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  • Open Access

    ARTICLE

    Performance Study of Dynamic Intake and Exhaust Façades in Hot and Dry Climates: Iraq Case Study

    S. M. Hosseinalipour*, S. Asiaei*, Ammar A. Hussain Al-Taee

    Frontiers in Heat and Mass Transfer, Vol.22, No.3, pp. 747-767, 2024, DOI:10.32604/fhmt.2024.051541

    Abstract This paper is part of a series addressing the urgent need for effective technologies to reduce energy demand and mitigate climate impact. This study focused on the implementation and development of dynamic insulation technology for a sustainable and energy-efficient future in the region, especially in Iraq. The study assessed the energy efficiency of dynamic insulation technology by analyzing three wall models (static, dynamic, and modified) during the winter season. This paper expands the analysis to include a hot, dry summer scenario, providing valuable insights into the year-round performance of dynamic walls and enabling sustainable and More >

  • Open Access

    ARTICLE

    Efficient Penetration Testing Path Planning Based on Reinforcement Learning with Episodic Memory

    Ziqiao Zhou1, Tianyang Zhou1,*, Jinghao Xu2, Junhu Zhu1

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2613-2634, 2024, DOI:10.32604/cmes.2023.028553

    Abstract Intelligent penetration testing is of great significance for the improvement of the security of information systems, and the critical issue is the planning of penetration test paths. In view of the difficulty for attackers to obtain complete network information in realistic network scenarios, Reinforcement Learning (RL) is a promising solution to discover the optimal penetration path under incomplete information about the target network. Existing RL-based methods are challenged by the sizeable discrete action space, which leads to difficulties in the convergence. Moreover, most methods still rely on experts’ knowledge. To address these issues, this paper… More >

  • Open Access

    ARTICLE

    Lysine demethylase 5B transcriptionally regulates TREM1 in human cardiac fibroblasts

    CHUNLING LIANG1,#, JING CHEN2,#, XIAOJIE CHEN1, WEI YAN3, JIE YU4,*

    BIOCELL, Vol.48, No.7, pp. 1105-1113, 2024, DOI:10.32604/biocell.2024.050509

    Abstract Background: A differential gene, triggering receptor expressed on myeloid cells 1 (TREM1), was identified in blood sequencing datasets from myocardial infarction patients and healthy controls. Myocardial fibrosis following myocardial infarction significantly contributes to cardiac dysfunction. Objectives: This study aimed to unveil the intrinsic regulatory mechanism of TREM1 in myocardial fibrosis. Methods: Mimicking pathology by angiotensin II (Ang II) treatment of human cardiac fibroblasts (HCFs), the impacts of TREM1 knockdown on its proliferation, migration, and secretion of the pro-fibrotic matrix were identified. Using the Human Transcription Factor Database (HumanTFDB) website, lysine-specific demethylase 5B (KDM5B) was found to… More >

  • Open Access

    ARTICLE

    Mesenchymal stromal cells modulate unfolded protein response and preserve β-cell mass in type 1 diabetes

    SIYUAN LIU, YUAN ZHAO, YU YU, DOU YE, QIAN WANG, ZHAOYAN WANG, ZUO LUAN*

    BIOCELL, Vol.48, No.7, pp. 1115-1126, 2024, DOI:10.32604/biocell.2024.050493

    Abstract Introduction: Transplantation of mesenchymal stromal cells (MSCs) is a promising therapy for type 1 diabetes (T1D). However, whether the infused MSCs affect the endoplasmic reticulum stress or subsequent unfolded protein response in β cells remains unclear. Methods: To investigate this, we induced early-onset T1D in non-obese diabetic mice using streptozotocin. Subsequently, T1D mice were randomly assigned to receive either MSCs or phosphate-buffered saline. We observed the in vivo homing of MSCs and assessed their effectiveness by analyzing blood glucose levels, body weight, histopathology, pancreatic protein expression, and serum levels of cytokines, proinsulin, and C-peptide. Results: Infused MSCs… More > Graphic Abstract

    Mesenchymal stromal cells modulate unfolded protein response and preserve β-cell mass in type 1 diabetes

  • Open Access

    ARTICLE

    Silvestrol alleviates glioblastoma progression through ERK pathway modulation and MANBA and NRG-1 expression

    LAN ZHOU1,#, QI ZHANG2,#, BO TIAN1,*, FENG YANG1,*

    BIOCELL, Vol.48, No.7, pp. 1081-1093, 2024, DOI:10.32604/biocell.2024.049878

    Abstract Background: Glioblastoma, a notably malignant tumor within the central nervous system, is distinguished by its aggressive behavior. Silvestrol, a robust inhibitor of the RNA helicase eukaryotic initiation factor 4A (eIF4A), has shown significant potential as an anticancer compound. Yet, the impact of silvestrol on glioblastoma, especially its molecular mechanisms, has not been fully elucidated. Methods: This investigation employed a variety of in vitro assays, such as cell counting kit-8 (CCK-8), clonogenic, 5-ethynyl-2′-deoxyuridine (EDU), wound healing, and flow cytometry, to evaluate cell cycle progression, apoptosis, cell viability, and migration. Western blot analysis was also performed to study… More >

