More > Graphic Abstract

SHUO YU, MIN WANG, XU LI, XINGJUN GUO, RENYI QIN^*

Oncology Research, Vol.33, No.2, pp. 369-380, 2025, DOI:10.32604/or.2024.046774 - 16 January 2025

Abstract Background: Circular RNAs (circRNAs) play a pivotal role in the development and advancement of various cancer types. However, the involvement of circ-PAN3 in hepatocellular carcinoma (HCC) is not well understood. To shed light on this, we conducted a comprehensive study through biochemistry, cell biology, molecular biology, and bioinformatics techniques to investigate the role of circ-PAN3 and its associated pathway in the progression of HCC. Methods: Cell Counting Kit-8 (CCK-8) assay and colony formation assay were utilized to evaluate cell proliferation; Quantitative real-time PCR (RT-qPCR) and Western blot were adopted for assessing mRNA and protein expression;… More >

HAIYING PANG^1,#, FENGBO WU^1,#, YU ZHANG¹, NAN ZHANG², CHUNTING WANG¹, QIU LI¹, GU HE^1,*, PENG ZHANG^3,*

Oncology Research, Vol.33, No.2, pp. 443-464, 2025, DOI:10.32604/or.2024.043948 - 16 January 2025

Abstract Background: EMP2 is a tumor-associated membrane protein belonging to the GAS-3/PMP22 gene family. EMP2 expression demonstrates significant tissue specificity and heterogeneity in various human tissues and tumor tissues, where it may play a role in either promoting or inhibiting tumor growth. This study aimed to investigate the expression level, biological functions, and molecular mechanisms of EMP2 in liver cancer. Methods: we analyzed the mRNA expression levels of EMPs family genes in hepatocellular carcinoma (HCC) tissues and normal liver tissues based on the TCGA database and immunohistochemical analysis of tissue microarrays. Subsequently, we constructed HCC cell… More > Graphic Abstract

Ruikun Xu¹, Jiu Li¹, Wenjie Li¹, Wei Zhang^2,*

Structural Durability & Health Monitoring, Vol.19, No.2, pp. 285-305, 2025, DOI:10.32604/sdhm.2024.057513 - 15 January 2025

Abstract This study investigates the bond performance at the interfacial region shared by Ultra-High Performance Concrete (UHPC) and steel tubes through push-out tests. This study examines how changes in steel fiber volumetric ratio and thickness of steel tube influence the bond strength characteristics. The results show that as the enhancement of the steel tube wall thickness, the ultimate bond strength at the interface improves significantly, whereas the initial bond strength exhibits only slight variations. The influence of steel fiber volumetric ratio presents a nonlinear trend, with initial bond strength decreasing at low fiber content and increasing More >

Zhao-Jun Zhang¹, Jing-Shui Zhen¹, Bo-Cheng Li¹, De-Cheng Cai¹, Yang-Yang Du¹, Wen-Wei Wang^2,*

Structural Durability & Health Monitoring, Vol.19, No.2, pp. 327-346, 2025, DOI:10.32604/sdhm.2024.054671 - 15 January 2025

Abstract To mitigate the challenges in managing the damage level of reinforced concrete (RC) pier columns subjected to cyclic reverse loading, this study conducted a series of cyclic reverse tests on RC pier columns. By analyzing the outcomes of destructive testing on various specimens and fine-tuning the results with the aid of the IMK (Ibarra Medina Krawinkler) recovery model, the energy dissipation capacity coefficient of the pier columns were able to be determined. Furthermore, utilizing the calibrated damage model parameters, the damage index for each specimen were calculated. Based on the obtained damage levels, three distinct More >

Rivky Afanda¹, Ahmad Zaki^1,2,*

Structural Durability & Health Monitoring, Vol.19, No.2, pp. 265-284, 2025, DOI:10.32604/sdhm.2024.053084 - 15 January 2025

Abstract Concrete is one of the most important elements in building construction. However, concrete used in construction is susceptible to damage due to corrosion. The influence of corrosive substances causes changes in the reinforcing steel and affects the strength of the structure. The repair method is one approach to overcome this problem. This research aims to determine the effect of grouting and jacketing repairs on corroded concrete. The concrete used has dimensions of 15 cm × 15 cm × 60 cm with planned corrosion variations of 50%, 60%, and 70%. The test objects were tested using… More >