  • Open Access

    ARTICLE

    Cholic acid mitigates osteoarthritis by inhibiting the NF-κB/PERK/SIRT1 signaling pathway

    JIAOE SHENG1, ZUMIN YI2, SANSHAN HE1, QINGCHAO WU1, XIA HUANG1, GUOQING YAN1, YUFANG DAI1,*, LINCHONG SU1,*

    BIOCELL, Vol.48, No.7, pp. 1095-1104, 2024, DOI:10.32604/biocell.2024.028421

    Abstract Introduction: Cholic acid (CA) is a natural steroid useful in treating chronic bronchitis and cholecystitis. On the other hand, its potential impact on osteoarthritis (OA) is unknown. Objective: Using an in vitro and in vivo osteoarthritis model, we sought to assess the chondroprotective properties of CA. Methods: We employed the Cell Counting Kit-8 to measure the impact of CA on chondrocyte activity to assess the toxicity of the cells. Multiple molecular biology experimental techniques were used to investigate potential signaling pathways that CA may use to prevent inflammation and give chondrocytes protection. Furthermore, how CA affects the OA… More >

  • Open Access

    ARTICLE

    The MtRGF6 Peptide Differentially Regulates Root Development and Symbiotic Nodulation of Medicago truncatula and Lotus japonicus

    Junhui Yan1, Yawen Wang1, Qiong Li1, Yu Zhou2, Xu Wang2,*, Li Luo1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1237-1248, 2024, DOI:10.32604/phyton.2024.051517

    Abstract Rhizobia induces nitrogen-fixing nodules in legumes used in agricultural production, providing a direct source of combined nitrogen to leguminous crops. Small peptides, such as CLAVATA3/EMBRYO SURROUNDING REGION peptides (CLE), are known to regulate the formation and development of nitrogen-fixing nodules in legumes. Root meristem growth factor (RGF) peptides from Medicago truncatula not only regulate root development but also modulate nodulation symbiosis with Sinorhizobium meliloti. However, the impact of RGF peptides from one leguminous species on the others remains unclear. In this study, we investigate the effects of the RGF family peptide MtRGF6p from M. truncatula on nodulation symbiosis… More >

  • Open Access

    REVIEW

    Endophytic Occupation in Nodules of Rhynchosia Plants from Semiarid Regions of Argentina

    Cinthia T. Lucero1, María de los Á. Ruíz2, Fabiola Pagliero1, Carolina Castaño1, Mariela L. Ambrosino1, Graciela S. Lorda1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1081-1099, 2024, DOI:10.32604/phyton.2024.050762

    Abstract Beneficial microbes can improve soil health by promoting soil structure, nutrient cycling, and disease suppression. In addition, a wide array of rhizospheric microbes are responsible for producing metabolically active compounds including various types of plant growth regulators. So, microbial biodiversity studies could contribute to the improvement of agricultural practices in deprived areas, such as the Pampean semiarid region. The vast majority of studies conducted on endophytic microorganisms have focused on intensive crop legume species. In contrast, little attention has been paid to microorganisms of native legumes, whose ecology is not directly affected by human action.… More >

  • Open Access

    ARTICLE

    The NAC Transcription Factor ANAC089 Modulates Seed Vigor through the ABI5-VTC2 Module in Arabidopsis thaliana

    Yuan Tian, Lulu Zhi, Ping Li*, Xiangyang Hu*

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1101-1116, 2024, DOI:10.32604/phyton.2024.050220

    Abstract Seed viability is an essential feature for genetic resource conservation as well as sustainable crop production. Long-term storage induces seed viability deterioration or seed aging, accompanied by the accumulation of toxic reactive oxygen species (ROS) to suppress seed germination. Controlled deterioration treatment (CDT) is a general approach for mimicking seed aging. The transcription factor ANAC089 was previously reported to modulate seed primary germination. In this study, we evaluated the ability of ANAC089 to control seed viability during aging. Compared with that in the wild-type line, the mutation of ANAC089 significantly increased HO, thereby reducing seed viability after… More >

  • Open Access

    ARTICLE

    A Numerical Investigation of the Effect of Boundary Conditions on Acoustic Pressure Distribution in a Sonochemical Reactor Chamber

    Ivan Sboev1,*, Tatyana Lyubimova2,3, Konstantin Rybkin3, Michael Kuchinskiy2,3

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1425-1439, 2024, DOI:10.32604/fdmp.2024.051341

    Abstract The intensification of physicochemical processes in the sonochemical reactor chamber is widely used in problems of synthesis, extraction and separation. One of the most important mechanisms at play in such processes is the acoustic cavitation due to the non-uniform distribution of acoustic pressure in the chamber. Cavitation has a strong impact on the surface degradation mechanisms. In this work, a numerical calculation of the acoustic pressure distribution inside the reactor chamber was performed using COMSOL Multiphysics. The numerical results have revealed the dependence of the structure of the acoustic pressure field on the boundary conditions More > Graphic Abstract

    A Numerical Investigation of the Effect of Boundary Conditions on Acoustic Pressure Distribution in a Sonochemical Reactor Chamber

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